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• Activity deltas table
• Regulatory interactions
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Motif ID: SPIB.p2

Z-value: 4.577

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_-_159466019	22.219	NM_054114 NM_138810 NM_152133	TAGAP	T-cell activation RhoGTPase activating protein
chr12_-_15114495	16.673	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr6_+_31554475	15.777	NM_205837	LST1	leukocyte specific transcript 1
chr6_-_32160289	15.318		GPSM3	G-protein signaling modulator 3
chrX_+_48542193	14.396		WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_+_113885145	14.210		IL1RN	interleukin 1 receptor antagonist
chr14_+_88471467	13.768	NM_003608	GPR65	G protein-coupled receptor 65
chr6_+_31553955	12.996	NM_205838 NM_205839	LST1	leukocyte specific transcript 1
chr2_+_113885137	12.811	NM_173842	IL1RN	interleukin 1 receptor antagonist
chr16_+_29674282	12.373	NM_001030288	SPN	sialophorin
chr17_+_34640030	12.209	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr17_+_34431219	12.175	NM_002984	CCL4	chemokine (C-C motif) ligand 4
chrX_+_48542159	12.038	NM_000377	WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr12_+_6898605	11.851	NM_000616 NM_001195014 NM_001195015 NM_001195016 NM_001195017	CD4	CD4 molecule
chr12_-_9760481	11.798	NM_002258	KLRB1	killer cell lectin-like receptor subfamily B, member 1
chr17_-_72709010	11.741	NM_139018	CD300LF	CD300 molecule-like family member f
chr8_-_6856678	11.330	NM_004084 NM_001042500	DEFA1 DEFA1B	defensin, alpha 1 defensin, alpha 1B
chr19_+_49838673	11.030	NM_001040031 NM_001774	CD37	CD37 molecule
chr19_+_49838700	10.715		CD37	CD37 molecule
chr7_-_38375172	10.529		TRGV7	T cell receptor gamma variable 7 (pseudogene)
chr20_-_35274557	10.228	NM_032214 NM_175077	SLA2	Src-like-adaptor 2
chr6_-_32160637	10.146		GPSM3	G-protein signaling modulator 3
chr12_-_8693391	10.054	NM_014358	CLEC4E	C-type lectin domain family 4, member E
chr19_+_49838646	10.006		CD37	CD37 molecule
chr19_+_3178735	9.920	NM_003775	S1PR4	sphingosine-1-phosphate receptor 4
chr12_+_6898705	9.789		CD4	CD4 molecule
chr8_-_6837568	9.745	NM_004084 NM_001042500	DEFA1 DEFA1B	defensin, alpha 1 defensin, alpha 1B
chr7_+_139528951	9.725	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr12_+_54891539	9.685		NCKAP1L	NCK-associated protein 1-like
chr1_-_25256364	9.631		RUNX3	runt-related transcription factor 3
chr2_+_103035148	9.469	NM_003853	IL18RAP	interleukin 18 receptor accessory protein
chr16_-_53405040	9.467	NM_001207030	LOC643802	u3 small nucleolar ribonucleoprotein protein MPP10-like
chr1_+_161676761	9.178	NM_001184866 NM_001184867 NM_001184870 NM_001184871 NM_001184872 NM_001184873 NM_032738	FCRLA	Fc receptor-like A
chr5_-_169724614	9.050		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_+_34538464	9.000	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr12_+_6898673	8.954		CD4	CD4 molecule
chr1_-_183560010	8.951	NM_001127651	NCF2	neutrophil cytosolic factor 2
chr12_+_6898699	8.777		CD4	CD4 molecule
chr19_+_49838734	8.718		CD37	CD37 molecule
chr2_-_175499275	8.600	NM_003387	WIPF1	WAS/WASL interacting protein family, member 1
chr1_-_183559669	8.572	NM_000433 NM_001190789 NM_001190794	NCF2	neutrophil cytosolic factor 2
chr12_+_54891522	8.496		NCKAP1L	NCK-associated protein 1-like
chr1_-_183559463	8.478		NCF2	neutrophil cytosolic factor 2
chr3_-_112218383	8.410	NM_001085357 NM_181780	BTLA	B and T lymphocyte associated
chr5_-_169724782	8.404		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169724734	8.395		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_54891491	8.323	NM_005337	NCKAP1L	NCK-associated protein 1-like
chr5_-_169724817	8.129	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_+_64107687	8.068	NM_032251	CCDC88B	coiled-coil domain containing 88B
chr1_-_160492982	8.039	NM_001184714 NM_001184715 NM_001184716 NM_052931	SLAMF6	SLAM family member 6
chr4_+_40198526	7.885	NM_004310	RHOH	ras homolog gene family, member H
chr5_+_35856990	7.833	NM_002185	IL7R	interleukin 7 receptor
chr16_+_29674568	7.804	NM_003123	SPN	sialophorin
chr18_-_67615088	7.789		CD226	CD226 molecule
chr17_+_76126835	7.708	NM_152468	TMC8	transmembrane channel-like 8
chr1_-_207095198	7.697	NM_001193338 NM_001142473 NM_005449	FAIM3	Fas apoptotic inhibitory molecule 3
chr12_+_10124007	7.578	NM_138337 NM_201623	CLEC12A CLEC12B	C-type lectin domain family 12, member A C-type lectin domain family 12, member B
chr4_+_68424444	7.463	NM_012108	STAP1	signal transducing adaptor family member 1
chr19_-_41859253	7.292		TGFB1	transforming growth factor, beta 1
chr1_+_112016588	7.292	NM_174896	C1orf162	chromosome 1 open reading frame 162
chr16_+_29674564	7.239		SPN	sialophorin
chr19_-_51875790	7.221	NM_005601	NKG7	natural killer cell group 7 sequence
chr16_-_30393856	7.201		SEPT1	septin 1
chr19_-_54804172	7.155	NM_001172654 NM_006865	LILRA3 LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr5_+_169064274	7.142		DOCK2	dedicator of cytokinesis 2
chrX_-_100641143	7.141	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr3_-_27763784	7.130	NM_005442	EOMES	eomesodermin
chr3_-_27764197	7.080		EOMES	eomesodermin
chr2_+_204801453	7.064	NM_012092	ICOS	inducible T-cell co-stimulator
chrX_-_70331297	7.049	NM_000206	IL2RG	interleukin 2 receptor, gamma
chr9_+_273025	7.005	NM_001190458 NM_001193536	DOCK8	dedicator of cytokinesis 8
chr17_-_43487747	6.942		ARHGAP27	Rho GTPase activating protein 27
chr12_+_47610244	6.902		FAM113B	family with sequence similarity 113, member B
chr16_+_30194925	6.877		CORO1A	coronin, actin binding protein, 1A
chr6_+_31582978	6.867	NM_004847 NM_001623	AIF1	allograft inflammatory factor 1
chr1_+_209929378	6.813	NM_025228	TRAF3IP3	TRAF3 interacting protein 3
chr15_+_77287738	6.810		PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr9_+_120466453	6.798	NM_138554	TLR4	toll-like receptor 4
chr15_+_77287428	6.798	NM_003978	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr19_-_36233311	6.709	NM_024660	IGFLR1	IGF-like family receptor 1
chr11_-_67205151	6.702	NM_005608	PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein
chr16_+_28505920	6.688	NM_018690	APOBR	apolipoprotein B receptor
chr13_+_108921976	6.675	NM_001145645 NM_006573	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr11_-_58980321	6.604	NM_001039396	MPEG1	macrophage expressed 1
chr12_-_96390002	6.556	NM_002108	HAL	histidine ammonia-lyase
chr22_+_23222897	6.553		CYAT1	immunoglobulin lambda light chain-like
chr6_-_24936177	6.467		FAM65B	family with sequence similarity 65, member B
chr1_-_162381805	6.440	NM_053282	SH2D1B	SH2 domain containing 1B
chr5_+_57787260	6.417	NM_152687	GAPT	GRB2-binding adaptor protein, transmembrane
chr15_+_77287688	6.388		PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr13_+_108922474	6.309		TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr8_-_133772808	6.245	NM_001145153 NM_144649	TMEM71	transmembrane protein 71
chr17_+_47288068	6.200		ABI3	ABI family, member 3
chr5_-_176936542	6.190
chr5_-_149465989	6.176		CSF1R	colony stimulating factor 1 receptor
chrX_+_37639306	6.171		CYBB	cytochrome b-245, beta polypeptide
chr6_+_116782555	6.140	NM_001010919	FAM26F	family with sequence similarity 26, member F
chrX_-_47489243	6.121	NM_001145252	CFP	complement factor properdin
chr12_+_8666135	6.109	NM_080387	CLEC4D	C-type lectin domain family 4, member D
chr4_-_123377471	6.082	NM_000586	IL2	interleukin 2
chr19_-_18508407	6.074	NM_145256	LRRC25	leucine rich repeat containing 25
chr12_+_7060554	6.072		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr16_-_30394133	6.071	NM_052838	SEPT1	septin 1
chr16_+_30484049	6.069		ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr1_-_153518265	5.969	NM_002961 NM_019554	S100A4	S100 calcium binding protein A4
chr12_+_7060517	5.960		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr15_+_81589240	5.953	NM_004513	IL16	interleukin 16
chr2_+_233925035	5.950	NM_001017915 NM_005541	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr2_+_233925104	5.946		INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr5_-_176936857	5.929	NM_024872	DOK3	docking protein 3
chr8_-_134087255	5.882		SLA	Src-like-adaptor
chr17_-_29648631	5.881	NM_001003927 NM_014210	EVI2A	ecotropic viral integration site 2A
chr12_+_7060538	5.880		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr16_+_28943259	5.827	NM_001178098 NM_001770	CD19	CD19 molecule
chr12_+_7060433	5.825	NM_002831 NM_080549	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr11_+_122709205	5.806	NM_019604	CRTAM	cytotoxic and regulatory T cell molecule
chr12_+_7060543	5.781		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chrX_+_37639246	5.776	NM_000397	CYBB	cytochrome b-245, beta polypeptide
chr5_-_176936834	5.772		DOK3	docking protein 3
chr16_+_30483959	5.767	NM_001114380 NM_002209	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr5_-_149466110	5.753		CSF1R	colony stimulating factor 1 receptor
chr12_+_7060531	5.751		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060473	5.715		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr10_-_98480174	5.700	NM_152309	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1
chr19_-_54692132	5.677		MBOAT7	membrane bound O-acyltransferase domain containing 7
chr5_-_149466126	5.665		CSF1R	colony stimulating factor 1 receptor
chr16_-_3306586	5.657	NM_000243 NM_001198536	MEFV	Mediterranean fever
chr12_-_89745997	5.562		DUSP6	dual specificity phosphatase 6
chr5_+_96211643	5.558	NM_001130140 NM_022350	ERAP2	endoplasmic reticulum aminopeptidase 2
chr7_+_128580725	5.518	NM_001098627	IRF5	interferon regulatory factor 5
chr17_+_7239847	5.506	NM_014716	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr17_+_40439564	5.489	NM_003152	STAT5A	signal transducer and activator of transcription 5A
chr9_+_135854097	5.480	NM_001135031 NM_004188	GFI1B	growth factor independent 1B transcription repressor
chr3_-_150920946	5.474	NM_013308	GPR171	G protein-coupled receptor 171
chr12_-_57871631	5.472	NM_001080156	ARHGAP9	Rho GTPase activating protein 9
chr4_-_164534656	5.455	NM_017923	MARCH1	membrane-associated ring finger (C3HC4) 1
chr13_+_108922205	5.451		TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr9_+_120466607	5.387		TLR4	toll-like receptor 4
chr8_-_101734290	5.378		PABPC1	poly(A) binding protein, cytoplasmic 1
chr19_+_14693895	5.341	NM_001204118 NM_207390	CLEC17A	C-type lectin domain family 17, member A
chr16_-_50715116	5.337		SNX20	sorting nexin 20
chr2_-_198175324	5.335		ANKRD44	ankyrin repeat domain 44
chr12_+_47610051	5.334	NM_138371	FAM113B	family with sequence similarity 113, member B
chr12_-_89746244	5.320	NM_001946 NM_022652	DUSP6	dual specificity phosphatase 6
chr19_-_41859519	5.302		TGFB1	transforming growth factor, beta 1
chr16_-_50715240	5.264	NM_001144972 NM_153337 NM_182854	SNX20	sorting nexin 20
chr12_+_56732658	5.231	NM_016584	IL23A	interleukin 23, alpha subunit p19
chr17_-_18950238	5.211	NM_006613	GRAP	GRB2-related adaptor protein
chr12_+_25205180	5.205	NM_001204126 NM_001204127 NM_006152	LRMP	lymphoid-restricted membrane protein
chr3_-_121379757	5.198	NM_005335	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr6_+_31543340	5.195	NM_000594	TNF	tumor necrosis factor
chr9_+_120466625	5.190		TLR4	toll-like receptor 4
chr5_+_133451297	5.187	NM_001134851 NM_201632 NM_201634 NM_213648	TCF7	transcription factor 7 (T-cell specific, HMG-box)
chr19_-_6481765	5.165	NM_024898	DENND1C	DENN/MADD domain containing 1C
chr12_-_89746238	5.160		DUSP6	dual specificity phosphatase 6
chr10_-_72362513	5.145	NM_001083116 NM_005041	PRF1	perforin 1 (pore forming protein)
chr12_-_54694647	5.139		NFE2	nuclear factor (erythroid-derived 2), 45kDa
chr22_+_23029175	5.131		IGLV3-25	immunoglobulin lambda variable 3-25
chr6_-_41254392	5.100	NM_001242589 NM_001242590 NM_018643	TREM1	triggering receptor expressed on myeloid cells 1
chr19_+_42082530	5.097	NM_001098506 NM_033543	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21
chr2_-_198175494	5.081	NM_001195144 NM_153697	ANKRD44	ankyrin repeat domain 44
chr5_-_149466173	5.071		CSF1R	colony stimulating factor 1 receptor
chr6_+_106534188	5.060	NM_001198	PRDM1	PR domain containing 1, with ZNF domain
chr14_-_35344852	5.010	NM_013448 NM_182648	BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr12_-_6745087	5.007	NM_020400	LPAR5	lysophosphatidic acid receptor 5
chr7_+_150148078	5.006		GIMAP8	GTPase, IMAP family member 8
chr16_+_30484108	4.999
chr19_-_54726927	4.993	NM_001081450 NM_006864	LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr3_-_121379701	4.992		HCLS1	hematopoietic cell-specific Lyn substrate 1
chr10_+_26727282	4.959		APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr7_+_143079354	4.945		ZYX	zyxin
chr7_+_150147882	4.943		GIMAP8	GTPase, IMAP family member 8
chr6_+_36973409	4.927	NM_173558	FGD2	FYVE, RhoGEF and PH domain containing 2
chr21_+_30517897	4.907		C21orf7	chromosome 21 open reading frame 7
chr17_-_29641094	4.850	NM_006495	EVI2B	ecotropic viral integration site 2B
chr8_-_101734313	4.849	NM_002568	PABPC1	poly(A) binding protein, cytoplasmic 1
chr2_-_161130151	4.827		RBMS1	RNA binding motif, single stranded interacting protein 1
chr10_-_72362441	4.817		PRF1	perforin 1 (pore forming protein)
chr8_+_11351509	4.815	NM_001715	BLK	B lymphoid tyrosine kinase
chr10_+_26727262	4.810	NM_019043	APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr14_-_23588819	4.778	NM_001805	CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon
chr17_-_7017558	4.761	NM_080914	ASGR2	asialoglycoprotein receptor 2
chr4_-_25864430	4.756	NM_015187	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_-_58343308	4.754	NM_004811	LPXN	leupaxin
chr19_+_36393381	4.734	NM_001007469 NM_014266	HCST	hematopoietic cell signal transducer
chr13_+_108922560	4.719		TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr7_+_106505876	4.719	NM_002649	PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr11_-_33890931	4.690		LMO2	LIM domain only 2 (rhombotin-like 1)
chrX_+_109246338	4.684	NM_032227	TMEM164	transmembrane protein 164
chr2_+_102508333	4.679		MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr19_-_41859332	4.667		TGFB1	transforming growth factor, beta 1
chr1_-_25291474	4.661	NM_001031680	RUNX3	runt-related transcription factor 3
chr8_-_101734162	4.660		PABPC1	poly(A) binding protein, cytoplasmic 1
chr19_-_14887623	4.623		EMR2	egf-like module containing, mucin-like, hormone receptor-like 2
chr7_+_99971132	4.614		PILRA	paired immunoglobin-like type 2 receptor alpha
chr7_+_99971067	4.586	NM_013439 NM_178272 NM_178273	PILRA	paired immunoglobin-like type 2 receptor alpha
chr17_-_29641068	4.568		EVI2B	ecotropic viral integration site 2B
chrX_-_129244652	4.542	NM_001127197	ELF4	E74-like factor 4 (ets domain transcription factor)
chr12_-_57873364	4.542	NM_001080157	ARHGAP9	Rho GTPase activating protein 9
chr19_-_41859830	4.527	NM_000660	TGFB1	transforming growth factor, beta 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
4.01	1.37e-80	GO:0002376	immune system process
4.32	7.91e-55	GO:0006955	immune response
4.39	2.43e-52	GO:0002682	regulation of immune system process
5.03	2.88e-44	GO:0050776	regulation of immune response
4.85	1.87e-40	GO:0002684	positive regulation of immune system process
1.65	1.34e-38	GO:0050896	response to stimulus
2.02	7.45e-38	GO:0007165	signal transduction
2.51	1.41e-37	GO:0048583	regulation of response to stimulus
3.52	5.56e-37	GO:0006952	defense response
6.12	1.10e-36	GO:0050865	regulation of cell activation
6.12	4.13e-35	GO:0002694	regulation of leukocyte activation
6.85	6.28e-34	GO:0050867	positive regulation of cell activation
4.18	1.05e-32	GO:0001775	cell activation
6.19	2.01e-32	GO:0051249	regulation of lymphocyte activation
6.75	2.24e-32	GO:0002696	positive regulation of leukocyte activation
1.87	9.65e-32	GO:0023052	signaling
5.74	4.87e-31	GO:0045321	leukocyte activation
6.78	2.64e-30	GO:0051251	positive regulation of lymphocyte activation
1.78	2.20e-29	GO:0051716	cellular response to stimulus
6.22	6.23e-29	GO:0046649	lymphocyte activation
2.34	9.93e-29	GO:0007166	cell surface receptor linked signaling pathway
6.36	5.92e-27	GO:0050863	regulation of T cell activation
2.07	8.26e-27	GO:0006950	response to stress
1.46	1.70e-26	GO:0050789	regulation of biological process
1.43	5.57e-26	GO:0065007	biological regulation
6.89	3.72e-25	GO:0050870	positive regulation of T cell activation
2.92	4.51e-25	GO:0009611	response to wounding
7.44	1.37e-24	GO:0042110	T cell activation
4.59	7.39e-23	GO:0050778	positive regulation of immune response
2.90	1.27e-21	GO:0048584	positive regulation of response to stimulus
1.44	2.79e-21	GO:0050794	regulation of cellular process
7.70	4.42e-21	GO:0050851	antigen receptor-mediated signaling pathway
1.88	6.21e-21	GO:0048518	positive regulation of biological process
7.18	6.37e-21	GO:0002768	immune response-regulating cell surface receptor signaling pathway
7.28	1.33e-20	GO:0002429	immune response-activating cell surface receptor signaling pathway
5.39	4.17e-20	GO:0002764	immune response-regulating signaling pathway
5.40	1.01e-19	GO:0002757	immune response-activating signal transduction
5.77	3.08e-19	GO:0002697	regulation of immune effector process
4.60	1.43e-17	GO:0002253	activation of immune response
1.85	3.80e-17	GO:0048522	positive regulation of cellular process
8.51	2.05e-16	GO:0031294	lymphocyte costimulation
8.51	2.05e-16	GO:0031295	T cell costimulation
3.63	1.51e-14	GO:0031347	regulation of defense response
3.02	5.82e-14	GO:0007596	blood coagulation
3.02	5.82e-14	GO:0050817	coagulation
3.00	8.43e-14	GO:0007599	hemostasis
3.35	1.19e-13	GO:0045087	innate immune response
3.76	3.74e-13	GO:0001817	regulation of cytokine production
2.75	6.80e-13	GO:0042060	wound healing
6.79	1.02e-12	GO:0002699	positive regulation of immune effector process
3.61	1.97e-12	GO:0006954	inflammatory response
7.42	4.20e-12	GO:0045619	regulation of lymphocyte differentiation
2.70	1.01e-11	GO:0050878	regulation of body fluid levels
5.02	1.47e-11	GO:0002521	leukocyte differentiation
7.82	1.65e-11	GO:0045580	regulation of T cell differentiation
4.59	1.84e-11	GO:0050900	leukocyte migration
6.28	9.91e-11	GO:0050852	T cell receptor signaling pathway
2.72	9.96e-11	GO:0080134	regulation of response to stress
5.56	1.01e-10	GO:0030098	lymphocyte differentiation
3.49	1.10e-10	GO:0048534	hemopoietic or lymphoid organ development
1.95	1.55e-10	GO:0009966	regulation of signal transduction
1.99	2.59e-10	GO:0051239	regulation of multicellular organismal process
6.91	3.55e-10	GO:0050864	regulation of B cell activation
5.28	4.21e-10	GO:0050670	regulation of lymphocyte proliferation
8.14	4.89e-10	GO:0045621	positive regulation of lymphocyte differentiation
3.30	5.03e-10	GO:0002520	immune system development
5.23	5.54e-10	GO:0032944	regulation of mononuclear cell proliferation
1.85	5.63e-10	GO:0023051	regulation of signaling
3.57	5.81e-10	GO:0030097	hemopoiesis
6.69	7.77e-10	GO:0030217	T cell differentiation
8.48	8.80e-10	GO:0045582	positive regulation of T cell differentiation
5.08	1.23e-09	GO:0070663	regulation of leukocyte proliferation
2.08	1.25e-09	GO:0043067	regulation of programmed cell death
2.08	1.76e-09	GO:0042981	regulation of apoptosis
2.55	2.19e-09	GO:0006928	cellular component movement
6.28	3.36e-09	GO:0002703	regulation of leukocyte mediated immunity
2.05	3.37e-09	GO:0010941	regulation of cell death
4.01	6.63e-09	GO:0031349	positive regulation of defense response
2.79	7.40e-09	GO:0051707	response to other organism
2.16	9.36e-09	GO:0040011	locomotion
5.63	1.40e-08	GO:0042035	regulation of cytokine biosynthetic process
2.12	1.56e-08	GO:0051704	multi-organism process
2.54	3.16e-08	GO:0009607	response to biotic stimulus
6.63	3.84e-08	GO:0006968	cellular defense response
11.90	4.10e-08	GO:0050853	B cell receptor signaling pathway
7.94	6.37e-08	GO:0046634	regulation of alpha-beta T cell activation
6.40	8.02e-08	GO:0002706	regulation of lymphocyte mediated immunity
3.98	1.49e-07	GO:0002252	immune effector process
1.16	1.51e-07	GO:0009987	cellular process
1.83	1.98e-07	GO:0035556	intracellular signal transduction
7.36	2.54e-07	GO:0050871	positive regulation of B cell activation
5.42	2.58e-07	GO:0050671	positive regulation of lymphocyte proliferation
5.35	3.42e-07	GO:0032946	positive regulation of mononuclear cell proliferation
5.28	4.52e-07	GO:0070665	positive regulation of leukocyte proliferation
2.43	5.25e-07	GO:0009967	positive regulation of signal transduction
3.17	9.87e-07	GO:0030168	platelet activation
8.00	1.00e-06	GO:0032663	regulation of interleukin-2 production
10.91	1.12e-06	GO:0045076	regulation of interleukin-2 biosynthetic process
2.11	1.14e-06	GO:2000026	regulation of multicellular organismal development
2.38	1.23e-06	GO:0006935	chemotaxis
2.38	1.23e-06	GO:0042330	taxis
5.01	1.31e-06	GO:0043900	regulation of multi-organism process
1.56	1.67e-06	GO:0048519	negative regulation of biological process
4.27	2.78e-06	GO:0050727	regulation of inflammatory response
2.32	3.31e-06	GO:0010647	positive regulation of cell communication
6.28	3.91e-06	GO:0050729	positive regulation of inflammatory response
2.31	4.20e-06	GO:0023056	positive regulation of signaling
5.19	4.53e-06	GO:0042129	regulation of T cell proliferation
5.47	4.73e-06	GO:0060333	interferon-gamma-mediated signaling pathway
1.56	4.98e-06	GO:0042221	response to chemical stimulus
2.32	5.01e-06	GO:0008284	positive regulation of cell proliferation
7.90	5.09e-06	GO:0046635	positive regulation of alpha-beta T cell activation
6.16	5.52e-06	GO:0042102	positive regulation of T cell proliferation
2.33	5.96e-06	GO:0043065	positive regulation of apoptosis
1.90	6.12e-06	GO:0009605	response to external stimulus
5.72	6.21e-06	GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.31	7.58e-06	GO:0043068	positive regulation of programmed cell death
5.62	8.42e-06	GO:0002819	regulation of adaptive immune response
8.38	9.53e-06	GO:0046637	regulation of alpha-beta T cell differentiation
4.32	1.08e-05	GO:0032103	positive regulation of response to external stimulus
2.73	1.14e-05	GO:0034097	response to cytokine stimulus
4.45	1.38e-05	GO:0001818	negative regulation of cytokine production
2.27	1.42e-05	GO:0010942	positive regulation of cell death
5.80	1.47e-05	GO:0042108	positive regulation of cytokine biosynthetic process
2.63	1.50e-05	GO:0045597	positive regulation of cell differentiation
9.01	1.64e-05	GO:0002712	regulation of B cell mediated immunity
9.01	1.64e-05	GO:0002889	regulation of immunoglobulin mediated immune response
6.15	1.79e-05	GO:0002700	regulation of production of molecular mediator of immune response
6.15	1.79e-05	GO:0032649	regulation of interferon-gamma production
1.84	1.93e-05	GO:0010646	regulation of cell communication
3.05	2.38e-05	GO:0071345	cellular response to cytokine stimulus
4.99	2.41e-05	GO:0071346	cellular response to interferon-gamma
4.49	2.69e-05	GO:0050730	regulation of peptidyl-tyrosine phosphorylation
8.64	2.89e-05	GO:0002637	regulation of immunoglobulin production
5.17	3.47e-05	GO:0002831	regulation of response to biotic stimulus
2.84	3.55e-05	GO:0009617	response to bacterium
3.63	4.43e-05	GO:0001819	positive regulation of cytokine production
1.53	4.93e-05	GO:0048523	negative regulation of cellular process
1.88	5.22e-05	GO:0050793	regulation of developmental process
2.84	5.41e-05	GO:0051241	negative regulation of multicellular organismal process
5.01	5.85e-05	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
12.57	6.16e-05	GO:0032673	regulation of interleukin-4 production
1.85	6.28e-05	GO:0042127	regulation of cell proliferation
4.71	6.40e-05	GO:0042113	B cell activation
10.60	6.47e-05	GO:0043029	T cell homeostasis
2.31	7.83e-05	GO:0051094	positive regulation of developmental process
3.07	9.27e-05	GO:0019221	cytokine-mediated signaling pathway
6.45	9.44e-05	GO:0030888	regulation of B cell proliferation
2.85	1.25e-04	GO:0032101	regulation of response to external stimulus
9.98	1.31e-04	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation
9.98	1.31e-04	GO:2000514	regulation of CD4-positive, alpha-beta T cell activation
8.57	1.50e-04	GO:0046638	positive regulation of alpha-beta T cell differentiation
11.60	1.53e-04	GO:0045086	positive regulation of interleukin-2 biosynthetic process
1.73	1.61e-04	GO:0031325	positive regulation of cellular metabolic process
1.51	1.65e-04	GO:0065008	regulation of biological quality
2.37	1.69e-04	GO:0010627	regulation of intracellular protein kinase cascade
4.94	1.83e-04	GO:0050866	negative regulation of cell activation
2.00	1.85e-04	GO:0045595	regulation of cell differentiation
1.70	1.99e-04	GO:0009893	positive regulation of metabolic process
5.50	2.80e-04	GO:0002263	cell activation involved in immune response
5.50	2.80e-04	GO:0002366	leukocyte activation involved in immune response
1.72	2.96e-04	GO:0010604	positive regulation of macromolecule metabolic process
5.05	3.46e-04	GO:0002695	negative regulation of leukocyte activation
4.24	3.67e-04	GO:0034341	response to interferon-gamma
5.39	3.73e-04	GO:0050688	regulation of defense response to virus
5.39	3.73e-04	GO:0051250	negative regulation of lymphocyte activation
2.28	3.74e-04	GO:0016477	cell migration
3.58	4.07e-04	GO:0042742	defense response to bacterium
7.85	4.13e-04	GO:0002260	lymphocyte homeostasis
5.70	4.98e-04	GO:0030595	leukocyte chemotaxis
1.85	5.91e-04	GO:0031328	positive regulation of cellular biosynthetic process
2.44	6.26e-04	GO:0051098	regulation of binding
7.54	6.56e-04	GO:0001776	leukocyte homeostasis
3.06	7.95e-04	GO:0001934	positive regulation of protein phosphorylation
5.95	8.62e-04	GO:0002705	positive regulation of leukocyte mediated immunity
5.95	8.62e-04	GO:0002708	positive regulation of lymphocyte mediated immunity
1.81	1.15e-03	GO:0009891	positive regulation of biosynthetic process
1.88	1.16e-03	GO:0010557	positive regulation of macromolecule biosynthetic process
6.98	1.54e-03	GO:0007159	leukocyte cell-cell adhesion
2.52	1.59e-03	GO:0010740	positive regulation of intracellular protein kinase cascade
3.69	1.67e-03	GO:0002683	negative regulation of immune system process
4.80	1.78e-03	GO:0060326	cell chemotaxis
11.00	1.79e-03	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation
11.00	1.79e-03	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation
1.87	1.85e-03	GO:0006468	protein phosphorylation
4.01	1.93e-03	GO:0048872	homeostasis of number of cells
2.33	2.02e-03	GO:0051240	positive regulation of multicellular organismal process
2.90	2.36e-03	GO:0045088	regulation of innate immune response
8.87	2.38e-03	GO:0032660	regulation of interleukin-17 production
8.87	2.38e-03	GO:0045058	T cell selection
3.14	2.39e-03	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade
2.12	2.39e-03	GO:0048870	cell motility
2.12	2.39e-03	GO:0051674	localization of cell
2.17	2.97e-03	GO:0007243	intracellular protein kinase cascade
2.17	2.97e-03	GO:0023014	signal transduction via phosphorylation event
2.34	3.33e-03	GO:0051050	positive regulation of transport
8.38	4.09e-03	GO:0032653	regulation of interleukin-10 production
2.96	4.29e-03	GO:0009615	response to virus
2.80	4.63e-03	GO:0042327	positive regulation of phosphorylation
2.75	6.41e-03	GO:0010562	positive regulation of phosphorus metabolic process
2.75	6.41e-03	GO:0045937	positive regulation of phosphate metabolic process
5.03	6.49e-03	GO:0002274	myeloid leukocyte activation
6.08	6.65e-03	GO:0031341	regulation of cell killing
3.14	7.00e-03	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
9.42	7.05e-03	GO:0002286	T cell activation involved in immune response
9.42	7.05e-03	GO:0046640	regulation of alpha-beta T cell proliferation
1.59	9.63e-03	GO:0010033	response to organic substance
7.54	1.07e-02	GO:0046631	alpha-beta T cell activation
8.80	1.26e-02	GO:0033003	regulation of mast cell activation
3.68	1.32e-02	GO:0045637	regulation of myeloid cell differentiation
3.12	1.37e-02	GO:0045089	positive regulation of innate immune response
2.92	1.41e-02	GO:0002237	response to molecule of bacterial origin
2.12	1.45e-02	GO:0032270	positive regulation of cellular protein metabolic process
6.28	1.56e-02	GO:0032729	positive regulation of interferon-gamma production
6.28	1.56e-02	GO:0050690	regulation of defense response to virus by virus
3.82	1.58e-02	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.11	1.78e-02	GO:0007264	small GTPase mediated signal transduction
3.77	1.88e-02	GO:0002576	platelet degranulation
18.85	1.94e-02	GO:0030656	regulation of vitamin metabolic process
18.85	1.94e-02	GO:0045589	regulation of regulatory T cell differentiation
18.85	1.94e-02	GO:0060556	regulation of vitamin D biosynthetic process
4.94	2.05e-02	GO:0045639	positive regulation of myeloid cell differentiation
4.52	2.14e-02	GO:0001816	cytokine production
6.06	2.19e-02	GO:0001910	regulation of leukocyte mediated cytotoxicity
6.06	2.19e-02	GO:0030890	positive regulation of B cell proliferation
3.72	2.23e-02	GO:0002250	adaptive immune response
1.78	2.40e-02	GO:0006915	apoptosis
6.85	2.47e-02	GO:0050848	regulation of calcium-mediated signaling
3.51	2.51e-02	GO:0030099	myeloid cell differentiation
1.76	2.90e-02	GO:0051049	regulation of transport
2.87	3.04e-02	GO:0051099	positive regulation of binding
1.70	3.38e-02	GO:0016310	phosphorylation
7.76	3.47e-02	GO:0030101	natural killer cell activation
7.76	3.47e-02	GO:0046006	regulation of activated T cell proliferation
2.09	3.63e-02	GO:0051056	regulation of small GTPase mediated signal transduction
2.92	3.67e-02	GO:0032496	response to lipopolysaccharide
3.77	3.76e-02	GO:0051092	positive regulation of NF-kappaB transcription factor activity
9.42	3.79e-02	GO:0045191	regulation of isotype switching
9.42	3.79e-02	GO:0045577	regulation of B cell differentiation
1.75	3.83e-02	GO:0012501	programmed cell death
5.66	4.12e-02	GO:0032945	negative regulation of mononuclear cell proliferation
5.66	4.12e-02	GO:0050672	negative regulation of lymphocyte proliferation
2.39	4.32e-02	GO:0006897	endocytosis
2.39	4.32e-02	GO:0010324	membrane invagination
2.03	4.41e-02	GO:0051247	positive regulation of protein metabolic process
1.62	4.43e-02	GO:0006793	phosphorus metabolic process
1.62	4.43e-02	GO:0006796	phosphate metabolic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.58	4.10e-18	GO:0071944	cell periphery
1.57	2.36e-17	GO:0005886	plasma membrane
1.30	1.28e-12	GO:0016020	membrane
4.78	1.32e-12	GO:0009897	external side of plasma membrane
1.70	2.85e-11	GO:0044459	plasma membrane part
1.31	1.58e-09	GO:0044425	membrane part
1.89	4.28e-09	GO:0005887	integral to plasma membrane
1.87	6.67e-09	GO:0031226	intrinsic to plasma membrane
1.34	1.22e-08	GO:0031224	intrinsic to membrane
1.34	1.46e-08	GO:0016021	integral to membrane
2.69	2.15e-08	GO:0009986	cell surface
14.14	1.81e-07	GO:0042101	T cell receptor complex
3.66	2.27e-06	GO:0043235	receptor complex
4.30	2.00e-03	GO:0031091	platelet alpha granule
1.06	2.99e-03	GO:0044464	cell part
1.06	3.06e-03	GO:0005623	cell
2.80	3.34e-03	GO:0045121	membrane raft
4.35	3.96e-03	GO:0031983	vesicle lumen
1.39	7.49e-03	GO:0005829	cytosol
4.41	7.84e-03	GO:0031093	platelet alpha granule lumen
8.70	8.06e-03	GO:0001772	immunological synapse
4.32	9.69e-03	GO:0034774	secretory granule lumen
4.15	1.45e-02	GO:0060205	cytoplasmic membrane-bounded vesicle lumen
2.17	1.71e-02	GO:0000323	lytic vacuole
2.17	1.71e-02	GO:0005764	lysosome
5.20	2.85e-02	GO:0008305	integrin complex

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.92	7.40e-18	GO:0004871	signal transducer activity
1.92	7.40e-18	GO:0060089	molecular transducer activity
1.97	2.05e-15	GO:0004872	receptor activity
1.27	9.18e-09	GO:0005515	protein binding
10.91	2.24e-07	GO:0005164	tumor necrosis factor receptor binding
4.19	8.34e-07	GO:0019955	cytokine binding
3.21	1.30e-06	GO:0005125	cytokine activity
2.34	1.98e-06	GO:0030695	GTPase regulator activity
6.77	2.74e-06	GO:0004715	non-membrane spanning protein tyrosine kinase activity
3.25	2.90e-06	GO:0005126	cytokine receptor binding
6.60	4.01e-06	GO:0003823	antigen binding
2.27	5.12e-06	GO:0060589	nucleoside-triphosphatase regulator activity
9.42	9.47e-06	GO:0001637	G-protein chemoattractant receptor activity
9.42	9.47e-06	GO:0004950	chemokine receptor activity
10.60	1.29e-05	GO:0019865	immunoglobulin binding
8.57	3.01e-05	GO:0019956	chemokine binding
2.98	3.89e-05	GO:0005529	sugar binding
5.39	7.46e-05	GO:0005070	SH3/SH2 adaptor activity
6.69	1.39e-04	GO:0032813	tumor necrosis factor receptor superfamily binding
4.71	1.85e-04	GO:0035591	signaling adaptor activity
14.14	2.76e-04	GO:0019864	IgG binding
2.50	5.80e-04	GO:0005096	GTPase activator activity
1.59	1.08e-03	GO:0004888	transmembrane receptor activity
2.14	1.09e-03	GO:0008047	enzyme activator activity
1.69	1.28e-03	GO:0030234	enzyme regulator activity
2.32	1.64e-03	GO:0005083	small GTPase regulator activity
2.12	2.40e-03	GO:0030246	carbohydrate binding
1.64	2.69e-03	GO:0005102	receptor binding
3.09	9.16e-03	GO:0017124	SH3 domain binding
11.78	1.00e-02	GO:0030675	Rac GTPase activator activity
1.70	1.04e-02	GO:0019899	enzyme binding
2.24	1.15e-02	GO:0032403	protein complex binding
2.77	1.62e-02	GO:0004713	protein tyrosine kinase activity
2.85	2.71e-02	GO:0030674	protein binding, bridging
1.87	3.57e-02	GO:0019904	protein domain specific binding