Motif ID: SPIB.p2

Z-value: 4.577


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPIBhg19_v1_chr19_+_50922194_509222150.551.0e-03Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_159466019 22.219 NM_054114
NM_138810
NM_152133
 TAGAP


T-cell activation RhoGTPase activating protein


chr12_-_15114495 16.673 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_+_31554475 15.777 NM_205837
 LST1
leukocyte specific transcript 1
chr6_-_32160289 15.318 GPSM3
G-protein signaling modulator 3
chrX_+_48542193 14.396 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_+_113885145 14.210 IL1RN
interleukin 1 receptor antagonist
chr14_+_88471467 13.768 NM_003608
 GPR65
G protein-coupled receptor 65
chr6_+_31553955 12.996 NM_205838
NM_205839
 LST1

leukocyte specific transcript 1

chr2_+_113885137 12.811 NM_173842
 IL1RN
interleukin 1 receptor antagonist
chr16_+_29674282 12.373 NM_001030288
 SPN
sialophorin
chr17_+_34640030 12.209 NM_207007
NM_001001435
 CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr17_+_34431219 12.175 NM_002984
 CCL4
chemokine (C-C motif) ligand 4
chrX_+_48542159 12.038 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr12_+_6898605 11.851 NM_000616
NM_001195014
NM_001195015
NM_001195016
NM_001195017
 CD4




CD4 molecule




chr12_-_9760481 11.798 NM_002258
 KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr17_-_72709010 11.741 NM_139018
 CD300LF
CD300 molecule-like family member f
chr8_-_6856678 11.330 NM_004084
NM_001042500
 DEFA1
DEFA1B
defensin, alpha 1
defensin, alpha 1B
chr19_+_49838673 11.030 NM_001040031
NM_001774
 CD37

CD37 molecule

chr19_+_49838700 10.715 CD37
CD37 molecule
chr7_-_38375172 10.529 TRGV7
T cell receptor gamma variable 7 (pseudogene)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 247 entries
Enrichment   P-value GO Accession GO Term
18.85 1.94e-02 GO:0030656 regulation of vitamin metabolic process
18.85 1.94e-02 GO:0045589 regulation of regulatory T cell differentiation
18.85 1.94e-02 GO:0060556 regulation of vitamin D biosynthetic process
12.57 6.16e-05 GO:0032673 regulation of interleukin-4 production
11.90 4.10e-08 GO:0050853 B cell receptor signaling pathway
11.60 1.53e-04 GO:0045086 positive regulation of interleukin-2 biosynthetic process
11.00 1.79e-03 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
11.00 1.79e-03 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation
10.91 1.12e-06 GO:0045076 regulation of interleukin-2 biosynthetic process
10.60 6.47e-05 GO:0043029 T cell homeostasis
9.98 1.31e-04 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
9.98 1.31e-04 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
9.42 7.05e-03 GO:0002286 T cell activation involved in immune response
9.42 7.05e-03 GO:0046640 regulation of alpha-beta T cell proliferation
9.42 3.79e-02 GO:0045191 regulation of isotype switching
9.42 3.79e-02 GO:0045577 regulation of B cell differentiation
9.01 1.64e-05 GO:0002712 regulation of B cell mediated immunity
9.01 1.64e-05 GO:0002889 regulation of immunoglobulin mediated immune response
8.87 2.38e-03 GO:0032660 regulation of interleukin-17 production
8.87 2.38e-03 GO:0045058 T cell selection

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
Enrichment   P-value GO Accession GO Term
14.14 1.81e-07 GO:0042101 T cell receptor complex
8.70 8.06e-03 GO:0001772 immunological synapse
5.20 2.85e-02 GO:0008305 integrin complex
4.78 1.32e-12 GO:0009897 external side of plasma membrane
4.41 7.84e-03 GO:0031093 platelet alpha granule lumen
4.35 3.96e-03 GO:0031983 vesicle lumen
4.32 9.69e-03 GO:0034774 secretory granule lumen
4.30 2.00e-03 GO:0031091 platelet alpha granule
4.15 1.45e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.66 2.27e-06 GO:0043235 receptor complex
2.80 3.34e-03 GO:0045121 membrane raft
2.69 2.15e-08 GO:0009986 cell surface
2.17 1.71e-02 GO:0000323 lytic vacuole
2.17 1.71e-02 GO:0005764 lysosome
1.89 4.28e-09 GO:0005887 integral to plasma membrane
1.87 6.67e-09 GO:0031226 intrinsic to plasma membrane
1.70 2.85e-11 GO:0044459 plasma membrane part
1.58 4.10e-18 GO:0071944 cell periphery
1.57 2.36e-17 GO:0005886 plasma membrane
1.39 7.49e-03 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
14.14 2.76e-04 GO:0019864 IgG binding
11.78 1.00e-02 GO:0030675 Rac GTPase activator activity
10.91 2.24e-07 GO:0005164 tumor necrosis factor receptor binding
10.60 1.29e-05 GO:0019865 immunoglobulin binding
9.42 9.47e-06 GO:0001637 G-protein chemoattractant receptor activity
9.42 9.47e-06 GO:0004950 chemokine receptor activity
8.57 3.01e-05 GO:0019956 chemokine binding
6.77 2.74e-06 GO:0004715 non-membrane spanning protein tyrosine kinase activity
6.69 1.39e-04 GO:0032813 tumor necrosis factor receptor superfamily binding
6.60 4.01e-06 GO:0003823 antigen binding
5.39 7.46e-05 GO:0005070 SH3/SH2 adaptor activity
4.71 1.85e-04 GO:0035591 signaling adaptor activity
4.19 8.34e-07 GO:0019955 cytokine binding
3.25 2.90e-06 GO:0005126 cytokine receptor binding
3.21 1.30e-06 GO:0005125 cytokine activity
3.09 9.16e-03 GO:0017124 SH3 domain binding
2.98 3.89e-05 GO:0005529 sugar binding
2.85 2.71e-02 GO:0030674 protein binding, bridging
2.77 1.62e-02 GO:0004713 protein tyrosine kinase activity
2.50 5.80e-04 GO:0005096 GTPase activator activity