Motif ID: SPZ1.p2

Z-value: 1.626


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPZ1hg19_v1_chr5_+_79615789_796158420.134.6e-01Click!


Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_44258210 2.455 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chrX_-_13956530 2.351 GPM6B
glycoprotein M6B
chrX_-_13956445 2.319


chr14_+_96342728 2.306 LOC100507043
uncharacterized LOC100507043
chr12_+_41086189 2.209 NM_001843
NM_175038
CNTN1

contactin 1

chr8_+_104512975 2.193 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chrX_-_13956644 2.110 NM_001001994
GPM6B
glycoprotein M6B
chr2_-_193059599 1.913 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr19_-_38714781 1.804 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr16_+_29912146 1.803 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr7_+_94285620 1.732 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr6_-_110500803 1.688 WASF1
WAS protein family, member 1
chr17_+_42836546 1.676 NM_002390
ADAM11
ADAM metallopeptidase domain 11
chr1_-_40157067 1.672 NM_016257
HPCAL4
hippocalcin like 4
chr2_-_9143742 1.658 NM_138799
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr6_-_84418705 1.627 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr6_-_84418492 1.610 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr2_-_230579198 1.558 NM_139072
DNER
delta/notch-like EGF repeat containing
chr16_+_4838397 1.550 NM_001253790
NM_001253791
LOC440335

uncharacterized LOC440335

chr19_-_38720330 1.544 DPF1
D4, zinc and double PHD fingers family 1
chr18_+_33877630 1.542 NM_025135
FHOD3
formin homology 2 domain containing 3
chr12_-_49392909 1.541 NM_015086
DDN
dendrin
chr6_+_56819923 1.509 BEND6
BEN domain containing 6
chr19_+_54385429 1.476 NM_002739
PRKCG
protein kinase C, gamma
chr12_+_79258448 1.436 NM_005639
SYT1
synaptotagmin I
chr3_-_187388105 1.434 NM_001048
SST
somatostatin
chr16_+_12995454 1.422 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr4_-_44450509 1.406 KCTD8
potassium channel tetramerisation domain containing 8
chrX_-_51239426 1.389 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr8_-_22089850 1.378 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr2_-_217236666 1.371 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr4_-_168155576 1.367 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_39890882 1.363 NM_001079870
NM_001079871
NM_177977
HAP1


huntingtin-associated protein 1


chr19_-_51143091 1.356 NM_001160328
NM_001160329
SYT3

synaptotagmin III

chr16_+_2039945 1.351 NM_004209
SYNGR3
synaptogyrin 3
chr11_-_46939908 1.351 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr10_+_64133915 1.304 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr8_+_35092963 1.299 NM_080872
UNC5D
unc-5 homolog D (C. elegans)
chr2_-_193059249 1.294 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr19_-_38720312 1.292 NM_001135156
DPF1
D4, zinc and double PHD fingers family 1
chr12_+_79258588 1.292 SYT1
synaptotagmin I
chr10_+_63422718 1.283 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr2_+_79740059 1.264 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr11_-_35440514 1.247 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_-_77607958 1.239 ZDHHC22
zinc finger, DHHC-type containing 22
chrX_+_53449804 1.238 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chr17_-_37764165 1.228 NM_006160
NEUROD2
neurogenic differentiation 2
chr17_+_64960754 1.224 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chrX_+_49126326 1.205 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr5_+_159656436 1.204 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr6_+_30851860 1.200 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr9_-_139948448 1.183 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr11_+_112832281 1.174 NCAM1
neural cell adhesion molecule 1
chr12_+_79258517 1.171 SYT1
synaptotagmin I
chr2_+_105471745 1.167 NM_006236
POU3F3
POU class 3 homeobox 3
chr17_+_7554415 1.166 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr18_-_40695483 1.158 NM_002930
RIT2
Ras-like without CAAX 2
chr19_-_47164289 1.156 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr9_-_122131579 1.145 NM_014618
DBC1
deleted in bladder cancer 1
chr10_-_101190201 1.138 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr17_+_48638339 1.135 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr20_+_44657858 1.119 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr5_-_114515733 1.111 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr8_-_75233461 1.111 NM_020647
JPH1
junctophilin 1
chr1_-_109825767 1.103 NM_001005290
NM_001032291
NM_032636
PSRC1


proline/serine-rich coiled-coil 1


chr8_+_24771276 1.101 NEFM
neurofilament, medium polypeptide
chrX_-_51239295 1.095 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr1_-_41950296 1.093 NM_001956
EDN2
endothelin 2
chr11_+_63871240 1.090 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr1_+_70034029 1.088 LRRC7
leucine rich repeat containing 7
chr6_+_96463844 1.081 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr10_+_121485593 1.065 INPP5F
inositol polyphosphate-5-phosphatase F
chr12_-_120806893 1.056 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr10_+_121485638 1.056 INPP5F
inositol polyphosphate-5-phosphatase F
chr1_+_116916029 1.042 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_20812271 1.032 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr12_-_6809965 1.024 NM_001244014
NM_153685
C12orf53

chromosome 12 open reading frame 53

chr17_-_42988797 1.017 GFAP
glial fibrillary acidic protein
chr7_+_128432049 1.016 NM_022742
CCDC136
coiled-coil domain containing 136
chr15_+_41786055 1.007 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr1_-_75139421 1.000 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chrX_+_49126299 0.999 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chrX_+_135570124 0.995 NM_001727
BRS3
bombesin-like receptor 3
chr1_-_21995793 0.987 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr11_+_20691116 0.983 NM_006157
NM_201551
NELL1

NEL-like 1 (chicken)

chr1_-_109825683 0.979 PSRC1
proline/serine-rich coiled-coil 1
chr7_-_45128492 0.978 NM_001146334
NACAD
NAC alpha domain containing
chr1_+_77747727 0.968 AK5
adenylate kinase 5
chr2_+_79740171 0.964 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr8_+_24771268 0.957 NM_005382
NEFM
neurofilament, medium polypeptide
chr8_-_109095836 0.956 NM_178565
RSPO2
R-spondin 2
chr15_-_23115243 0.950 LOC283683
uncharacterized LOC283683
chr13_+_39261172 0.946 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr2_-_46384 0.946 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr11_-_32457059 0.938 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr1_-_241520467 0.937 NM_002924
RGS7
regulator of G-protein signaling 7
chr11_+_61522860 0.922 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr10_+_17686123 0.922 NM_003473
STAM
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr22_-_44708730 0.917 NM_001099294
KIAA1644
KIAA1644
chr19_+_12949258 0.916 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr8_-_22785228 0.912 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr19_-_6502224 0.905 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr10_+_105036783 0.900 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr1_-_109825745 0.895


chr3_-_50540853 0.890 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr16_-_67427335 0.889 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr4_+_53728481 0.886 NM_023940
RASL11B
RAS-like, family 11, member B
chr3_-_133614421 0.885 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr18_-_24765178 0.884 NM_031422
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr13_-_102068705 0.881 NM_052867
NALCN
sodium leak channel, non-selective
chr11_+_12132063 0.878 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr1_-_32229635 0.878 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr8_-_22089517 0.878 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr1_+_109792640 0.877 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr22_-_46373007 0.876 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr8_-_30669934 0.866 PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr1_-_184006491 0.860 GLT25D2
glycosyltransferase 25 domain containing 2
chr11_+_369723 0.857 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr1_+_161228516 0.856 NM_001102566
PCP4L1
Purkinje cell protein 4 like 1
chr3_-_47621729 0.856 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr14_-_23821423 0.850 NM_020372
SLC22A17
solute carrier family 22, member 17
chrX_+_105969875 0.849 NM_194463
RNF128
ring finger protein 128
chr19_-_36523770 0.849 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr12_+_569542 0.847 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr6_-_32119717 0.846 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr15_-_83240499 0.846 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr2_+_219824346 0.840 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr11_-_124622133 0.837 VSIG2
V-set and immunoglobulin domain containing 2
chr1_+_155829259 0.836 NM_152280
SYT11
synaptotagmin XI
chr17_+_48610045 0.835 NM_017957
EPN3
epsin 3
chr19_-_7934806 0.834 FLJ22184
putative uncharacterized protein FLJ22184
chr20_+_24449834 0.832 NM_024893
SYNDIG1
synapse differentiation inducing 1
chr11_+_17757494 0.830 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr12_-_22487566 0.827 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr9_+_124922189 0.827 NM_198469
MORN5
MORN repeat containing 5
chr13_+_35516390 0.825 NM_015678
NBEA
neurobeachin
chr12_-_130388211 0.825 NM_133448
TMEM132D
transmembrane protein 132D
chr5_+_173472692 0.819 NM_015980
HMP19
HMP19 protein
chr16_+_58498182 0.819 NDRG4
NDRG family member 4
chr3_-_49907304 0.817 NM_024046
CAMKV
CaM kinase-like vesicle-associated
chr1_+_200863948 0.804 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr16_+_29823408 0.802 NM_145239
PRRT2
proline-rich transmembrane protein 2
chr9_-_138591318 0.797 NM_001012415
NM_001101677
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr1_-_223537400 0.796 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr1_+_77747602 0.789 NM_174858
AK5
adenylate kinase 5
chr8_+_69242956 0.788 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr4_-_21699317 0.784 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr12_-_6809595 0.784 NM_001244015
C12orf53
chromosome 12 open reading frame 53
chr7_+_94536926 0.783 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr11_-_124622085 0.783 NM_014312
VSIG2
V-set and immunoglobulin domain containing 2
chrX_+_18443702 0.782 NM_003159
CDKL5
cyclin-dependent kinase-like 5
chr8_+_85097099 0.782 NM_001100391
RALYL
RALY RNA binding protein-like
chr11_-_130298305 0.780 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr4_-_153700892 0.777 NM_145720
TIGD4
tigger transposable element derived 4
chr6_+_83903031 0.777 NM_033411
RWDD2A
RWD domain containing 2A
chr2_-_158184145 0.775 NM_001009959
ERMN
ermin, ERM-like protein
chr1_-_86622107 0.771 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chrX_-_102319080 0.771 BEX1
brain expressed, X-linked 1
chr3_-_9290592 0.771 SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr17_+_44068828 0.768 MAPT
microtubule-associated protein tau
chr3_-_186079776 0.766 NM_001080744
NM_001080745
NM_001346
DGKG


diacylglycerol kinase, gamma 90kDa


chr20_+_42875905 0.763 NM_024034
GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr6_-_31846751 0.762 SLC44A4
solute carrier family 44, member 4
chrX_-_139587224 0.761 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr14_-_25519076 0.761 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr2_-_51259536 0.761 NM_001135659
NM_004801
NRXN1

neurexin 1

chr6_+_72596405 0.756 RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_73936299 0.754 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr11_+_119020572 0.750 ABCG4
ATP-binding cassette, sub-family G (WHITE), member 4
chr12_-_62586547 0.749 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr16_+_84402125 0.746 NM_014861
ATP2C2
ATPase, Ca++ transporting, type 2C, member 2
chr9_-_34522972 0.741 NM_198573
ENHO
energy homeostasis associated
chr6_-_46138584 0.739 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr3_-_197024879 0.735 DLG1
discs, large homolog 1 (Drosophila)
chr1_-_26232890 0.735 NM_001145454
NM_005563
STMN1

stathmin 1

chrX_+_14547419 0.734 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr2_-_139537803 0.732 NM_007226
NXPH2
neurexophilin 2
chr1_+_2005083 0.732 NM_001033581
PRKCZ
protein kinase C, zeta
chr11_-_57414978 0.728 YPEL4
yippee-like 4 (Drosophila)
chr7_-_98467483 0.727 TMEM130
transmembrane protein 130
chr17_+_29718777 0.727 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chrX_-_128788913 0.726 NM_017413
APLN
apelin
chr15_+_43809805 0.724 NM_002373
MAP1A
microtubule-associated protein 1A
chr1_+_16370246 0.723 NM_000085
CLCNKB
chloride channel Kb
chr14_+_79745653 0.723 NM_001105250
NM_138970
NRXN3

neurexin 3

chr17_+_20059192 0.722 NM_001033554
NM_001033555
NM_001243438
SPECC1


sperm antigen with calponin homology and coiled-coil domains 1


chr13_+_96743092 0.719 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr10_+_119806334 0.718 CASC2
cancer susceptibility candidate 2 (non-protein coding)
chr17_-_42988677 0.717 GFAP
glial fibrillary acidic protein
chr1_-_169396654 0.717 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr5_-_78809658 0.716 NM_004272
HOMER1
homer homolog 1 (Drosophila)
chr5_+_173472737 0.713 HMP19
HMP19 protein
chr1_+_209757044 0.707 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr2_-_175351755 0.705 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr11_-_32456910 0.702 WT1
Wilms tumor 1
chr5_-_54529424 0.702 NM_021147
CCNO
cyclin O
chr6_+_72596648 0.698 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_63257545 0.697 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr1_+_155290639 0.695 NM_001105203
NM_001105204
RUSC1

RUN and SH3 domain containing 1

chr1_-_202612580 0.692 NM_001136504
SYT2
synaptotagmin II

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.42 3.23e-03 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
8.10 8.00e-06 GO:0043005 neuron projection
66.24 3.18e-05 GO:0032589 neuron projection membrane
6.55 7.83e-04 GO:0045202 synapse
30.44 8.37e-04 GO:0042734 presynaptic membrane
1.79 1.27e-03 GO:0044425 membrane part
4.15 2.25e-03 GO:0042995 cell projection
9.95 2.87e-03 GO:0043025 neuronal cell body
9.67 3.38e-03 GO:0044297 cell body
187.65 3.64e-03 GO:0032591 dendritic spine membrane
9.45 3.83e-03 GO:0031252 cell leading edge
6.86 6.51e-03 GO:0044456 synapse part
17.61 7.50e-03 GO:0031256 leading edge membrane
2.50 1.47e-02 GO:0044459 plasma membrane part
4.48 1.51e-02 GO:0030054 cell junction
1.56 1.95e-02 GO:0016020 membrane
1.75 2.51e-02 GO:0031224 intrinsic to membrane
1.92 2.64e-02 GO:0005886 plasma membrane
1.89 3.36e-02 GO:0071944 cell periphery
8.01 3.81e-02 GO:0030424 axon
1.72 4.52e-02 GO:0016021 integral to membrane

Nothing significant found in function category.