Motif ID: SREBF1,2.p2

Z-value: 1.460


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF1hg19_v1_chr17_-_17726855_17726954-0.421.6e-02Click!
SREBF2hg19_v1_chr22_+_42229107_42229117-0.173.5e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_160390128 8.736 NM_000876
 IGF2R
insulin-like growth factor 2 receptor
chr19_+_50922194 5.887 NM_001243998
NM_001243999
NM_001244000
NM_003121
 SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr19_+_49458031 4.387 NM_004324
NM_138761
NM_138763
NM_138764
 BAX



BCL2-associated X protein



chr11_+_67159421 4.299 NM_004584
 RAD9A
RAD9 homolog A (S. pombe)
chrY_+_15016698 4.190 NM_004660
 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr20_+_44519965 4.144 CTSA
cathepsin A
chr12_-_46662779 4.120 SLC38A1
solute carrier family 38, member 1
chr19_+_49458129 4.084 BAX
BCL2-associated X protein
chr1_+_44440673 3.961 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr20_+_44520203 3.944 CTSA
cathepsin A
chr11_-_36310934 3.882 COMMD9
COMM domain containing 9
chr7_+_102074002 3.858 ORAI2
ORAI calcium release-activated calcium modulator 2
chr19_+_49458151 3.801 BAX
BCL2-associated X protein
chr12_-_46662709 3.798 SLC38A1
solute carrier family 38, member 1
chr20_+_44519924 3.774 CTSA
cathepsin A
chr1_+_44440642 3.670 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr11_-_6640644 3.560 TPP1
tripeptidyl peptidase I
chr16_-_5083913 3.543 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr20_+_44520021 3.530 CTSA
cathepsin A
chr16_+_28986024 3.434 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
 SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
19.46 5.45e-05 GO:0007040 lysosome organization
17.52 1.21e-04 GO:0015682 ferric iron transport
17.52 1.21e-04 GO:0033572 transferrin transport
14.08 1.37e-05 GO:0007033 vacuole organization
9.22 1.16e-02 GO:0006826 iron ion transport
8.83 3.70e-03 GO:0055072 iron ion homeostasis
8.09 2.78e-02 GO:0006879 cellular iron ion homeostasis
4.76 1.87e-03 GO:0006897 endocytosis
4.76 1.87e-03 GO:0010324 membrane invagination
4.47 4.44e-02 GO:0046649 lymphocyte activation
3.35 9.24e-04 GO:0019725 cellular homeostasis
3.31 1.13e-02 GO:0055082 cellular chemical homeostasis
3.30 1.17e-02 GO:0016044 cellular membrane organization
3.28 1.25e-02 GO:0061024 membrane organization
3.23 2.66e-02 GO:0006873 cellular ion homeostasis
3.16 2.08e-02 GO:0050801 ion homeostasis
2.97 4.65e-02 GO:0001775 cell activation
2.82 2.27e-02 GO:0048878 chemical homeostasis
2.65 1.68e-02 GO:0016192 vesicle-mediated transport
2.55 9.06e-03 GO:0042592 homeostatic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
18.77 1.15e-03 GO:0033176 proton-transporting V-type ATPase complex
9.88 6.66e-09 GO:0005765 lysosomal membrane
9.58 2.55e-11 GO:0005774 vacuolar membrane
9.15 5.94e-11 GO:0044437 vacuolar part
8.34 1.72e-02 GO:0031901 early endosome membrane
8.06 2.94e-15 GO:0000323 lytic vacuole
8.06 2.94e-15 GO:0005764 lysosome
7.80 3.13e-17 GO:0005773 vacuole
5.78 7.45e-04 GO:0005769 early endosome
5.78 5.84e-03 GO:0005770 late endosome
4.26 1.31e-03 GO:0010008 endosome membrane
4.22 1.44e-03 GO:0044440 endosomal part
3.84 1.65e-05 GO:0005768 endosome
2.69 1.04e-03 GO:0031410 cytoplasmic vesicle
2.60 1.85e-03 GO:0031982 vesicle
2.53 9.91e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.48 1.32e-02 GO:0031988 membrane-bounded vesicle
1.99 1.97e-04 GO:0031090 organelle membrane
1.76 2.64e-02 GO:0005829 cytosol
1.52 1.69e-05 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
45.04 5.86e-03 GO:0004185 serine-type carboxypeptidase activity
37.53 1.16e-02 GO:0070008 serine-type exopeptidase activity
20.02 9.57e-03 GO:0005247 voltage-gated chloride channel activity
13.65 4.77e-02 GO:0008308 voltage-gated anion channel activity
6.26 3.64e-03 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
1.68 4.64e-02 GO:0016787 hydrolase activity
1.38 7.57e-04 GO:0005515 protein binding