Motif ID: SRF.p3

Z-value: 4.472


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFhg19_v1_chr6_+_43139190_431391960.803.2e-08Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_45826131 74.254 CKM
creatine kinase, muscle
chr19_-_45826232 46.446 NM_001824
 CKM
creatine kinase, muscle
chr2_+_74120132 43.077 ACTG2
actin, gamma 2, smooth muscle, enteric
chr15_-_35087748 42.367 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr1_-_229569839 40.271 NM_001100
 ACTA1
actin, alpha 1, skeletal muscle
chr2_+_74120092 39.327 NM_001199893
NM_001615
 ACTG2

actin, gamma 2, smooth muscle, enteric

chr20_+_35169876 32.651 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr14_-_94443065 29.473 NM_001202429
 ASB2
ankyrin repeat and SOCS box containing 2
chr19_-_36247917 29.096 NM_144617
 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr10_-_29923841 27.795


chr20_+_35169897 27.484 MYL9
myosin, light chain 9, regulatory
chr6_-_123957941 23.050 NM_001251987
NM_006073
 TRDN

triadin

chr14_-_23877480 22.250 NM_002471
 MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr17_+_33474835 21.367 NM_001033576
NM_173167
 UNC45B

unc-45 homolog B (C. elegans)

chr14_-_94442894 21.043 ASB2
ankyrin repeat and SOCS box containing 2
chr8_+_86351055 20.480 NM_005181
 CA3
carbonic anhydrase III, muscle specific
chr10_+_88428263 20.267 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
 LDB3




LIM domain binding 3




chr10_-_29923900 18.805 NM_021738
 SVIL
supervillin
chr3_-_151987332 18.608 LOC401093
uncharacterized LOC401093
chr6_-_105584982 18.518 NM_001199563
 BVES
blood vessel epicardial substance

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
28.89 8.47e-10 GO:0030049 muscle filament sliding
28.89 8.47e-10 GO:0033275 actin-myosin filament sliding
28.13 1.14e-09 GO:0070252 actin-mediated cell contraction
23.06 9.15e-10 GO:0030048 actin filament-based movement
20.36 3.05e-02 GO:0030239 myofibril assembly
19.80 3.60e-03 GO:0031032 actomyosin structure organization
17.59 2.41e-22 GO:0006936 muscle contraction
16.16 2.38e-21 GO:0003012 muscle system process
11.04 6.66e-12 GO:0007517 muscle organ development
10.69 1.57e-02 GO:0008360 regulation of cell shape
10.35 1.90e-02 GO:0007519 skeletal muscle tissue development
9.85 5.47e-03 GO:0007015 actin filament organization
9.72 2.73e-02 GO:0060538 skeletal muscle organ development
9.44 3.24e-02 GO:0006937 regulation of muscle contraction
8.32 7.02e-11 GO:0030029 actin filament-based process
8.29 2.87e-04 GO:0060537 muscle tissue development
8.26 3.26e-10 GO:0061061 muscle structure development
8.16 1.28e-03 GO:0014706 striated muscle tissue development
7.88 2.38e-02 GO:0003007 heart morphogenesis
7.80 2.55e-02 GO:0031589 cell-substrate adhesion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
Enrichment   P-value GO Accession GO Term
35.63 4.80e-04 GO:0043034 costamere
32.89 6.88e-04 GO:0031672 A band
29.70 7.28e-05 GO:0005859 muscle myosin complex
26.73 7.69e-07 GO:0001725 stress fiber
26.73 1.30e-04 GO:0016460 myosin II complex
25.92 7.81e-08 GO:0042641 actomyosin
24.94 1.30e-06 GO:0032432 actin filament bundle
24.67 2.99e-02 GO:0005865 striated muscle thin filament
23.76 2.84e-03 GO:0032982 myosin filament
20.28 9.45e-21 GO:0030016 myofibril
20.05 7.49e-08 GO:0031674 I band
19.99 1.32e-21 GO:0043292 contractile fiber
19.87 1.49e-19 GO:0044449 contractile fiber part
18.55 4.47e-15 GO:0030017 sarcomere
16.88 1.83e-04 GO:0030018 Z disc
15.72 2.10e-03 GO:0005884 actin filament
13.37 1.95e-05 GO:0016459 myosin complex
12.96 1.89e-08 GO:0005925 focal adhesion
12.34 3.40e-08 GO:0005924 cell-substrate adherens junction
11.88 5.31e-08 GO:0030055 cell-substrate junction

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
71.26 4.67e-02 GO:0002162 dystroglycan binding
27.35 2.72e-11 GO:0008307 structural constituent of muscle
26.73 2.22e-03 GO:0000146 microfilament motor activity
17.11 1.44e-02 GO:0017022 myosin binding
6.13 1.61e-07 GO:0003779 actin binding
4.36 2.67e-06 GO:0008092 cytoskeletal protein binding
3.59 7.09e-03 GO:0042803 protein homodimerization activity
3.53 3.44e-04 GO:0005198 structural molecule activity
1.19 4.20e-02 GO:0005488 binding