Motif ID: SRY.p2

Z-value: 1.033


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRYhg19_v1_chrY_-_2655478_2655791-0.241.8e-01Click!


Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_39509069 7.036 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr18_+_29171729 6.108 NM_000371
TTR
transthyretin
chr9_-_104198045 5.039 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr7_+_107110501 3.864 NM_005295
GPR22
G protein-coupled receptor 22
chr11_-_35440514 3.343 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_-_65409445 2.902 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_-_176733413 2.608 GPM6A
glycoprotein M6A
chr5_-_39364562 2.486 NM_001737
C9
complement component 9
chr12_-_21487831 2.410 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr2_-_21230572 2.392 APOB
apolipoprotein B (including Ag(x) antigen)
chr7_+_26400503 2.368 NM_001199837
SNX10
sorting nexin 10
chr12_-_10151689 2.297 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr2_+_102927961 2.205 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr4_+_74269971 2.205 NM_000477
ALB
albumin
chr9_+_77112251 2.185 NM_006914
RORB
RAR-related orphan receptor B
chr1_-_193155723 2.149 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_+_135596185 2.097 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_-_158182154 2.062 NM_020711
ERMN
ermin, ERM-like protein
chr5_+_173472737 2.034 HMP19
HMP19 protein
chr17_-_26697224 2.026 VTN
vitronectin
chr11_+_124789145 1.989 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr3_-_165555167 1.979 BCHE
butyrylcholinesterase
chr3_-_148939784 1.947 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_+_151032683 1.941 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_+_120079423 1.924 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr3_-_165555252 1.840 NM_000055
BCHE
butyrylcholinesterase
chr4_+_72204769 1.831 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_-_159684274 1.829 NM_000567
CRP
C-reactive protein, pentraxin-related
chr11_+_22696318 1.762 NM_005256
GAS2
growth arrest-specific 2
chr4_+_155484131 1.755 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr17_-_67138013 1.747 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr12_-_75603510 1.726 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr1_+_151032866 1.721 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr18_+_72201799 1.712 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr8_+_80523048 1.704 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr16_+_24266873 1.697 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr8_-_110655418 1.696 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr1_+_151032880 1.674 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr16_-_21314371 1.669 NM_001014444
NM_001888
CRYM

crystallin, mu

chrX_+_28605558 1.665 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr2_+_158958381 1.646 NM_173355
UPP2
uridine phosphorylase 2
chr4_-_176733378 1.636 GPM6A
glycoprotein M6A
chr17_-_26697293 1.629 VTN
vitronectin
chr2_+_210444364 1.624 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr4_+_166131170 1.621 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr3_+_52811601 1.618 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chrX_-_13835213 1.580 GPM6B
glycoprotein M6B
chr4_-_70518964 1.576 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr8_+_85095501 1.554 NM_173848
RALYL
RALY RNA binding protein-like
chr17_-_26697358 1.538 NM_000638
VTN
vitronectin
chr18_+_72201669 1.531 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr4_-_155511838 1.528 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr18_-_3874688 1.528 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr10_-_101841593 1.508 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr13_-_45775174 1.507 NM_198404
KCTD4
potassium channel tetramerisation domain containing 4
chr5_-_147211235 1.505 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr4_+_88896838 1.488 SPP1
secreted phosphoprotein 1
chr12_+_52056547 1.483 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr5_+_173472692 1.475 NM_015980
HMP19
HMP19 protein
chr1_+_151032906 1.467 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_-_40755328 1.451 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr8_-_17752847 1.447 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr18_-_3874252 1.428 NM_001242764
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr4_-_69536314 1.422 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr1_+_50574601 1.400 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_-_60392324 1.389 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr17_-_29648631 1.388 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr1_-_93342706 1.344 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr11_-_35441501 1.339 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr18_-_64271215 1.333 NM_021153
CDH19
cadherin 19, type 2
chr11_+_112831968 1.325 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr3_-_120400957 1.321 HGD
homogentisate 1,2-dioxygenase
chr19_+_30863318 1.320 NM_014717
ZNF536
zinc finger protein 536
chr2_-_2334887 1.315 NM_015025
MYT1L
myelin transcription factor 1-like
chr1_+_84630575 1.314 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr4_-_70361578 1.309 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr8_-_18666295 1.308 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_161275897 1.292 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_+_79439432 1.277 NM_001135806
SYT1
synaptotagmin I
chr7_-_83270746 1.277 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_+_57828457 1.274 NM_005538
INHBC
inhibin, beta C
chr9_-_104145800 1.268 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr11_+_22696381 1.267 GAS2
growth arrest-specific 2
chr12_-_81763127 1.259 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_-_18258315 1.253 SAA4
serum amyloid A4, constitutive
chr5_-_83016850 1.248 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr10_+_96522457 1.228 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr1_-_60392461 1.226 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr2_-_216246961 1.221 FN1
fibronectin 1
chr5_-_147211141 1.215 SPINK1
serine peptidase inhibitor, Kazal type 1
chrX_-_99891690 1.214 NM_003270
TSPAN6
tetraspanin 6
chr11_-_18258383 1.207 NM_006512
SAA4
serum amyloid A4, constitutive
chr4_-_186732047 1.206 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr7_+_29519485 1.198 NM_001039936
CHN2
chimerin (chimaerin) 2
chr15_+_43885251 1.191 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr8_-_86253863 1.190 NM_001164830
CA1
carbonic anhydrase I
chr4_+_74286846 1.188 ALB
albumin
chr2_-_216245573 1.183 FN1
fibronectin 1
chr3_-_93747453 1.180 NM_001001850
STX19
syntaxin 19
chr7_-_126883568 1.179 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr1_+_1361507 1.175 NM_001146685
TMEM88B
transmembrane protein 88B
chr7_+_149570004 1.175 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr10_-_91102430 1.171 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr11_-_35441099 1.161 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_89392464 1.151 NM_153696
FOLH1B
folate hydrolase 1B
chr1_-_156217717 1.150 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr2_-_224467049 1.148 SCG2
secretogranin II
chr3_+_142342265 1.143 NM_002670
PLS1
plastin 1
chr2_-_31030271 1.141 NM_144575
CAPN13
calpain 13
chr8_-_6795783 1.139 NM_001925
DEFA4
defensin, alpha 4, corticostatin
chr4_-_186697065 1.133 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr11_+_112832089 1.130 NCAM1
neural cell adhesion molecule 1
chr3_+_115342302 1.121 GAP43
growth associated protein 43
chr4_-_105416050 1.118 CXXC4
CXXC finger protein 4
chr16_+_58534045 1.111 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr7_-_16505292 1.106 NM_015464
SOSTDC1
sclerostin domain containing 1
chr19_-_11564568 1.095 ELAVL3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr9_+_71819926 1.089 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr7_-_50628744 1.078 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr5_-_146435589 1.069 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr9_-_8733893 1.060 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr20_-_7921068 1.055 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr10_-_123356158 1.051 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr7_-_99573637 1.045 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr12_-_109458844 1.023 NM_018711
SVOP
SV2 related protein homolog (rat)
chr2_+_102953716 1.023 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr1_+_162039469 1.022 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr3_+_133464883 1.021 NM_001063
TF
transferrin
chr7_-_100239136 1.012 NM_003227
TFR2
transferrin receptor 2
chr16_-_4852856 1.011


chr5_+_175308843 1.008 CPLX2
complexin 2
chr12_-_16758312 1.001 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_56716713 0.995 DST
dystonin
chr12_+_8666135 0.994 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr4_-_155533800 0.989 FGG
fibrinogen gamma chain
chr4_-_186732208 0.987 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr2_+_149633173 0.985


chr13_+_24844846 0.975 SPATA13
spermatogenesis associated 13
chr9_-_116840673 0.973 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_72102249 0.963 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr2_-_224467095 0.961 SCG2
secretogranin II
chr3_+_63428752 0.960 NM_144642
SYNPR
synaptoporin
chr4_+_118955499 0.954 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr11_+_63137260 0.940 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr8_-_27115897 0.940 NM_030795
STMN4
stathmin-like 4
chr1_+_50571963 0.937 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr10_+_7745354 0.936 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_72273965 0.921 EYA1
eyes absent homolog 1 (Drosophila)
chr4_+_110749149 0.910 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr2_-_21233930 0.910 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_-_57272344 0.910 NM_172337
OTX2
orthodenticle homeobox 2
chr12_-_75603214 0.905 KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr22_+_41074994 0.904 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chrX_+_103031797 0.904 PLP1
proteolipid protein 1
chr2_+_234621637 0.897 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr11_+_112832201 0.897 NCAM1
neural cell adhesion molecule 1
chr1_+_155099935 0.897 EFNA1
ephrin-A1
chr4_+_74281884 0.886 ALB
albumin
chr4_+_69681709 0.885 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr2_-_77749335 0.885 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr3_+_181417387 0.881 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chr3_-_120401401 0.875 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr6_-_135271206 0.874 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr4_-_72649734 0.866 NM_000583
GC
group-specific component (vitamin D binding protein)
chr5_+_36606456 0.863 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr8_-_27115935 0.859 STMN4
stathmin-like 4
chr7_-_19812403 0.852 NM_152774
TMEM196
transmembrane protein 196
chr16_-_67977956 0.850 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr11_+_20049128 0.847 NAV2
neuron navigator 2
chrX_-_151619669 0.846 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr5_+_36606667 0.843 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_128175989 0.842 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr3_-_170744458 0.830 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr2_+_166095911 0.830 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr11_-_116663106 0.822 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_115342150 0.817 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr7_-_14025826 0.816 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr2_+_102979096 0.816 NM_003855
IL18R1
interleukin 18 receptor 1
chr11_+_19372270 0.814 NM_001111018
NAV2
neuron navigator 2
chr5_-_121814781 0.813


chr2_-_21231406 0.808 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_56492938 0.807 RNF43
ring finger protein 43
chr11_-_72380107 0.806 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr21_+_41239346 0.806 NM_006198
PCP4
Purkinje cell protein 4
chr11_+_131781303 0.806 NTM
neurotrimin
chr10_+_74653338 0.806 NM_152635
OIT3
oncoprotein induced transcript 3
chr12_-_371994 0.803 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chr9_-_116840604 0.798 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_216242916 0.797 FN1
fibronectin 1
chr10_-_52645384 0.796 A1CF
APOBEC1 complementation factor
chr2_+_162272619 0.795 NM_006593
TBR1
T-box, brain, 1
chr8_+_24774587 0.795 NEFM
neurofilament, medium polypeptide
chr11_+_113775517 0.793 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr4_+_100495972 0.789 MTTP
microsomal triglyceride transfer protein
chr11_-_6462129 0.788 NM_000613
HPX
hemopexin
chrX_-_13835313 0.783 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr4_+_86699846 0.779 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr4_+_88896801 0.778 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr2_+_115822246 0.775 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr10_+_7745341 0.775 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
154.94 2.27e-02 GO:0001907 killing by symbiont of host cells
154.94 2.27e-02 GO:0019836 hemolysis by symbiont of host erythrocytes
154.94 2.27e-02 GO:0044004 disruption by symbiont of host cells
154.94 2.27e-02 GO:0044179 hemolysis in other organism
154.94 2.27e-02 GO:0051715 cytolysis in other organism
154.94 2.27e-02 GO:0051801 cytolysis in other organism involved in symbiotic interaction
154.94 2.27e-02 GO:0052025 modification by symbiont of host cell membrane
154.94 2.27e-02 GO:0052043 modification by symbiont of host cellular component
154.94 2.27e-02 GO:0052111 modification by symbiont of host structure
154.94 2.27e-02 GO:0052185 modification of structure of other organism involved in symbiotic interaction
154.94 2.27e-02 GO:0052188 modification of cellular component in other organism involved in symbiotic interaction
154.94 2.27e-02 GO:0052331 hemolysis in other organism involved in symbiotic interaction
154.94 2.27e-02 GO:0052332 modification by organism of cell membrane in other organism involved in symbiotic interaction
5.67 4.51e-02 GO:0008202 steroid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
88.54 6.97e-06 GO:0005577 fibrinogen complex
3.54 6.01e-04 GO:0005615 extracellular space
3.05 1.36e-03 GO:0044421 extracellular region part
2.28 2.18e-03 GO:0005576 extracellular region
14.91 2.54e-03 GO:0031983 vesicle lumen
4.00 2.41e-02 GO:0045202 synapse
13.19 2.92e-02 GO:0031093 platelet alpha granule lumen
12.92 3.17e-02 GO:0034774 secretory granule lumen
23.25 3.43e-02 GO:0044304 main axon
12.40 3.71e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.98 4.80e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
46.49 4.61e-03 GO:0050997 quaternary ammonium group binding