Motif ID: STAT2,4,6.p2

Z-value: 2.393


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT4hg19_v1_chr2_-_192015934_192015985-0.602.8e-04Click!
STAT2hg19_v1_chr12_-_56753912_56753915-0.431.3e-02Click!
STAT6hg19_v1_chr12_-_57505121_57505170-0.048.5e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_95078713 10.080 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_-_7245006 9.441 NM_001733
C1R
complement component 1, r subcomponent
chr12_-_7245048 8.003 C1R
complement component 1, r subcomponent
chr5_-_147211235 5.917 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr5_-_147211141 5.899 SPINK1
serine peptidase inhibitor, Kazal type 1
chr17_-_76356153 5.536 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr4_-_155533800 5.524 FGG
fibrinogen gamma chain
chr5_+_40909558 5.522 NM_000587
C7
complement component 7
chr12_+_53443834 5.487 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_155511838 5.421 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr4_-_155533882 5.324 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr12_-_9268522 5.320 NM_000014
A2M
alpha-2-macroglobulin
chr4_-_155533757 5.199 FGG
fibrinogen gamma chain
chr5_+_40909617 5.072 C7
complement component 7
chr4_-_155533850 4.965 FGG
fibrinogen gamma chain
chr11_+_57365026 4.928 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr2_+_201450730 4.872 NM_001159
AOX1
aldehyde oxidase 1
chr3_+_52828783 4.795 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr17_+_1646129 4.769 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr17_+_1646290 4.661 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr5_-_121814781 4.592


chr1_+_201979689 4.585 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr1_-_68299047 4.562 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr5_+_40909487 4.505 C7
complement component 7
chr3_-_52864687 4.478 NM_001166449
NM_002218
ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr17_+_1646143 4.389 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr11_+_114167197 4.326 NNMT
nicotinamide N-methyltransferase
chr12_+_7167979 4.280 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr14_-_94919085 4.275 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr1_+_22970117 4.191 NM_001114101
NM_172369
C1QC

complement component 1, q subcomponent, C chain

chr16_-_56701904 4.162 NM_005950
MT1G
metallothionein 1G
chr14_-_65409445 4.114 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr11_+_57365577 3.987 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr11_+_114167168 3.960 NNMT
nicotinamide N-methyltransferase
chr19_+_35773409 3.717 NM_021175
HAMP
hepcidin antimicrobial peptide
chrX_+_106171328 3.715 CLDN2
claudin 2
chr19_+_15218141 3.690 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_+_201450579 3.612 AOX1
aldehyde oxidase 1
chr11_-_119187811 3.575 NM_006500
MCAM
melanoma cell adhesion molecule
chrX_+_106045880 3.511 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr6_-_35464716 3.472 NM_003214
TEAD3
TEA domain family member 3
chr11_-_116663106 3.453 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr10_+_17851342 3.419 NM_002438
MRC1
mannose receptor, C type 1
chr12_-_9268440 3.315 A2M
alpha-2-macroglobulin
chr1_-_230849863 3.275 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_+_72088507 3.258 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_201979747 3.247 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr7_-_150038689 3.229 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr12_-_9268475 3.218 A2M
alpha-2-macroglobulin
chr3_+_186330844 3.206 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr19_+_45418063 3.178 APOC1
apolipoprotein C-I
chr3_+_186330859 3.144 AHSG
alpha-2-HS-glycoprotein
chr12_-_9268513 3.125 A2M
alpha-2-macroglobulin
chr4_+_155484131 3.080 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_+_31913852 3.052 CFB
complement factor B
chr3_-_50649110 3.043 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr16_-_28550227 3.041 NUPR1
nuclear protein, transcriptional regulator, 1
chr5_+_176516550 3.040 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr17_+_4675175 3.031 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr3_-_148939784 3.028 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_+_31913920 3.000 CFB
complement factor B
chr2_-_151344145 2.978 NM_005168
RND3
Rho family GTPase 3
chr16_+_30996462 2.929 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr1_+_207262583 2.884 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr3_+_186330711 2.834 AHSG
alpha-2-HS-glycoprotein
chr1_-_230850335 2.828 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230849847 2.796 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr4_+_88896838 2.780 SPP1
secreted phosphoprotein 1
chr7_+_90032771 2.769 CLDN12
claudin 12
chr19_-_4540035 2.750 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr15_+_50474357 2.721 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr6_+_31913763 2.720 CFB
complement factor B
chr1_+_155099935 2.692 EFNA1
ephrin-A1
chr17_+_32582295 2.683 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chrX_+_106143393 2.682 NM_001171092
CLDN2
claudin 2
chr16_-_28550324 2.681 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr7_+_90032647 2.650 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr4_-_72671236 2.647 NM_001204306
GC
group-specific component (vitamin D binding protein)
chrX_+_138612894 2.638 NM_000133
F9
coagulation factor IX
chr19_+_7828034 2.636 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr19_-_49339667 2.618 HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr6_+_31913708 2.600 NM_001710
CFB
complement factor B
chr4_+_88896801 2.598 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr14_-_94759594 2.543 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr21_-_42879908 2.533 NM_001135099
TMPRSS2
transmembrane protease, serine 2
chr4_+_88896868 2.509 SPP1
secreted phosphoprotein 1
chr10_-_52645430 2.505 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr11_+_43963809 2.504 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr9_-_117880411 2.456 NM_002160
TNC
tenascin C
chr17_-_53800074 2.449 NM_018286
TMEM100
transmembrane protein 100
chr17_-_26697358 2.433 NM_000638
VTN
vitronectin
chr20_-_14318200 2.421 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr4_+_22694547 2.408 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr17_-_26697224 2.404 VTN
vitronectin
chr19_+_10381516 2.397 NM_000201
ICAM1
intercellular adhesion molecule 1
chr1_-_230849936 2.389 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_+_10381763 2.369 ICAM1
intercellular adhesion molecule 1
chr3_-_64673330 2.368 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr12_+_12938540 2.341 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr17_-_26697310 2.333 VTN
vitronectin
chr6_-_32151996 2.318 NM_001136
NM_001206929
NM_001206932
NM_001206934
NM_001206936
NM_001206940
NM_001206954
NM_001206966
NM_172197
AGER








advanced glycosylation end product-specific receptor








chr4_+_88896899 2.314 SPP1
secreted phosphoprotein 1
chr2_-_44065888 2.303 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chrX_-_133119475 2.292 GPC3
glypican 3
chr2_+_44066102 2.286 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr22_+_21128378 2.282 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr9_+_97766414 2.272 C9orf3
chromosome 9 open reading frame 3
chr6_+_161123224 2.265 NM_000301
NM_001168338
PLG

plasminogen

chr5_+_38846260 2.253 OSMR
oncostatin M receptor
chr1_+_209859524 2.236 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr1_+_32712817 2.229 NM_032648
FAM167B
family with sequence similarity 167, member B
chr17_-_26697293 2.214 VTN
vitronectin
chr20_-_49308074 2.193


chr19_-_49339913 2.181 NM_016246
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr5_+_38845962 2.171 NM_003999
OSMR
oncostatin M receptor
chr16_+_67204404 2.153 NM_001185058
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr5_-_138842291 2.153 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr4_-_101439071 2.144 NM_001159694
NM_016242
EMCN

endomucin

chr3_-_158450230 2.140 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr11_+_58695101 2.127 NM_001220494
GLYATL1
glycine-N-acyltransferase-like 1
chr10_+_74653338 2.121 NM_152635
OIT3
oncoprotein induced transcript 3
chr6_+_30130982 2.119 NM_033229
TRIM15
tripartite motif containing 15
chr7_-_120498009 2.115 TSPAN12
tetraspanin 12
chr11_-_6462129 2.101 NM_000613
HPX
hemopexin
chr15_+_84322809 2.089 NM_207517
ADAMTSL3
ADAMTS-like 3
chr3_-_158450271 2.087 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr15_-_45493372 2.080 NM_138356
SHF
Src homology 2 domain containing F
chrX_+_73641084 2.072 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chrX_+_152770083 2.049 BGN
biglycan
chr17_+_32683470 2.046 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr7_+_134464417 2.038 CALD1
caldesmon 1
chr1_-_27693336 2.032 NM_004672
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr3_-_158450205 2.025 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_-_50649080 2.021 CISH
cytokine inducible SH2-containing protein
chr7_+_117120016 2.012 NM_000492
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr12_+_93964801 2.005 SOCS2
suppressor of cytokine signaling 2
chrX_-_133119624 2.001 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr2_-_75796847 1.994 NM_032181
FAM176A
family with sequence similarity 176, member A
chr10_+_88728187 1.980 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr12_+_53442972 1.975 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr19_-_7812396 1.971 NM_001144893
NM_001144894
NM_001144895
NM_001144896
NM_001144897
NM_001144899
NM_021155
CD209






CD209 molecule






chr5_+_57878901 1.962 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr3_-_124653571 1.942 NM_033049
MUC13
mucin 13, cell surface associated
chr5_+_71502700 1.911 MAP1B
microtubule-associated protein 1B
chr14_-_53417272 1.884 FERMT2
fermitin family member 2
chr3_+_171561138 1.880 NM_001164436
TMEM212
transmembrane protein 212
chr7_-_120498128 1.877 NM_012338
TSPAN12
tetraspanin 12
chr1_+_207262211 1.857 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr22_+_38598065 1.849 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr16_-_20338808 1.841 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr1_-_11107150 1.838 MASP2
mannan-binding lectin serine peptidase 2
chr2_+_234959345 1.822 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr6_+_31895401 1.815 C2
complement component 2
chr2_+_108994366 1.801 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr10_+_75673346 1.792 PLAU
plasminogen activator, urokinase
chr3_-_184095927 1.790 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr6_-_46889620 1.790 NM_001098518
GPR116
G protein-coupled receptor 116
chr12_-_93964636 1.783


chr19_-_44860798 1.778 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr10_-_52645384 1.774 A1CF
APOBEC1 complementation factor
chr14_-_54423448 1.769 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr19_+_35532617 1.752 HPN
hepsin
chr19_-_5839702 1.731 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr20_+_36974823 1.725 NM_004139
LBP
lipopolysaccharide binding protein
chr5_-_102898450 1.724 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr8_+_18248754 1.696 NM_000015
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr4_+_77356252 1.691 NM_020859
SHROOM3
shroom family member 3
chr1_-_204120909 1.687 ETNK2
ethanolamine kinase 2
chr5_+_42549657 1.681 NM_001242404
GHR
growth hormone receptor
chr17_-_73505914 1.679 NM_001142643
CASKIN2
CASK interacting protein 2
chr14_+_38678280 1.675 SSTR1
somatostatin receptor 1
chr2_+_79347610 1.674 REG1A
regenerating islet-derived 1 alpha
chr13_+_111134933 1.667 COL4A2
collagen, type IV, alpha 2
chr19_-_4540078 1.656 LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_+_79347487 1.645 NM_002909
REG1A
regenerating islet-derived 1 alpha
chr1_+_22138757 1.629 NM_001013693
LDLRAD2
low density lipoprotein receptor class A domain containing 2
chrX_-_99891690 1.625 NM_003270
TSPAN6
tetraspanin 6
chr16_-_52581713 1.616 NM_001146188
TOX3
TOX high mobility group box family member 3
chr4_-_186697065 1.607 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr10_-_101841593 1.605 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_+_233498206 1.601 NM_025202
EFHD1
EF-hand domain family, member D1
chr7_+_134464372 1.599 CALD1
caldesmon 1
chr4_+_174451608 1.583 NBLA00301
Nbla00301
chr2_-_31805968 1.580 NM_000348
SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
chr3_+_52812438 1.578 NM_001166434
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr15_+_33010174 1.572 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr1_+_46640748 1.570 NM_005727
TSPAN1
tetraspanin 1
chr7_-_100239136 1.570 NM_003227
TFR2
transferrin receptor 2
chr16_-_75285383 1.551 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr2_-_190044330 1.548 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_+_52627007 1.547 KRT7
keratin 7
chrX_+_37208527 1.540 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr10_-_90750955 1.529 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr6_-_31845446 1.524 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr1_+_95285900 1.519 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr19_-_36001336 1.516 NM_001126059
DMKN
dermokine
chr6_-_28304151 1.508 NM_001243241
NM_001243242
NM_001243244
NM_030899
ZNF323



zinc finger protein 323



chr1_-_201368716 1.500 LAD1
ladinin 1
chr20_-_45313122 1.496 NM_001011554
NM_001193340
SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr2_+_27301434 1.494 NM_007046
EMILIN1
elastin microfibril interfacer 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
17.44 6.30e-13 GO:0072376 protein activation cascade
25.74 1.49e-11 GO:0006958 complement activation, classical pathway
20.58 3.39e-11 GO:0006956 complement activation
22.80 8.35e-11 GO:0002455 humoral immune response mediated by circulating immunoglobulin
12.58 5.72e-09 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
12.25 8.39e-09 GO:0002250 adaptive immune response
3.51 9.74e-09 GO:0006952 defense response
11.64 1.75e-08 GO:0006959 humoral immune response
14.51 3.36e-08 GO:0016064 immunoglobulin mediated immune response
12.53 3.58e-08 GO:0002449 lymphocyte mediated immunity
14.25 4.22e-08 GO:0019724 B cell mediated immunity
3.27 4.57e-08 GO:0009611 response to wounding
2.75 4.41e-07 GO:0002376 immune system process
2.33 5.77e-07 GO:0048583 regulation of response to stimulus
9.94 7.44e-07 GO:0002443 leukocyte mediated immunity
1.46 8.23e-07 GO:0065007 biological regulation
3.32 1.06e-06 GO:0006955 immune response
11.99 2.03e-06 GO:0010951 negative regulation of endopeptidase activity
7.03 4.98e-06 GO:0002252 immune effector process
2.05 6.49e-06 GO:0006950 response to stress
4.27 1.58e-05 GO:0045087 innate immune response
2.07 4.09e-05 GO:0065008 regulation of biological quality
14.38 8.08e-05 GO:0006953 acute-phase response
11.08 1.31e-04 GO:0002526 acute inflammatory response
4.50 1.57e-04 GO:0006954 inflammatory response
7.95 1.72e-04 GO:0010466 negative regulation of peptidase activity
1.87 2.08e-04 GO:0048518 positive regulation of biological process
1.96 2.59e-04 GO:0042221 response to chemical stimulus
4.88 2.68e-04 GO:0032101 regulation of response to external stimulus
1.47 3.89e-04 GO:0050896 response to stimulus
2.95 4.29e-04 GO:0002682 regulation of immune system process
1.39 5.59e-04 GO:0050789 regulation of biological process
6.29 6.31e-04 GO:0051346 negative regulation of hydrolase activity
3.43 1.35e-03 GO:0002684 positive regulation of immune system process
3.39 1.58e-03 GO:0050776 regulation of immune response
2.14 2.22e-03 GO:0009653 anatomical structure morphogenesis
7.98 2.35e-03 GO:0002576 platelet degranulation
2.99 2.58e-03 GO:0042060 wound healing
5.00 2.90e-03 GO:0052548 regulation of endopeptidase activity
3.97 4.15e-03 GO:0040012 regulation of locomotion
33.25 4.29e-03 GO:0030212 hyaluronan metabolic process
4.81 4.51e-03 GO:0052547 regulation of peptidase activity
3.93 4.79e-03 GO:0050778 positive regulation of immune response
4.12 5.36e-03 GO:0030334 regulation of cell migration
4.37 5.73e-03 GO:0002253 activation of immune response
3.11 6.10e-03 GO:0007596 blood coagulation
3.11 6.10e-03 GO:0050817 coagulation
4.07 6.23e-03 GO:2000145 regulation of cell motility
2.63 6.46e-03 GO:0007155 cell adhesion
2.63 6.46e-03 GO:0022610 biological adhesion
3.09 6.76e-03 GO:0007599 hemostasis
2.56 7.16e-03 GO:0048584 positive regulation of response to stimulus
2.83 1.06e-02 GO:0009887 organ morphogenesis
2.66 1.18e-02 GO:0009790 embryo development
3.85 1.22e-02 GO:0035295 tube development
8.95 1.56e-02 GO:0048771 tissue remodeling
2.84 1.56e-02 GO:0050878 regulation of body fluid levels
1.89 1.61e-02 GO:0048513 organ development
3.71 1.91e-02 GO:0051270 regulation of cellular component movement
3.33 2.15e-02 GO:0043009 chordate embryonic development
3.29 2.49e-02 GO:0009792 embryo development ending in birth or egg hatching
2.93 2.55e-02 GO:0048585 negative regulation of response to stimulus
2.41 2.99e-02 GO:0006508 proteolysis
9.98 3.53e-02 GO:0030301 cholesterol transport
1.73 4.08e-02 GO:0048519 negative regulation of biological process
9.73 4.08e-02 GO:0015918 sterol transport
5.65 4.10e-02 GO:0050727 regulation of inflammatory response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.52 8.86e-30 GO:0005576 extracellular region
4.19 5.51e-20 GO:0044421 extracellular region part
4.20 7.17e-15 GO:0005615 extracellular space
4.24 1.09e-06 GO:0031012 extracellular matrix
12.73 4.91e-06 GO:0031093 platelet alpha granule lumen
12.47 5.96e-06 GO:0034774 secretory granule lumen
11.97 8.67e-06 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
11.51 1.24e-05 GO:0031983 vesicle lumen
10.50 2.84e-05 GO:0031091 platelet alpha granule
1.96 3.57e-05 GO:0044459 plasma membrane part
37.99 2.89e-04 GO:0005577 fibrinogen complex
3.70 7.17e-04 GO:0005578 proteinaceous extracellular matrix
1.50 3.44e-03 GO:0071944 cell periphery
1.51 3.51e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
6.93 1.15e-06 GO:0004252 serine-type endopeptidase activity
5.98 8.70e-06 GO:0008236 serine-type peptidase activity
5.87 1.10e-05 GO:0017171 serine hydrolase activity
8.41 1.83e-05 GO:0004867 serine-type endopeptidase inhibitor activity
6.05 2.15e-05 GO:0030414 peptidase inhibitor activity
5.92 7.99e-05 GO:0004866 endopeptidase inhibitor activity
3.75 1.15e-04 GO:0004175 endopeptidase activity
5.69 1.27e-04 GO:0061135 endopeptidase regulator activity
5.06 1.93e-04 GO:0061134 peptidase regulator activity
4.16 2.06e-04 GO:0004857 enzyme inhibitor activity
2.95 6.16e-04 GO:0008233 peptidase activity
2.37 6.60e-04 GO:0005102 receptor binding
10.58 9.43e-04 GO:0043498 cell surface binding
2.93 1.13e-03 GO:0070011 peptidase activity, acting on L-amino acid peptides
3.28 2.77e-03 GO:0030246 carbohydrate binding
6.65 6.60e-03 GO:0005201 extracellular matrix structural constituent
4.60 7.26e-03 GO:0001871 pattern binding
4.60 7.26e-03 GO:0030247 polysaccharide binding
9.73 7.77e-03 GO:0005044 scavenger receptor activity
33.25 1.59e-02 GO:0046790 virion binding
3.77 4.36e-02 GO:0005125 cytokine activity