Motif ID: STAT2,4,6.p2

Z-value: 2.393


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT4hg19_v1_chr2_-_192015934_192015985-0.602.8e-04Click!
STAT2hg19_v1_chr12_-_56753912_56753915-0.431.3e-02Click!
STAT6hg19_v1_chr12_-_57505121_57505170-0.048.5e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_95078713 10.080 NM_001085
 SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_-_7245006 9.441 NM_001733
 C1R
complement component 1, r subcomponent
chr12_-_7245048 8.003 C1R
complement component 1, r subcomponent
chr5_-_147211235 5.917 NM_003122
 SPINK1
serine peptidase inhibitor, Kazal type 1
chr5_-_147211141 5.899 SPINK1
serine peptidase inhibitor, Kazal type 1
chr17_-_76356153 5.536 NM_003955
 SOCS3
suppressor of cytokine signaling 3
chr4_-_155533800 5.524 FGG
fibrinogen gamma chain
chr5_+_40909558 5.522 NM_000587
 C7
complement component 7
chr12_+_53443834 5.487 NM_170754
 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_155511838 5.421 NM_000508
NM_021871
 FGA

fibrinogen alpha chain

chr4_-_155533882 5.324 NM_000509
NM_021870
 FGG

fibrinogen gamma chain

chr12_-_9268522 5.320 NM_000014
 A2M
alpha-2-macroglobulin
chr4_-_155533757 5.199 FGG
fibrinogen gamma chain
chr5_+_40909617 5.072 C7
complement component 7
chr4_-_155533850 4.965 FGG
fibrinogen gamma chain
chr11_+_57365026 4.928 NM_000062
 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr2_+_201450730 4.872 NM_001159
 AOX1
aldehyde oxidase 1
chr3_+_52828783 4.795 NM_002217
 ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr17_+_1646129 4.769 NM_000934
NM_001165921
 SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr17_+_1646290 4.661 NM_001165920
 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
Enrichment   P-value GO Accession GO Term
33.25 4.29e-03 GO:0030212 hyaluronan metabolic process
25.74 1.49e-11 GO:0006958 complement activation, classical pathway
22.80 8.35e-11 GO:0002455 humoral immune response mediated by circulating immunoglobulin
20.58 3.39e-11 GO:0006956 complement activation
17.44 6.30e-13 GO:0072376 protein activation cascade
14.51 3.36e-08 GO:0016064 immunoglobulin mediated immune response
14.38 8.08e-05 GO:0006953 acute-phase response
14.25 4.22e-08 GO:0019724 B cell mediated immunity
12.58 5.72e-09 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
12.53 3.58e-08 GO:0002449 lymphocyte mediated immunity
12.25 8.39e-09 GO:0002250 adaptive immune response
11.99 2.03e-06 GO:0010951 negative regulation of endopeptidase activity
11.64 1.75e-08 GO:0006959 humoral immune response
11.08 1.31e-04 GO:0002526 acute inflammatory response
9.98 3.53e-02 GO:0030301 cholesterol transport
9.94 7.44e-07 GO:0002443 leukocyte mediated immunity
9.73 4.08e-02 GO:0015918 sterol transport
8.95 1.56e-02 GO:0048771 tissue remodeling
7.98 2.35e-03 GO:0002576 platelet degranulation
7.95 1.72e-04 GO:0010466 negative regulation of peptidase activity

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
37.99 2.89e-04 GO:0005577 fibrinogen complex
12.73 4.91e-06 GO:0031093 platelet alpha granule lumen
12.47 5.96e-06 GO:0034774 secretory granule lumen
11.97 8.67e-06 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
11.51 1.24e-05 GO:0031983 vesicle lumen
10.50 2.84e-05 GO:0031091 platelet alpha granule
4.24 1.09e-06 GO:0031012 extracellular matrix
4.20 7.17e-15 GO:0005615 extracellular space
4.19 5.51e-20 GO:0044421 extracellular region part
3.70 7.17e-04 GO:0005578 proteinaceous extracellular matrix
3.52 8.86e-30 GO:0005576 extracellular region
1.96 3.57e-05 GO:0044459 plasma membrane part
1.51 3.51e-03 GO:0005886 plasma membrane
1.50 3.44e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
33.25 1.59e-02 GO:0046790 virion binding
10.58 9.43e-04 GO:0043498 cell surface binding
9.73 7.77e-03 GO:0005044 scavenger receptor activity
8.41 1.83e-05 GO:0004867 serine-type endopeptidase inhibitor activity
6.93 1.15e-06 GO:0004252 serine-type endopeptidase activity
6.65 6.60e-03 GO:0005201 extracellular matrix structural constituent
6.05 2.15e-05 GO:0030414 peptidase inhibitor activity
5.98 8.70e-06 GO:0008236 serine-type peptidase activity
5.92 7.99e-05 GO:0004866 endopeptidase inhibitor activity
5.87 1.10e-05 GO:0017171 serine hydrolase activity
5.69 1.27e-04 GO:0061135 endopeptidase regulator activity
5.06 1.93e-04 GO:0061134 peptidase regulator activity
4.60 7.26e-03 GO:0001871 pattern binding
4.60 7.26e-03 GO:0030247 polysaccharide binding
4.16 2.06e-04 GO:0004857 enzyme inhibitor activity
3.77 4.36e-02 GO:0005125 cytokine activity
3.75 1.15e-04 GO:0004175 endopeptidase activity
3.28 2.77e-03 GO:0030246 carbohydrate binding
2.95 6.16e-04 GO:0008233 peptidase activity
2.93 1.13e-03 GO:0070011 peptidase activity, acting on L-amino acid peptides