Motif ID: STAT5{A,B}.p2

Z-value: 2.001


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT5Bhg19_v1_chr17_-_40428391_404284730.077.2e-01Click!
STAT5Ahg19_v1_chr17_+_40439564_40439564-0.057.8e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_44556163 5.450 NM_013361
 ZNF223
zinc finger protein 223
chrX_+_107288199 3.825 NM_001170553
NM_182607
 VSIG1

V-set and immunoglobulin domain containing 1

chr19_+_37709068 3.439 ZNF383
zinc finger protein 383
chr19_+_35225124 3.260 ZNF181
zinc finger protein 181
chr1_+_149754245 3.195 NM_000566
 FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr1_-_120935893 3.186 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr1_-_120935943 3.180 NM_001004340
NM_001017986
NM_001244910
 FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr9_+_130186652 3.038 NM_007135
 ZNF79
zinc finger protein 79
chr19_-_57183122 2.949 NM_001005850
 ZNF835
zinc finger protein 835
chr19_-_57988891 2.920 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr19_+_44331443 2.822 NM_181845
 ZNF283
zinc finger protein 283
chr19_+_35225095 2.770 ZNF181
zinc finger protein 181
chr2_+_63816092 2.746 MDH1
malate dehydrogenase 1, NAD (soluble)
chr18_-_43684198 2.661 NM_001001937
 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr15_+_90895476 2.594 NM_001004309
 ZNF774
zinc finger protein 774
chr19_-_40596781 2.586 NM_001010880
NM_001142577
NM_001142578
NM_001142579
 ZNF780A



zinc finger protein 780A



chr3_-_183735617 2.557 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr19_+_44507076 2.484 NM_006300
 ZNF230
zinc finger protein 230
chr19_+_40502942 2.481 NM_178544
 ZNF546
zinc finger protein 546
chr19_-_44439410 2.476 NM_003425
 ZNF45
zinc finger protein 45

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
4.69 1.35e-16 GO:0006355 regulation of transcription, DNA-dependent
4.52 5.17e-16 GO:0051252 regulation of RNA metabolic process
4.23 5.13e-15 GO:2000112 regulation of cellular macromolecule biosynthetic process
4.12 1.28e-14 GO:0010556 regulation of macromolecule biosynthetic process
4.00 3.56e-14 GO:0010468 regulation of gene expression
3.93 2.06e-14 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.83 1.58e-13 GO:0031326 regulation of cellular biosynthetic process
3.81 5.94e-14 GO:0051171 regulation of nitrogen compound metabolic process
3.79 2.32e-13 GO:0009889 regulation of biosynthetic process
3.13 5.53e-11 GO:0060255 regulation of macromolecule metabolic process
3.04 5.52e-11 GO:0080090 regulation of primary metabolic process
3.00 8.88e-11 GO:0031323 regulation of cellular metabolic process
2.73 2.39e-09 GO:0019222 regulation of metabolic process
1.83 1.07e-05 GO:0050794 regulation of cellular process
1.73 8.61e-05 GO:0050789 regulation of biological process
1.65 2.56e-04 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
2.01 3.52e-06 GO:0005634 nucleus
1.66 1.02e-06 GO:0043231 intracellular membrane-bounded organelle
1.65 1.07e-06 GO:0043227 membrane-bounded organelle
1.57 1.54e-06 GO:0043229 intracellular organelle
1.56 1.68e-06 GO:0043226 organelle
1.38 2.32e-04 GO:0044424 intracellular part
1.34 7.94e-04 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
58.65 2.82e-02 GO:0019864 IgG binding
5.27 2.20e-21 GO:0008270 zinc ion binding
4.64 3.66e-19 GO:0046914 transition metal ion binding
4.54 3.46e-18 GO:0003677 DNA binding
3.27 2.47e-13 GO:0003676 nucleic acid binding
2.89 3.54e-12 GO:0046872 metal ion binding
2.86 5.41e-12 GO:0043169 cation binding
2.85 5.94e-12 GO:0043167 ion binding
1.27 2.89e-02 GO:0005488 binding