Motif ID: T.p2

Z-value: 1.610


Transcription factors associated with T.p2:

Gene SymbolEntrez IDGene Name
T 6862 T, brachyury homolog (mouse)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thg19_v1_chr6_-_166582129_166582130-0.412.1e-02Click!


Activity profile for motif T.p2.

activity profile for motif T.p2


Sorted Z-values histogram for motif T.p2

Sorted Z-values for motif T.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of T.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_54320083 14.203 NM_002104
 GZMK
granzyme K (granzyme 3; tryptase II)
chr14_-_107113943 11.666 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_128913881 10.445 NM_018990
 SASH3
SAM and SH3 domain containing 3
chr14_-_107013474 10.375 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_130536417 9.761 NM_152552
 SAMD3
sterile alpha motif domain containing 3
chr4_-_74847669 8.953 NM_002619
 PF4
platelet factor 4
chrX_+_128913897 8.729 SASH3
SAM and SH3 domain containing 3
chr17_+_34431219 8.376 NM_002984
 CCL4
chemokine (C-C motif) ligand 4
chr14_-_107211131 7.826 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_209941894 7.709 TRAF3IP3
TRAF3 interacting protein 3
chr1_-_205290756 7.401 NM_030952
 NUAK2
NUAK family, SNF1-like kinase, 2
chr5_-_39270708 6.942 NM_001243093
 FYB
FYN binding protein
chr17_-_43502992 6.692 NM_199282
 ARHGAP27
Rho GTPase activating protein 27
chr12_-_53074172 6.392 NM_006121
 KRT1
keratin 1
chr2_-_219031646 6.199 NM_000634
 CXCR1
chemokine (C-X-C motif) receptor 1
chr9_+_135894806 6.094 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr6_+_167536240 5.901 NM_031409
 CCR6
chemokine (C-C motif) receptor 6
chr1_-_114414245 5.657 NM_001193431
NM_012411
NM_015967
 PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr17_+_25958217 5.584 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_200992510 5.560 KIF21B
kinesin family member 21B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
87.06 1.93e-03 GO:0032692 negative regulation of interleukin-1 production
18.34 3.41e-02 GO:0030888 regulation of B cell proliferation
18.34 3.41e-02 GO:0050707 regulation of cytokine secretion
16.99 4.62e-02 GO:0050871 positive regulation of B cell activation
14.52 1.24e-02 GO:0050864 regulation of B cell activation
6.74 1.26e-02 GO:0051249 regulation of lymphocyte activation
6.13 8.12e-03 GO:0001817 regulation of cytokine production
6.12 2.52e-02 GO:0002694 regulation of leukocyte activation
5.90 1.10e-02 GO:0006954 inflammatory response
5.89 3.31e-02 GO:0050865 regulation of cell activation
5.12 6.11e-07 GO:0006955 immune response
4.66 1.17e-02 GO:0050776 regulation of immune response
4.22 2.89e-02 GO:0001775 cell activation
3.92 9.51e-07 GO:0002376 immune system process
3.87 6.70e-03 GO:0002682 regulation of immune system process
3.65 1.57e-03 GO:0009611 response to wounding
2.49 8.77e-03 GO:0048583 regulation of response to stimulus
2.17 2.76e-02 GO:0006950 response to stress
1.78 4.86e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
14.83 1.36e-02 GO:0031093 platelet alpha granule lumen
14.52 1.48e-02 GO:0034774 secretory granule lumen
13.94 1.73e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
13.40 2.02e-02 GO:0031983 vesicle lumen
12.23 2.88e-02 GO:0031091 platelet alpha granule
2.29 4.03e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
30.48 3.09e-07 GO:0003823 antigen binding
15.15 1.70e-02 GO:0008009 chemokine activity
13.66 2.54e-02 GO:0042379 chemokine receptor binding