Motif ID: TBP.p2

Z-value: 4.533


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBPhg19_v1_chr6_+_170863420_170863508-0.355.1e-02Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_142829169 30.403 NM_002652
 PIP
prolactin-induced protein
chr11_+_18287807 24.664 NM_000331
NM_001178006
NM_199161
 SAA1


serum amyloid A1


chr11_-_18270167 24.602 NM_001199744
NM_001127380
NM_030754
 SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr1_-_59042827 16.187 TACSTD2
tumor-associated calcium signal transducer 2
chr3_+_193853930 15.115 NM_005524
 HES1
hairy and enhancer of split 1, (Drosophila)
chr12_+_52627007 14.659 KRT7
keratin 7
chr21_-_43735462 14.357 TFF3
trefoil factor 3 (intestinal)
chr19_+_18496966 14.303 NM_004864
 GDF15
growth differentiation factor 15
chr11_-_5248180 13.687 NM_000518
 HBB
hemoglobin, beta
chr17_-_39780762 13.363 NM_000422
 KRT17
keratin 17
chr3_+_193853937 13.330 HES1
hairy and enhancer of split 1, (Drosophila)
chr2_-_151344145 13.217 NM_005168
 RND3
Rho family GTPase 3
chr16_-_56701904 12.639 NM_005950
 MT1G
metallothionein 1G
chr21_-_43735705 12.636 NM_003226
 TFF3
trefoil factor 3 (intestinal)
chr15_-_62457481 12.617 NM_001007595
 C2CD4B
C2 calcium-dependent domain containing 4B
chr17_+_32683470 11.798 NM_005408
 CCL13
chemokine (C-C motif) ligand 13
chr2_-_216300770 11.602 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr19_-_36247917 11.589 NM_144617
 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr15_+_45722762 11.500 NM_032413
NM_197955
 C15orf48

chromosome 15 open reading frame 48

chr17_-_34344933 11.425 NM_005064
NM_145898
 CCL23

chemokine (C-C motif) ligand 23


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 159 entries
Enrichment   P-value GO Accession GO Term
40.08 1.62e-06 GO:0042738 exogenous drug catabolic process
40.08 3.91e-02 GO:0015793 glycerol transport
40.08 3.91e-02 GO:0030185 nitric oxide transport
40.08 3.91e-02 GO:0033860 regulation of NAD(P)H oxidase activity
40.08 3.91e-02 GO:0043589 skin morphogenesis
32.07 1.18e-05 GO:0042737 drug catabolic process
30.54 6.05e-03 GO:0010873 positive regulation of cholesterol esterification
26.72 7.68e-04 GO:0034374 low-density lipoprotein particle remodeling
26.72 1.19e-02 GO:0003078 regulation of natriuresis
26.72 1.19e-02 GO:0044062 regulation of excretion
23.75 2.12e-02 GO:0010872 regulation of cholesterol esterification
21.38 3.48e-02 GO:0071285 cellular response to lithium ion
20.56 3.75e-03 GO:0010744 positive regulation of macrophage derived foam cell differentiation
19.44 4.96e-06 GO:0034367 macromolecular complex remodeling
19.44 4.96e-06 GO:0034368 protein-lipid complex remodeling
19.44 4.96e-06 GO:0034369 plasma lipoprotein particle remodeling
19.09 5.74e-03 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
17.82 8.48e-03 GO:0044058 regulation of digestive system process
16.45 2.27e-05 GO:0071825 protein-lipid complex subunit organization
16.45 2.27e-05 GO:0071827 plasma lipoprotein particle organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
Enrichment   P-value GO Accession GO Term
26.72 5.68e-06 GO:0005833 hemoglobin complex
22.91 3.72e-02 GO:0005577 fibrinogen complex
11.14 1.19e-02 GO:0034364 high-density lipoprotein particle
10.69 5.27e-04 GO:0032994 protein-lipid complex
10.69 5.27e-04 GO:0034358 plasma lipoprotein particle
9.25 7.24e-05 GO:0031983 vesicle lumen
8.91 4.37e-04 GO:0034774 secretory granule lumen
8.55 6.02e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
8.02 2.56e-04 GO:0000786 nucleosome
7.96 4.08e-03 GO:0031093 platelet alpha granule lumen
6.57 1.46e-02 GO:0031091 platelet alpha granule
6.17 1.03e-42 GO:0005615 extracellular space
5.30 1.77e-42 GO:0044421 extracellular region part
5.08 1.01e-06 GO:0030141 stored secretory granule
5.07 1.16e-02 GO:0032993 protein-DNA complex
4.59 1.88e-10 GO:0031012 extracellular matrix
4.43 5.53e-04 GO:0005882 intermediate filament
4.02 2.29e-06 GO:0005578 proteinaceous extracellular matrix
3.84 2.88e-03 GO:0045111 intermediate filament cytoskeleton
3.78 1.16e-45 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 20 of 36 entries
Enrichment   P-value GO Accession GO Term
42.76 1.45e-04 GO:0046870 cadmium ion binding
40.08 6.36e-03 GO:0015168 glycerol transmembrane transporter activity
40.08 6.36e-03 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
40.08 6.36e-03 GO:0034875 caffeine oxidase activity
24.67 1.49e-05 GO:0005344 oxygen transporter activity
15.44 2.45e-10 GO:0019825 oxygen binding
13.36 9.86e-04 GO:0070330 aromatase activity
12.34 1.64e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
11.62 2.30e-06 GO:0008009 chemokine activity
10.48 6.64e-06 GO:0042379 chemokine receptor binding
9.72 3.14e-04 GO:0043498 cell surface binding
8.26 2.85e-10 GO:0020037 heme binding
8.22 1.17e-03 GO:0005507 copper ion binding
7.75 9.07e-10 GO:0046906 tetrapyrrole binding
7.35 6.12e-05 GO:0004497 monooxygenase activity
6.48 7.11e-05 GO:0005179 hormone activity
6.20 1.86e-10 GO:0005506 iron ion binding
6.02 4.17e-03 GO:0005201 extracellular matrix structural constituent
6.02 1.23e-02 GO:0005200 structural constituent of cytoskeleton
5.78 2.49e-04 GO:0008201 heparin binding