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Motif ID: TBX4,5.p2

Z-value: 1.328

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrY_+_15016698	3.364	NM_004660	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr17_+_34431219	3.271	NM_002984	CCL4	chemokine (C-C motif) ligand 4
chr1_-_156399183	2.975	NM_006365	C1orf61	chromosome 1 open reading frame 61
chr17_+_34538464	2.761	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chrY_+_15016018	2.315	NM_001122665	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr19_-_39108534	2.209	NM_001042600 NM_007181	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr1_+_26737306	2.198		LIN28A	lin-28 homolog A (C. elegans)
chr19_+_7828034	2.193	NM_001144904 NM_001144905 NM_001144906 NM_001144907 NM_001144908 NM_001144909 NM_001144910 NM_001144911 NM_014257	CLEC4M	C-type lectin domain family 4, member M
chr19_+_7741934	2.181	NM_174918	C19orf59	chromosome 19 open reading frame 59
chr11_+_60223281	2.012	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr6_-_130536417	2.008	NM_152552	SAMD3	sterile alpha motif domain containing 3
chr5_-_131347518	1.934	NM_001205248 NM_001205251 NM_001205250	ACSL6	acyl-CoA synthetase long-chain family member 6
chr1_-_202129731	1.905		PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr12_-_6756597	1.897		ACRBP	acrosin binding protein
chr1_+_26737232	1.871	NM_024674	LIN28A	lin-28 homolog A (C. elegans)
chr5_+_54320083	1.831	NM_002104	GZMK	granzyme K (granzyme 3; tryptase II)
chr6_+_31543340	1.821	NM_000594	TNF	tumor necrosis factor
chr5_-_131347249	1.791	NM_001009185 NM_001205247 NM_015256	ACSL6	acyl-CoA synthetase long-chain family member 6
chr12_+_10183275	1.784	NM_207345	CLEC9A	C-type lectin domain family 9, member A
chr9_+_137772653	1.779	NM_004108 NM_015837	FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
chr1_-_202129705	1.732		PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr12_-_45270071	1.724		NELL2	NEL-like 2 (chicken)
chr1_-_202129118	1.685	NM_080588	PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr15_+_81071708	1.653	NM_018689	KIAA1199	KIAA1199
chr6_-_41122025	1.606	NM_178174	TREML1	triggering receptor expressed on myeloid cells-like 1
chr19_+_49838673	1.557	NM_001040031 NM_001774	CD37	CD37 molecule
chr17_+_56414563	1.519		LOC100506779	uncharacterized LOC100506779
chr17_-_7017558	1.498	NM_080914	ASGR2	asialoglycoprotein receptor 2
chr22_+_27053392	1.498		MIAT	myocardial infarction associated transcript (non-protein coding)
chr12_-_6756533	1.467	NM_032489	ACRBP	acrosin binding protein
chr1_+_178482211	1.460	NM_001170722 NM_001170723 NM_001170724 NM_032126	C1orf49	chromosome 1 open reading frame 49
chr20_-_4804067	1.458	NM_014737	RASSF2	Ras association (RalGDS/AF-6) domain family member 2
chr1_+_206680863	1.458	NM_182663 NM_182664	RASSF5	Ras association (RalGDS/AF-6) domain family member 5
chr14_-_106967080	1.457		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_76227390	1.443	NM_001204210 NM_001204211 NM_001204212	TMEM235	transmembrane protein 235
chr5_-_66492574	1.438	NM_005582	CD180	CD180 molecule
chr19_+_49838700	1.434		CD37	CD37 molecule
chr1_-_36948423	1.375		CSF3R	colony stimulating factor 3 receptor (granulocyte)
chr19_+_49838734	1.368		CD37	CD37 molecule
chr3_+_186330859	1.366		AHSG	alpha-2-HS-glycoprotein
chr1_-_36948914	1.358	NM_000760 NM_156039 NM_172313	CSF3R	colony stimulating factor 3 receptor (granulocyte)
chr1_-_35370983	1.341	NM_001080418	DLGAP3	discs, large (Drosophila) homolog-associated protein 3
chr19_+_49838646	1.301		CD37	CD37 molecule
chr14_-_21058880	1.268	NM_001024822	RNASE12	ribonuclease, RNase A family, 12 (non-active)
chr22_-_37545944	1.247	NM_000878	IL2RB	interleukin 2 receptor, beta
chr12_-_45270157	1.234	NM_001145108 NM_006159	NELL2	NEL-like 2 (chicken)
chr6_-_32160637	1.221		GPSM3	G-protein signaling modulator 3
chr2_-_61697899	1.212		USP34	ubiquitin specific peptidase 34
chr15_-_31523049	1.203	NM_001243538	LOC283710	uncharacterized LOC283710
chr6_-_24936177	1.190		FAM65B	family with sequence similarity 65, member B
chr9_-_137809710	1.185	NM_002003	FCN1	ficolin (collagen/fibrinogen domain containing) 1
chr5_-_114515733	1.176	NM_001017397 NM_001017398 NM_018700	TRIM36	tripartite motif containing 36
chr14_-_88737160	1.175	NM_138318	KCNK10	potassium channel, subfamily K, member 10
chr5_-_39203061	1.171		FYB	FYN binding protein
chr3_-_182880463	1.170	NM_014398	LAMP3	lysosomal-associated membrane protein 3
chr21_+_34398210	1.168	NM_005806	OLIG2	oligodendrocyte lineage transcription factor 2
chr1_-_156786500	1.158	NM_001161441 NM_001161442 NM_001161444 NM_003975	SH2D2A	SH2 domain containing 2A
chr22_-_30662787	1.157	NM_020530	OSM	oncostatin M
chr5_-_146258143	1.155	NM_004576 NM_181675 NM_001127381	PPP2R2B	protein phosphatase 2, regulatory subunit B, beta
chr1_+_172628157	1.145	NM_000639	FASLG	Fas ligand (TNF superfamily, member 6)
chr18_+_55102777	1.131	NM_004852	ONECUT2	one cut homeobox 2
chr16_+_57576536	1.130		GPR114	G protein-coupled receptor 114
chr12_-_91348950	1.130	NM_152638	C12orf12	chromosome 12 open reading frame 12
chr8_-_130951896	1.098		FAM49B	family with sequence similarity 49, member B
chr17_+_30814552	1.097		CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_-_114414245	1.095	NM_001193431 NM_012411 NM_015967	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr15_-_38856830	1.086	NM_001128602 NM_005739	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr2_+_219745243	1.082	NM_025216	WNT10A	wingless-type MMTV integration site family, member 10A
chr11_+_118764100	1.075	NM_032966	CXCR5	chemokine (C-X-C motif) receptor 5
chr7_+_26331493	1.069	NM_001199835 NM_013322	SNX10	sorting nexin 10
chr11_+_122709205	1.064	NM_019604	CRTAM	cytotoxic and regulatory T cell molecule
chr19_-_2308155	1.055	NM_001101391	LINGO3	leucine rich repeat and Ig domain containing 3
chr1_-_200992510	1.053		KIF21B	kinesin family member 21B
chr12_+_51818592	1.049	NM_001039960 NM_004858	SLC4A8	solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr7_+_148036528	1.047		CNTNAP2	contactin associated protein-like 2
chr11_+_119020572	1.041		ABCG4	ATP-binding cassette, sub-family G (WHITE), member 4
chr16_-_50715240	1.039	NM_001144972 NM_153337 NM_182854	SNX20	sorting nexin 20
chr12_+_69742130	1.038	NM_000239	LYZ	lysozyme
chr19_+_10400646	1.029	NM_003259	ICAM5	intercellular adhesion molecule 5, telencephalin
chr11_+_61522860	1.028	NM_013279	C11orf9	chromosome 11 open reading frame 9
chr16_-_50715116	1.022		SNX20	sorting nexin 20
chr3_+_113251217	1.019	NM_017699	SIDT1	SID1 transmembrane family, member 1
chr12_+_69742140	1.016		LYZ	lysozyme
chr9_+_140032774	1.014		GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr12_-_45269953	1.012		NELL2	NEL-like 2 (chicken)
chr1_-_241520384	1.005		RGS7	regulator of G-protein signaling 7
chr4_+_78432905	1.002	NM_006419	CXCL13	chemokine (C-X-C motif) ligand 13
chr3_-_183273407	0.997	NM_130446	KLHL6	kelch-like 6 (Drosophila)
chrY_+_15016775	0.992		DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr8_+_24151579	0.992	NM_014265 NM_021777	ADAM28	ADAM metallopeptidase domain 28
chr16_+_57576576	0.988	NM_153837	GPR114	G protein-coupled receptor 114
chr1_-_241520467	0.983	NM_002924	RGS7	regulator of G-protein signaling 7
chrX_-_70331297	0.980	NM_000206	IL2RG	interleukin 2 receptor, gamma
chr6_+_167525294	0.980	NM_004367	CCR6	chemokine (C-C motif) receptor 6
chr2_-_175869910	0.975	NM_001822 NM_001025201	CHN1	chimerin (chimaerin) 1
chr1_-_242612757	0.973	NM_001195811 NM_001195812	PLD5	phospholipase D family, member 5
chr9_+_139872014	0.971		PTGDS	prostaglandin D2 synthase 21kDa (brain)
chr14_-_107113943	0.963		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_9913415	0.963	NM_001781	CD69	CD69 molecule
chr4_-_123377471	0.962	NM_000586	IL2	interleukin 2
chr1_+_26644458	0.958		CD52	CD52 molecule
chrX_+_78200828	0.957	NM_014499 NM_198333	P2RY10	purinergic receptor P2Y, G-protein coupled, 10
chr12_+_104850986	0.955		CHST11	carbohydrate (chondroitin 4) sulfotransferase 11
chr7_-_100239136	0.952	NM_003227	TFR2	transferrin receptor 2
chr17_-_16875388	0.946	NM_012452	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B
chr14_+_105391154	0.944		PLD4	phospholipase D family, member 4
chr14_-_106478129	0.940		IGHV4-31 IGHD IGHG3 IGHM	immunoglobulin heavy variable 4-31 immunoglobulin heavy constant delta immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu
chr9_-_34397786	0.940	NM_032596	C9orf24	chromosome 9 open reading frame 24
chr1_-_205290756	0.922	NM_030952	NUAK2	NUAK family, SNF1-like kinase, 2
chr4_-_165304406	0.921	NM_001166373	MARCH1	membrane-associated ring finger (C3HC4) 1
chr1_+_206730497	0.914		RASSF5	Ras association (RalGDS/AF-6) domain family member 5
chr17_+_28256873	0.909	NM_001145053	EFCAB5	EF-hand calcium binding domain 5
chr1_+_206730456	0.908	NM_182665	RASSF5	Ras association (RalGDS/AF-6) domain family member 5
chr1_-_207095198	0.907	NM_001193338 NM_001142473 NM_005449	FAIM3	Fas apoptotic inhibitory molecule 3
chr5_+_161275185	0.906		GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr19_-_14887623	0.905		EMR2	egf-like module containing, mucin-like, hormone receptor-like 2
chr7_-_994259	0.903	NM_006869	ADAP1	ArfGAP with dual PH domains 1
chr10_-_73848278	0.901		SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr22_+_24823529	0.897	NM_000675	ADORA2A	adenosine A2a receptor
chr3_+_186330844	0.883	NM_001622	AHSG	alpha-2-HS-glycoprotein
chr19_-_14887655	0.878		EMR2	egf-like module containing, mucin-like, hormone receptor-like 2
chr12_+_51818669	0.877		SLC4A8	solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr5_+_161274939	0.872	NM_001127644	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr13_+_100633977	0.864	NM_007129	ZIC2	Zic family member 2
chr5_+_176784947	0.863
chr17_-_38020421	0.862	NM_012481 NM_183228 NM_183229 NM_183230 NM_183231 NM_183232	IKZF3	IKAROS family zinc finger 3 (Aiolos)
chr13_+_100634257	0.860		ZIC2	Zic family member 2
chr12_+_48722762	0.851	NM_181788	H1FNT	H1 histone family, member N, testis-specific
chr22_+_23229959	0.851	NM_001178126	IGLL5 IGLC1	immunoglobulin lambda-like polypeptide 5 immunoglobulin lambda constant 1 (Mcg marker)
chr2_+_113993082	0.847		LOC654433	uncharacterized LOC654433
chr16_+_24267672	0.845		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr17_+_38024416	0.844	NM_198844 NM_199321	ZPBP2	zona pellucida binding protein 2
chr2_-_60780404	0.834	NM_018014 NM_022893 NM_138559	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)
chr7_-_994371	0.834		ADAP1	ArfGAP with dual PH domains 1
chr7_-_994008	0.833		ADAP1	ArfGAP with dual PH domains 1
chr6_+_167536240	0.826	NM_031409	CCR6	chemokine (C-C motif) receptor 6
chr12_-_109027654	0.822	NM_003006	SELPLG	selectin P ligand
chr14_+_23352430	0.820	NM_173527	REM2	RAS (RAD and GEM)-like GTP binding 2
chr1_+_11539177	0.818	NM_020780	PTCHD2	patched domain containing 2
chr16_+_12058963	0.818	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr20_-_1538303	0.815	NM_178460	SIRPD	signal-regulatory protein delta
chr3_+_167453431	0.813	NM_001122752 NM_005025	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr13_+_111973014	0.813	NM_152324	C13orf16	chromosome 13 open reading frame 16
chr1_-_25256767	0.812	NM_004350	RUNX3	runt-related transcription factor 3
chr1_-_26232890	0.810	NM_001145454 NM_005563	STMN1	stathmin 1
chr17_+_45810609	0.806	NM_013351	TBX21	T-box 21
chr10_+_135192694	0.806	NM_152911 NM_207127 NM_207128	PAOX	polyamine oxidase (exo-N4-amino)
chr14_-_106774311	0.802		IGHA1	immunoglobulin heavy constant alpha 1
chr17_-_72619794	0.801	NM_181449	CD300E	CD300e molecule
chr14_+_105391150	0.800		PLD4	phospholipase D family, member 4
chr5_+_176853673	0.799	NM_001004105 NM_001004106 NM_002082	GRK6	G protein-coupled receptor kinase 6
chr1_+_168250277	0.796	NM_005149	TBX19	T-box 19
chr3_+_19189969	0.792	NM_144633	KCNH8	potassium voltage-gated channel, subfamily H (eag-related), member 8
chr9_-_117156684	0.791	NM_030767	AKNA	AT-hook transcription factor
chr11_-_67205151	0.790	NM_005608	PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein
chr4_-_155511838	0.782	NM_000508 NM_021871	FGA	fibrinogen alpha chain
chr3_+_10857867	0.778	NM_014229	SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr7_+_50348255	0.777		IKZF1	IKAROS family zinc finger 1 (Ikaros)
chr12_-_45270632	0.772	NM_001145107	NELL2	NEL-like 2 (chicken)
chr1_+_15736387	0.768	NM_024329	EFHD2	EF-hand domain family, member D2
chr1_-_159684274	0.768	NM_000567	CRP	C-reactive protein, pentraxin-related
chr6_+_42883726	0.764	NM_001243168 NM_001243169 NM_001243170 NM_138296	PTCRA	pre T-cell antigen receptor alpha
chr2_-_87018802	0.763	NM_001768 NM_171827	CD8A	CD8a molecule
chr19_-_54327428	0.762	NM_144687	NLRP12	NLR family, pyrin domain containing 12
chr22_+_39493228	0.758	NM_001166002 NM_001166003 NM_001166004 NM_181773	APOBEC3H	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chr2_-_100722328	0.755		AFF3	AF4/FMR2 family, member 3
chr8_-_143833924	0.754	NM_205545	LYPD2	LY6/PLAUR domain containing 2
chr8_+_104831415	0.754	NM_014677	RIMS2	regulating synaptic membrane exocytosis 2
chr19_-_51875790	0.753	NM_005601	NKG7	natural killer cell group 7 sequence
chr17_-_76899282	0.752	NM_001243540 NM_001243541	LOC100653515	differential display clone 8
chrX_-_19688991	0.752	NM_001184960	SH3KBP1	SH3-domain kinase binding protein 1
chr6_-_89827605	0.744	NM_080743	SRSF12	serine/arginine-rich splicing factor 12
chr17_+_30814708	0.741
chr2_-_192016293	0.738	NM_001243835	STAT4	signal transducer and activator of transcription 4
chr3_-_48594209	0.737	NM_004567	PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr10_+_12391728	0.737		CAMK1D	calcium/calmodulin-dependent protein kinase ID
chr13_+_31287614	0.737	NM_001204406	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr20_+_816710	0.736	NM_207121	FAM110A	family with sequence similarity 110, member A
chrX_+_153524026	0.734	NM_001145933 NM_012253	TKTL1	transketolase-like 1
chr1_-_161193190	0.733		APOA2	apolipoprotein A-II
chr17_+_43922255	0.732	NM_175882	IMP5	intramembrane protease 5
chr1_+_206730893	0.730		RASSF5	Ras association (RalGDS/AF-6) domain family member 5
chr17_-_34195745	0.726	NM_152781	C17orf66	chromosome 17 open reading frame 66
chr6_+_31583766	0.724	NM_032955	AIF1	allograft inflammatory factor 1
chr10_-_6104113	0.723	NM_000417	IL2RA	interleukin 2 receptor, alpha
chr6_-_32160289	0.720		GPSM3	G-protein signaling modulator 3
chr12_-_109027615	0.719		SELPLG	selectin P ligand
chr2_+_27498288	0.719	NM_173650	DNAJC5G	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr1_+_206730591	0.718		RASSF5	Ras association (RalGDS/AF-6) domain family member 5
chr3_-_10332408	0.716	NM_001134941 NM_016362	GHRL	ghrelin/obestatin prepropeptide
chr2_+_71295685	0.714		NAGK	N-acetylglucosamine kinase
chr12_-_109027565	0.710		SELPLG	selectin P ligand
chr12_+_100041527	0.702	NM_153364	FAM71C	family with sequence similarity 71, member C
chr6_+_42123143	0.701	NM_000409	GUCA1A	guanylate cyclase activator 1A (retina)
chr17_-_43502992	0.701	NM_199282	ARHGAP27	Rho GTPase activating protein 27
chr4_-_84255895	0.700	NM_001199830	HPSE	heparanase
chr22_+_32750871	0.697	NM_006604	RFPL3	ret finger protein-like 3
chr2_-_158184145	0.697	NM_001009959	ERMN	ermin, ERM-like protein
chr4_+_81118639	0.693	NM_001099403	PRDM8	PR domain containing 8
chr8_+_32405727	0.689	NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013960 NM_013964	NRG1	neuregulin 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
2.31	3.18e-04	GO:0023052	signaling
4.76	8.84e-04	GO:0006955	immune response
3.58	2.03e-03	GO:0002376	immune system process
2.22	5.72e-03	GO:0007165	signal transduction
165.57	1.98e-02	GO:0060544	regulation of necroptosis
165.57	1.98e-02	GO:0060545	positive regulation of necroptosis
165.57	1.98e-02	GO:0060553	induction of necroptosis
165.57	1.98e-02	GO:0060555	induction of necroptosis by extracellular signals
1.95	2.91e-02	GO:0051716	cellular response to stimulus
17.44	3.20e-02	GO:0008037	cell recognition
6.55	3.54e-02	GO:0006954	inflammatory response
124.18	3.94e-02	GO:0010940	positive regulation of necrotic cell death
124.18	3.94e-02	GO:0070265	necrotic cell death
32.41	4.22e-02	GO:0043525	positive regulation of neuron apoptosis

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
3.68	1.31e-02	GO:0005615	extracellular space
2.36	2.76e-02	GO:0005576	extracellular region
1.82	3.11e-02	GO:0005886	plasma membrane
1.79	4.00e-02	GO:0071944	cell periphery

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
24.85	1.67e-03	GO:0003823	antigen binding
8.29	6.97e-03	GO:0005126	cytokine receptor binding
7.70	1.05e-02	GO:0005125	cytokine activity