Motif ID: TCF4_dimer.p2

Z-value: 2.597


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF4hg19_v1_chr18_-_53068755_530689220.281.3e-01Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_49392909 20.502 NM_015086
 DDN
dendrin
chr8_-_75233461 17.153 NM_020647
 JPH1
junctophilin 1
chr19_-_45826131 12.457 CKM
creatine kinase, muscle
chr9_-_35689799 11.648 TPM2
tropomyosin 2 (beta)
chr4_-_177190258 11.614 NM_080874
 ASB5
ankyrin repeat and SOCS box containing 5
chr9_-_35689902 11.442 NM_003289
NM_213674
 TPM2

tropomyosin 2 (beta)

chr2_+_220283098 10.500 NM_001927
 DES
desmin
chr19_-_49658645 10.423 NM_002152
 HRC
histidine rich calcium binding protein
chr2_+_27505296 8.330 NM_032546
NM_187841
 TRIM54

tripartite motif containing 54

chr2_+_170366211 8.237 NM_006063
 KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr3_-_39234071 8.081 NM_194293
NM_001198621
 XIRP1

xin actin-binding repeat containing 1

chr3_-_69171536 7.957 NM_198271
 LMOD3
leiomodin 3 (fetal)
chr20_+_30407175 7.955 NM_033118
 MYLK2
myosin light chain kinase 2
chr3_-_195310770 7.930 APOD
apolipoprotein D
chr11_-_47470687 7.797 NM_005055
NM_032645
 RAPSN

receptor-associated protein of the synapse

chr1_+_150255228 7.733 NM_144697
 C1orf51
chromosome 1 open reading frame 51
chr3_-_195310985 7.593 NM_001647
 APOD
apolipoprotein D
chr5_+_137203559 7.477 MYOT
myotilin
chr3_+_121312169 7.383 NM_016298
 FBXO40
F-box protein 40
chr15_-_44487237 7.355 NM_032892
 FRMD5
FERM domain containing 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 82 entries
Enrichment   P-value GO Accession GO Term
16.60 7.03e-03 GO:0055003 cardiac myofibril assembly
12.26 7.07e-03 GO:0055006 cardiac cell development
12.26 7.07e-03 GO:0055013 cardiac muscle cell development
12.20 7.60e-12 GO:0030049 muscle filament sliding
12.20 7.60e-12 GO:0033275 actin-myosin filament sliding
11.88 1.33e-11 GO:0070252 actin-mediated cell contraction
11.48 1.61e-10 GO:0006941 striated muscle contraction
11.38 5.29e-05 GO:0030239 myofibril assembly
9.96 2.99e-02 GO:0060048 cardiac muscle contraction
9.84 4.75e-05 GO:0031032 actomyosin structure organization
9.29 9.77e-03 GO:0003015 heart process
9.29 9.77e-03 GO:0060047 heart contraction
9.29 9.77e-03 GO:0060079 regulation of excitatory postsynaptic membrane potential
8.85 4.30e-09 GO:0030048 actin filament-based movement
8.13 3.39e-07 GO:0055002 striated muscle cell development
8.08 2.80e-02 GO:0055007 cardiac muscle cell differentiation
7.75 3.82e-02 GO:0060078 regulation of postsynaptic membrane potential
7.73 1.98e-07 GO:0055001 muscle cell development
7.56 4.98e-24 GO:0006936 muscle contraction
7.26 2.57e-24 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
14.30 4.30e-05 GO:0005865 striated muscle thin filament
13.28 6.20e-04 GO:0030315 T-tubule
11.11 3.57e-30 GO:0030017 sarcomere
11.06 4.71e-14 GO:0031674 I band
10.48 7.72e-10 GO:0030018 Z disc
10.11 1.26e-29 GO:0044449 contractile fiber part
10.07 2.82e-30 GO:0030016 myofibril
9.72 3.47e-30 GO:0043292 contractile fiber
6.00 3.63e-02 GO:0043204 perikaryon
5.16 1.19e-04 GO:0042383 sarcolemma
4.15 3.81e-02 GO:0016459 myosin complex
3.39 5.27e-05 GO:0030425 dendrite
3.25 2.60e-07 GO:0015629 actin cytoskeleton
3.05 1.28e-02 GO:0045211 postsynaptic membrane
2.88 2.50e-07 GO:0045202 synapse
2.81 3.88e-03 GO:0034702 ion channel complex
2.81 2.28e-02 GO:0043025 neuronal cell body
2.73 3.32e-02 GO:0044297 cell body
2.58 1.40e-03 GO:0044456 synapse part
2.57 5.01e-05 GO:0043005 neuron projection

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
13.59 7.30e-18 GO:0008307 structural constituent of muscle
7.97 2.88e-02 GO:0004683 calmodulin-dependent protein kinase activity
4.49 5.24e-03 GO:0005200 structural constituent of cytoskeleton
3.55 3.90e-10 GO:0003779 actin binding
3.30 1.28e-14 GO:0008092 cytoskeletal protein binding
3.16 3.40e-02 GO:0005267 potassium channel activity
2.70 3.67e-02 GO:0005244 voltage-gated ion channel activity
2.70 3.67e-02 GO:0022832 voltage-gated channel activity
2.68 3.81e-09 GO:0005198 structural molecule activity
2.65 5.55e-04 GO:0022836 gated channel activity
2.62 3.47e-03 GO:0005261 cation channel activity
2.33 1.93e-03 GO:0022838 substrate-specific channel activity
2.30 3.58e-03 GO:0005216 ion channel activity
2.26 3.72e-03 GO:0015267 channel activity
2.26 3.92e-03 GO:0022803 passive transmembrane transporter activity