Motif ID: TCF4_dimer.p2

Z-value: 2.597


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF4hg19_v1_chr18_-_53068755_530689220.281.3e-01Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_49392909 20.502 NM_015086
DDN
dendrin
chr8_-_75233461 17.153 NM_020647
JPH1
junctophilin 1
chr19_-_45826131 12.457 CKM
creatine kinase, muscle
chr9_-_35689799 11.648 TPM2
tropomyosin 2 (beta)
chr4_-_177190258 11.614 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr9_-_35689902 11.442 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr2_+_220283098 10.500 NM_001927
DES
desmin
chr19_-_49658645 10.423 NM_002152
HRC
histidine rich calcium binding protein
chr2_+_27505296 8.330 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr2_+_170366211 8.237 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr3_-_39234071 8.081 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr3_-_69171536 7.957 NM_198271
LMOD3
leiomodin 3 (fetal)
chr20_+_30407175 7.955 NM_033118
MYLK2
myosin light chain kinase 2
chr3_-_195310770 7.930 APOD
apolipoprotein D
chr11_-_47470687 7.797 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr1_+_150255228 7.733 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr3_-_195310985 7.593 NM_001647
APOD
apolipoprotein D
chr5_+_137203559 7.477 MYOT
myotilin
chr3_+_121312169 7.383 NM_016298
FBXO40
F-box protein 40
chr15_-_44487237 7.355 NM_032892
FRMD5
FERM domain containing 5
chr3_+_35681008 7.274 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr8_-_41522724 7.225 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr2_-_175629140 7.205 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr11_-_63933493 7.127 NM_014067
MACROD1
MACRO domain containing 1
chr2_-_220436267 6.895 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr1_-_1850704 6.878 NM_178545
TMEM52
transmembrane protein 52
chr5_+_137203544 6.744 NM_001135940
NM_006790
MYOT

myotilin

chr5_+_173472692 6.655 NM_015980
HMP19
HMP19 protein
chr11_+_1860232 6.552 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr3_+_42727010 6.534 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr12_-_70093064 6.470 NM_032735
BEST3
bestrophin 3
chr17_-_79792867 6.395 PPP1R27
protein phosphatase 1, regulatory subunit 27
chr11_+_1860718 6.321 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr12_+_101988746 6.312 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr5_-_136834231 6.284 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr17_-_10452939 6.269 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr2_+_220299699 6.213 NM_005876
SPEG
SPEG complex locus
chr16_+_330605 6.205 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr11_-_63933204 6.157 MACROD1
MACRO domain containing 1
chr17_+_33474835 6.057 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr6_-_53530505 6.006 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr15_-_44487468 5.928 FRMD5
FERM domain containing 5
chr11_-_17410205 5.796 NM_000525
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr13_-_114107838 5.738 NM_138430
ADPRHL1
ADP-ribosylhydrolase like 1
chr5_-_136834418 5.674 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr22_-_36013303 5.663 NM_005368
NM_203378
MB

myoglobin

chr4_+_114214102 5.650 ANK2
ankyrin 2, neuronal
chr10_-_92680784 5.639 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr14_-_65346554 5.547 SPTB
spectrin, beta, erythrocytic
chr1_-_16345284 5.525 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr10_-_92681025 5.497 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_27339326 5.473 NM_052943
FAM46B
family with sequence similarity 46, member B
chr19_-_12886263 5.460 HOOK2
hook homolog 2 (Drosophila)
chr11_-_17410863 5.373 NM_001166290
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr16_+_7382750 5.200 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr5_+_173472737 5.179 HMP19
HMP19 protein
chr2_-_220436010 5.115 OBSL1
obscurin-like 1
chrX_-_71933709 4.937 NM_001122670
NM_001172436
NM_002637
PHKA1


phosphorylase kinase, alpha 1 (muscle)


chr2_+_233390869 4.937 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr13_-_24471124 4.852 NM_001007537
C1QTNF9B
C1q and tumor necrosis factor related protein 9B
chr2_-_152590983 4.790 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr10_+_103348040 4.778 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr6_-_45983279 4.769 NM_016929
CLIC5
chloride intracellular channel 5
chr3_+_50712671 4.760 NM_004947
DOCK3
dedicator of cytokinesis 3
chr7_-_22396511 4.743 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_+_41258941 4.702 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_241759627 4.613 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr10_-_75410778 4.592 NM_024875
SYNPO2L
synaptopodin 2-like
chr4_+_113970784 4.525 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr19_-_45826232 4.518 NM_001824
CKM
creatine kinase, muscle
chr8_+_86351055 4.504 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr12_-_111358353 4.446 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr11_-_119234628 4.437 USP2
ubiquitin specific peptidase 2
chr2_+_79740059 4.427 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr10_+_99332197 4.398 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr1_+_203097427 4.382 ADORA1
adenosine A1 receptor
chr2_+_223916861 4.380 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr2_+_239047362 4.376 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr2_+_88367298 4.308 NM_198274
SMYD1
SET and MYND domain containing 1
chr3_-_118753428 4.273 IGSF11
immunoglobulin superfamily, member 11
chr3_-_118753665 4.244 NM_001015887
IGSF11
immunoglobulin superfamily, member 11
chr4_-_8160435 4.208 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr19_+_50936159 4.180 NM_004533
MYBPC2
myosin binding protein C, fast type
chrX_+_12156584 4.143 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr3_-_119379269 4.135 NM_022135
POPDC2
popeye domain containing 2
chr1_+_57110745 4.092 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr2_-_211179765 4.083 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr6_+_87865261 4.082 NM_015021
ZNF292
zinc finger protein 292
chr6_+_124125068 4.080 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr2_-_179672056 4.065 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr1_+_6615337 4.027 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr13_+_31480311 4.012 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr17_+_65040651 3.911 NM_000727
CACNG1
calcium channel, voltage-dependent, gamma subunit 1
chrX_+_70521627 3.898 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr10_-_102988688 3.891 NM_006562
LBX1
ladybird homeobox 1
chr1_-_6662681 3.888 KLHL21
kelch-like 21 (Drosophila)
chr14_-_23821423 3.864 NM_020372
SLC22A17
solute carrier family 22, member 17
chr1_+_13910251 3.826 NM_006474
NM_198389
PDPN

podoplanin

chr1_+_46379258 3.819 MAST2
microtubule associated serine/threonine kinase 2
chr6_-_33714681 3.812 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr3_+_8775485 3.760 NM_001234
NM_033337
CAV3

caveolin 3

chr1_-_17445865 3.707 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr6_+_41020939 3.700 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr1_+_160160284 3.697 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr5_+_150040402 3.685 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr15_-_51397472 3.656 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr8_+_136470108 3.645 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr3_-_195306274 3.636 APOD
apolipoprotein D
chr5_+_6448735 3.634 NM_001145161
UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1
chr19_-_6502224 3.623 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr1_+_201159952 3.615 NM_001164586
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr7_-_44105162 3.606 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr17_+_4487833 3.593 NM_001114974
SMTNL2
smoothelin-like 2
chr18_+_33877630 3.583 NM_025135
FHOD3
formin homology 2 domain containing 3
chr19_+_13205956 3.534 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_36359346 3.513 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr14_+_105781180 3.508 PACS2
phosphofurin acidic cluster sorting protein 2
chr4_-_101111606 3.508 NM_145244
DDIT4L
DNA-damage-inducible transcript 4-like
chr4_+_75310852 3.506 NM_001657
AREG
amphiregulin
chr19_-_47137938 3.498 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr5_+_6449114 3.496 UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1
chr5_-_149669187 3.492 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr5_-_149669400 3.458 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr11_+_3666357 3.449 NM_004314
ART1
ADP-ribosyltransferase 1
chr12_-_117799410 3.444 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr1_-_201081693 3.437 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr1_-_201915467 3.418 LMOD1
leiomodin 1 (smooth muscle)
chr12_+_130822590 3.372 PIWIL1
piwi-like 1 (Drosophila)
chr7_-_107302151 3.356 LOC286002
uncharacterized LOC286002
chr17_-_41738901 3.328 NM_004527
NM_013999
MEOX1

mesenchyme homeobox 1

chr17_-_8702438 3.316 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr6_+_150464156 3.286 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr4_+_120056938 3.278 NM_016599
MYOZ2
myozenin 2
chr11_+_73358593 3.275 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr17_+_40811261 3.260 NM_016437
TUBG2
tubulin, gamma 2
chr18_-_24445652 3.240 NM_001650
AQP4
aquaporin 4
chr19_-_12886421 3.225 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr16_-_46782104 3.222 NM_182493
MYLK3
myosin light chain kinase 3
chr10_+_71211215 3.204 NM_012339
TSPAN15
tetraspanin 15
chr17_+_47653176 3.162 NM_007225
NXPH3
neurexophilin 3
chrX_-_13956644 3.146 NM_001001994
GPM6B
glycoprotein M6B
chrX_-_13956445 3.138


chr3_-_87040246 3.133 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr9_+_17578952 3.126 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr7_-_44365019 3.126 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr3_+_85008031 3.123 NM_001167674
NM_001167675
CADM2

cell adhesion molecule 2

chr10_-_21463019 3.120 NM_001173484
NM_213569
NEBL

nebulette

chr2_-_183731279 3.118 NM_001463
FRZB
frizzled-related protein
chr15_-_42749710 3.114 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr8_-_124553253 3.110 FBXO32
F-box protein 32
chr3_+_32148136 3.105 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr9_+_34990715 3.085 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_-_217559497 3.082 IGFBP5
insulin-like growth factor binding protein 5
chr4_+_75480628 3.082 NM_001657
AREG
amphiregulin
chr17_-_79792923 3.081 NM_001007533
PPP1R27
protein phosphatase 1, regulatory subunit 27
chr19_-_49222956 3.069 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_-_154842725 3.067 NM_001204087
NM_002249
KCNN3

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

chr2_+_220325533 3.047 NM_001173476
SPEG
SPEG complex locus
chr5_+_80529138 3.019 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr14_-_65289812 3.015 NM_000347
NM_001024858
SPTB

spectrin, beta, erythrocytic

chrX_-_110039285 3.012 NM_001143981
NM_001143982
NM_001143983
CHRDL1


chordin-like 1


chr10_-_21462987 2.995 NEBL
nebulette
chr16_-_15835382 2.991 MYH11
myosin, heavy chain 11, smooth muscle
chr4_-_41216455 2.984 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr4_-_75719686 2.972 NM_001729
BTC
betacellulin
chr17_+_47653474 2.968 NXPH3
neurexophilin 3
chr2_-_179659680 2.964 TTN
titin
chr9_+_976963 2.956 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr22_-_38379790 2.949 SOX10
SRY (sex determining region Y)-box 10
chr16_+_1031807 2.945 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr12_-_109458844 2.938 NM_018711
SVOP
SV2 related protein homolog (rat)
chr20_-_590909 2.926 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr12_+_50497790 2.920 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr11_+_111789600 2.912 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr8_-_139509064 2.906 NM_015912
FAM135B
family with sequence similarity 135, member B
chr19_-_36247917 2.894 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chrX_-_33146543 2.894 NM_004010
NM_004009
DMD

dystrophin

chr1_+_145413190 2.890 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chrX_-_13956530 2.888 GPM6B
glycoprotein M6B
chr20_-_3149070 2.877 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr19_-_42569921 2.850 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr8_-_144512601 2.846 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr11_-_694842 2.844 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr6_+_73331808 2.831 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr17_+_21279667 2.831 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr14_+_105190533 2.829 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr15_+_75118950 2.819 NM_001030005
CPLX3
complexin 3
chr2_+_220309373 2.802 SPEG
SPEG complex locus
chr7_+_140774031 2.799 NM_001195278
LOC100507421
transmembrane protein 178-like
chr11_-_2018703 2.770 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_-_97356007 2.764 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr13_+_35516390 2.744 NM_015678
NBEA
neurobeachin
chr1_-_27339448 2.729 FAM46B
family with sequence similarity 46, member B
chr1_-_24438625 2.728 NM_152372
MYOM3
myomesin family, member 3
chr7_+_29846112 2.712 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr18_+_18822168 2.707 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr5_-_180632110 2.704 NM_033342
NM_203293
TRIM7

tripartite motif containing 7

chr2_+_205410716 2.695 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chrX_-_33357725 2.682 NM_000109
DMD
dystrophin
chr5_+_137774632 2.681 NM_016606
REEP2
receptor accessory protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.26 2.57e-24 GO:0003012 muscle system process
7.56 4.98e-24 GO:0006936 muscle contraction
1.65 7.14e-20 GO:0032501 multicellular organismal process
1.86 7.57e-19 GO:0007275 multicellular organismal development
5.02 8.43e-18 GO:0061061 muscle structure development
1.88 1.44e-17 GO:0048856 anatomical structure development
1.77 3.07e-17 GO:0032502 developmental process
1.92 1.87e-16 GO:0048731 system development
2.06 3.17e-14 GO:0030154 cell differentiation
2.02 1.40e-13 GO:0048869 cellular developmental process
5.20 5.22e-13 GO:0007517 muscle organ development
12.20 7.60e-12 GO:0030049 muscle filament sliding
12.20 7.60e-12 GO:0033275 actin-myosin filament sliding
11.88 1.33e-11 GO:0070252 actin-mediated cell contraction
2.17 2.05e-11 GO:0007399 nervous system development
5.90 3.79e-11 GO:0042692 muscle cell differentiation
2.04 4.74e-11 GO:0003008 system process
11.48 1.61e-10 GO:0006941 striated muscle contraction
3.52 4.22e-09 GO:0044057 regulation of system process
8.85 4.30e-09 GO:0030048 actin filament-based movement
3.00 9.98e-08 GO:0007268 synaptic transmission
6.47 1.09e-07 GO:0051146 striated muscle cell differentiation
2.28 1.36e-07 GO:0048468 cell development
7.73 1.98e-07 GO:0055001 muscle cell development
2.40 2.93e-07 GO:0007267 cell-cell signaling
8.13 3.39e-07 GO:0055002 striated muscle cell development
4.81 6.62e-07 GO:0042391 regulation of membrane potential
4.95 8.96e-07 GO:0014706 striated muscle tissue development
1.91 1.06e-06 GO:0009653 anatomical structure morphogenesis
2.73 1.39e-06 GO:0019226 transmission of nerve impulse
2.73 1.39e-06 GO:0035637 multicellular organismal signaling
2.10 3.50e-06 GO:0007154 cell communication
4.53 5.21e-06 GO:0060537 muscle tissue development
1.74 7.38e-06 GO:0048513 organ development
3.15 1.92e-05 GO:0030029 actin filament-based process
1.89 3.81e-05 GO:0051239 regulation of multicellular organismal process
9.84 4.75e-05 GO:0031032 actomyosin structure organization
11.38 5.29e-05 GO:0030239 myofibril assembly
2.04 1.21e-04 GO:0022008 neurogenesis
3.22 1.75e-04 GO:0007507 heart development
5.24 2.37e-04 GO:0090257 regulation of muscle system process
5.95 3.40e-04 GO:0048738 cardiac muscle tissue development
5.47 3.57e-04 GO:0006937 regulation of muscle contraction
2.20 7.44e-04 GO:0032989 cellular component morphogenesis
2.40 8.08e-04 GO:0072358 cardiovascular system development
2.40 8.08e-04 GO:0072359 circulatory system development
5.31 1.39e-03 GO:0051147 regulation of muscle cell differentiation
2.71 1.50e-03 GO:0060284 regulation of cell development
1.22 1.88e-03 GO:0065007 biological regulation
1.96 2.01e-03 GO:0048699 generation of neurons
2.68 2.98e-03 GO:0007610 behavior
6.64 3.06e-03 GO:0051899 membrane depolarization
1.23 3.51e-03 GO:0050789 regulation of biological process
1.24 3.83e-03 GO:0050794 regulation of cellular process
2.25 4.31e-03 GO:0007417 central nervous system development
1.14 4.57e-03 GO:0009987 cellular process
1.38 4.97e-03 GO:0023052 signaling
2.03 5.35e-03 GO:0030182 neuron differentiation
2.15 5.50e-03 GO:0048666 neuron development
16.60 7.03e-03 GO:0055003 cardiac myofibril assembly
12.26 7.07e-03 GO:0055006 cardiac cell development
12.26 7.07e-03 GO:0055013 cardiac muscle cell development
9.29 9.77e-03 GO:0003015 heart process
9.29 9.77e-03 GO:0060047 heart contraction
9.29 9.77e-03 GO:0060079 regulation of excitatory postsynaptic membrane potential
1.85 1.23e-02 GO:0050793 regulation of developmental process
3.37 1.25e-02 GO:0045165 cell fate commitment
1.81 1.27e-02 GO:0032879 regulation of localization
1.99 1.40e-02 GO:0045595 regulation of cell differentiation
2.26 1.64e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
2.97 1.66e-02 GO:0003013 circulatory system process
2.97 1.66e-02 GO:0008015 blood circulation
2.17 1.74e-02 GO:0000904 cell morphogenesis involved in differentiation
1.50 1.96e-02 GO:0065008 regulation of biological quality
8.08 2.80e-02 GO:0055007 cardiac muscle cell differentiation
2.15 2.82e-02 GO:0030001 metal ion transport
2.17 2.95e-02 GO:0050801 ion homeostasis
9.96 2.99e-02 GO:0060048 cardiac muscle contraction
6.64 3.41e-02 GO:0048747 muscle fiber development
2.03 3.57e-02 GO:0006812 cation transport
7.75 3.82e-02 GO:0060078 regulation of postsynaptic membrane potential
3.20 4.35e-02 GO:0043269 regulation of ion transport

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
10.07 2.82e-30 GO:0030016 myofibril
9.72 3.47e-30 GO:0043292 contractile fiber
11.11 3.57e-30 GO:0030017 sarcomere
10.11 1.26e-29 GO:0044449 contractile fiber part
11.06 4.71e-14 GO:0031674 I band
10.48 7.72e-10 GO:0030018 Z disc
1.94 7.88e-09 GO:0005856 cytoskeleton
2.88 2.50e-07 GO:0045202 synapse
3.25 2.60e-07 GO:0015629 actin cytoskeleton
1.62 1.05e-05 GO:0044459 plasma membrane part
1.41 1.08e-05 GO:0005886 plasma membrane
1.40 1.29e-05 GO:0071944 cell periphery
14.30 4.30e-05 GO:0005865 striated muscle thin filament
2.57 5.01e-05 GO:0043005 neuron projection
3.39 5.27e-05 GO:0030425 dendrite
5.16 1.19e-04 GO:0042383 sarcolemma
13.28 6.20e-04 GO:0030315 T-tubule
2.11 6.45e-04 GO:0030054 cell junction
2.58 1.40e-03 GO:0044456 synapse part
1.43 1.75e-03 GO:0043228 non-membrane-bounded organelle
1.43 1.75e-03 GO:0043232 intracellular non-membrane-bounded organelle
2.81 3.88e-03 GO:0034702 ion channel complex
3.05 1.28e-02 GO:0045211 postsynaptic membrane
2.81 2.28e-02 GO:0043025 neuronal cell body
2.26 3.03e-02 GO:0005578 proteinaceous extracellular matrix
2.73 3.32e-02 GO:0044297 cell body
6.00 3.63e-02 GO:0043204 perikaryon
4.15 3.81e-02 GO:0016459 myosin complex
1.62 3.99e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
13.59 7.30e-18 GO:0008307 structural constituent of muscle
3.30 1.28e-14 GO:0008092 cytoskeletal protein binding
3.55 3.90e-10 GO:0003779 actin binding
2.68 3.81e-09 GO:0005198 structural molecule activity
2.65 5.55e-04 GO:0022836 gated channel activity
2.33 1.93e-03 GO:0022838 substrate-specific channel activity
2.62 3.47e-03 GO:0005261 cation channel activity
2.30 3.58e-03 GO:0005216 ion channel activity
2.26 3.72e-03 GO:0015267 channel activity
2.26 3.92e-03 GO:0022803 passive transmembrane transporter activity
4.49 5.24e-03 GO:0005200 structural constituent of cytoskeleton
7.97 2.88e-02 GO:0004683 calmodulin-dependent protein kinase activity
3.16 3.40e-02 GO:0005267 potassium channel activity
2.70 3.67e-02 GO:0005244 voltage-gated ion channel activity
2.70 3.67e-02 GO:0022832 voltage-gated channel activity