Motif ID: TEAD1.p2

Z-value: 3.862


Transcription factors associated with TEAD1.p2:

Gene SymbolEntrez IDGene Name
TEAD1 7003 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 8463 TEA domain family member 2
TEAD3 7005 TEAD3 TEA domain family member 3
TEAD4 7004 TEAD4 TEA domain family member 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TEAD1hg19_v1_chr11_+_12960793_129608300.897.0e-12Click!
TEAD3hg19_v1_chr6_-_35464716_354649080.854.8e-10Click!
TEAD2hg19_v1_chr19_-_49865638_498657130.797.3e-08Click!
TEAD4hg19_v1_chr12_+_3068442_30687470.781.8e-07Click!


Activity profile for motif TEAD1.p2.

activity profile for motif TEAD1.p2


Sorted Z-values histogram for motif TEAD1.p2

Sorted Z-values for motif TEAD1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_34972866 34.910 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr6_-_132272311 27.080 NM_001901
 CTGF
connective tissue growth factor
chr1_-_214724974 24.143 NM_005401
 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr3_-_119379269 19.348 NM_022135
 POPDC2
popeye domain containing 2
chr1_-_16344438 18.233 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr1_-_214724844 17.992 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_203317366 16.513 FMOD
fibromodulin
chr3_-_52488030 15.273 NM_003280
 TNNC1
troponin C type 1 (slow)
chr2_-_217540722 15.264 IGFBP5
insulin-like growth factor binding protein 5
chr14_-_23904849 14.375 NM_000257
 MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr5_-_138842291 13.647 NM_001077693
 ECSCR
endothelial cell-specific chemotaxis regulator
chr10_-_90712510 13.566 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr17_-_40575117 13.485 NM_012232
 PTRF
polymerase I and transcript release factor
chr4_-_186733372 12.972 NM_003603
NM_001145670
 SORBS2

sorbin and SH3 domain containing 2

chr4_+_24797203 12.840 SOD3
superoxide dismutase 3, extracellular
chr3_-_112359962 12.618 NM_199511
NM_199512
 CCDC80

coiled-coil domain containing 80

chr15_+_63335086 12.242 TPM1
tropomyosin 1 (alpha)
chr1_-_26393984 12.007 NM_032588
 TRIM63
tripartite motif containing 63
chr6_-_75915566 11.519 NM_004370
NM_080645
 COL12A1

collagen, type XII, alpha 1

chr3_-_112359443 11.425 CCDC80
coiled-coil domain containing 80

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 82 entries
Enrichment   P-value GO Accession GO Term
20.58 3.01e-03 GO:0045214 sarcomere organization
15.09 3.07e-04 GO:0030239 myofibril assembly
13.46 3.86e-07 GO:0030049 muscle filament sliding
13.46 3.86e-07 GO:0033275 actin-myosin filament sliding
13.42 1.15e-04 GO:0031032 actomyosin structure organization
13.32 3.61e-02 GO:0043462 regulation of ATPase activity
13.21 8.64e-04 GO:0003229 ventricular cardiac muscle tissue development
13.21 8.64e-04 GO:0055010 ventricular cardiac muscle tissue morphogenesis
13.11 5.32e-07 GO:0070252 actin-mediated cell contraction
11.32 4.96e-04 GO:0003208 cardiac ventricle morphogenesis
10.66 1.18e-06 GO:0030048 actin filament-based movement
10.23 5.74e-03 GO:0055008 cardiac muscle tissue morphogenesis
9.91 7.21e-03 GO:0060415 muscle tissue morphogenesis
9.24 1.34e-04 GO:0055002 striated muscle cell development
9.06 3.10e-03 GO:0003231 cardiac ventricle development
8.57 2.01e-02 GO:0006941 striated muscle contraction
8.43 5.52e-03 GO:0003206 cardiac chamber morphogenesis
8.34 2.41e-02 GO:0048644 muscle organ morphogenesis
8.23 4.23e-04 GO:0055001 muscle cell development
7.81 7.11e-04 GO:0048738 cardiac muscle tissue development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
Enrichment   P-value GO Accession GO Term
37.73 6.54e-06 GO:0005587 collagen type IV
32.34 2.25e-05 GO:0030935 sheet-forming collagen
22.64 4.39e-02 GO:0001527 microfibril
13.93 3.09e-02 GO:0031672 A band
12.94 4.25e-02 GO:0031528 microvillus membrane
12.58 8.15e-07 GO:0005581 collagen
12.58 7.49e-03 GO:0005859 muscle myosin complex
11.32 1.31e-02 GO:0016460 myosin II complex
8.41 8.06e-07 GO:0005604 basement membrane
8.02 1.24e-10 GO:0044420 extracellular matrix part
7.42 1.99e-09 GO:0030016 myofibril
7.39 9.34e-08 GO:0030017 sarcomere
7.36 6.43e-10 GO:0043292 contractile fiber
7.21 1.14e-08 GO:0044449 contractile fiber part
7.08 2.80e-04 GO:0016459 myosin complex
4.44 1.89e-09 GO:0005578 proteinaceous extracellular matrix
4.39 4.44e-11 GO:0031012 extracellular matrix
4.36 2.20e-02 GO:0005924 cell-substrate adherens junction
4.19 3.02e-02 GO:0030055 cell-substrate junction
3.95 5.88e-03 GO:0005912 adherens junction

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
27.17 3.08e-02 GO:0032036 myosin heavy chain binding
13.69 1.47e-09 GO:0008307 structural constituent of muscle
10.87 4.13e-03 GO:0050840 extracellular matrix binding
9.06 5.25e-09 GO:0005201 extracellular matrix structural constituent
6.89 1.85e-02 GO:0001948 glycoprotein binding
6.77 4.91e-07 GO:0019838 growth factor binding
6.53 8.52e-07 GO:0008201 heparin binding
5.13 4.47e-06 GO:0001871 pattern binding
5.13 4.47e-06 GO:0030247 polysaccharide binding
4.93 4.94e-05 GO:0005539 glycosaminoglycan binding
3.78 2.57e-02 GO:0004252 serine-type endopeptidase activity
3.46 4.25e-05 GO:0003779 actin binding
2.99 5.60e-07 GO:0005198 structural molecule activity
2.73 1.42e-04 GO:0008092 cytoskeletal protein binding
2.17 1.98e-02 GO:0005509 calcium ion binding
2.16 6.65e-03 GO:0042802 identical protein binding
1.32 1.18e-04 GO:0005515 protein binding