Motif ID: TFAP2{A,C}.p2

Z-value: 2.744


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Chg19_v1_chr20_+_55204307_552045540.193.1e-01Click!
TFAP2Ahg19_v1_chr6_-_10419786_10419796-0.096.3e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_121103670 8.569 NM_002193
 INHBB
inhibin, beta B
chr7_-_44365019 6.815 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr8_-_144512601 6.191 NM_201589
 MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr19_-_18717467 5.906 CRLF1
cytokine receptor-like factor 1
chr2_+_42275017 5.560 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr8_-_80679897 5.509 NM_001040708
NM_012258
 HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr15_-_55880508 5.482 PYGO1
pygopus homolog 1 (Drosophila)
chr14_-_65346554 5.386 SPTB
spectrin, beta, erythrocytic
chr3_-_38691118 5.321 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
 SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr19_-_15311773 5.156 NM_000435
 NOTCH3
notch 3
chrX_+_152953751 4.997 NM_001142805
NM_005629
 SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr9_+_95947211 4.972 NM_006648
 WNK2
WNK lysine deficient protein kinase 2
chr19_-_18717631 4.948 NM_004750
 CRLF1
cytokine receptor-like factor 1
chr2_+_18059923 4.939 NM_002252
 KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr6_+_107811272 4.867 NM_018013
 SOBP
sine oculis binding protein homolog (Drosophila)
chr19_-_18717577 4.846 CRLF1
cytokine receptor-like factor 1
chr1_-_16344438 4.816 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_-_45236521 4.642 NM_016932
 SIX2
SIX homeobox 2
chr6_+_17281773 4.590 NM_001143942
 RBM24
RNA binding motif protein 24
chr15_-_48937068 4.571 FBN1
fibrillin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 144 entries
Enrichment   P-value GO Accession GO Term
11.24 2.68e-03 GO:0045446 endothelial cell differentiation
10.26 5.37e-03 GO:0003158 endothelium development
7.61 4.69e-02 GO:0035051 cardiac cell differentiation
6.58 3.90e-02 GO:0035050 embryonic heart tube development
6.44 1.45e-06 GO:0030326 embryonic limb morphogenesis
6.44 1.45e-06 GO:0035113 embryonic appendage morphogenesis
5.81 1.19e-02 GO:0048704 embryonic skeletal system morphogenesis
5.78 2.91e-06 GO:0048736 appendage development
5.78 2.91e-06 GO:0060173 limb development
5.68 1.10e-05 GO:0035107 appendage morphogenesis
5.68 1.10e-05 GO:0035108 limb morphogenesis
5.50 4.11e-11 GO:0007517 muscle organ development
5.32 2.08e-04 GO:0003007 heart morphogenesis
5.22 1.83e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
5.11 3.91e-02 GO:0060538 skeletal muscle organ development
5.08 7.85e-14 GO:0061061 muscle structure development
4.82 5.72e-05 GO:0042692 muscle cell differentiation
4.76 3.09e-02 GO:0032355 response to estradiol stimulus
4.70 3.49e-02 GO:0048706 embryonic skeletal system development
4.57 6.89e-04 GO:0014706 striated muscle tissue development

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
6.74 3.43e-06 GO:0005604 basement membrane
6.21 2.65e-02 GO:0030018 Z disc
4.77 5.29e-05 GO:0044420 extracellular matrix part
3.88 7.25e-03 GO:0044449 contractile fiber part
3.79 3.68e-02 GO:0030017 sarcomere
3.78 9.59e-03 GO:0030016 myofibril
3.56 1.77e-02 GO:0043292 contractile fiber
3.47 2.02e-03 GO:0070161 anchoring junction
3.17 3.41e-02 GO:0005912 adherens junction
3.09 3.25e-05 GO:0005578 proteinaceous extracellular matrix
2.80 9.48e-05 GO:0031012 extracellular matrix
2.62 1.39e-06 GO:0030054 cell junction
1.47 2.46e-02 GO:0044459 plasma membrane part
1.30 4.85e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
4.89 2.84e-02 GO:0019902 phosphatase binding
2.69 2.69e-03 GO:0003779 actin binding
2.55 2.89e-05 GO:0008092 cytoskeletal protein binding
2.40 1.06e-08 GO:0001071 nucleic acid binding transcription factor activity
2.40 1.06e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
2.36 2.91e-05 GO:0043565 sequence-specific DNA binding
2.23 5.53e-07 GO:0030528 transcription regulator activity
1.31 1.75e-06 GO:0005515 protein binding
1.15 1.46e-04 GO:0005488 binding