Motif ID: TFAP2B.p2

Z-value: 1.487


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Bhg19_v1_chr6_+_50786438_50786632-0.281.2e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_160114318 3.255 NM_000636
NM_001024465
NM_001024466
SOD2


superoxide dismutase 2, mitochondrial


chr6_-_160114186 3.124 SOD2
superoxide dismutase 2, mitochondrial
chr20_-_62130390 2.866 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr8_-_124553448 2.600 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr8_-_141645603 2.410 NM_001164623
NM_012154
EIF2C2

eukaryotic translation initiation factor 2C, 2

chr5_+_7396030 2.264 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr17_+_78234626 2.260 NM_020914
NM_020954
RNF213

ring finger protein 213

chr2_+_241508103 2.219 RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr3_-_38691118 2.177 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr1_+_236849753 2.135 NM_001103
ACTN2
actinin, alpha 2
chr2_+_241507928 2.127 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr20_+_57466509 2.114 GNAS
GNAS complex locus
chr2_-_240322620 2.108 NM_006037
HDAC4
histone deacetylase 4
chr2_-_240322692 2.096 HDAC4
histone deacetylase 4
chr22_-_50699938 2.074 NM_002969
MAPK12
mitogen-activated protein kinase 12
chr20_+_57466248 2.072 NM_000516
NM_001077488
NM_001077489
NM_080426
GNAS



GNAS complex locus



chr6_+_157099262 2.047 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr1_-_33336289 2.009 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr5_-_78809658 2.003 NM_004272
HOMER1
homer homolog 1 (Drosophila)
chr7_-_150946031 1.968 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr7_-_44365019 1.952 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr2_-_127864505 1.951 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr14_+_105190533 1.928 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr5_+_154135029 1.926 LARP1
La ribonucleoprotein domain family, member 1
chr6_+_108882104 1.906 FOXO3
forkhead box O3
chr7_+_128470462 1.883 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr9_+_137218324 1.877 RXRA
retinoid X receptor, alpha
chrX_+_152953751 1.835 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr2_+_241375207 1.820 GPC1
glypican 1
chr6_+_157099203 1.816


chr6_+_157099041 1.804 NM_017519
NM_020732
ARID1B

AT rich interactive domain 1B (SWI1-like)

chr15_+_63335086 1.778 TPM1
tropomyosin 1 (alpha)
chr4_+_6784453 1.753 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr19_+_50706868 1.718 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr10_-_98592186 1.715


chr6_+_163835783 1.704 QKI
QKI, KH domain containing, RNA binding
chr12_-_10875848 1.690 NM_001145426
NM_003651
CSDA

cold shock domain protein A

chr14_-_105261850 1.653 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr8_-_144512601 1.637 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr4_+_6784462 1.625 KIAA0232
KIAA0232
chr14_-_102976096 1.614 NM_152326
ANKRD9
ankyrin repeat domain 9
chr8_+_145321462 1.614 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr20_+_57267818 1.602 NM_024663
NPEPL1
aminopeptidase-like 1
chr19_-_4065467 1.595 ZBTB7A
zinc finger and BTB domain containing 7A
chr17_-_56032494 1.586 CUEDC1
CUE domain containing 1
chr1_-_184943532 1.583 FAM129A
family with sequence similarity 129, member A
chr14_-_102975996 1.575 ANKRD9
ankyrin repeat domain 9
chr5_+_10564431 1.572 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr10_+_123922940 1.570 TACC2
transforming, acidic coiled-coil containing protein 2
chr8_+_145490548 1.564 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr11_-_17410863 1.557 NM_001166290
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr22_-_50699687 1.540 MAPK12
mitogen-activated protein kinase 12
chr6_+_108882068 1.539 NM_001455
FOXO3
forkhead box O3
chr1_+_16010838 1.529 PLEKHM2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr18_+_33877630 1.508 NM_025135
FHOD3
formin homology 2 domain containing 3
chr9_+_137218313 1.483 NM_002957
RXRA
retinoid X receptor, alpha
chr7_+_101459092 1.465 NM_001202543
NM_001202544
NM_001202545
NM_001913
NM_181500
NM_001202546
CUX1





cut-like homeobox 1





chr20_+_57466721 1.460 GNAS
GNAS complex locus
chr6_+_71998514 1.459 OGFRL1
opioid growth factor receptor-like 1
chr18_+_8609407 1.448 NM_001025300
RAB12
RAB12, member RAS oncogene family
chr5_+_154134853 1.447 LARP1
La ribonucleoprotein domain family, member 1
chr14_+_105781180 1.442 PACS2
phosphofurin acidic cluster sorting protein 2
chr5_+_179248089 1.438 SQSTM1
sequestosome 1
chr8_-_145050896 1.431 NM_000445
PLEC
plectin
chr6_+_71998476 1.428 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr6_-_45983279 1.426 NM_016929
CLIC5
chloride intracellular channel 5
chr8_+_37553269 1.426 NM_025069
ZNF703
zinc finger protein 703
chr9_-_114246225 1.417 KIAA0368
KIAA0368
chr11_-_119234628 1.413 USP2
ubiquitin specific peptidase 2
chr1_+_110009220 1.389 SYPL2
synaptophysin-like 2
chr3_+_54156573 1.386 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr9_-_74979625 1.386 ZFAND5
zinc finger, AN1-type domain 5
chr10_-_126432618 1.376 FAM53B
family with sequence similarity 53, member B
chr9_+_100263818 1.359 NM_003275
TMOD1
tropomodulin 1
chr15_+_85291850 1.350 ZNF592
zinc finger protein 592
chr10_+_11060069 1.349 CELF2
CUGBP, Elav-like family member 2
chr12_-_124018066 1.322 NM_178314
RILPL1
Rab interacting lysosomal protein-like 1
chr5_+_6448735 1.306 NM_001145161
UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1
chr14_-_65346554 1.297 SPTB
spectrin, beta, erythrocytic
chr8_-_41754244 1.296 NM_001142446
ANK1
ankyrin 1, erythrocytic
chr7_-_152132924 1.295 MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr14_+_105780903 1.295 PACS2
phosphofurin acidic cluster sorting protein 2
chr1_-_1284297 1.291 NM_004421
DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr9_-_114245815 1.287 KIAA0368
KIAA0368
chr6_+_71998508 1.277 OGFRL1
opioid growth factor receptor-like 1
chr3_+_160473286 1.269 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr1_+_110009099 1.258 NM_001040709
SYPL2
synaptophysin-like 2
chr19_+_35521591 1.233 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr14_+_64319607 1.224 NM_015180
NM_182914
SYNE2

spectrin repeat containing, nuclear envelope 2

chr18_+_8609670 1.221


chr9_-_112260529 1.221 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr15_-_55880508 1.219 PYGO1
pygopus homolog 1 (Drosophila)
chr10_+_11060105 1.216 CELF2
CUGBP, Elav-like family member 2
chr7_-_139477437 1.213 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr4_+_41362843 1.210


chr9_-_134615216 1.207 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr1_+_16010816 1.199 NM_015164
PLEKHM2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr1_-_40137709 1.193 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr5_+_179234002 1.189 NM_001142299
SQSTM1
sequestosome 1
chr5_+_179247911 1.186 SQSTM1
sequestosome 1
chr6_+_150464156 1.172 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chrX_-_19533378 1.169 NM_001001671
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr7_+_152161119 1.159 LOC100128822
uncharacterized LOC100128822
chr20_-_60718358 1.156 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr10_-_126432784 1.155 FAM53B
family with sequence similarity 53, member B
chr10_+_120789227 1.153 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr2_-_99347430 1.149 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr4_+_41362565 1.147 LIMCH1
LIM and calponin homology domains 1
chr10_+_123923104 1.147 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr16_+_89238160 1.138 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr1_-_6662681 1.129 KLHL21
kelch-like 21 (Drosophila)
chr2_-_105946104 1.127 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1

chr1_+_201857997 1.124 SHISA4
shisa homolog 4 (Xenopus laevis)
chr19_-_18717467 1.117 CRLF1
cytokine receptor-like factor 1
chr10_-_30024594 1.116 NM_003174
SVIL
supervillin
chr14_-_99947113 1.105 SETD3
SET domain containing 3
chr21_+_45285026 1.101 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr7_+_1570321 1.101 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_-_56065596 1.101 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr16_+_11762235 1.096 NM_003498
SNN
stannin
chr16_-_4166185 1.094 NM_001116
ADCY9
adenylate cyclase 9
chr11_+_33279167 1.092 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr12_-_93322911 1.092 EEA1
early endosome antigen 1
chr10_-_126432893 1.090 NM_014661
FAM53B
family with sequence similarity 53, member B
chr14_-_31676680 1.087 NM_015382
HECTD1
HECT domain containing 1
chr19_-_14228362 1.081 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr5_+_79330990 1.078 NM_003248
THBS4
thrombospondin 4
chr6_-_105627857 1.078 NM_022361
POPDC3
popeye domain containing 3
chr17_-_56065474 1.076 VEZF1
vascular endothelial zinc finger 1
chr21_+_45285101 1.072 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr1_-_13840157 1.066 NM_001010847
LRRC38
leucine rich repeat containing 38
chr14_-_99947080 1.061 SETD3
SET domain containing 3
chr19_-_18717631 1.061 NM_004750
CRLF1
cytokine receptor-like factor 1
chr1_+_214454276 1.059 NM_020197
SMYD2
SET and MYND domain containing 2
chr9_+_134269509 1.059 PRRC2B
proline-rich coiled-coil 2B
chr8_+_61591358 1.054 CHD7
chromodomain helicase DNA binding protein 7
chr18_+_67956242 1.053 SOCS6
suppressor of cytokine signaling 6
chr18_+_11981457 1.052 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr3_+_49726961 1.049 RNF123
ring finger protein 123
chr8_-_75233461 1.044 NM_020647
JPH1
junctophilin 1
chr4_+_6784487 1.031 KIAA0232
KIAA0232
chr20_-_32031425 1.027 NM_003098
SNTA1
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
chr8_+_146277830 1.026 C8orf33
chromosome 8 open reading frame 33
chr12_-_93323006 1.022 EEA1
early endosome antigen 1
chr10_+_134210691 1.020 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr1_-_40042415 1.018 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr20_+_48807460 1.014 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_-_1284755 1.014 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr13_+_113344354 1.013 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chr1_-_184943673 1.012 NM_052966
FAM129A
family with sequence similarity 129, member A
chr7_+_4722091 1.010 FOXK1
forkhead box K1
chr4_-_8160435 1.010 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr10_-_133795311 1.007 NM_004052
BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr1_+_10270680 1.002 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr10_-_133795447 0.998 BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr3_+_20081853 0.998 KAT2B
K(lysine) acetyltransferase 2B
chr20_-_3766905 0.997 NM_001810
CENPB
centromere protein B, 80kDa
chr6_-_17987693 0.996 KIF13A
kinesin family member 13A
chr8_-_71315487 0.992 NCOA2
nuclear receptor coactivator 2
chr11_-_119234859 0.991 NM_171997
USP2
ubiquitin specific peptidase 2
chr2_+_173940589 0.991 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr9_+_96338671 0.981 NM_005392
PHF2
PHD finger protein 2
chr15_+_85291521 0.981 ZNF592
zinc finger protein 592
chr1_-_10754464 0.978 CASZ1
castor zinc finger 1
chr12_-_58132028 0.972 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_-_48130633 0.969 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr5_+_179247903 0.966 SQSTM1
sequestosome 1
chr17_+_4487833 0.964 NM_001114974
SMTNL2
smoothelin-like 2
chr6_-_35656610 0.960 FKBP5
FK506 binding protein 5
chr3_+_135684463 0.960 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chrX_+_109246338 0.960 NM_032227
TMEM164
transmembrane protein 164
chrX_+_109246350 0.957 TMEM164
transmembrane protein 164
chr2_+_29338207 0.955 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr17_-_27916395 0.952 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr17_+_45608738 0.949 NPEPPS
aminopeptidase puromycin sensitive
chr17_+_80009775 0.948 GPS1
G protein pathway suppressor 1
chrX_-_15872882 0.947 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr12_-_124018428 0.945 RILPL1
Rab interacting lysosomal protein-like 1
chr7_-_150945731 0.945 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_+_80009739 0.945 NM_004127
NM_212492
GPS1

G protein pathway suppressor 1

chr5_+_179247841 0.940 NM_003900
SQSTM1
sequestosome 1
chr16_-_3930120 0.939 NM_001079846
NM_004380
CREBBP

CREB binding protein

chr2_-_242212502 0.938 HDLBP
high density lipoprotein binding protein
chr7_+_140774031 0.936 NM_001195278
LOC100507421
transmembrane protein 178-like
chr17_-_4269610 0.932 UBE2G1
ubiquitin-conjugating enzyme E2G 1
chr19_-_15443307 0.924 BRD4
bromodomain containing 4
chr12_-_111180730 0.922 NM_001244974
NM_002710
PPP1CC

protein phosphatase 1, catalytic subunit, gamma isozyme

chr10_+_105726846 0.922 SLK
STE20-like kinase
chr14_-_91282642 0.922


chr13_+_113863926 0.921 NM_001008895
CUL4A
cullin 4A
chr19_+_3359138 0.920 NM_001245005
NM_205843
NFIC

nuclear factor I/C (CCAAT-binding transcription factor)

chr3_+_49727014 0.919 RNF123
ring finger protein 123
chr7_+_55955129 0.918 ZNF713
zinc finger protein 713
chr14_-_91282760 0.916 NM_001010854
TTC7B
tetratricopeptide repeat domain 7B
chr1_+_64058891 0.915 NM_002633
PGM1
phosphoglucomutase 1
chr17_-_27507195 0.914 NM_078471
NM_203318
MYO18A

myosin XVIIIA

chr20_-_60718407 0.913 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr3_-_14989399 0.912 LOC100505641
uncharacterized LOC100505641
chr18_+_11981421 0.904 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr6_+_108881010 0.903 NM_201559
FOXO3
forkhead box O3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.46 4.34e-05 GO:0061061 muscle structure development
10.22 7.33e-04 GO:0042692 muscle cell differentiation
7.88 1.35e-03 GO:0007517 muscle organ development
2.20 4.62e-03 GO:0071842 cellular component organization at cellular level
7.49 7.46e-03 GO:0003012 muscle system process
2.12 9.82e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.85 1.97e-02 GO:0032502 developmental process
2.29 2.22e-02 GO:0030154 cell differentiation
3.12 2.97e-02 GO:0048468 cell development
2.23 3.55e-02 GO:0048869 cellular developmental process
7.13 3.70e-02 GO:0006936 muscle contraction

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
13.87 3.21e-07 GO:0030016 myofibril
13.09 5.70e-07 GO:0043292 contractile fiber
12.82 4.23e-06 GO:0044449 contractile fiber part
13.14 2.12e-05 GO:0030017 sarcomere
21.17 4.67e-04 GO:0030018 Z disc
2.69 6.68e-04 GO:0005856 cytoskeleton
16.76 1.52e-03 GO:0031674 I band
5.07 9.19e-03 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.01 1.43e-05 GO:0008092 cytoskeletal protein binding
6.16 7.59e-05 GO:0003779 actin binding
107.23 1.69e-02 GO:0046975 histone methyltransferase activity (H3-K36 specific)
14.97 2.08e-02 GO:0008307 structural constituent of muscle
1.72 2.50e-02 GO:0046872 metal ion binding
1.70 3.19e-02 GO:0043169 cation binding
1.69 3.37e-02 GO:0043167 ion binding