Motif ID: TFAP4.p2

Z-value: 2.157


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP4hg19_v1_chr16_-_4323000_43230250.222.2e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_2018703 5.006 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr3_-_87040246 4.919 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr14_-_107083398 4.589 IGH@
IGHA1
IGHG1
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_23229959 3.782 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr1_+_209848994 3.530 G0S2
G0/G1switch 2
chr1_+_209848659 3.339 NM_015714
G0S2
G0/G1switch 2
chr1_-_161059085 3.287 PVRL4
poliovirus receptor-related 4
chr1_-_59043165 3.269 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr20_-_23066828 3.243 NM_012072
CD93
CD93 molecule
chr3_-_87040268 3.207 VGLL3
vestigial like 3 (Drosophila)
chr14_-_106780535 3.132 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106641585 3.108 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr8_+_104383785 3.097 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr6_+_32006092 3.073 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr14_-_106877689 3.054 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr1_+_156030965 3.021 NM_020387
RAB25
RAB25, member RAS oncogene family
chr11_-_2018334 2.976 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr22_+_22764094 2.962


chr14_-_106774311 2.944 IGHA1
immunoglobulin heavy constant alpha 1
chr8_+_104383701 2.902 CTHRC1
collagen triple helix repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
66.23 9.38e-05 GO:0048251 elastic fiber assembly
47.31 6.44e-04 GO:0085029 extracellular matrix assembly
20.70 3.07e-02 GO:0001738 morphogenesis of a polarized epithelium
7.05 1.67e-02 GO:0030198 extracellular matrix organization
5.65 2.98e-02 GO:0016055 Wnt receptor signaling pathway
5.32 5.74e-05 GO:0001568 blood vessel development
5.28 1.13e-03 GO:0048514 blood vessel morphogenesis
5.26 2.65e-05 GO:0001944 vasculature development
3.85 2.71e-04 GO:0072358 cardiovascular system development
3.85 2.71e-04 GO:0072359 circulatory system development
3.04 7.08e-04 GO:0006955 immune response
3.03 7.67e-04 GO:0007155 cell adhesion
3.03 7.67e-04 GO:0022610 biological adhesion
2.75 1.56e-05 GO:0002376 immune system process
2.23 4.01e-03 GO:0009653 anatomical structure morphogenesis
1.62 1.49e-06 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
82.78 2.13e-02 GO:0043260 laminin-11 complex
7.33 1.66e-04 GO:0044420 extracellular matrix part
7.10 2.94e-02 GO:0005604 basement membrane
5.22 2.30e-02 GO:0031225 anchored to membrane
5.05 7.49e-08 GO:0031012 extracellular matrix
4.60 2.90e-05 GO:0005578 proteinaceous extracellular matrix
3.45 2.47e-07 GO:0005615 extracellular space
3.17 5.62e-08 GO:0044421 extracellular region part
2.87 8.85e-14 GO:0005576 extracellular region
1.49 3.06e-02 GO:0005886 plasma membrane
1.47 4.76e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
24.84 5.93e-12 GO:0003823 antigen binding
15.77 2.12e-02 GO:0017147 Wnt-protein binding
7.25 1.03e-02 GO:0005201 extracellular matrix structural constituent