Motif ID: TLX2.p2

Z-value: 1.697


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX2hg19_v1_chr2_+_74740585_74740717-0.494.1e-03Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_52264452 4.165 NM_001005738
FPR2
formyl peptide receptor 2
chr14_-_106321626 3.231


chr11_+_62186506 3.227 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr4_-_155533800 3.005 FGG
fibrinogen gamma chain
chr1_-_153363544 2.863 NM_002964
S100A8
S100 calcium binding protein A8
chr4_-_155533757 2.791 FGG
fibrinogen gamma chain
chr11_+_60223281 2.478 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr9_+_117085302 2.389 NM_000607
ORM1
orosomucoid 1
chr3_+_42544094 2.308 NM_001251883
NM_001251884
NM_001251885
NM_004624
VIPR1



vasoactive intestinal peptide receptor 1



chr1_+_160765927 2.280 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr9_+_117092068 2.264 NM_000608
ORM2
orosomucoid 2
chr4_-_155533850 2.249 FGG
fibrinogen gamma chain
chr2_+_102927961 2.236 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr3_+_42544131 2.203 VIPR1
vasoactive intestinal peptide receptor 1
chr4_-_155533882 2.148 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr2_+_102979096 1.990 NM_003855
IL18R1
interleukin 18 receptor 1
chr6_-_32151996 1.974 NM_001136
NM_001206929
NM_001206932
NM_001206934
NM_001206936
NM_001206940
NM_001206954
NM_001206966
NM_172197
AGER








advanced glycosylation end product-specific receptor








chr1_+_153330329 1.969 NM_002965
S100A9
S100 calcium binding protein A9
chr5_+_147258273 1.952 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr15_-_41805993 1.871 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr17_-_72619794 1.860 NM_181449
CD300E
CD300e molecule
chr1_+_159772172 1.858 NM_001004310
FCRL6
Fc receptor-like 6
chr6_-_133084585 1.858 NM_078488
VNN2
vanin 2
chr14_-_25078818 1.841 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr11_-_59633942 1.718 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr8_-_82024277 1.713 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr8_-_99057594 1.709 RPL30
ribosomal protein L30
chr15_-_90347534 1.709 ANPEP
alanyl (membrane) aminopeptidase
chr3_+_121774208 1.706 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr1_-_114414245 1.694 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_32739711 1.692 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr9_-_33447527 1.686 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr8_-_99057751 1.679 RPL30
ribosomal protein L30
chr6_+_32605182 1.675 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_+_228678556 1.657 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr15_-_31523049 1.656 NM_001243538
LOC283710
uncharacterized LOC283710
chr2_+_204801453 1.656 NM_012092
ICOS
inducible T-cell co-stimulator
chr2_+_98330030 1.583 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr20_+_24929904 1.582 CST7
cystatin F (leukocystatin)
chr3_+_108541544 1.568 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr17_+_57915192 1.564


chr1_-_161601251 1.558 NM_001244753
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr7_+_28475233 1.541 NM_004904
CREB5
cAMP responsive element binding protein 5
chr16_+_82068910 1.522 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_31230594 1.513 LAPTM5
lysosomal protein transmembrane 5
chrX_-_19817854 1.504 SH3KBP1
SH3-domain kinase binding protein 1
chr6_-_31550065 1.502 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr8_-_99057766 1.489 NM_000989
RPL30
ribosomal protein L30
chr1_-_27953046 1.489 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr19_+_840970 1.473 NM_002777
PRTN3
proteinase 3
chr16_+_82068958 1.464 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr12_-_109027565 1.464 SELPLG
selectin P ligand
chr1_-_161519526 1.463 FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr19_-_51920841 1.441 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr7_+_139528951 1.439 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr19_+_49838700 1.437 CD37
CD37 molecule
chr7_-_99573637 1.436 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr16_+_29674568 1.432 NM_003123
SPN
sialophorin
chr19_+_1067293 1.427 HMHA1
histocompatibility (minor) HA-1
chr19_-_52150007 1.401 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr11_-_128391888 1.400 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr20_-_1373744 1.394 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr20_-_1472004 1.391 SIRPB2
signal-regulatory protein beta 2
chr16_+_29674979 1.381 SPN
sialophorin
chrX_-_19817907 1.375 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_157789832 1.360 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr12_-_109027654 1.347 NM_003006
SELPLG
selectin P ligand
chr18_+_3247774 1.342 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr12_-_109027615 1.339 SELPLG
selectin P ligand
chr16_+_82068830 1.337 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_80267972 1.322 CD36
CD36 molecule (thrombospondin receptor)
chr10_+_90521162 1.320 NM_001102469
LIPN
lipase, family member N
chr8_-_86290333 1.304 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr20_-_1373702 1.302 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr3_+_151986731 1.300 MBNL1
muscleblind-like (Drosophila)
chr14_+_88471467 1.298 NM_003608
GPR65
G protein-coupled receptor 65
chr19_-_52133589 1.293 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr1_+_154975041 1.288 NM_001252405
NM_015872
ZBTB7B

zinc finger and BTB domain containing 7B

chr9_-_117692874 1.283 NM_001244
NM_001252290
TNFSF8

tumor necrosis factor (ligand) superfamily, member 8

chr21_-_46340776 1.272 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_49838646 1.271 CD37
CD37 molecule
chr6_+_26365397 1.269 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr3_+_46395574 1.269 CCR2
chemokine (C-C motif) receptor 2
chr16_+_29674564 1.263 SPN
sialophorin
chr16_-_11680756 1.261 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr6_-_31324955 1.253 HLA-B
major histocompatibility complex, class I, B
chr1_-_153518265 1.251 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr20_-_1472168 1.226 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr1_-_153348057 1.225 NM_005621
S100A12
S100 calcium binding protein A12
chr19_+_7733971 1.218 NM_001193374
NM_020415
RETN

resistin

chr3_+_46395224 1.215 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr5_-_157002739 1.211 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr3_-_112693711 1.211 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr6_-_32557431 1.210 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr20_-_35274557 1.204 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr19_+_49838673 1.202 NM_001040031
NM_001774
CD37

CD37 molecule

chr7_+_48128939 1.200 UPP1
uridine phosphorylase 1
chr7_-_38375172 1.199 TRGV7
T cell receptor gamma variable 7 (pseudogene)
chr12_-_51740422 1.197 NM_001971
CELA1
chymotrypsin-like elastase family, member 1
chr19_-_8642337 1.193 MYO1F
myosin IF
chr3_-_46249787 1.192 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr1_+_154975201 1.181 NM_001252406
ZBTB7B
zinc finger and BTB domain containing 7B
chr3_-_182880463 1.178 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr21_-_46340821 1.178 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_+_121796695 1.177 NM_006889
NM_176892
CD86

CD86 molecule

chr1_+_111772332 1.177 NM_001025199
CHI3L2
chitinase 3-like 2
chr10_-_135090325 1.177 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr6_-_39282095 1.175 NM_031460
NM_001135111
KCNK17

potassium channel, subfamily K, member 17

chr20_+_37434294 1.172 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr4_-_145061787 1.171 NM_002099
GYPA
glycophorin A (MNS blood group)
chr18_+_3247825 1.163 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr14_-_106110894 1.158 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr20_-_1472126 1.155 SIRPB2
signal-regulatory protein beta 2
chr19_+_16999871 1.155 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr19_-_8642232 1.151 MYO1F
myosin IF
chr1_-_157746863 1.145 NM_030764
FCRL2
Fc receptor-like 2
chr1_-_25291474 1.143 NM_001031680
RUNX3
runt-related transcription factor 3
chr17_+_7239847 1.141 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr19_+_827821 1.135 NM_001700
AZU1
azurocidin 1
chr20_+_54987167 1.131 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr1_-_160990862 1.125 F11R
F11 receptor
chr20_+_24929862 1.117 NM_003650
CST7
cystatin F (leukocystatin)
chr14_-_106725620 1.111 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr19_-_8642309 1.111 NM_012335
MYO1F
myosin IF
chr6_-_32497925 1.109 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_39270708 1.109 NM_001243093
FYB
FYN binding protein
chr6_+_31554975 1.095 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr19_+_1026271 1.095 NM_004368
NM_201277
CNN2

calponin 2

chr16_+_81478774 1.093 NM_198390
CMIP
c-Maf inducing protein
chr6_-_31324975 1.088 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr6_-_32920812 1.088 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr20_-_62710787 1.087 NM_005873
RGS19
regulator of G-protein signaling 19
chr7_+_99971067 1.085 NM_013439
NM_178272
NM_178273
PILRA


paired immunoglobin-like type 2 receptor alpha


chr20_-_1373571 1.082 FKBP1A
FK506 binding protein 1A, 12kDa
chrX_+_67867510 1.079 NM_001142503
NM_014725
STARD8

StAR-related lipid transfer (START) domain containing 8

chr19_-_54850385 1.079 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr18_+_61582744 1.079 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr19_+_840963 1.078 PRTN3
proteinase 3
chr18_+_3247815 1.068 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr3_+_151531860 1.062 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr1_-_161519817 1.056 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chr7_+_99971132 1.037 PILRA
paired immunoglobin-like type 2 receptor alpha
chr6_-_31324898 1.035 HLA-B
major histocompatibility complex, class I, B
chr16_-_89007605 1.034 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr19_+_1026624 1.032 CNN2
calponin 2
chr7_-_99277518 1.027 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr3_+_148847370 1.026 NM_032383
HPS3
Hermansky-Pudlak syndrome 3
chr4_-_38858407 1.022 NM_006068
TLR6
toll-like receptor 6
chr20_+_42544781 1.020 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr19_+_51728319 1.018 NM_001082618
NM_001177608
NM_001772
CD33


CD33 molecule


chr1_+_207495070 1.017 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr22_+_43547558 1.016 TSPO
translocator protein (18kDa)
chr13_+_24553919 1.014 SPATA13
spermatogenesis associated 13
chr17_-_7017558 1.013 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr19_+_1026627 1.011 CNN2
calponin 2
chr1_+_207495086 1.010 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr19_+_859658 1.007 NM_001928
CFD
complement factor D (adipsin)
chr7_+_139478033 1.002 NM_001130966
NM_001166254
TBXAS1

thromboxane A synthase 1 (platelet)

chr4_+_166248816 1.002 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr2_+_169923531 1.001 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_31371355 1.000 NM_000247
NM_001177519
MICA

MHC class I polypeptide-related sequence A

chr1_+_26856259 1.000 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr18_-_28681885 0.999 NM_004949
NM_024422
DSC2

desmocollin 2

chr6_+_106546736 0.999 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr19_+_1026608 0.998 CNN2
calponin 2
chr1_+_207495009 0.994 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr10_+_11865310 0.988 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr11_-_118084073 0.977 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr4_+_74270832 0.976 ALB
albumin
chr1_+_26872306 0.975 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chrX_+_70765479 0.972 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr19_-_11688508 0.970 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr18_+_52495618 0.969 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr13_+_97999289 0.968


chr1_-_169599349 0.966 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr1_+_161551128 0.964 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr3_+_111261039 0.959 CD96
CD96 molecule
chr7_+_80267922 0.958 CD36
CD36 molecule (thrombospondin receptor)
chr11_+_65082288 0.957 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chrX_+_78200828 0.952 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr22_-_39639967 0.940 PDGFB
platelet-derived growth factor beta polypeptide
chr7_+_150434679 0.939 GIMAP5
GTPase, IMAP family member 5
chr3_+_157154579 0.938 NM_002852
PTX3
pentraxin 3, long
chr6_+_32407618 0.936 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr12_+_13044352 0.934 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr15_-_38856830 0.933 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr1_-_160990971 0.927 NM_016946
F11R
F11 receptor
chr4_-_83347222 0.925 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr19_+_51728369 0.925 CD33
CD33 molecule
chr8_+_86376130 0.924 NM_000067
CA2
carbonic anhydrase II
chr19_-_8642297 0.922 MYO1F
myosin IF
chr2_+_63815742 0.922 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr19_+_16999807 0.913 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr22_+_24823529 0.911 NM_000675
ADORA2A
adenosine A2a receptor
chr1_+_16174358 0.909 NM_015001
SPEN
spen homolog, transcriptional regulator (Drosophila)
chr1_+_207494816 0.906 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr11_-_128457452 0.905 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_+_24286311 0.903 PNRC2
proline-rich nuclear receptor coactivator 2
chr1_+_165600433 0.902 MGST3
microsomal glutathione S-transferase 3
chr8_-_134584012 0.900 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.15 5.90e-23 GO:0002376 immune system process
7.70 8.25e-20 GO:0006955 immune response
6.93 1.06e-14 GO:0002682 regulation of immune system process
8.49 3.16e-13 GO:0050776 regulation of immune response
7.50 2.92e-10 GO:0002684 positive regulation of immune system process
5.33 3.31e-10 GO:0006952 defense response
3.30 7.65e-09 GO:0048583 regulation of response to stimulus
10.26 1.01e-08 GO:0002253 activation of immune response
1.91 1.99e-08 GO:0050896 response to stimulus
8.77 2.21e-08 GO:0006954 inflammatory response
8.60 2.92e-08 GO:0050778 positive regulation of immune response
15.86 5.38e-08 GO:0002429 immune response-activating cell surface receptor signaling pathway
15.26 8.25e-08 GO:0002768 immune response-regulating cell surface receptor signaling pathway
9.85 8.56e-08 GO:0051249 regulation of lymphocyte activation
11.08 9.46e-08 GO:0002757 immune response-activating signal transduction
4.48 1.15e-07 GO:0009611 response to wounding
10.82 1.26e-07 GO:0002764 immune response-regulating signaling pathway
8.95 3.07e-07 GO:0002694 regulation of leukocyte activation
15.66 4.54e-07 GO:0050851 antigen receptor-mediated signaling pathway
8.61 5.09e-07 GO:0050865 regulation of cell activation
10.53 8.88e-07 GO:0050863 regulation of T cell activation
4.40 2.32e-06 GO:0048584 positive regulation of response to stimulus
2.47 6.88e-06 GO:0048518 positive regulation of biological process
15.54 2.58e-05 GO:0050852 T cell receptor signaling pathway
18.54 5.37e-05 GO:0019882 antigen processing and presentation
2.16 5.75e-05 GO:0007165 signal transduction
2.00 5.78e-05 GO:0051716 cellular response to stimulus
1.58 6.52e-05 GO:0065007 biological regulation
8.89 1.10e-04 GO:0051251 positive regulation of lymphocyte activation
1.60 1.56e-04 GO:0050789 regulation of biological process
9.79 2.04e-04 GO:0050870 positive regulation of T cell activation
8.28 2.12e-04 GO:0002696 positive regulation of leukocyte activation
8.14 2.48e-04 GO:0050867 positive regulation of cell activation
2.00 3.83e-04 GO:0023052 signaling
2.62 5.83e-04 GO:0007166 cell surface receptor linked signaling pathway
4.49 1.64e-03 GO:0001775 cell activation
14.10 2.40e-03 GO:0031294 lymphocyte costimulation
14.10 2.40e-03 GO:0031295 T cell costimulation
34.26 2.73e-03 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
2.22 3.58e-03 GO:0006950 response to stress
3.25 5.60e-03 GO:0051704 multi-organism process
8.95 7.82e-03 GO:0042110 T cell activation
8.79 8.76e-03 GO:0042742 defense response to bacterium
4.68 1.40e-02 GO:0045087 innate immune response
48.53 1.50e-02 GO:0008347 glial cell migration
14.01 1.64e-02 GO:0042108 positive regulation of cytokine biosynthetic process
5.71 1.72e-02 GO:0045321 leukocyte activation
5.49 2.32e-02 GO:0009617 response to bacterium
13.01 2.35e-02 GO:0002695 negative regulation of leukocyte activation
6.30 2.39e-02 GO:0046649 lymphocyte activation
7.39 2.69e-02 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
2.07 2.89e-02 GO:0048522 positive regulation of cellular process
11.94 3.57e-02 GO:0050866 negative regulation of cell activation
1.48 3.78e-02 GO:0050794 regulation of cellular process
5.13 3.94e-02 GO:0001817 regulation of cytokine production
6.89 4.19e-02 GO:0050900 leukocyte migration

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.94 6.16e-09 GO:0044459 plasma membrane part
2.20 1.14e-08 GO:0005886 plasma membrane
2.17 2.09e-08 GO:0071944 cell periphery
1.77 4.34e-07 GO:0044425 membrane part
2.68 2.92e-06 GO:0005576 extracellular region
27.30 7.50e-06 GO:0042611 MHC protein complex
1.59 8.56e-06 GO:0016020 membrane
41.60 2.09e-04 GO:0042613 MHC class II protein complex
2.90 3.31e-04 GO:0005887 integral to plasma membrane
1.68 3.77e-04 GO:0031224 intrinsic to membrane
2.85 4.54e-04 GO:0031226 intrinsic to plasma membrane
1.66 1.11e-03 GO:0016021 integral to membrane
8.95 1.40e-03 GO:0005765 lysosomal membrane
7.39 4.82e-03 GO:0009897 external side of plasma membrane
6.85 7.84e-03 GO:0005774 vacuolar membrane
5.03 8.20e-03 GO:0000323 lytic vacuole
5.03 8.20e-03 GO:0005764 lysosome
6.54 1.05e-02 GO:0044437 vacuolar part
4.26 2.84e-02 GO:0005773 vacuole

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.35 5.59e-04 GO:0004871 signal transducer activity
2.35 5.59e-04 GO:0060089 molecular transducer activity
2.50 8.75e-04 GO:0004872 receptor activity
18.21 1.05e-03 GO:0003823 antigen binding