Motif ID: TLX2.p2

Z-value: 1.697


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX2hg19_v1_chr2_+_74740585_74740717-0.494.1e-03Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_52264452 4.165 NM_001005738
 FPR2
formyl peptide receptor 2
chr14_-_106321626 3.231


chr11_+_62186506 3.227 NM_003357
 SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr4_-_155533800 3.005 FGG
fibrinogen gamma chain
chr1_-_153363544 2.863 NM_002964
 S100A8
S100 calcium binding protein A8
chr4_-_155533757 2.791 FGG
fibrinogen gamma chain
chr11_+_60223281 2.478 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr9_+_117085302 2.389 NM_000607
 ORM1
orosomucoid 1
chr3_+_42544094 2.308 NM_001251883
NM_001251884
NM_001251885
NM_004624
 VIPR1



vasoactive intestinal peptide receptor 1



chr1_+_160765927 2.280 NM_001033667
NM_002348
 LY9

lymphocyte antigen 9

chr9_+_117092068 2.264 NM_000608
 ORM2
orosomucoid 2
chr4_-_155533850 2.249 FGG
fibrinogen gamma chain
chr2_+_102927961 2.236 NM_016232
 IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr3_+_42544131 2.203 VIPR1
vasoactive intestinal peptide receptor 1
chr4_-_155533882 2.148 NM_000509
NM_021870
 FGG

fibrinogen gamma chain

chr2_+_102979096 1.990 NM_003855
 IL18R1
interleukin 18 receptor 1
chr6_-_32151996 1.974 NM_001136
NM_001206929
NM_001206932
NM_001206934
NM_001206936
NM_001206940
NM_001206954
NM_001206966
NM_172197
 AGER








advanced glycosylation end product-specific receptor








chr1_+_153330329 1.969 NM_002965
 S100A9
S100 calcium binding protein A9
chr5_+_147258273 1.952 NM_054023
 SCGB3A2
secretoglobin, family 3A, member 2
chr15_-_41805993 1.871 NM_001135685
NM_002344
NM_206961
 LTK


leukocyte receptor tyrosine kinase



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 56 entries
Enrichment   P-value GO Accession GO Term
48.53 1.50e-02 GO:0008347 glial cell migration
34.26 2.73e-03 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
18.54 5.37e-05 GO:0019882 antigen processing and presentation
15.86 5.38e-08 GO:0002429 immune response-activating cell surface receptor signaling pathway
15.66 4.54e-07 GO:0050851 antigen receptor-mediated signaling pathway
15.54 2.58e-05 GO:0050852 T cell receptor signaling pathway
15.26 8.25e-08 GO:0002768 immune response-regulating cell surface receptor signaling pathway
14.10 2.40e-03 GO:0031294 lymphocyte costimulation
14.10 2.40e-03 GO:0031295 T cell costimulation
14.01 1.64e-02 GO:0042108 positive regulation of cytokine biosynthetic process
13.01 2.35e-02 GO:0002695 negative regulation of leukocyte activation
11.94 3.57e-02 GO:0050866 negative regulation of cell activation
11.08 9.46e-08 GO:0002757 immune response-activating signal transduction
10.82 1.26e-07 GO:0002764 immune response-regulating signaling pathway
10.53 8.88e-07 GO:0050863 regulation of T cell activation
10.26 1.01e-08 GO:0002253 activation of immune response
9.85 8.56e-08 GO:0051249 regulation of lymphocyte activation
9.79 2.04e-04 GO:0050870 positive regulation of T cell activation
8.95 3.07e-07 GO:0002694 regulation of leukocyte activation
8.95 7.82e-03 GO:0042110 T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
41.60 2.09e-04 GO:0042613 MHC class II protein complex
27.30 7.50e-06 GO:0042611 MHC protein complex
8.95 1.40e-03 GO:0005765 lysosomal membrane
7.39 4.82e-03 GO:0009897 external side of plasma membrane
6.85 7.84e-03 GO:0005774 vacuolar membrane
6.54 1.05e-02 GO:0044437 vacuolar part
5.03 8.20e-03 GO:0000323 lytic vacuole
5.03 8.20e-03 GO:0005764 lysosome
4.26 2.84e-02 GO:0005773 vacuole
2.94 6.16e-09 GO:0044459 plasma membrane part
2.90 3.31e-04 GO:0005887 integral to plasma membrane
2.85 4.54e-04 GO:0031226 intrinsic to plasma membrane
2.68 2.92e-06 GO:0005576 extracellular region
2.20 1.14e-08 GO:0005886 plasma membrane
2.17 2.09e-08 GO:0071944 cell periphery
1.77 4.34e-07 GO:0044425 membrane part
1.68 3.77e-04 GO:0031224 intrinsic to membrane
1.66 1.11e-03 GO:0016021 integral to membrane
1.59 8.56e-06 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
18.21 1.05e-03 GO:0003823 antigen binding
2.50 8.75e-04 GO:0004872 receptor activity
2.35 5.59e-04 GO:0004871 signal transducer activity
2.35 5.59e-04 GO:0060089 molecular transducer activity