Motif ID: TP53.p2

Z-value: 1.307


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP53hg19_v1_chr17_-_7578810_75788100.355.3e-02Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_22960326 4.490 NM_003841
 TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr11_-_47400096 3.725 NM_001080547
NM_003120
 SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr11_-_47399986 3.084 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47399903 3.038


chr19_+_827821 2.840 NM_001700
 AZU1
azurocidin 1
chr8_-_23021447 2.818 NM_003840
 TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr8_-_23082572 2.817 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr18_+_57567191 2.643 NM_021127
 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr10_-_105212149 2.514 NM_015916
 CALHM2
calcium homeostasis modulator 2
chr10_-_105212022 2.497 CALHM2
calcium homeostasis modulator 2
chr22_-_18257194 2.420 BID
BH3 interacting domain death agonist
chr17_+_76210329 2.310 BIRC5
baculoviral IAP repeat containing 5
chr8_-_22926406 2.248 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr11_+_36397534 2.126 NM_001160168
NM_024841
 PRR5L

proline rich 5 like

chr11_+_289113 2.096 NM_025092
 ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr10_+_90751044 2.046 FAS
Fas (TNF receptor superfamily, member 6)
chr6_-_32163299 2.026 NM_022107
 GPSM3
G-protein signaling modulator 3
chr6_+_36098261 1.989 NM_002754
 MAPK13
mitogen-activated protein kinase 13
chr1_-_150738232 1.977 CTSS
cathepsin S
chr14_-_106610338 1.967 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 28 entries
Enrichment   P-value GO Accession GO Term
92.80 2.95e-05 GO:0008625 induction of apoptosis via death domain receptors
53.87 1.19e-05 GO:0008633 activation of pro-apoptotic gene products
50.28 1.07e-02 GO:0001836 release of cytochrome c from mitochondria
34.81 3.36e-02 GO:0008637 apoptotic mitochondrial changes
23.21 8.22e-05 GO:0008629 induction of apoptosis by intracellular signals
23.21 9.14e-04 GO:0006919 activation of caspase activity
19.60 2.12e-03 GO:0043280 positive regulation of caspase activity
18.29 2.62e-02 GO:0071214 cellular response to abiotic stimulus
17.35 3.87e-03 GO:0010952 positive regulation of peptidase activity
17.09 5.09e-04 GO:0043281 regulation of caspase activity
13.85 1.16e-02 GO:0008624 induction of apoptosis by extracellular signals
11.44 2.90e-02 GO:0007005 mitochondrion organization
10.48 8.60e-03 GO:0052548 regulation of endopeptidase activity
10.07 1.08e-02 GO:0052547 regulation of peptidase activity
9.30 3.59e-05 GO:0006917 induction of apoptosis
9.27 3.69e-05 GO:0012502 induction of programmed cell death
6.54 8.98e-04 GO:0043065 positive regulation of apoptosis
6.50 9.51e-04 GO:0043068 positive regulation of programmed cell death
6.39 1.11e-03 GO:0010942 positive regulation of cell death
5.14 2.73e-03 GO:0006915 apoptosis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
301.57 1.01e-08 GO:0045569 TRAIL binding
50.28 2.58e-03 GO:0008656 caspase activator activity
47.63 3.05e-03 GO:0016505 apoptotic protease activator activity
31.76 6.89e-04 GO:0043028 caspase regulator activity
29.20 1.38e-02 GO:0016504 peptidase activator activity