Motif ID: TP53.p2

Z-value: 1.307


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP53hg19_v1_chr17_-_7578810_75788100.355.3e-02Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_22960326 4.490 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr11_-_47400096 3.725 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr11_-_47399986 3.084 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47399903 3.038


chr19_+_827821 2.840 NM_001700
AZU1
azurocidin 1
chr8_-_23021447 2.818 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr8_-_23082572 2.817 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr18_+_57567191 2.643 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr10_-_105212149 2.514 NM_015916
CALHM2
calcium homeostasis modulator 2
chr10_-_105212022 2.497 CALHM2
calcium homeostasis modulator 2
chr22_-_18257194 2.420 BID
BH3 interacting domain death agonist
chr17_+_76210329 2.310 BIRC5
baculoviral IAP repeat containing 5
chr8_-_22926406 2.248 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr11_+_36397534 2.126 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr11_+_289113 2.096 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr10_+_90751044 2.046 FAS
Fas (TNF receptor superfamily, member 6)
chr6_-_32163299 2.026 NM_022107
GPSM3
G-protein signaling modulator 3
chr6_+_36098261 1.989 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr1_-_150738232 1.977 CTSS
cathepsin S
chr14_-_106610338 1.967 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_11796211 1.850 AGTRAP
angiotensin II receptor-associated protein
chr19_-_6591082 1.840 CD70
CD70 molecule
chr4_-_10118358 1.822 WDR1
WD repeat domain 1
chr1_+_11796177 1.711 AGTRAP
angiotensin II receptor-associated protein
chr2_+_11295602 1.683 PQLC3
PQ loop repeat containing 3
chr2_+_11295569 1.584 PQLC3
PQ loop repeat containing 3
chr12_-_14720790 1.577 NM_024829
PLBD1
phospholipase B domain containing 1
chr15_-_64455206 1.480 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr4_-_40516567 1.476 RBM47
RNA binding motif protein 47
chr1_-_38412725 1.463 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr2_+_11295539 1.458 NM_152391
PQLC3
PQ loop repeat containing 3
chr22_-_18257221 1.449 BID
BH3 interacting domain death agonist
chr11_+_94277566 1.433 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr4_-_10118378 1.426 WDR1
WD repeat domain 1
chr6_-_109775423 1.423 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_+_17905935 1.409 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr10_+_90750384 1.368 FAS
Fas (TNF receptor superfamily, member 6)
chr1_+_11796128 1.368 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr8_-_22926490 1.358 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr2_+_47168362 1.332 TTC7A
tetratricopeptide repeat domain 7A
chr1_-_150738292 1.318 NM_001199739
NM_004079
CTSS

cathepsin S

chr16_-_31106125 1.310 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr11_+_67171379 1.300 TBC1D10C
TBC1 domain family, member 10C
chr15_-_64455158 1.277 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr15_-_64455184 1.254 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr16_+_30194730 1.238 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr5_+_17217474 1.217 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr15_-_64455299 1.200 NM_000942
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr12_-_14720553 1.199 PLBD1
phospholipase B domain containing 1
chr6_-_74230732 1.197 NM_001402
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_-_153508495 1.195 S100A6
S100 calcium binding protein A6
chr6_+_116692098 1.190 NM_013352
DSE
dermatan sulfate epimerase
chr20_-_1373571 1.188 FKBP1A
FK506 binding protein 1A, 12kDa
chr1_-_38412720 1.176 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr4_+_106067031 1.175 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr12_+_99038918 1.153 NM_001160
NM_013229
NM_181861
NM_181868
NM_181869
APAF1




apoptotic peptidase activating factor 1




chr20_-_1373702 1.152 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr19_-_42721802 1.147 NM_133328
DEDD2
death effector domain containing 2
chr2_-_38303265 1.134 CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chrX_+_129305553 1.122 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr2_-_38303307 1.119 NM_000104
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr1_-_150738255 1.114 CTSS
cathepsin S
chr15_-_64455190 1.102 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr2_+_74757127 1.100 HTRA2
HtrA serine peptidase 2
chr16_-_31106093 1.096 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr22_-_39715609 1.092 NM_000967
NM_001033853
RPL3

ribosomal protein L3

chr4_-_108641291 1.091 NM_005443
PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr4_-_10118286 1.090


chr4_+_103422479 1.087 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr7_+_150434679 1.085 GIMAP5
GTPase, IMAP family member 5
chr19_+_42364322 1.071 RPS19
ribosomal protein S19
chr7_+_98972351 1.069 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr6_+_36644236 1.050 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr16_-_31106049 1.048 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr18_-_28622624 1.032 NM_001941
NM_024423
DSC3

desmocollin 3

chr19_-_6481765 1.023 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr20_-_62205559 1.019 NM_001037335
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr20_+_61583998 1.017 NM_022082
SLC17A9
solute carrier family 17, member 9
chr2_+_74757116 1.017 HTRA2
HtrA serine peptidase 2
chr19_+_49458129 1.012 BAX
BCL2-associated X protein
chr3_+_127771342 1.006


chrX_+_152086408 1.003 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chrX_+_40440229 1.003 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr4_-_10118296 0.996 WDR1
WD repeat domain 1
chr1_-_153508463 0.994 S100A6
S100 calcium binding protein A6
chr1_+_161494035 0.991 NM_002155
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr1_+_25598883 0.989 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr1_-_54483802 0.988 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr19_-_53290015 0.985 NM_198457
ZNF600
zinc finger protein 600
chr11_+_67171400 0.981 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr19_-_47735858 0.978 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chrX_+_40440261 0.975 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr2_+_74757158 0.964 HTRA2
HtrA serine peptidase 2
chr3_-_182880432 0.950 LAMP3
lysosomal-associated membrane protein 3
chr17_-_61523544 0.947 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr19_+_42364262 0.942 RPS19
ribosomal protein S19
chr7_+_98972326 0.939 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr19_+_56652689 0.937 ZNF444
zinc finger protein 444
chr22_+_40766649 0.930 SGSM3
small G protein signaling modulator 3
chr11_-_9286832 0.928 NM_001243254
NM_015213
DENND5A

DENN/MADD domain containing 5A

chr4_+_48988264 0.923 NM_025087
CWH43
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
chr22_+_40766563 0.921 NM_015705
SGSM3
small G protein signaling modulator 3
chr4_-_10118444 0.920 WDR1
WD repeat domain 1
chr2_+_74756986 0.912 HTRA2
HtrA serine peptidase 2
chr3_+_52529370 0.906 STAB1
stabilin 1
chr11_+_94277005 0.904 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr10_+_47746919 0.901 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr19_+_49458151 0.895 BAX
BCL2-associated X protein
chr17_+_14204326 0.881 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr17_-_9929567 0.879 NM_001130831
GAS7
growth arrest-specific 7
chr20_-_52790511 0.877 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr6_-_30712294 0.873 NM_003897
IER3
immediate early response 3
chr17_-_80407601 0.867 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr22_+_37447615 0.863 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr12_-_54694647 0.863 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_+_104850986 0.853 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr5_-_131826426 0.851 NM_002198
IRF1
interferon regulatory factor 1
chr22_+_40766636 0.851 SGSM3
small G protein signaling modulator 3
chr20_-_1373744 0.847 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr3_-_9005070 0.842 NM_020165
RAD18
RAD18 homolog (S. cerevisiae)
chr22_+_40766617 0.817 SGSM3
small G protein signaling modulator 3
chr1_-_38412667 0.809 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr14_-_92302612 0.806 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chrX_-_109561314 0.800 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr3_+_127771287 0.799 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr3_+_196466724 0.796 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr9_-_116037823 0.790 NM_139286
CDC26
cell division cycle 26 homolog (S. cerevisiae)
chr22_+_40766630 0.789 SGSM3
small G protein signaling modulator 3
chr1_-_38412704 0.785 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr7_+_48128225 0.776 NM_181597
UPP1
uridine phosphorylase 1
chr4_+_103422553 0.774 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_151584665 0.767 SNX27
sorting nexin family member 27
chr12_+_10124007 0.767 NM_138337
NM_201623
CLEC12A

CLEC12B
C-type lectin domain family 12, member A

C-type lectin domain family 12, member B
chr16_+_57653909 0.764 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr17_+_78234626 0.762 NM_020914
NM_020954
RNF213

ring finger protein 213

chrX_-_109561427 0.761 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr17_+_76210276 0.760 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr12_-_45270071 0.756 NELL2
NEL-like 2 (chicken)
chr3_-_182880463 0.749 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr11_+_65154040 0.749 NM_031904
FRMD8
FERM domain containing 8
chr12_-_113772900 0.746 NM_024959
SLC24A6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
chr21_-_44846927 0.745 NM_173354
SIK1
salt-inducible kinase 1
chr16_-_31105922 0.740


chr1_-_93646245 0.736 NM_001167830
NM_016040
TMED5

transmembrane emp24 protein transport domain containing 5

chr12_+_104850750 0.720 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_45805606 0.718 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr19_+_49458031 0.715 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr1_-_160832466 0.713 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr1_-_93645903 0.710 TMED5
transmembrane emp24 protein transport domain containing 5
chr7_+_43622638 0.710 NM_004760
STK17A
serine/threonine kinase 17a
chr19_+_17970670 0.708 NM_000980
RPL18A
ribosomal protein L18a
chr10_-_73611050 0.708 NM_001042465
NM_001042466
NM_002778
PSAP


prosaposin


chr11_+_65154093 0.700 FRMD8
FERM domain containing 8
chr21_+_30671736 0.697 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_+_74757243 0.694 HTRA2
HtrA serine peptidase 2
chr15_-_50405512 0.692 ATP8B4
ATPase, class I, type 8B, member 4
chr2_+_163200623 0.690 GCA
grancalcin, EF-hand calcium binding protein
chr2_-_24307179 0.684 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr12_+_104850641 0.683 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr12_+_104850784 0.683 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_223316589 0.682 NM_003268
TLR5
toll-like receptor 5
chr1_+_224544590 0.679 NM_014184
CNIH4
cornichon homolog 4 (Drosophila)
chr15_+_41056243 0.679 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chrX_+_40440145 0.671 NM_005765
ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr4_+_153457407 0.669 DKFZP434I0714
uncharacterized protein DKFZP434I0714
chr19_-_40931880 0.666 NM_013376
SERTAD1
SERTA domain containing 1
chr12_-_6451156 0.660 NM_001065
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr2_+_113403433 0.659 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr19_+_5904842 0.654 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr5_+_135364583 0.652 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr20_+_61584094 0.648 SLC17A9
solute carrier family 17, member 9
chr14_+_64971226 0.643 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr22_+_21336575 0.639 LZTR1
leucine-zipper-like transcription regulator 1
chr3_+_127771126 0.638 NM_013336
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr16_-_15149827 0.625 NM_173474
NTAN1
N-terminal asparagine amidase
chr6_+_32939371 0.623 NM_001199455
BRD2
bromodomain containing 2
chr12_+_22778085 0.621 ETNK1
ethanolamine kinase 1
chr4_+_6675798 0.617 LOC93622
Morf4 family associated protein 1-like 1 pseudogene
chr11_+_9685624 0.613 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr12_+_104850762 0.613 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr16_+_57653649 0.610 GPR56
G protein-coupled receptor 56
chr15_-_55700456 0.609 NM_004748
NM_001204450
NM_001204451
NM_020739
CCPG1



cell cycle progression 1



chr1_+_27153130 0.604 NM_032283
ZDHHC18
zinc finger, DHHC-type containing 18
chr4_-_10118500 0.600 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr2_+_47168312 0.598 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr3_+_52529351 0.598 NM_015136
STAB1
stabilin 1
chr19_+_56652529 0.592 NM_001253792
NM_018337
ZNF444

zinc finger protein 444

chr1_+_151584514 0.584 NM_030918
SNX27
sorting nexin family member 27
chr13_+_52158592 0.584 WDFY2
WD repeat and FYVE domain containing 2
chr3_+_9944511 0.583 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr19_-_2456954 0.582 NM_032737
LMNB2
lamin B2
chr19_-_4817502 0.579 TICAM1
toll-like receptor adaptor molecule 1
chrX_-_109561298 0.579 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_+_241544819 0.579 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr11_-_44972227 0.575 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr16_-_14788429 0.572 NM_003561
PLA2G10
phospholipase A2, group X
chr7_+_48128738 0.571 NM_003364
UPP1
uridine phosphorylase 1
chr3_+_14166582 0.571 TMEM43
transmembrane protein 43
chrX_-_106959597 0.571 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr18_+_3594056 0.566 FLJ35776
uncharacterized LOC649446

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
53.87 1.19e-05 GO:0008633 activation of pro-apoptotic gene products
92.80 2.95e-05 GO:0008625 induction of apoptosis via death domain receptors
9.30 3.59e-05 GO:0006917 induction of apoptosis
9.27 3.69e-05 GO:0012502 induction of programmed cell death
4.87 8.08e-05 GO:0042981 regulation of apoptosis
23.21 8.22e-05 GO:0008629 induction of apoptosis by intracellular signals
4.82 9.02e-05 GO:0043067 regulation of programmed cell death
4.75 1.11e-04 GO:0010941 regulation of cell death
17.09 5.09e-04 GO:0043281 regulation of caspase activity
6.54 8.98e-04 GO:0043065 positive regulation of apoptosis
23.21 9.14e-04 GO:0006919 activation of caspase activity
6.50 9.51e-04 GO:0043068 positive regulation of programmed cell death
6.39 1.11e-03 GO:0010942 positive regulation of cell death
19.60 2.12e-03 GO:0043280 positive regulation of caspase activity
5.14 2.73e-03 GO:0006915 apoptosis
4.63 2.80e-03 GO:0008219 cell death
4.61 2.95e-03 GO:0016265 death
5.06 3.15e-03 GO:0012501 programmed cell death
17.35 3.87e-03 GO:0010952 positive regulation of peptidase activity
10.48 8.60e-03 GO:0052548 regulation of endopeptidase activity
50.28 1.07e-02 GO:0001836 release of cytochrome c from mitochondria
10.07 1.08e-02 GO:0052547 regulation of peptidase activity
13.85 1.16e-02 GO:0008624 induction of apoptosis by extracellular signals
2.64 1.53e-02 GO:0048522 positive regulation of cellular process
2.50 1.88e-02 GO:0048518 positive regulation of biological process
18.29 2.62e-02 GO:0071214 cellular response to abiotic stimulus
11.44 2.90e-02 GO:0007005 mitochondrion organization
34.81 3.36e-02 GO:0008637 apoptotic mitochondrial changes

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
301.57 1.01e-08 GO:0045569 TRAIL binding
31.76 6.89e-04 GO:0043028 caspase regulator activity
50.28 2.58e-03 GO:0008656 caspase activator activity
47.63 3.05e-03 GO:0016505 apoptotic protease activator activity
29.20 1.38e-02 GO:0016504 peptidase activator activity