Motif ID: UUGUUCG

Z-value: 1.703


Mature miRNA associated with seed UUGUUCG:

NamemiRBase Accession
hsa-miR-375 MIMAT0000728



Activity profile for motif UUGUUCG.

activity profile for motif UUGUUCG


Sorted Z-values histogram for motif UUGUUCG

Sorted Z-values for motif UUGUUCG



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_105584982 5.132 NM_001199563
BVES
blood vessel epicardial substance
chr6_-_105584542 4.928 NM_007073
BVES
blood vessel epicardial substance
chr4_+_95679075 4.580 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr6_-_166075520 4.517 NM_006661
NM_001130690
PDE10A

phosphodiesterase 10A

chr11_+_101980736 4.442 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr2_+_155555092 4.442 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr6_-_105584220 4.388 NM_147147
BVES
blood vessel epicardial substance
chr1_+_110009099 4.239 NM_001040709
SYPL2
synaptophysin-like 2
chr16_+_77822400 4.118 NM_020927
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like
chr10_+_115312777 4.074 NM_004132
HABP2
hyaluronan binding protein 2
chr5_-_136834887 4.061 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr10_+_115310589 3.924 NM_001177660
HABP2
hyaluronan binding protein 2
chr1_+_169075869 3.893 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr1_+_57110745 3.663 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr7_+_140774031 3.516 NM_001195278
LOC100507421
transmembrane protein 178-like
chr3_-_69171536 3.381 NM_198271
LMOD3
leiomodin 3 (fetal)
chr22_+_26138110 3.353 NM_032608
MYO18B
myosin XVIIIB
chr11_+_12695851 3.319 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr11_-_89224413 3.252 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr8_+_120220554 3.236 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr11_-_118047336 3.228 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr9_-_112191105 3.227 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr3_-_160822625 3.166 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr11_-_16430425 3.136 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr9_-_112260529 3.120 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr8_+_77593506 3.080 NM_024721
ZFHX4
zinc finger homeobox 4
chr14_-_30396811 2.976 NM_002742
PRKD1
protein kinase D1
chr5_-_146833150 2.953 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr17_-_17399494 2.949 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr5_+_40909558 2.925 NM_000587
C7
complement component 7
chr9_+_127539382 2.916 NM_182487
OLFML2A
olfactomedin-like 2A
chr5_-_146889618 2.892 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr9_-_23821477 2.881 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_-_25902639 2.865 NM_022659
EBF2
early B-cell factor 2
chr3_+_148415657 2.827 NM_000685
NM_004835
NM_009585
NM_031850
AGTR1



angiotensin II receptor, type 1



chr10_+_60936346 2.825 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr5_-_137475076 2.743 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr6_+_101846860 2.732 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr3_-_169487602 2.710 NM_032487
ARPM1
actin related protein M1
chrX_+_73641084 2.697 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr9_-_112213663 2.678 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr6_+_41020939 2.658 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr5_+_148961035 2.582 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr15_+_36932805 2.579 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr19_-_42569921 2.557 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr6_-_35696359 2.550 NM_001145775
FKBP5
FK506 binding protein 5
chr4_+_155665150 2.545 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chrX_+_70521627 2.537 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr9_-_23821842 2.537 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr10_+_102505337 2.517 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr4_+_72204769 2.515 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr11_+_101983170 2.448 NM_001195045
YAP1
Yes-associated protein 1
chr2_-_213403280 2.441 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr8_+_98881277 2.400 NM_002380
NM_030583
MATN2

matrilin 2

chr11_-_16497917 2.381 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chrX_-_107681555 2.377 NM_033641
COL4A6
collagen, type IV, alpha 6
chr17_-_36105005 2.351 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr2_-_178937472 2.332 NM_016953
PDE11A
phosphodiesterase 11A
chr4_+_72052354 2.330 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr12_+_26205490 2.258 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr10_-_131762017 2.255 NM_001005463
EBF3
early B-cell factor 3
chr12_+_26126687 2.245 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr5_+_147648374 2.233 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr11_-_115375065 2.216 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr5_+_150040402 2.211 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr15_-_65360297 2.195 NM_016563
RASL12
RAS-like, family 12
chr10_+_60937226 2.192 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr7_+_75831194 2.179 NM_001110199
SRRM3
serine/arginine repetitive matrix 3
chr8_-_75233461 2.162 NM_020647
JPH1
junctophilin 1
chr8_+_106331146 2.153 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr13_+_39261172 2.128 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr8_+_11561710 2.104 NM_002052
GATA4
GATA binding protein 4
chr1_+_38022514 2.081 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr14_+_55034329 2.033 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr1_+_82266081 2.014 NM_012302
LPHN2
latrophilin 2
chrX_-_112066353 1.990 NM_001113490
AMOT
angiomotin
chr2_-_178753464 1.980 NM_001077196
PDE11A
phosphodiesterase 11A
chr5_+_95066628 1.959 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr9_+_35161950 1.958 NM_006377
UNC13B
unc-13 homolog B (C. elegans)
chr11_-_89322778 1.951 NM_001143837
NOX4
NADPH oxidase 4
chr9_-_93405066 1.935 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr12_-_120806893 1.912 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr17_-_37381920 1.895 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr3_+_120627026 1.870 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr10_-_99393175 1.857 NM_178832
MORN4
MORN repeat containing 4
chr8_-_74005379 1.852 NM_153225
C8orf84
chromosome 8 open reading frame 84
chr8_-_81787015 1.831 NM_001033723
ZNF704
zinc finger protein 704
chr20_+_45523247 1.829 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr5_+_31193761 1.826 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr4_+_120056938 1.817 NM_016599
MYOZ2
myozenin 2
chr4_-_53617781 1.814 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr2_+_11674241 1.813 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr10_-_735522 1.802 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr10_+_18429605 1.797 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chr9_+_74729510 1.789 NM_001242507
GDA
guanine deaminase
chr18_-_30050394 1.780 NM_001242409
NM_022751
FAM59A

family with sequence similarity 59, member A

chr8_-_65711104 1.779 NM_004820
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr1_+_33004771 1.775 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr4_-_53525316 1.772 NM_022832
USP46
ubiquitin specific peptidase 46
chr16_+_4421774 1.770 NM_138440
VASN
vasorin
chr2_-_198650008 1.748 NM_033030
BOLL
bol, boule-like (Drosophila)
chr1_-_225840660 1.707 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr2_-_178973065 1.702 NM_001077197
PDE11A
phosphodiesterase 11A
chr21_+_19289656 1.690 NM_001204175
NM_001204176
NM_001204177
NM_001204178
CHODL



chondrolectin



chr2_-_228029274 1.685 NM_000092
COL4A4
collagen, type IV, alpha 4
chr2_+_150187028 1.678 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr7_+_45614081 1.667 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr19_+_57019196 1.654 NM_020813
ZNF471
zinc finger protein 471
chr2_-_172750724 1.652 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr2_+_9346876 1.632 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr12_-_49182718 1.622 NM_020983
ADCY6
adenylate cyclase 6
chr6_+_146348781 1.611 NM_000838
NM_001114329
GRM1

glutamate receptor, metabotropic 1

chr1_+_18807423 1.606 NM_152375
KLHDC7A
kelch domain containing 7A
chr11_-_88781039 1.592 NM_001143831
GRM5
glutamate receptor, metabotropic 5
chr3_-_114343052 1.591 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_154832187 1.587 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr3_-_55521330 1.585 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr12_+_3068442 1.585 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr3_+_155860750 1.568 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr3_+_156008775 1.567 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr12_-_131002409 1.547 NM_015347
RIMBP2
RIMS binding protein 2
chr12_-_117799410 1.542 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr13_+_35516390 1.536 NM_015678
NBEA
neurobeachin
chr2_+_170366211 1.527 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr14_+_32798478 1.525 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr17_-_1613661 1.523 NM_001164407
TLCD2
TLC domain containing 2
chr14_+_67707825 1.521 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr10_+_18549583 1.520 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr17_+_12569206 1.516 NM_001146312
NM_153604
MYOCD

myocardin

chr11_+_33563772 1.511 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr18_-_47721165 1.511 NM_001080467
MYO5B
myosin VB
chr6_+_97010423 1.498 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr2_+_133174146 1.490 NM_001508
GPR39
G protein-coupled receptor 39
chr4_+_184020343 1.489 NM_024949
WWC2
WW and C2 domain containing 2
chr6_-_84419108 1.489 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr1_+_2985730 1.481 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr12_-_63546589 1.479 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr7_-_126892304 1.477 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr12_+_125811161 1.475 NM_052907
TMEM132B
transmembrane protein 132B
chr9_-_23826062 1.475 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_84418705 1.474 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr22_+_51113069 1.453 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr14_-_89020888 1.447 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr2_+_150186498 1.434 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr1_+_78354199 1.429 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr9_+_74764266 1.426 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr4_-_164253946 1.424 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr21_+_18885104 1.415 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr1_+_65613771 1.409 NM_013410
AK4
adenylate kinase 4
chr5_+_32710742 1.395 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr14_+_74486049 1.391 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr13_-_36788665 1.390 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr10_+_18629613 1.382 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr13_+_36050885 1.351 NM_001204197
NBEA
neurobeachin
chr2_+_204192915 1.344 NM_005759
ABI2
abl-interactor 2
chr20_-_33999780 1.341 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chr1_+_65613211 1.331 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr12_-_49177876 1.327 NM_015270
ADCY6
adenylate cyclase 6
chr11_-_31832855 1.312 NM_000280
NM_001604
PAX6

paired box 6

chr4_+_128651518 1.305 NM_031291
SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr8_+_98787808 1.305 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr13_+_51796363 1.303 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr4_-_46995440 1.291 NM_001204266
NM_001204267
GABRA4

gamma-aminobutyric acid (GABA) A receptor, alpha 4

chr13_-_107187312 1.289 NM_004093
EFNB2
ephrin-B2
chr12_+_26111951 1.279 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chrX_-_112084006 1.274 NM_133265
AMOT
angiomotin
chr13_-_36429798 1.268 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr8_+_70405027 1.268 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr10_+_18689512 1.264 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_+_140372 1.255 NM_052909
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr8_+_70378858 1.253 NM_001128204
NM_015170
SULF1

sulfatase 1

chr6_-_132272311 1.252 NM_001901
CTGF
connective tissue growth factor
chr10_+_101292689 1.246 NM_145285
NKX2-3
NK2 homeobox 3
chr3_+_119421865 1.236 NM_033364
C3orf15
chromosome 3 open reading frame 15
chrX_+_53449804 1.230 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chr3_-_66024508 1.229 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr12_+_54378929 1.223 NM_017409
HOXC10
homeobox C10
chr2_-_198650937 1.223 NM_197970
BOLL
bol, boule-like (Drosophila)
chr4_-_53522756 1.218 NM_001134223
USP46
ubiquitin specific peptidase 46
chr17_-_7832752 1.206 NM_004732
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr3_-_114343791 1.201 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_120439117 1.198 NM_021794
ADAM30
ADAM metallopeptidase domain 30
chrX_-_49056638 1.195 NM_003179
SYP
synaptophysin
chr10_-_99393851 1.195 NM_001098831
MORN4
MORN repeat containing 4
chr6_+_118228688 1.190 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr8_+_12869772 1.188 NM_001099677
KIAA1456
KIAA1456
chr12_-_117747214 1.185 NM_001204214
NOS1
nitric oxide synthase 1 (neuronal)
chr11_+_68079999 1.184 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr11_-_83393436 1.184 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr8_-_122653493 1.162 NM_005328
HAS2
hyaluronan synthase 2
chr17_-_46703613 1.148 NM_024017
HOXB9
homeobox B9
chr7_+_56032065 1.145 NM_001202469
NM_001483
GBAS

glioblastoma amplified sequence

chr10_-_35930357 1.143 NM_031866
FZD8
frizzled family receptor 8
chr1_-_147232684 1.137 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr5_+_32711437 1.135 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr9_-_16870719 1.133 NM_017637
BNC2
basonuclin 2
chr10_-_30024594 1.129 NM_003174
SVIL
supervillin
chr17_+_55163077 1.128 NM_001242903
NM_001242902
AKAP1

A kinase (PRKA) anchor protein 1

chr17_+_38599651 1.118 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr3_+_148447966 1.112 NM_032049
AGTR1
angiotensin II receptor, type 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.05 1.84e-05 GO:0048856 anatomical structure development
1.97 2.78e-05 GO:0007275 multicellular organismal development
2.09 5.73e-05 GO:0048731 system development
1.89 6.24e-05 GO:0032502 developmental process
2.25 1.25e-03 GO:0048513 organ development
1.61 1.59e-03 GO:0032501 multicellular organismal process
2.40 2.72e-03 GO:0009653 anatomical structure morphogenesis
4.21 1.25e-02 GO:0044057 regulation of system process
6.25 1.27e-02 GO:0043062 extracellular structure organization
2.02 1.51e-02 GO:0048869 cellular developmental process
2.03 1.97e-02 GO:0030154 cell differentiation
3.48 2.56e-02 GO:0072358 cardiovascular system development
3.48 2.56e-02 GO:0072359 circulatory system development
6.45 3.06e-02 GO:0051969 regulation of transmission of nerve impulse

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.21 2.63e-05 GO:0044459 plasma membrane part
4.13 2.69e-04 GO:0045202 synapse
1.69 4.55e-04 GO:0005886 plasma membrane
3.35 6.09e-04 GO:0030054 cell junction
1.67 7.59e-04 GO:0071944 cell periphery
49.97 2.80e-03 GO:0005587 collagen type IV
42.83 4.87e-03 GO:0030935 sheet-forming collagen
4.17 4.96e-03 GO:0044456 synapse part
2.57 1.02e-02 GO:0042995 cell projection
6.20 2.05e-02 GO:0044449 contractile fiber part
6.04 2.42e-02 GO:0030016 myofibril
5.69 3.47e-02 GO:0043292 contractile fiber

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.22 2.75e-03 GO:0016563 transcription activator activity