Motif ID: XBP1.p3

Z-value: 2.324


Transcription factors associated with XBP1.p3:

Gene SymbolEntrez IDGene Name
XBP1 7494 X-box binding protein 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
XBP1hg19_v1_chr22_-_29196452_291965310.584.6e-04Click!


Activity profile for motif XBP1.p3.

activity profile for motif XBP1.p3


Sorted Z-values histogram for motif XBP1.p3

Sorted Z-values for motif XBP1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of XBP1.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_2018703 11.274 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr22_+_38864015 10.697 NM_006855
NM_016657
 KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr7_+_94023872 10.251 NM_000089
 COL1A2
collagen, type I, alpha 2
chr10_+_89419352 6.468 NM_001015880
NM_004670
 PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr3_+_171758289 5.548 NM_001135095
 FNDC3B
fibronectin type III domain containing 3B
chr7_+_94024201 5.343 COL1A2
collagen, type I, alpha 2
chr5_-_121414011 5.167 NM_002317
 LOX
lysyl oxidase
chr7_-_27183225 4.752 NM_019102
 HOXA5
homeobox A5
chr6_+_132129154 4.711 NM_006208
 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_-_57583080 4.535 ARF4
ADP-ribosylation factor 4
chr2_-_69614321 4.469 NM_001244710
NM_002056
 GFPT1

glutamine--fructose-6-phosphate transaminase 1

chr11_-_2019070 4.411 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr3_-_132378492 4.386 NM_032169
 ACAD11
acyl-CoA dehydrogenase family, member 11
chr20_+_61584094 4.376 SLC17A9
solute carrier family 17, member 9
chr3_+_122785855 4.130 NM_006810
 PDIA5
protein disulfide isomerase family A, member 5
chr5_-_121413906 4.107 LOX
lysyl oxidase
chr6_-_7910278 4.034 NM_001145549
 TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr20_+_61583998 4.034 NM_022082
 SLC17A9
solute carrier family 17, member 9
chr4_+_38869346 4.013 NM_138389
 FAM114A1
family with sequence similarity 114, member A1
chr6_-_7910716 3.776 NM_030810
 TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
48.96 1.44e-02 GO:0006621 protein retention in ER lumen
48.96 1.44e-02 GO:0035437 maintenance of protein localization in endoplasmic reticulum
34.56 2.60e-03 GO:0070972 protein localization in endoplasmic reticulum
23.50 1.32e-02 GO:0006829 zinc ion transport
19.59 2.79e-02 GO:0006903 vesicle targeting
15.58 1.80e-04 GO:0045454 cell redox homeostasis
13.67 7.01e-05 GO:0018196 peptidyl-asparagine modification
13.67 7.01e-05 GO:0018279 protein N-linked glycosylation via asparagine
12.78 1.19e-04 GO:0006487 protein N-linked glycosylation
8.91 1.88e-03 GO:0048193 Golgi vesicle transport
8.22 8.76e-04 GO:0006486 protein glycosylation
8.22 8.76e-04 GO:0043413 macromolecule glycosylation
8.17 9.22e-04 GO:0070085 glycosylation
7.97 1.13e-03 GO:0043687 post-translational protein modification
6.89 3.72e-03 GO:0009101 glycoprotein biosynthetic process
5.63 1.87e-02 GO:0009100 glycoprotein metabolic process
5.28 6.24e-04 GO:0006886 intracellular protein transport
4.39 2.07e-03 GO:0034613 cellular protein localization
4.36 2.23e-03 GO:0070727 cellular macromolecule localization
4.32 1.28e-02 GO:0044262 cellular carbohydrate metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
97.90 1.82e-02 GO:0005784 Sec61 translocon complex
97.90 1.82e-02 GO:0071256 translocon complex
16.63 2.03e-04 GO:0005793 ER-Golgi intermediate compartment
16.03 2.54e-04 GO:0030176 integral to endoplasmic reticulum membrane
14.84 1.76e-07 GO:0005788 endoplasmic reticulum lumen
12.25 1.25e-03 GO:0031227 intrinsic to endoplasmic reticulum membrane
11.56 3.22e-04 GO:0042470 melanosome
11.56 3.22e-04 GO:0048770 pigment granule
7.68 4.78e-03 GO:0031301 integral to organelle membrane
6.60 1.25e-02 GO:0031300 intrinsic to organelle membrane
6.19 5.18e-14 GO:0044432 endoplasmic reticulum part
5.34 9.65e-16 GO:0005783 endoplasmic reticulum
4.76 3.11e-07 GO:0042175 nuclear membrane-endoplasmic reticulum network
4.64 1.21e-06 GO:0005789 endoplasmic reticulum membrane
3.66 4.81e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
3.64 2.54e-04 GO:0031410 cytoplasmic vesicle
3.59 6.18e-04 GO:0031988 membrane-bounded vesicle
3.57 3.54e-02 GO:0000139 Golgi membrane
3.53 4.01e-04 GO:0031982 vesicle
3.45 1.32e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
73.43 3.43e-02 GO:0046923 ER retention sequence binding
48.96 3.14e-03 GO:0003756 protein disulfide isomerase activity
48.96 3.14e-03 GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups
48.96 3.14e-03 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds
20.99 4.61e-03 GO:0015035 protein disulfide oxidoreductase activity
18.96 6.97e-03 GO:0015036 disulfide oxidoreductase activity
14.41 3.07e-03 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors