Motif ID: ZBTB16.p2

Z-value: 2.054


Transcription factors associated with ZBTB16.p2:

Gene SymbolEntrez IDGene Name
ZBTB16 7704 zinc finger and BTB domain containing 16

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB16hg19_v1_chr11_+_113931228_113931287-0.577.0e-04Click!


Activity profile for motif ZBTB16.p2.

activity profile for motif ZBTB16.p2


Sorted Z-values histogram for motif ZBTB16.p2

Sorted Z-values for motif ZBTB16.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB16.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_53600999 16.466 NM_000889
 ITGB7
integrin, beta 7
chr12_-_53601051 14.567 ITGB7
integrin, beta 7
chr5_+_156607847 14.156 NM_005546
 ITK
IL2-inducible T-cell kinase
chr12_-_10562142 13.888 NM_013431
 KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr5_+_57787260 13.303 NM_152687
 GAPT
GRB2-binding adaptor protein, transmembrane
chr13_-_99910548 12.659 NM_001098200
NM_005292
 GPR18

G protein-coupled receptor 18

chr1_+_172628157 12.589 NM_000639
 FASLG
Fas ligand (TNF superfamily, member 6)
chr1_+_198608136 11.970 NM_002838
NM_080921
NM_080923
 PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_198608216 11.508 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_-_10282680 11.382 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
 CLEC7A





C-type lectin domain family 7, member A





chr1_+_198608244 11.009 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_+_10460416 10.788 NM_002262
NM_007334
 KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr4_-_38784588 10.725 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
 TLR10




toll-like receptor 10




chr14_-_106478129 10.654 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr2_-_89292396 10.001 IGKC
immunoglobulin kappa constant
chr3_+_46395224 9.854 NM_001123041
NM_001123396
 CCR2

chemokine (C-C motif) receptor 2

chr19_-_54824343 9.641 NM_021250
NM_181879
NM_181985
NM_181986
 LILRA5



leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5



chr12_+_69742130 9.573 NM_000239
 LYZ
lysozyme
chr5_+_35856990 9.233 NM_002185
 IL7R
interleukin 7 receptor
chr4_+_74606222 9.086 NM_000584
 IL8
interleukin 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 75 entries
Enrichment   P-value GO Accession GO Term
25.75 1.27e-02 GO:0032700 negative regulation of interleukin-17 production
16.26 1.56e-03 GO:0050853 B cell receptor signaling pathway
15.45 2.20e-03 GO:0009595 detection of biotic stimulus
15.15 1.90e-02 GO:0032660 regulation of interleukin-17 production
12.87 1.14e-03 GO:0030890 positive regulation of B cell proliferation
10.84 7.66e-04 GO:0030888 regulation of B cell proliferation
9.01 1.46e-02 GO:0071260 cellular response to mechanical stimulus
8.79 1.74e-02 GO:0050871 positive regulation of B cell activation
8.58 1.22e-03 GO:0006968 cellular defense response
8.16 1.47e-07 GO:0002429 immune response-activating cell surface receptor signaling pathway
7.85 2.69e-07 GO:0002768 immune response-regulating cell surface receptor signaling pathway
7.76 2.16e-04 GO:0050671 positive regulation of lymphocyte proliferation
7.75 4.38e-06 GO:0050851 antigen receptor-mediated signaling pathway
7.66 2.49e-04 GO:0032946 positive regulation of mononuclear cell proliferation
7.55 2.87e-04 GO:0070665 positive regulation of leukocyte proliferation
6.87 2.76e-02 GO:0050864 regulation of B cell activation
6.33 2.66e-08 GO:0002757 immune response-activating signal transduction
6.33 6.39e-05 GO:0042110 T cell activation
6.18 4.15e-08 GO:0002764 immune response-regulating signaling pathway
6.18 7.59e-04 GO:0050670 regulation of lymphocyte proliferation

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
1.96 2.52e-03 GO:0005887 integral to plasma membrane
1.92 3.99e-03 GO:0031226 intrinsic to plasma membrane
1.62 1.14e-02 GO:0044459 plasma membrane part
1.47 9.15e-04 GO:0005886 plasma membrane
1.47 1.05e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
25.75 2.70e-03 GO:0016493 C-C chemokine receptor activity
22.89 4.78e-03 GO:0019957 C-C chemokine binding
17.91 2.11e-06 GO:0001608 nucleotide receptor activity, G-protein coupled
17.91 2.11e-06 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
15.45 1.05e-06 GO:0001614 purinergic nucleotide receptor activity
15.45 1.05e-06 GO:0016502 nucleotide receptor activity
13.73 4.72e-02 GO:0008329 pattern recognition receptor activity
13.63 3.60e-06 GO:0035586 purinergic receptor activity
12.87 1.01e-06 GO:0003823 antigen binding
12.26 1.24e-02 GO:0015026 coreceptor activity
4.88 1.03e-05 GO:0005529 sugar binding
3.25 2.46e-04 GO:0030246 carbohydrate binding
2.12 1.29e-06 GO:0004872 receptor activity
2.00 1.65e-03 GO:0004888 transmembrane receptor activity
1.92 1.04e-05 GO:0004871 signal transducer activity
1.92 1.04e-05 GO:0060089 molecular transducer activity