Motif ID: ZBTB6.p2

Z-value: 1.356


Transcription factors associated with ZBTB6.p2:

Gene SymbolEntrez IDGene Name
ZBTB6 10773 zinc finger and BTB domain containing 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB6hg19_v1_chr9_-_125675571_1256756080.336.2e-02Click!


Activity profile for motif ZBTB6.p2.

activity profile for motif ZBTB6.p2


Sorted Z-values histogram for motif ZBTB6.p2

Sorted Z-values for motif ZBTB6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_230579198 3.692 NM_139072
DNER
delta/notch-like EGF repeat containing
chr5_+_139175385 3.657 NM_032289
PSD2
pleckstrin and Sec7 domain containing 2
chr14_+_24540742 3.320 NM_006032
CPNE6
copine VI (neuronal)
chr8_+_104512975 3.293 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_181429711 3.251 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr9_+_34958320 2.988 KIAA1045
KIAA1045
chr22_+_26565424 2.917 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chr3_+_10857867 2.651 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr5_+_175298604 2.615 CPLX2
complexin 2
chr4_+_159131642 2.527 TMEM144
transmembrane protein 144
chr1_-_160039946 2.458 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr11_+_33563772 2.421 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr22_-_39240016 2.417 NM_014293
NPTXR
neuronal pentraxin receptor
chr9_+_87284625 2.398 NM_001007097
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr5_+_175298492 2.305 NM_001008220
CPLX2
complexin 2
chr9_+_87284680 2.298 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr3_+_181430075 2.288 SOX2
SRY (sex determining region Y)-box 2
chr12_-_6809595 2.277 NM_001244015
C12orf53
chromosome 12 open reading frame 53
chr5_+_175308843 2.275 CPLX2
complexin 2
chr4_-_163085117 2.272 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr14_-_60337350 2.253 NM_021136
RTN1
reticulon 1
chr15_-_83378488 2.247 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr10_-_61469322 2.208 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr9_+_87284733 2.197 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr5_+_175298538 2.173 CPLX2
complexin 2
chr20_-_62103815 2.103 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr12_-_6809965 2.066 NM_001244014
NM_153685
C12orf53

chromosome 12 open reading frame 53

chr1_+_110693131 2.066 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr14_+_29236882 2.036 FOXG1
forkhead box G1
chr3_-_62860561 2.004


chr19_+_54385429 1.984 NM_002739
PRKCG
protein kinase C, gamma
chr2_-_220174058 1.936 PTPRN
protein tyrosine phosphatase, receptor type, N
chr9_+_87284637 1.917 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr19_+_36359346 1.883 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr13_-_25745778 1.816 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr3_+_159943628 1.803 C3orf80
chromosome 3 open reading frame 80
chr4_+_159131400 1.788 NM_018342
TMEM144
transmembrane protein 144
chr7_-_100493481 1.778 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr5_+_167956545 1.753


chr11_-_45687135 1.734 NM_003654
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr10_-_99790584 1.732 NM_001206528
NM_018058
CRTAC1

cartilage acidic protein 1

chr16_+_56225301 1.723 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr17_-_42992852 1.722 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr22_+_26565623 1.712 SEZ6L
seizure related 6 homolog (mouse)-like
chr9_+_87284573 1.704 NM_001018065
NM_001018066
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr11_-_12030882 1.696 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr3_-_58563490 1.644 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr1_+_116380404 1.626 NHLH2
nescient helix loop helix 2
chr4_+_30721865 1.612 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr8_+_63161499 1.586 NM_173688
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr16_+_87636574 1.584 JPH3
junctophilin 3
chr21_-_43916298 1.582 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr13_-_25745620 1.561 FAM123A
family with sequence similarity 123A
chr4_+_1795004 1.551 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr4_-_139163222 1.549 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr5_-_176057324 1.548 NM_001001502
NM_003085
SNCB

synuclein, beta

chrX_-_153095996 1.542 NM_032512
PDZD4
PDZ domain containing 4
chr4_+_41258941 1.534 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr17_+_7608413 1.530 NM_001406
EFNB3
ephrin-B3
chr11_-_12030757 1.526 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr22_-_39239733 1.520


chr10_+_116853118 1.505 NM_207303
ATRNL1
attractin-like 1
chrX_-_51239426 1.500 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr13_+_37248048 1.497 NM_203451
SERTM1
serine-rich and transmembrane domain containing 1
chr20_+_57875481 1.489 NM_000114
NM_207032
NM_207033
NM_207034
EDN3



endothelin 3



chr12_+_79258794 1.486 SYT1
synaptotagmin I
chr9_-_101470836 1.467 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr21_+_34442446 1.449 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr11_+_17757494 1.443 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr5_-_146258143 1.438 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr10_-_108924287 1.438 NM_001013031
NM_001206569
NM_001206570
NM_001206571
NM_001206572
NM_052918
SORCS1





sortilin-related VPS10 domain containing receptor 1





chr15_+_84115979 1.404 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr12_+_79258588 1.400 SYT1
synaptotagmin I
chr15_+_84116172 1.398 SH3GL3
SH3-domain GRB2-like 3
chr11_-_75379414 1.361 NM_033063
NM_207577
MAP6

microtubule-associated protein 6

chr5_+_173472692 1.355 NM_015980
HMP19
HMP19 protein
chr5_-_146257633 1.351 PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr11_-_12030622 1.350 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr4_+_41258909 1.345 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr10_+_119806334 1.345 CASC2
cancer susceptibility candidate 2 (non-protein coding)
chr19_-_55691468 1.342 NM_003180
SYT5
synaptotagmin V
chrX_-_92928566 1.338 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr15_+_80696569 1.330 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr22_+_26565454 1.324 SEZ6L
seizure related 6 homolog (mouse)-like
chr11_-_12030539 1.324 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_-_15090349 1.309 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr11_-_12030838 1.309 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr3_+_6902812 1.308 GRM7
glutamate receptor, metabotropic 7
chr3_+_63428752 1.302 NM_144642
SYNPR
synaptoporin
chr12_+_79258517 1.293 SYT1
synaptotagmin I
chr4_-_5889992 1.287 CRMP1
collapsin response mediator protein 1
chr22_+_42372763 1.277 NM_019106
NM_145733
SEPT3

septin 3

chr9_+_137979513 1.270 OLFM1
olfactomedin 1
chr4_+_41258895 1.251 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_+_6902797 1.248 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr11_-_75379113 1.242 MAP6
microtubule-associated protein 6
chr13_+_88324777 1.235 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr18_-_35145603 1.233 CELF4
CUGBP, Elav-like family member 4
chr7_-_4998744 1.232 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr8_-_21646327 1.226 NM_001165038
NM_001165039
NM_001495
GFRA2


GDNF family receptor alpha 2


chr11_+_61520000 1.218 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr3_-_56502364 1.209 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr15_+_71184781 1.202 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_-_51239295 1.196 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr7_-_143059696 1.196 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr4_+_134073180 1.187 PCDH10
protocadherin 10
chr3_-_62861012 1.183 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr22_+_31518923 1.180 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr5_+_78985645 1.167 NM_153610
CMYA5
cardiomyopathy associated 5
chr19_-_19007395 1.166 CERS1
ceramide synthase 1
chr5_+_169931023 1.159 NM_001034837
NM_014592
KCNIP1

Kv channel interacting protein 1

chr2_-_154335181 1.155 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr8_-_40755328 1.154 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr2_-_193059599 1.153 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr6_+_150464156 1.149 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr20_+_57875647 1.148 EDN3
endothelin 3
chr15_-_79382839 1.146 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr16_+_2039945 1.144 NM_004209
SYNGR3
synaptogyrin 3
chr9_-_139948448 1.140 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr5_+_173472737 1.137 HMP19
HMP19 protein
chr12_+_121078421 1.132 NM_001033677
CABP1
calcium binding protein 1
chrX_+_110366304 1.124 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr11_-_79151694 1.117 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr2_-_119916338 1.111 NM_182528
C1QL2
complement component 1, q subcomponent-like 2
chr6_-_88875766 1.109 NM_001160226
NM_001160258
NM_001160259
NM_016083
CNR1



cannabinoid receptor 1 (brain)



chr10_+_101089109 1.109 CNNM1
cyclin M1
chr2_+_39893021 1.108 NM_152390
TMEM178
transmembrane protein 178
chr18_+_48086402 1.107 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr11_+_20691116 1.104 NM_006157
NM_201551
NELL1

NEL-like 1 (chicken)

chr16_-_31021716 1.094 NM_052874
STX1B
syntaxin 1B
chr6_+_30850693 1.086 DDR1
discoidin domain receptor tyrosine kinase 1
chr4_-_66536182 1.077 EPHA5
EPH receptor A5
chr11_+_63753827 1.076 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr10_+_106400858 1.071 NM_014978
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr17_-_45056588 1.070 NM_203400
RPRML
reprimo-like
chr3_+_112052020 1.067 CD200
CD200 molecule
chr11_-_64377332 1.067


chr2_+_120302024 1.067 NM_001029996
PCDP1
primary ciliary dyskinesia protein 1
chr16_+_56225250 1.062 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr1_+_202091971 1.062 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr6_-_166721870 1.061 NM_175922
PRR18
proline rich 18
chr10_+_101088794 1.055 NM_020348
CNNM1
cyclin M1
chr4_-_6422844 1.049 NM_001206996
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr15_-_77924688 1.046 NM_032808
LINGO1
leucine rich repeat and Ig domain containing 1
chr5_-_63257545 1.045 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr3_+_147127151 1.044 NM_003412
ZIC1
Zic family member 1
chr21_-_31312229 1.034 NM_000830
NM_175611
GRIK1

glutamate receptor, ionotropic, kainate 1

chr1_+_205198058 1.032 NM_001242925
TMCC2
transmembrane and coiled-coil domain family 2
chr7_+_139208673 1.030 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr1_-_17445865 1.029 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr11_-_119293848 1.027 THY1
Thy-1 cell surface antigen
chr3_-_133614421 1.026 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr5_+_140220811 1.014 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr17_+_34058678 1.013 NM_033315
RASL10B
RAS-like, family 10, member B
chr12_+_119616594 1.010 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_+_79258448 1.006 NM_005639
SYT1
synaptotagmin I
chr17_+_40118792 1.005 CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr1_-_41131113 1.004 RIMS3
regulating synaptic membrane exocytosis 3
chr3_+_159943252 1.003 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr3_+_19189969 0.999 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr3_-_170303774 0.999 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr11_+_107461955 0.997 ELMOD1
ELMO/CED-12 domain containing 1
chr1_-_103574051 0.996 NM_001190709
NM_001854
NM_080629
NM_080630
COL11A1



collagen, type XI, alpha 1



chr1_+_181452685 0.991 NM_000721
NM_001205293
NM_001205294
CACNA1E


calcium channel, voltage-dependent, R type, alpha 1E subunit


chr11_-_35547144 0.979 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr19_+_18062110 0.978 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr11_+_107462073 0.976 ELMOD1
ELMO/CED-12 domain containing 1
chr2_+_166095911 0.976 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr14_+_33408458 0.975 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr22_+_51039178 0.972 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr3_-_47620186 0.970 NM_001206943
NM_001206944
NM_006574
CSPG5


chondroitin sulfate proteoglycan 5 (neuroglycan C)


chr1_+_203096835 0.967 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr19_+_4304590 0.959 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr1_+_205197031 0.953 NM_014858
TMCC2
transmembrane and coiled-coil domain family 2
chr18_+_43304091 0.951 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr22_+_51039100 0.946 NM_012324
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr8_+_61429390 0.945 NM_001242644
NM_002865
RAB2A

RAB2A, member RAS oncogene family

chr7_+_29846112 0.941 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr18_+_43304143 0.940 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr16_+_66460815 0.931 NM_001136106
NM_001178020
NM_001197224
NM_001197225
BEAN1



brain expressed, associated with NEDD4, 1



chr1_-_13840157 0.924 NM_001010847
LRRC38
leucine rich repeat containing 38
chr22_-_38379790 0.923 SOX10
SRY (sex determining region Y)-box 10
chr19_-_7990974 0.921 NM_206833
CTXN1
cortexin 1
chr1_+_151032150 0.918 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_-_21462987 0.917 NEBL
nebulette
chrX_+_12156584 0.914 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr1_+_163038934 0.913 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_-_45270632 0.912 NM_001145107
NELL2
NEL-like 2 (chicken)
chr4_+_30722191 0.907 PCDH7
protocadherin 7
chr5_+_89854610 0.903 NM_032119
GPR98
G protein-coupled receptor 98
chr22_-_38379868 0.902 SOX10
SRY (sex determining region Y)-box 10
chr18_-_74691951 0.901 MBP
myelin basic protein
chr14_-_25519076 0.899 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chrX_+_144902865 0.899 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr10_-_88126201 0.892 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr1_-_109825767 0.891 NM_001005290
NM_001032291
NM_032636
PSRC1


proline/serine-rich coiled-coil 1


chr9_+_126773851 0.890 NM_004789
LHX2
LIM homeobox 2
chrX_+_49644469 0.890 NM_001145073
USP27X
ubiquitin specific peptidase 27, X-linked
chr12_+_50451486 0.886 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr22_-_38851012 0.882 NM_152868
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.60 2.58e-08 GO:0007399 nervous system development
5.81 9.90e-07 GO:0019226 transmission of nerve impulse
5.81 9.90e-07 GO:0035637 multicellular organismal signaling
6.16 1.22e-06 GO:0007268 synaptic transmission
4.22 2.62e-05 GO:0007267 cell-cell signaling
3.50 1.37e-04 GO:0007154 cell communication
1.94 1.33e-03 GO:0023052 signaling
3.35 1.93e-03 GO:0022008 neurogenesis
3.37 3.38e-03 GO:0048699 generation of neurons
4.08 1.04e-02 GO:0007417 central nervous system development
3.46 1.60e-02 GO:0030182 neuron differentiation
1.99 1.78e-02 GO:0048731 system development
1.89 3.02e-02 GO:0048856 anatomical structure development
2.97 3.08e-02 GO:0048468 cell development
1.83 3.91e-02 GO:0007275 multicellular organismal development
8.50 4.32e-02 GO:0006836 neurotransmitter transport

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.41 1.27e-07 GO:0043005 neuron projection
6.33 1.54e-07 GO:0045202 synapse
1.61 1.94e-06 GO:0016020 membrane
1.71 6.51e-06 GO:0044425 membrane part
1.93 2.75e-05 GO:0071944 cell periphery
1.92 4.65e-05 GO:0005886 plasma membrane
2.42 6.57e-05 GO:0044459 plasma membrane part
6.02 8.16e-05 GO:0044456 synapse part
3.54 8.54e-05 GO:0042995 cell projection
1.73 9.21e-05 GO:0031224 intrinsic to membrane
1.70 2.86e-04 GO:0016021 integral to membrane
2.88 4.08e-04 GO:0005887 integral to plasma membrane
2.82 5.59e-04 GO:0031226 intrinsic to plasma membrane
6.92 6.97e-04 GO:0030425 dendrite
6.80 2.63e-03 GO:0043025 neuronal cell body
6.61 3.24e-03 GO:0044297 cell body
8.76 7.09e-03 GO:0019717 synaptosome
3.32 1.66e-02 GO:0030054 cell junction
12.84 2.89e-02 GO:0030672 synaptic vesicle membrane
8.50 3.40e-02 GO:0030665 clathrin coated vesicle membrane
8.30 3.79e-02 GO:0008021 synaptic vesicle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.46 4.32e-03 GO:0005509 calcium ion binding
11.46 1.14e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity