Motif ID: ZIC1..3.p2

Z-value: 2.269


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZIC3hg19_v1_chrX_+_136648313_1366483450.757.4e-07Click!
ZIC2hg19_v1_chr13_+_100633977_1006340630.731.8e-06Click!
ZIC1hg19_v1_chr3_+_147127151_1471271910.577.3e-04Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_73673978 10.832 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr11_-_75379414 8.064 NM_033063
NM_207577
 MAP6

microtubule-associated protein 6

chr8_-_22014263 7.452 NM_139278
 LGI3
leucine-rich repeat LGI family, member 3
chr11_-_75379651 6.905 MAP6
microtubule-associated protein 6
chr22_-_44258210 6.805 NM_014351
 SULT4A1
sulfotransferase family 4A, member 1
chr14_+_29236882 6.783 FOXG1
forkhead box G1
chr14_-_103988829 6.683 CKB
creatine kinase, brain
chr3_+_153839136 6.624 NM_001251963
NM_015595
 ARHGEF26

Rho guanine nucleotide exchange factor (GEF) 26

chr11_-_111782447 6.506 NM_001885
 CRYAB
crystallin, alpha B
chr19_-_47164289 6.281 NM_145056
 DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr11_-_75379113 6.078 MAP6
microtubule-associated protein 6
chr12_-_49392909 5.982 NM_015086
 DDN
dendrin
chr1_-_38512446 5.939 NM_002699
 POU3F1
POU class 3 homeobox 1
chr5_+_71403040 5.721 NM_005909
 MAP1B
microtubule-associated protein 1B
chr5_-_168727715 5.418 NM_003062
 SLIT3
slit homolog 3 (Drosophila)
chr3_+_63263814 5.412 NM_001130003
 SYNPR
synaptoporin
chrX_+_70364680 5.311 NM_001166660
NM_018977
NM_181303
 NLGN3


neuroligin 3


chr3_+_170136652 5.207 NM_005602
 CLDN11
claudin 11
chr8_+_75736771 5.193 NM_015886
 PI15
peptidase inhibitor 15
chr11_+_111783476 5.163 HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
Enrichment   P-value GO Accession GO Term
4.37 2.90e-02 GO:0006836 neurotransmitter transport
3.65 1.67e-10 GO:0019226 transmission of nerve impulse
3.65 1.67e-10 GO:0035637 multicellular organismal signaling
3.63 5.24e-09 GO:0007268 synaptic transmission
3.60 1.55e-02 GO:0030900 forebrain development
3.45 3.33e-06 GO:0007420 brain development
3.14 1.25e-11 GO:0007267 cell-cell signaling
3.06 1.47e-06 GO:0007417 central nervous system development
2.77 2.66e-02 GO:0001501 skeletal system development
2.70 3.14e-03 GO:0007409 axonogenesis
2.65 7.32e-10 GO:0007154 cell communication
2.61 6.25e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
2.56 8.69e-03 GO:0048812 neuron projection morphogenesis
2.54 3.21e-03 GO:0000904 cell morphogenesis involved in differentiation
2.48 8.92e-05 GO:0030182 neuron differentiation
2.47 1.96e-12 GO:0007399 nervous system development
2.44 1.03e-02 GO:0048858 cell projection morphogenesis
2.42 1.22e-02 GO:0032990 cell part morphogenesis
2.40 1.99e-02 GO:0031175 neuron projection development
2.39 1.30e-04 GO:0007155 cell adhesion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
Enrichment   P-value GO Accession GO Term
8.25 6.10e-05 GO:0030672 synaptic vesicle membrane
6.96 1.11e-03 GO:0043197 dendritic spine
6.68 1.58e-03 GO:0044309 neuron spine
5.55 1.35e-04 GO:0008021 synaptic vesicle
5.17 2.04e-03 GO:0014069 postsynaptic density
4.90 1.09e-13 GO:0044456 synapse part
4.77 4.36e-06 GO:0045211 postsynaptic membrane
4.59 1.77e-16 GO:0045202 synapse
4.37 2.29e-02 GO:0030665 clathrin coated vesicle membrane
3.59 1.39e-03 GO:0030424 axon
3.36 3.35e-03 GO:0030425 dendrite
3.14 4.83e-10 GO:0030054 cell junction
3.01 1.32e-05 GO:0043005 neuron projection
2.57 1.91e-03 GO:0044463 cell projection part
2.37 3.16e-02 GO:0031012 extracellular matrix
2.34 3.71e-02 GO:0009986 cell surface
2.09 4.75e-04 GO:0042995 cell projection
1.99 1.92e-10 GO:0044459 plasma membrane part
1.73 1.35e-02 GO:0005887 integral to plasma membrane
1.70 2.21e-02 GO:0031226 intrinsic to plasma membrane

Nothing significant found in function category.