Motif ID: ZNF423.p2

Z-value: 1.087


Transcription factors associated with ZNF423.p2:

Gene SymbolEntrez IDGene Name
ZNF423 23090 zinc finger protein 423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v1_chr16_-_49860917_498609170.028.9e-01Click!


Activity profile for motif ZNF423.p2.

activity profile for motif ZNF423.p2


Sorted Z-values histogram for motif ZNF423.p2

Sorted Z-values for motif ZNF423.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74735107 2.071 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr19_-_11689765 1.351 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr10_+_81370694 1.309 NM_001093770
NM_001164644
NM_001164645
NM_001164646
NM_001164647
NM_005411
SFTPA1





surfactant protein A1





chr19_-_36391448 1.304 NM_139239
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chrX_-_48828250 1.263 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr11_+_60691911 1.257 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr16_-_85145995 1.233 NM_198491
FAM92B
family with sequence similarity 92, member B
chr5_+_92920592 1.193 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr5_+_176784843 1.132 NM_006480
RGS14
regulator of G-protein signaling 14
chr8_+_65493610 1.091 BHLHE22
basic helix-loop-helix family, member e22
chr1_+_26644458 1.083 CD52
CD52 molecule
chr19_-_3786279 1.058 MATK
megakaryocyte-associated tyrosine kinase
chr10_-_135090325 1.037 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr1_-_27952591 1.032 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr22_+_22786283 1.031


chr14_-_106714594 1.007


chr19_-_11689591 0.993 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr1_+_27719151 0.992 NM_005281
GPR3
G protein-coupled receptor 3
chr19_+_11200146 0.969 LDLR
low density lipoprotein receptor
chr19_+_11200124 0.952 LDLR
low density lipoprotein receptor
chr6_+_151186884 0.927 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr8_+_22019167 0.874 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr17_+_72733350 0.855 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr2_-_224903933 0.847 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr17_-_72709010 0.841 NM_139018
CD300LF
CD300 molecule-like family member f
chr1_-_212873197 0.833 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr20_+_24929862 0.827 NM_003650
CST7
cystatin F (leukocystatin)
chr21_+_26934440 0.811 MIR155HG
MIR155 host gene (non-protein coding)
chrX_-_101410761 0.778 NM_001159560
NM_001012978
BEX5

brain expressed, X-linked 5

chr16_+_67679011 0.774 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr19_-_10420220 0.774 NM_001103167
ZGLP1
zinc finger, GATA-like protein 1
chr19_+_45971249 0.773 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr19_+_14247974 0.768 LOC100507373
uncharacterized LOC100507373
chr1_+_26644380 0.765 NM_001803
CD52
CD52 molecule
chr7_+_76139744 0.763 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr14_-_60097314 0.762 RTN1
reticulon 1
chr20_-_23402038 0.744 NM_022080
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta
chr19_+_46144904 0.742 NM_001242348
LOC100287177
uncharacterized LOC100287177
chr22_+_22735202 0.726


chr9_-_100881462 0.715 NM_014788
NM_033219
NM_033220
TRIM14


tripartite motif containing 14


chr19_+_11200037 0.709 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr1_+_110254863 0.708 NM_000851
GSTM5
glutathione S-transferase mu 5
chr6_+_151187064 0.701 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr6_+_151186814 0.701 NM_001242767
NM_001242769
NM_015440
MTHFD1L


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr19_-_11545900 0.697 NM_145045
CCDC151
coiled-coil domain containing 151
chr18_-_19284622 0.681 ABHD3
abhydrolase domain containing 3
chr17_+_76126835 0.679 NM_152468
TMC8
transmembrane channel-like 8
chr9_+_93564204 0.676 NM_001174168
SYK
spleen tyrosine kinase
chr12_-_120554453 0.671 RAB35
RAB35, member RAS oncogene family
chr10_-_6104113 0.669 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr22_+_22735134 0.668 CYAT1
immunoglobulin lambda light chain-like
chr8_-_125486808 0.667


chr16_+_57392694 0.653 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr19_-_1863546 0.652 NM_031918
KLF16
Kruppel-like factor 16
chr19_+_45251933 0.642 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr19_+_4640028 0.640 NM_001167942
TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr9_-_130742803 0.640 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr5_+_176784947 0.638


chr17_+_72732958 0.635 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr18_-_19284737 0.630 NM_138340
ABHD3
abhydrolase domain containing 3
chr8_-_133493003 0.625 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr9_+_93564063 0.621 SYK
spleen tyrosine kinase
chr1_-_27953046 0.612 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr9_-_37034358 0.610 NM_016734
PAX5
paired box 5
chr3_-_50374749 0.610 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr11_-_130298305 0.609 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr2_-_233352530 0.609 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr20_+_62368035 0.608 LIME1
Lck interacting transmembrane adaptor 1
chr20_+_30639981 0.607 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr15_-_95870310 0.607 LOC400456
uncharacterized LOC400456
chr11_-_441995 0.604 NM_001012302
ANO9
anoctamin 9
chr11_+_46403279 0.601 MDK
midkine (neurite growth-promoting factor 2)
chr3_-_50374795 0.601 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr19_-_10628111 0.600 NM_030760
S1PR5
sphingosine-1-phosphate receptor 5
chr6_-_32160289 0.600 GPSM3
G-protein signaling modulator 3
chr7_+_27135983 0.599


chr19_-_3786382 0.599 NM_139354
NM_139355
MATK

megakaryocyte-associated tyrosine kinase

chr9_+_137967401 0.596 OLFM1
olfactomedin 1
chr16_+_27325244 0.595 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr12_-_120554551 0.595 RAB35
RAB35, member RAS oncogene family
chr17_-_37764165 0.595 NM_006160
NEUROD2
neurogenic differentiation 2
chr12_-_50100966 0.587


chr11_-_441956 0.586 ANO9
anoctamin 9
chr12_-_50101127 0.586 FMNL3
formin-like 3
chr2_-_242800989 0.580 NM_005018
PDCD1
programmed cell death 1
chr7_-_30029284 0.579 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr7_+_48128225 0.576 NM_181597
UPP1
uridine phosphorylase 1
chr22_+_37309618 0.572 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr11_-_107729523 0.567 SLC35F2
solute carrier family 35, member F2
chr12_+_79258588 0.564 SYT1
synaptotagmin I
chr17_+_7788094 0.564 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr3_-_50374875 0.563 NM_170713
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr9_+_127019782 0.561 NM_001166167
NM_001145001
NM_014397
NEK6


NIMA (never in mitosis gene a)-related kinase 6


chr15_+_64443909 0.561 NM_024798
SNX22
sorting nexin 22
chr11_+_46403302 0.559 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr2_-_175869910 0.557 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr9_+_93564099 0.556 SYK
spleen tyrosine kinase
chr9_+_93564011 0.556 NM_001135052
NM_003177
SYK

spleen tyrosine kinase

chr4_-_90758126 0.555 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr19_+_7741934 0.545 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr20_+_24929904 0.543 CST7
cystatin F (leukocystatin)
chr1_-_182573393 0.536 NM_002928
RGS16
regulator of G-protein signaling 16
chr20_+_62367945 0.535 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr1_+_155278677 0.532 NM_001135821
FDPS
farnesyl diphosphate synthase
chr9_-_97401588 0.531 FBP1
fructose-1,6-bisphosphatase 1
chr22_+_22735207 0.530 IGLJ3
immunoglobulin lambda joining 3
chr1_+_9711781 0.526 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr8_-_133492556 0.525 KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr10_+_134973935 0.520 NM_152643
KNDC1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr11_-_61062697 0.519 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr9_+_112542496 0.518 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_-_40254131 0.511 BMP8B
bone morphogenetic protein 8b
chr12_+_54410893 0.510 HOXC5
HOXC6
homeobox C5
homeobox C6
chr19_-_51220194 0.499 NM_016148
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr12_+_54410641 0.498 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr3_+_133465204 0.496 TF
transferrin
chr1_-_212873306 0.495 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr7_+_100081549 0.495 NM_173564
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr6_+_42897184 0.494 CNPY3
canopy 3 homolog (zebrafish)
chr7_-_100171269 0.483 NM_001168682
SAP25
Sin3A-associated protein, 25kDa
chr19_+_55085237 0.481 NM_001130917
NM_006866
LILRA2

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

chr2_-_145274916 0.481 ZEB2
zinc finger E-box binding homeobox 2
chr7_+_26191732 0.479 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr1_+_109642814 0.478 SCARNA2
small Cajal body-specific RNA 2
chr6_-_2840683 0.478 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_+_155278727 0.473 FDPS
farnesyl diphosphate synthase
chr12_-_125348346 0.473 SCARB1
scavenger receptor class B, member 1
chr1_+_1115076 0.471 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr11_-_107729492 0.468 SLC35F2
solute carrier family 35, member F2
chr19_-_46476556 0.466 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr14_-_60097531 0.463 NM_206852
RTN1
reticulon 1
chr16_+_71392615 0.461 NM_001740
NM_007088
CALB2

calbindin 2

chr18_-_47018777 0.460 RPL17
ribosomal protein L17
chr7_-_5570188 0.458 NM_001101
ACTB
actin, beta
chr17_+_48638339 0.454 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr12_-_120554557 0.453 RAB35
RAB35, member RAS oncogene family
chr12_+_79258517 0.451 SYT1
synaptotagmin I
chr4_-_74964836 0.451 CXCL2
chemokine (C-X-C motif) ligand 2
chr5_-_180018465 0.451 NM_052863
SCGB3A1
secretoglobin, family 3A, member 1
chr12_-_125348422 0.449 NM_001082959
NM_005505
SCARB1

scavenger receptor class B, member 1

chr22_+_35777051 0.448 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr19_+_38810461 0.448 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr17_+_7311501 0.447 NM_020795
NLGN2
neuroligin 2
chr16_+_27325269 0.445 IL4R
interleukin 4 receptor
chr9_-_100881515 0.445 TRIM14
tripartite motif containing 14
chr7_-_97601654 0.445


chr14_-_106209380 0.444 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr18_-_5543967 0.442 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr2_+_98330030 0.441 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr6_-_30654978 0.439 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr6_-_166401526 0.438 LINC00473
long intergenic non-protein coding RNA 473
chr19_+_38810751 0.436 KCNK6
potassium channel, subfamily K, member 6
chr21_+_45719953 0.434 PFKL
phosphofructokinase, liver
chr7_+_150102376 0.433


chr19_+_7828034 0.431 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr11_-_44972227 0.431 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr7_+_50344255 0.431 NM_001220765
NM_001220766
NM_001220767
NM_001220768
NM_001220769
NM_001220770
NM_001220771
NM_001220772
NM_001220773
NM_001220774
NM_001220775
NM_001220776
NM_006060
IKZF1












IKAROS family zinc finger 1 (Ikaros)












chr12_-_6665220 0.430 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr6_+_42897236 0.430 CNPY3
canopy 3 homolog (zebrafish)
chr19_-_41858948 0.429 TGFB1
transforming growth factor, beta 1
chr3_+_6902797 0.429 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr22_+_39853316 0.428 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr12_+_79258448 0.426 NM_005639
SYT1
synaptotagmin I
chr9_+_93564073 0.425 SYK
spleen tyrosine kinase
chr6_+_151187310 0.425 NM_001242768
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr3_-_158450205 0.425 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr11_+_43665772 0.425


chr19_-_10679620 0.424 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr12_-_120554558 0.423 RAB35
RAB35, member RAS oncogene family
chr22_+_23154240 0.422


chr20_+_57766074 0.422 NM_178457
ZNF831
zinc finger protein 831
chr12_-_50297575 0.419 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr12_-_125348266 0.411 SCARB1
scavenger receptor class B, member 1
chr6_+_31543340 0.410 NM_000594
TNF
tumor necrosis factor
chr1_-_85462622 0.409 NM_153259
MCOLN2
mucolipin 2
chr10_+_102792161 0.407 SFXN3
sideroflexin 3
chr19_+_18530423 0.405


chr19_-_1863425 0.400 KLF16
Kruppel-like factor 16
chr6_+_42896859 0.399 NM_006586
CNPY3
canopy 3 homolog (zebrafish)
chr19_+_38810540 0.397 KCNK6
potassium channel, subfamily K, member 6
chr17_+_39969205 0.396 FKBP10
FK506 binding protein 10, 65 kDa
chr14_-_60097223 0.395 RTN1
reticulon 1
chr17_+_7608413 0.393 NM_001406
EFNB3
ephrin-B3
chrX_-_153881757 0.393 NM_020994
NM_172377
CTAG2

cancer/testis antigen 2

chr19_-_48673559 0.392 NM_000234
LIG1
ligase I, DNA, ATP-dependent
chr12_+_65218351 0.387 NM_015279
TBC1D30
TBC1 domain family, member 30
chr1_-_102462789 0.386 NM_058170
OLFM3
olfactomedin 3
chr19_-_36523540 0.386 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr14_-_106518424 0.385 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr4_-_46391771 0.385 NM_000807
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr2_+_74776146 0.385 NM_001197260
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr10_+_102792166 0.385 SFXN3
sideroflexin 3
chr2_-_198175324 0.376 ANKRD44
ankyrin repeat domain 44
chr1_+_210406194 0.374 NM_019605
SERTAD4
SERTA domain containing 4
chr1_+_67218148 0.374 TCTEX1D1
Tctex1 domain containing 1
chr19_+_7733971 0.372 NM_001193374
NM_020415
RETN

resistin

chr11_-_47400096 0.372 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr4_+_4387982 0.371 NM_001040101
NM_014392
D4S234E

DNA segment on chromosome 4 (unique) 234 expressed sequence

chr22_+_35777087 0.371 HMOX1
heme oxygenase (decycling) 1
chr20_+_44650260 0.368 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
375.33 1.85e-03 GO:0070245 positive regulation of thymocyte apoptosis
321.72 2.59e-03 GO:0070234 positive regulation of T cell apoptosis
281.52 3.45e-03 GO:0070230 positive regulation of lymphocyte apoptosis
281.52 3.45e-03 GO:2000108 positive regulation of leukocyte apoptosis
225.23 5.54e-03 GO:0070243 regulation of thymocyte apoptosis
187.70 8.12e-03 GO:0070232 regulation of T cell apoptosis
150.17 1.29e-02 GO:0033081 regulation of T cell differentiation in thymus
125.16 1.88e-02 GO:0070228 regulation of lymphocyte apoptosis
118.57 2.10e-02 GO:2000106 regulation of leukocyte apoptosis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
250.24 1.04e-03 GO:0003706 ligand-regulated transcription factor activity
57.80 2.12e-02 GO:0004715 non-membrane spanning protein tyrosine kinase activity
44.22 3.63e-02 GO:0003707 steroid hormone receptor activity
41.76 4.07e-02 GO:0004879 ligand-dependent nuclear receptor activity