Motif ID: bHLH_family.p2

Z-value: 2.190


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MLXIPLhg19_v1_chr7_-_73038814_730389270.691.1e-05Click!
OLIG1hg19_v1_chr21_+_34444004_34444086-0.631.2e-04Click!
MNThg19_v1_chr17_-_2304217_2304415-0.585.3e-04Click!
MXD3hg19_v1_chr5_-_176738831_176738938-0.531.7e-03Click!
ID1hg19_v1_chr20_+_30193083_301931900.373.5e-02Click!
MXD4hg19_v1_chr4_-_2263808_2263839-0.373.9e-02Click!
OLIG2hg19_v1_chr21_+_34398210_34398292-0.355.2e-02Click!
NPAS2hg19_v1_chr2_+_101436491_1014370410.345.7e-02Click!
HES6hg19_v1_chr2_-_239148626_239148690-0.318.5e-02Click!
ARNTL2hg19_v1_chr12_+_27485767_27485992-0.309.1e-02Click!
TFE3hg19_v1_chrX_-_48900932_48900989-0.309.6e-02Click!
ARNTLhg19_v1_chr11_+_13299329_13299336-0.232.0e-01Click!
MITFhg19_v1_chr3_+_69915374_699154290.212.5e-01Click!
MXI1hg19_v1_chr10_+_111967302_111967416-0.183.1e-01Click!
HEY2hg19_v1_chr6_+_126070895_1260709220.183.2e-01Click!
CLOCKhg19_v1_chr4_-_56412968_56413015-0.134.8e-01Click!
HEYLhg19_v1_chr1_-_40098639_40098671-0.105.7e-01Click!
HEY1hg19_v1_chr8_-_80679897_806800970.038.9e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_50497790 10.789 NM_005276
 GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr8_-_75233461 9.657 NM_020647
 JPH1
junctophilin 1
chr11_-_116663106 7.429 NM_001166598
NM_052968
 APOA5

apolipoprotein A-V

chr1_-_1850704 7.365 NM_178545
 TMEM52
transmembrane protein 52
chr9_+_133320093 6.814 NM_000050
NM_054012
 ASS1

argininosuccinate synthase 1

chr4_-_100242487 5.385 NM_000668
 ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr9_+_133320247 5.375 ASS1
argininosuccinate synthase 1
chr1_-_161193375 5.202 NM_001643
 APOA2
apolipoprotein A-II
chr11_-_2018568 5.186 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018703 5.010 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_-_154193073 4.862 NM_001098616
NM_015449
NM_138740
 C1orf43


chromosome 1 open reading frame 43


chr1_+_150255228 4.747 NM_144697
 C1orf51
chromosome 1 open reading frame 51
chr11_-_2018446 4.712 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr20_+_30407175 4.645 NM_033118
 MYLK2
myosin light chain kinase 2
chr11_-_119252364 4.565 NM_001243759
NM_004205
 USP2

ubiquitin specific peptidase 2

chr1_-_154192882 4.450 C1orf43
chromosome 1 open reading frame 43
chr8_+_17354562 4.393 NM_001008539
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr11_+_111789600 4.370 NM_080659
 C11orf52
chromosome 11 open reading frame 52
chr11_-_66725790 4.272 NM_000920
NM_001040716
 PC

pyruvate carboxylase

chr1_+_110009099 4.236 NM_001040709
 SYPL2
synaptophysin-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
Enrichment   P-value GO Accession GO Term
16.33 1.13e-02 GO:0034377 plasma lipoprotein particle assembly
16.33 1.13e-02 GO:0065005 protein-lipid complex assembly
9.80 3.82e-02 GO:0042304 regulation of fatty acid biosynthetic process
9.14 1.29e-02 GO:0050994 regulation of lipid catabolic process
9.04 7.17e-04 GO:0031100 organ regeneration
8.47 5.36e-03 GO:0006941 striated muscle contraction
8.25 6.64e-03 GO:0070252 actin-mediated cell contraction
6.76 2.92e-03 GO:0019217 regulation of fatty acid metabolic process
5.60 4.65e-02 GO:0046890 regulation of lipid biosynthetic process
5.47 2.88e-03 GO:0008652 cellular amino acid biosynthetic process
4.70 1.43e-02 GO:0016125 sterol metabolic process
4.64 3.88e-02 GO:0008203 cholesterol metabolic process
4.47 1.65e-05 GO:0007517 muscle organ development
4.32 3.27e-03 GO:0019216 regulation of lipid metabolic process
4.04 1.60e-02 GO:0006006 glucose metabolic process
3.78 2.08e-05 GO:0061061 muscle structure development
3.54 2.02e-02 GO:0019318 hexose metabolic process
3.44 8.81e-03 GO:0016053 organic acid biosynthetic process
3.44 8.81e-03 GO:0046394 carboxylic acid biosynthetic process
3.28 1.27e-06 GO:0006066 alcohol metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
19.59 5.38e-05 GO:0042627 chylomicron
11.76 1.90e-03 GO:0034361 very-low-density lipoprotein particle
11.76 1.90e-03 GO:0034385 triglyceride-rich lipoprotein particle
9.80 6.03e-03 GO:0034364 high-density lipoprotein particle
8.96 5.40e-04 GO:0032994 protein-lipid complex
8.96 5.40e-04 GO:0034358 plasma lipoprotein particle
4.40 1.00e-02 GO:0030017 sarcomere
4.39 2.07e-03 GO:0030016 myofibril
4.16 7.91e-03 GO:0044449 contractile fiber part
4.14 3.93e-03 GO:0043292 contractile fiber
2.42 8.25e-03 GO:0031966 mitochondrial membrane
2.41 6.52e-03 GO:0005740 mitochondrial envelope
2.28 7.27e-04 GO:0044429 mitochondrial part
2.21 6.41e-08 GO:0005739 mitochondrion
1.55 7.68e-13 GO:0044444 cytoplasmic part
1.53 2.18e-02 GO:0031090 organelle membrane
1.53 3.13e-02 GO:0005829 cytosol
1.34 9.23e-09 GO:0005737 cytoplasm
1.27 3.49e-02 GO:0044422 organelle part
1.25 3.34e-05 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
14.25 4.43e-02 GO:0017127 cholesterol transporter activity
6.38 3.64e-02 GO:0008307 structural constituent of muscle
4.52 5.10e-03 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
4.39 3.10e-03 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
3.73 2.52e-05 GO:0048037 cofactor binding
3.69 2.86e-03 GO:0050662 coenzyme binding
2.62 2.29e-02 GO:0003779 actin binding
2.21 2.36e-02 GO:0008092 cytoskeletal protein binding
2.11 8.19e-03 GO:0016491 oxidoreductase activity