ISMARA results: ACAUUCA

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Illumina Body Map 2, young vs old

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Results for ACAUUCA

Z-value: 2.41

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miRNA associated with seed ACAUUCA

Name	miRBASE accession
hsa-miR-181a-5p miRBase	MIMAT0000256
hsa-miR-181b-5p miRBase	MIMAT0000257
hsa-miR-181c-5p miRBase	MIMAT0000258
hsa-miR-181d-5p miRBase	MIMAT0002821
hsa-miR-4262 miRBase	MIMAT0016894

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_156887027 Show fit	2.77	ENST00000435489.2 ENST00000311946.7	NIPAL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	NIPA-like domain containing 4
chr5_+_161274685 Show fit	2.37	ENST00000428797.2	GABRA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_+_50574585 Show fit	2.27	ENST00000371824.1 ENST00000371823.4	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr17_-_9929581 Show fit	2.18	ENST00000437099.2 ENST00000396115.2	GAS7 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth arrest-specific 7
chr19_+_589893 Show fit	2.00	ENST00000251287.2	HCN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr18_+_55018044 Show fit	1.97	ENST00000324000.3	ST8SIA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr5_-_131347306 Show fit	1.89	ENST00000296869.4 ENST00000379249.3 ENST00000379272.2 ENST00000379264.2	ACSL6 Ensembl NCBI GeneCards UniProt NextProt Show fit	acyl-CoA synthetase long-chain family member 6
chr4_-_46996424 Show fit	1.88	ENST00000264318.3	GABRA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr6_+_44238203 Show fit	1.82	ENST00000451188.2	TMEM151B Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 151B
chr13_-_84456527 Show fit	1.80	ENST00000377084.2	SLITRK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SLIT and NTRK-like family, member 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	3.5	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1	3.1	GO:0071420	cellular response to histamine(GO:0071420)
0.2	2.9	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.2	2.8	GO:0015693	magnesium ion transport(GO:0015693)
0.0	2.5	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.1	2.4	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.2	2.0	GO:2001023	regulation of response to drug(GO:2001023)
0.2	1.9	GO:0071321	cellular response to cGMP(GO:0071321)
0.0	1.9	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)

Showing 1 to 10 of 234 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.6	GO:0042734	presynaptic membrane(GO:0042734)
0.1	5.0	GO:1902711	GABA-A receptor complex(GO:1902711)
0.0	4.1	GO:0045211	postsynaptic membrane(GO:0045211)
1.2	3.7	GO:0098855	HCN channel complex(GO:0098855)
0.0	3.5	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	2.6	GO:0043198	dendritic shaft(GO:0043198)
0.0	2.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	1.9	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2	1.7	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)

Showing 1 to 10 of 74 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	3.7	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.1	2.7	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.2	2.4	GO:1904315	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2	2.4	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	2.0	GO:0017091	AU-rich element binding(GO:0017091)
0.0	2.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	2.0	GO:0030507	spectrin binding(GO:0030507)
0.1	1.9	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.1	1.9	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1	1.9	GO:0102391	decanoate--CoA ligase activity(GO:0102391)

Showing 1 to 10 of 148 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	2.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	2.7	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	2.6	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	2.0	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	1.8	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	1.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.6	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.6	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	1.1	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	4.0	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.0	3.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	3.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.9	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	1.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	1.6	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.1	1.5	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	1.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	1.5	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis

Showing 1 to 10 of 48 entries

Results for ACAUUCA

Z-value: 2.41

Motif logo

miRNA associated with seed ACAUUCA

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: