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Illumina Body Map 2, young vs old

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Results for AR_NR3C2

Z-value: 0.33

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_667644650.576.1e-04Click!
NR3C2hg19_v2_chr4_-_149363376_149363492-0.364.4e-02Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_18287721 16.48 ENST00000356524.4
SAA1
serum amyloid A1
chr11_+_18287801 16.47 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr12_+_53443963 11.95 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_53443680 11.91 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr16_+_56666563 11.40 ENST00000570233.1
MT1M
metallothionein 1M
chr16_+_56716336 8.54 ENST00000394485.4
ENST00000562939.1
MT1X
metallothionein 1X
chr13_-_40924439 7.98 ENST00000400432.3
RP11-172E9.2
RP11-172E9.2
chr1_+_22979474 7.90 ENST00000509305.1
C1QB
complement component 1, q subcomponent, B chain
chr10_+_60759378 7.75 ENST00000432535.1
LINC00844
long intergenic non-protein coding RNA 844
chr18_-_48346415 7.59 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr19_+_35630628 7.46 ENST00000588715.1
ENST00000588607.1
FXYD1
FXYD domain containing ion transport regulator 1
chr1_+_22979676 7.33 ENST00000432749.2
ENST00000314933.6
C1QB
complement component 1, q subcomponent, B chain
chr2_+_238395879 6.73 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
MLPH
melanophilin
chr3_-_58563094 6.47 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr19_+_35630926 6.43 ENST00000588081.1
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35630344 5.28 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr16_+_56659687 5.20 ENST00000568293.1
ENST00000330439.6
MT1E
metallothionein 1E
chr1_+_1846519 5.06 ENST00000378604.3
CALML6
calmodulin-like 6
chr18_-_48346298 5.05 ENST00000398439.3
MRO
maestro
chr22_+_30477000 4.58 ENST00000403975.1
HORMAD2
HORMA domain containing 2
chr18_-_48346130 3.91 ENST00000592966.1
MRO
maestro
chr16_+_56672571 3.68 ENST00000290705.8
MT1A
metallothionein 1A
chr16_+_56642489 3.66 ENST00000561491.1
MT2A
metallothionein 2A
chr19_-_42916499 3.63 ENST00000601189.1
ENST00000599211.1
LIPE
lipase, hormone-sensitive
chr2_+_102953608 3.62 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr14_-_21493884 3.56 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chrX_+_8432871 3.51 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
VCX3B
variable charge, X-linked 3B
chr8_+_19759228 3.48 ENST00000520959.1
LPL
lipoprotein lipase
chr9_-_35563896 3.47 ENST00000399742.2
FAM166B
family with sequence similarity 166, member B
chr16_+_56642041 3.35 ENST00000245185.5
MT2A
metallothionein 2A
chr18_+_47087055 3.25 ENST00000577628.1
LIPG
lipase, endothelial
chr17_-_19290483 3.24 ENST00000395592.2
ENST00000299610.4
MFAP4
microfibrillar-associated protein 4
chr3_+_125985620 3.16 ENST00000511512.1
ENST00000512435.1
RP11-71E19.1
RP11-71E19.1
chr13_+_113777105 3.14 ENST00000409306.1
ENST00000375551.3
ENST00000375559.3
F10
coagulation factor X
chr17_-_19290117 3.12 ENST00000497081.2
MFAP4
microfibrillar-associated protein 4
chr1_-_112903150 2.96 ENST00000427290.1
RP5-965F6.2
RP5-965F6.2
chr1_+_162335197 2.93 ENST00000431696.1
RP11-565P22.6
Uncharacterized protein
chr14_-_21493649 2.82 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr15_+_42694573 2.74 ENST00000397200.4
ENST00000569827.1
CAPN3
calpain 3, (p94)
chr14_-_23623577 2.60 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr14_+_105190514 2.59 ENST00000330877.2
ADSSL1
adenylosuccinate synthase like 1
chr4_+_75310851 2.58 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr8_-_49834299 2.50 ENST00000396822.1
SNAI2
snail family zinc finger 2
chrX_+_8433376 2.48 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr4_+_75311019 2.46 ENST00000502307.1
AREG
amphiregulin
chr4_+_75480629 2.44 ENST00000380846.3
AREGB
amphiregulin B
chr14_+_32414059 2.35 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr2_-_75788424 2.33 ENST00000410071.1
EVA1A
eva-1 homolog A (C. elegans)
chr8_+_62200509 2.30 ENST00000519846.1
ENST00000518592.1
ENST00000325897.4
CLVS1
clavesin 1
chr8_-_49833978 2.20 ENST00000020945.1
SNAI2
snail family zinc finger 2
chrX_-_6453159 2.15 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chr3_-_119396193 2.13 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
COX17
COX17 cytochrome c oxidase copper chaperone
chr12_-_53575120 2.04 ENST00000542115.1
CSAD
cysteine sulfinic acid decarboxylase
chr4_-_69817481 2.00 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr2_-_75788428 1.96 ENST00000432649.1
EVA1A
eva-1 homolog A (C. elegans)
chr2_+_238395803 1.95 ENST00000264605.3
MLPH
melanophilin
chrY_-_16098393 1.91 ENST00000250825.4
VCY
variable charge, Y-linked
chrY_+_16168097 1.90 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chr19_-_8408139 1.89 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr8_+_24298531 1.85 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr1_-_24469602 1.81 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr8_+_24298438 1.78 ENST00000441335.2
ADAM7
ADAM metallopeptidase domain 7
chr18_+_7754957 1.76 ENST00000400053.4
PTPRM
protein tyrosine phosphatase, receptor type, M
chr8_-_21669826 1.69 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr4_-_135122903 1.62 ENST00000421491.3
ENST00000529122.2
PABPC4L
poly(A) binding protein, cytoplasmic 4-like
chr13_+_114462193 1.61 ENST00000375353.3
TMEM255B
transmembrane protein 255B
chr7_-_96654133 1.59 ENST00000486603.2
ENST00000222598.4
DLX5
distal-less homeobox 5
chr17_+_37824217 1.56 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr8_+_24298597 1.56 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr7_-_94285402 1.52 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr17_+_79071365 1.52 ENST00000576756.1
BAIAP2
BAI1-associated protein 2
chr7_+_74379083 1.41 ENST00000361825.7
GATSL1
GATS protein-like 1
chr10_+_695888 1.40 ENST00000441152.2
PRR26
proline rich 26
chrX_+_17755563 1.38 ENST00000380045.3
ENST00000380041.3
ENST00000380043.3
ENST00000398080.1
SCML1
sex comb on midleg-like 1 (Drosophila)
chr5_+_140186647 1.38 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chrX_+_79270245 1.37 ENST00000373296.3
ENST00000442340.1
TBX22
T-box 22
chr16_+_67207838 1.37 ENST00000566871.1
ENST00000268605.7
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr18_+_47087390 1.37 ENST00000583083.1
LIPG
lipase, endothelial
chr7_-_94285511 1.33 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chrX_-_80377162 1.24 ENST00000430960.1
ENST00000447319.1
HMGN5
high mobility group nucleosome binding domain 5
chr10_-_87551311 1.22 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr9_+_131683174 1.22 ENST00000372592.3
ENST00000428610.1
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chrX_-_8139308 1.15 ENST00000317103.4
VCX2
variable charge, X-linked 2
chr12_+_51318513 1.15 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr3_-_24207039 1.14 ENST00000280696.5
THRB
thyroid hormone receptor, beta
chr7_-_4877677 1.12 ENST00000538469.1
RADIL
Ras association and DIL domains
chr1_+_61547405 1.11 ENST00000371189.4
NFIA
nuclear factor I/A
chr16_+_67207872 1.10 ENST00000563258.1
ENST00000568146.1
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr10_-_44274273 1.07 ENST00000419406.1
RP11-272J7.4
RP11-272J7.4
chrX_-_80377118 1.06 ENST00000373250.3
HMGN5
high mobility group nucleosome binding domain 5
chr3_-_134093738 1.06 ENST00000506107.1
AMOTL2
angiomotin like 2
chr2_-_242576864 1.05 ENST00000407315.1
THAP4
THAP domain containing 4
chr8_-_110615669 1.03 ENST00000533394.1
SYBU
syntabulin (syntaxin-interacting)
chr12_-_106480587 1.00 ENST00000548902.1
NUAK1
NUAK family, SNF1-like kinase, 1
chr16_-_67978016 0.99 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr10_-_375422 0.98 ENST00000434695.2
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr8_+_91013577 0.96 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr19_-_14945933 0.93 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr8_+_91013676 0.93 ENST00000519410.1
ENST00000522161.1
ENST00000517761.1
ENST00000520227.1
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr7_-_94285472 0.84 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr8_+_9046503 0.83 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr8_-_62602327 0.81 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr1_-_209979465 0.80 ENST00000542854.1
IRF6
interferon regulatory factor 6
chr6_-_26235206 0.80 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr3_+_118865028 0.80 ENST00000460150.1
C3orf30
chromosome 3 open reading frame 30
chr15_-_28344439 0.78 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
OCA2
oculocutaneous albinism II
chr12_-_10251603 0.77 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr1_-_204119009 0.77 ENST00000444817.1
ETNK2
ethanolamine kinase 2
chr3_-_118864861 0.72 ENST00000441144.2
IGSF11
immunoglobulin superfamily, member 11
chr1_+_248651885 0.71 ENST00000366473.2
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr3_+_118864991 0.71 ENST00000295622.1
C3orf30
chromosome 3 open reading frame 30
chr11_-_75380165 0.70 ENST00000304771.3
MAP6
microtubule-associated protein 6
chrX_-_117119243 0.70 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr17_-_79304150 0.70 ENST00000574093.1
TMEM105
transmembrane protein 105
chr11_-_114271139 0.70 ENST00000325636.4
C11orf71
chromosome 11 open reading frame 71
chr1_-_159832438 0.69 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr16_+_25703274 0.69 ENST00000331351.5
HS3ST4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr5_-_173043591 0.68 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr22_+_18632666 0.67 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr19_+_56187987 0.67 ENST00000411543.2
EPN1
epsin 1
chr6_-_111927062 0.65 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr2_-_27435390 0.61 ENST00000428518.1
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr6_+_123317116 0.61 ENST00000275162.5
CLVS2
clavesin 2
chr12_-_56848426 0.61 ENST00000257979.4
MIP
major intrinsic protein of lens fiber
chr9_+_139863695 0.61 ENST00000371629.1
C9orf141
chromosome 9 open reading frame 141
chr14_+_24616588 0.58 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr2_+_235346970 0.56 ENST00000418025.1
AC097713.3
AC097713.3
chr9_+_34957477 0.55 ENST00000544237.1
KIAA1045
KIAA1045
chr19_+_35741466 0.52 ENST00000599658.1
LSR
lipolysis stimulated lipoprotein receptor
chr17_-_14140166 0.50 ENST00000420162.2
ENST00000431716.2
CDRT15
CMT1A duplicated region transcript 15
chr1_-_27693349 0.48 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr18_+_45778672 0.47 ENST00000600091.1
AC091150.1
HCG1818186; Uncharacterized protein
chr19_-_45657028 0.45 ENST00000429338.1
ENST00000589776.1
NKPD1
NTPase, KAP family P-loop domain containing 1
chr1_-_10856694 0.45 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr11_+_41736067 0.44 ENST00000528720.1
RP11-375D13.2
RP11-375D13.2
chr1_+_209545365 0.43 ENST00000447257.1
RP11-372M18.2
RP11-372M18.2
chr17_-_61850894 0.43 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr4_+_87928140 0.43 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr4_+_186347388 0.42 ENST00000511138.1
ENST00000511581.1
C4orf47
chromosome 4 open reading frame 47
chr2_-_27435634 0.40 ENST00000430186.1
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr19_+_8117636 0.40 ENST00000253451.4
ENST00000315626.4
CCL25
chemokine (C-C motif) ligand 25
chr22_+_23046750 0.35 ENST00000390307.2
IGLV3-22
immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr4_-_186347099 0.35 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr6_+_127898312 0.33 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr14_-_24616426 0.30 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr10_+_48359344 0.29 ENST00000412534.1
ENST00000444585.1
ZNF488
zinc finger protein 488
chr11_+_236540 0.27 ENST00000532097.1
PSMD13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr4_-_8442438 0.25 ENST00000356406.5
ENST00000413009.2
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr3_-_118864893 0.25 ENST00000354673.2
ENST00000425327.2
IGSF11
immunoglobulin superfamily, member 11
chr10_+_696000 0.24 ENST00000381489.5
PRR26
proline rich 26
chr12_+_125549925 0.24 ENST00000316519.6
AACS
acetoacetyl-CoA synthetase
chr11_+_103907308 0.24 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr22_+_19939026 0.22 ENST00000406520.3
COMT
catechol-O-methyltransferase
chr14_+_22251210 0.22 ENST00000390429.3
TRAV7
T cell receptor alpha variable 7
chr11_-_236326 0.21 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3
sirtuin 3
chr19_+_8117881 0.20 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chr10_+_26932068 0.19 ENST00000544033.1
ENST00000454991.1
LINC00202-2
RP13-16H11.7
long intergenic non-protein coding RNA 202-2
RP13-16H11.7
chr12_+_56615761 0.19 ENST00000447747.1
ENST00000399713.2
NABP2
nucleic acid binding protein 2
chr16_-_66584059 0.17 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr1_+_248524883 0.15 ENST00000366475.1
OR2T4
olfactory receptor, family 2, subfamily T, member 4
chr16_-_25269134 0.14 ENST00000328086.7
ZKSCAN2
zinc finger with KRAB and SCAN domains 2
chr5_-_68339648 0.13 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr19_+_57874835 0.12 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr1_+_76262552 0.10 ENST00000263187.3
MSH4
mutS homolog 4
chr2_+_27435179 0.06 ENST00000606999.1
ENST00000405489.3
ATRAID
all-trans retinoic acid-induced differentiation factor
chr19_+_1261106 0.04 ENST00000588411.1
CIRBP
cold inducible RNA binding protein
chr16_-_787771 0.04 ENST00000568545.1
NARFL
nuclear prelamin A recognition factor-like
chr12_+_125549973 0.04 ENST00000536752.1
ENST00000261686.6
AACS
acetoacetyl-CoA synthetase
chr17_+_79031415 0.02 ENST00000572073.1
ENST00000573677.1
BAIAP2
BAI1-associated protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 19.2 GO:0010732 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
1.9 15.6 GO:0036018 cellular response to erythropoietin(GO:0036018)
1.6 4.7 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.2 4.6 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.8 5.0 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.8 2.5 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.7 3.6 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.7 33.0 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.6 19.9 GO:0071294 cellular response to zinc ion(GO:0071294)
0.5 2.6 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.5 3.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.5 8.7 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.5 4.6 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.5 6.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.4 2.0 GO:0042412 taurine biosynthetic process(GO:0042412)
0.4 1.6 GO:0060166 olfactory pit development(GO:0060166)
0.4 3.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.4 2.7 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.4 1.6 GO:0042418 epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418)
0.4 3.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.4 6.4 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2 1.1 GO:0008050 female courtship behavior(GO:0008050)
0.2 0.8 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 1.0 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.2 1.5 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.2 1.0 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887)
0.1 0.8 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.1 0.6 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 2.1 GO:0010155 regulation of proton transport(GO:0010155) mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 1.7 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 0.8 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 1.0 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 13.2 GO:0030449 regulation of complement activation(GO:0030449)
0.1 2.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 2.6 GO:0015695 organic cation transport(GO:0015695)
0.1 0.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 2.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.2 GO:0031337 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 1.8 GO:0010842 retina layer formation(GO:0010842)
0.0 1.1 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0006983 ER overload response(GO:0006983)
0.0 0.2 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 2.9 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.3 GO:0071394 response to oleic acid(GO:0034201) cellular response to testosterone stimulus(GO:0071394)
0.0 0.8 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 1.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 2.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.6 GO:0006833 water transport(GO:0006833)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.7 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 1.8 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.7 GO:0030201 heparan sulfate proteoglycan metabolic process(GO:0030201)
0.0 0.3 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 15.2 GO:0005602 complement component C1 complex(GO:0005602)
1.0 33.0 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.7 19.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.6 6.4 GO:0071953 elastic fiber(GO:0071953)
0.4 3.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 4.0 GO:0042627 chylomicron(GO:0042627)
0.1 0.6 GO:0071797 LUBAC complex(GO:0071797)
0.1 3.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 4.7 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.0 GO:0097433 dense body(GO:0097433)
0.1 8.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.0 5.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.7 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 4.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 41.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.7 GO:0030315 T-tubule(GO:0030315)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 7.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 7.5 GO:0005769 early endosome(GO:0005769)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 23.2 GO:0005730 nucleolus(GO:0005730)
0.0 2.3 GO:0000785 chromatin(GO:0000785)
0.0 1.0 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
1.2 3.6 GO:0002113 interleukin-33 binding(GO:0002113)
0.9 3.5 GO:0017129 triglyceride binding(GO:0017129)
0.9 2.6 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.6 33.0 GO:0042056 chemoattractant activity(GO:0042056)
0.5 1.6 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.5 1.9 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.4 7.0 GO:0046870 cadmium ion binding(GO:0046870)
0.4 2.0 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.4 2.1 GO:0016531 copper chaperone activity(GO:0016531)
0.4 4.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.3 1.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 0.8 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 19.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.5 GO:0035877 death effector domain binding(GO:0035877)
0.2 2.6 GO:0019534 toxin transporter activity(GO:0019534)
0.2 0.8 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.2 1.7 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 1.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.6 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 2.7 GO:0031432 titin binding(GO:0031432)
0.1 1.0 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 0.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 8.7 GO:0017022 myosin binding(GO:0017022)
0.1 0.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 2.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 4.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 16.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 5.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.2 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.2 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 4.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 1.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 23.2 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.0 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.8 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 33.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 15.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 7.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 6.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 5.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 5.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 15.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.0 33.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 3.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 3.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 6.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 2.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 2.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation