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Illumina Body Map 2, young vs old

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Results for ATF4

Z-value: 0.60

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.261.6e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_41245160 6.14 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr10_+_50507232 3.72 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chr21_-_31864275 3.69 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr8_-_38008783 3.49 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr16_-_28550320 3.34 ENST00000395641.2
NUPR1
nuclear protein, transcriptional regulator, 1
chr17_+_1665306 3.21 ENST00000571360.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_50507181 3.17 ENST00000323868.4
C10orf71
chromosome 10 open reading frame 71
chr1_-_178840157 3.09 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr16_-_28550348 2.88 ENST00000324873.6
NUPR1
nuclear protein, transcriptional regulator, 1
chr17_-_79895097 2.71 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_79895154 2.62 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_+_46133307 2.41 ENST00000580037.1
NFE2L1
nuclear factor, erythroid 2-like 1
chrX_-_15332665 2.34 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr10_-_14880002 2.26 ENST00000465530.1
CDNF
cerebral dopamine neurotrophic factor
chr17_+_1665345 2.17 ENST00000576406.1
ENST00000571149.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_-_56101826 1.81 ENST00000421626.1
PSPH
phosphoserine phosphatase
chr17_+_1665253 1.66 ENST00000254722.4
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_40828969 1.60 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr9_-_95055956 1.49 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr5_+_167956121 1.45 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr16_-_70323422 1.42 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr17_-_40829026 1.36 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr11_-_57092381 1.32 ENST00000358252.3
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr1_+_162602244 1.30 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chrX_-_80457385 1.27 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr7_+_30634297 1.24 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chrX_-_33357558 1.23 ENST00000288447.4
DMD
dystrophin
chr10_-_21806759 1.22 ENST00000444772.3
SKIDA1
SKI/DACH domain containing 1
chr22_-_29457832 1.21 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr16_+_46918235 1.20 ENST00000340124.4
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr2_+_65663812 1.11 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
AC074391.1
chr1_-_216978709 1.07 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr16_-_87812735 1.07 ENST00000570159.1
RP4-536B24.4
RP4-536B24.4
chr3_-_48130314 1.06 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr19_+_33865218 1.05 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chrX_-_133792480 1.01 ENST00000359237.4
PLAC1
placenta-specific 1
chr19_+_49258775 1.00 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr10_+_95848824 0.99 ENST00000371385.3
ENST00000371375.1
PLCE1
phospholipase C, epsilon 1
chr19_+_49259325 0.99 ENST00000222157.3
FGF21
fibroblast growth factor 21
chr3_+_148415571 0.98 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
AGTR1
angiotensin II receptor, type 1
chr11_-_3078616 0.98 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chr3_-_48130707 0.97 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chrX_+_24073048 0.96 ENST00000423068.1
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr3_-_99594948 0.95 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr5_+_33440802 0.90 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
TARS
threonyl-tRNA synthetase
chr9_-_34665983 0.89 ENST00000416454.1
ENST00000544078.2
ENST00000421828.2
ENST00000423809.1
RP11-195F19.5
HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015
chr10_-_101190202 0.88 ENST00000543866.1
ENST00000370508.5
GOT1
glutamic-oxaloacetic transaminase 1, soluble
chr11_-_3078838 0.83 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr7_-_50860565 0.83 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr11_+_62649158 0.82 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr8_+_30496078 0.79 ENST00000517349.1
SMIM18
small integral membrane protein 18
chr3_-_99595037 0.78 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr10_-_113943447 0.76 ENST00000369425.1
ENST00000348367.4
ENST00000423155.1
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr14_-_92413353 0.75 ENST00000556154.1
FBLN5
fibulin 5
chr10_+_14880364 0.69 ENST00000441647.1
HSPA14
heat shock 70kDa protein 14
chr1_+_52521928 0.69 ENST00000489308.2
BTF3L4
basic transcription factor 3-like 4
chr12_+_57624059 0.67 ENST00000557427.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr5_+_174151536 0.66 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr5_+_33441053 0.64 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS
threonyl-tRNA synthetase
chr17_+_39846114 0.63 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr1_+_162601774 0.63 ENST00000415555.1
DDR2
discoidin domain receptor tyrosine kinase 2
chr5_-_145562147 0.62 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr19_-_8809139 0.60 ENST00000324436.3
ACTL9
actin-like 9
chr17_+_73089382 0.59 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr14_-_92413727 0.59 ENST00000267620.10
FBLN5
fibulin 5
chr11_+_93754513 0.58 ENST00000315765.9
HEPHL1
hephaestin-like 1
chr16_-_18908196 0.58 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr12_+_57623907 0.56 ENST00000553529.1
ENST00000554310.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_+_52521797 0.56 ENST00000313334.8
BTF3L4
basic transcription factor 3-like 4
chr9_+_36169380 0.55 ENST00000335119.2
CCIN
calicin
chr7_-_48068699 0.54 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr10_+_63661053 0.54 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_57624119 0.53 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_23762777 0.52 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr12_+_57624085 0.52 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr2_-_216300784 0.51 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr7_-_138386097 0.51 ENST00000421622.1
SVOPL
SVOP-like
chr1_+_154244987 0.51 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr12_+_57914481 0.50 ENST00000548887.1
MBD6
methyl-CpG binding domain protein 6
chr1_+_241815577 0.49 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr1_-_220219775 0.49 ENST00000609181.1
EPRS
glutamyl-prolyl-tRNA synthetase
chr18_-_55288973 0.49 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
NARS
asparaginyl-tRNA synthetase
chr19_+_11350278 0.48 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr7_-_99006443 0.46 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr16_+_67694849 0.46 ENST00000602551.1
ENST00000458121.2
ENST00000219255.3
PARD6A
par-6 family cell polarity regulator alpha
chr5_+_179105615 0.45 ENST00000514383.1
CANX
calnexin
chr5_+_154135029 0.43 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr12_-_46662772 0.42 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr7_-_48068671 0.42 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr3_+_11314072 0.40 ENST00000444619.1
ATG7
autophagy related 7
chr11_-_128737259 0.40 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr2_-_46769694 0.40 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr12_+_57623477 0.39 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_220220000 0.38 ENST00000366923.3
EPRS
glutamyl-prolyl-tRNA synthetase
chr11_-_17555421 0.37 ENST00000526181.1
USH1C
Usher syndrome 1C (autosomal recessive, severe)
chr19_-_51192661 0.36 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr11_-_128737163 0.35 ENST00000324003.3
ENST00000392665.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chrX_-_68385274 0.35 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr12_+_57623869 0.33 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_6493406 0.32 ENST00000543190.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr17_+_56316054 0.31 ENST00000581008.1
LPO
lactoperoxidase
chr2_+_46769798 0.31 ENST00000238738.4
RHOQ
ras homolog family member Q
chrX_+_24072833 0.26 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr2_+_7118755 0.25 ENST00000433456.1
RNF144A
ring finger protein 144A
chr1_+_228353495 0.25 ENST00000366711.3
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chrX_-_68385354 0.24 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr7_+_48211048 0.23 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr10_+_14880287 0.22 ENST00000437161.2
HSPA14
heat shock 70kDa protein 14
chr12_-_46662888 0.22 ENST00000546893.1
SLC38A1
solute carrier family 38, member 1
chr4_+_95129061 0.21 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr19_-_54584634 0.21 ENST00000432826.1
TARM1
T cell-interacting, activating receptor on myeloid cells 1
chr1_-_44497024 0.20 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_-_88282595 0.20 ENST00000554519.1
RP11-1152H15.1
RP11-1152H15.1
chr6_+_73076432 0.20 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr4_-_21950356 0.19 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr1_-_167883353 0.18 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr12_-_25101920 0.18 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr20_+_23342783 0.17 ENST00000544236.1
ENST00000338121.5
ENST00000542987.1
ENST00000424216.1
GZF1
GDNF-inducible zinc finger protein 1
chr12_-_57914275 0.17 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr12_+_64798826 0.15 ENST00000540203.1
XPOT
exportin, tRNA
chr12_+_57914742 0.14 ENST00000551351.1
MBD6
methyl-CpG binding domain protein 6
chr1_-_167883327 0.11 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr14_+_75894391 0.10 ENST00000419727.2
JDP2
Jun dimerization protein 2
chr10_+_14880157 0.08 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr12_+_56862301 0.07 ENST00000338146.5
SPRYD4
SPRY domain containing 4
chr3_-_33686925 0.05 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr11_-_8680383 0.04 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr21_-_44495919 0.04 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr1_-_207143802 0.04 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr5_+_44809027 0.03 ENST00000507110.1
MRPS30
mitochondrial ribosomal protein S30
chr14_-_100841794 0.02 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chrX_+_48398053 0.00 ENST00000537536.1
ENST00000418627.1
TBC1D25
TBC1 domain family, member 25

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.0 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.9 3.5 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963)
0.8 5.3 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.6 1.8 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.5 1.5 GO:0033967 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.5 1.4 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.4 2.0 GO:1904640 response to methionine(GO:1904640)
0.4 1.5 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.4 1.5 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.3 1.2 GO:0015966 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.3 6.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.3 1.2 GO:0042851 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.3 3.0 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.3 6.2 GO:2000194 regulation of female gonad development(GO:2000194)
0.3 0.9 GO:0006106 fumarate metabolic process(GO:0006106) glycerol biosynthetic process(GO:0006114) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.3 0.9 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.3 2.0 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.0 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.2 0.7 GO:0051795 positive regulation of catagen(GO:0051795)
0.2 0.6 GO:0006429 glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429)
0.2 1.0 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.2 1.0 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.2 0.5 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.2 1.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 1.0 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 0.5 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.4 GO:0050894 determination of affect(GO:0050894)
0.1 0.8 GO:0060356 leucine import(GO:0060356)
0.1 1.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.4 GO:1904106 protein localization to microvillus(GO:1904106)
0.1 0.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.4 GO:0072752 cellular response to rapamycin(GO:0072752)
0.1 2.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.6 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.8 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.5 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.2 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 2.3 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 1.3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 1.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.7 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0039519 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) modulation by virus of host autophagy(GO:0039519) suppression by virus of host autophagy(GO:0039521)
0.0 0.6 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 3.7 GO:0031424 keratinization(GO:0031424)
0.0 1.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.6 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.3 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.0 GO:0043203 axon hillock(GO:0043203)
0.3 3.0 GO:0070552 BRISC complex(GO:0070552)
0.2 1.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 3.5 GO:0030061 mitochondrial crista(GO:0030061)
0.2 0.6 GO:0033150 cytoskeletal calyx(GO:0033150)
0.2 1.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 3.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.3 GO:0071953 elastic fiber(GO:0071953)
0.1 1.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.0 6.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.7 GO:0005882 intermediate filament(GO:0005882)
0.0 5.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.9 5.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.6 1.8 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.5 1.5 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.5 1.4 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.4 1.5 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.4 1.5 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.3 1.0 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.3 3.0 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 0.9 GO:0070546 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 0.9 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.3 1.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.3 0.8 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.2 0.6 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.2 1.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 1.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 3.5 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0032427 GBD domain binding(GO:0032427)
0.1 1.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 2.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 7.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 2.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 1.0 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 1.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.2 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 6.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.9 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 8.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 3.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels