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Illumina Body Map 2, young vs old

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.16

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
BHLHE22
ENSG00000180828.1 basic helix-loop-helix family member e22
BHLHA15
ENSG00000180535.3 basic helix-loop-helix family member a15
BHLHE23
ENSG00000125533.4 basic helix-loop-helix family member e23

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHA15hg19_v2_chr7_+_97840739_978407860.271.3e-01Click!
BHLHE23hg19_v2_chr20_-_61638313_616383870.261.5e-01Click!
BHLHE22hg19_v2_chr8_+_65492756_654928140.038.7e-01Click!

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_158295915 6.81 ENST00000418920.1
CYTIP
cytohesin 1 interacting protein
chrX_+_128913906 5.96 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr1_+_81106951 5.57 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr6_+_135502501 5.22 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr14_+_22675388 4.85 ENST00000390461.2
TRAV34
T cell receptor alpha variable 34
chr7_-_38403077 3.59 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr2_-_177627285 3.37 ENST00000430460.1
AC092162.1
AC092162.1
chr19_-_54876558 3.28 ENST00000391742.2
ENST00000434277.2
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr14_+_27342334 3.02 ENST00000548170.1
ENST00000552926.1
RP11-384J4.1
RP11-384J4.1
chr1_+_95975672 3.01 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr11_+_65405556 2.86 ENST00000534313.1
ENST00000533361.1
ENST00000526137.1
SIPA1
signal-induced proliferation-associated 1
chr1_+_244214577 2.84 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chrX_+_107288280 2.79 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr13_+_28813645 2.79 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chrX_-_19817869 2.39 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr7_-_27205136 2.38 ENST00000396345.1
ENST00000343483.6
HOXA9
homeobox A9
chr19_-_11450249 2.37 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr7_-_55930443 2.28 ENST00000388975.3
SEPT14
septin 14
chr19_+_42041860 2.25 ENST00000483481.2
ENST00000494375.2
AC006129.4
AC006129.4
chr19_+_42041702 2.21 ENST00000487420.2
AC006129.4
AC006129.4
chr18_-_5521372 2.09 ENST00000580989.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chrX_+_107288197 2.04 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr8_-_101724989 2.01 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr3_-_121379739 1.95 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_40013553 1.92 ENST00000308666.3
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr1_+_50569575 1.92 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr10_+_99627889 1.91 ENST00000596005.1
GOLGA7B
Golgin subfamily A member 7B; cDNA FLJ43465 fis, clone OCBBF2036476
chr14_-_107283278 1.89 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr19_+_18208603 1.89 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr8_+_38239882 1.88 ENST00000607047.1
RP11-350N15.5
RP11-350N15.5
chr2_+_66918558 1.85 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chrX_+_107288239 1.84 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr1_+_159272111 1.79 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr1_+_100810575 1.78 ENST00000542213.1
CDC14A
cell division cycle 14A
chr12_-_94673956 1.72 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr2_+_162480918 1.72 ENST00000272716.5
ENST00000446997.1
SLC4A10
solute carrier family 4, sodium bicarbonate transporter, member 10
chr1_-_157670647 1.70 ENST00000368184.3
FCRL3
Fc receptor-like 3
chr2_+_162480845 1.69 ENST00000375514.5
ENST00000415876.2
SLC4A10
solute carrier family 4, sodium bicarbonate transporter, member 10
chr6_-_112115103 1.63 ENST00000462598.3
FYN
FYN oncogene related to SRC, FGR, YES
chr14_+_77292715 1.61 ENST00000393774.3
ENST00000555189.1
ENST00000450042.2
C14orf166B
chromosome 14 open reading frame 166B
chr1_-_157670528 1.54 ENST00000368186.5
ENST00000496769.1
FCRL3
Fc receptor-like 3
chr9_+_18474163 1.53 ENST00000380566.4
ADAMTSL1
ADAMTS-like 1
chr9_-_136445368 1.43 ENST00000356873.3
FAM163B
family with sequence similarity 163, member B
chr2_-_32490801 1.43 ENST00000360906.5
ENST00000342905.6
NLRC4
NLR family, CARD domain containing 4
chr2_-_32490859 1.42 ENST00000404025.2
NLRC4
NLR family, CARD domain containing 4
chr5_-_137674000 1.42 ENST00000510119.1
ENST00000513970.1
CDC25C
cell division cycle 25C
chr5_+_156607829 1.39 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr5_-_114631958 1.38 ENST00000395557.4
CCDC112
coiled-coil domain containing 112
chr3_+_113251143 1.36 ENST00000264852.4
ENST00000393830.3
SIDT1
SID1 transmembrane family, member 1
chr5_-_111312622 1.36 ENST00000395634.3
NREP
neuronal regeneration related protein
chr2_-_182545603 1.31 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr7_-_48068699 1.29 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr8_-_38239732 1.14 ENST00000534155.1
ENST00000433384.2
ENST00000317025.8
ENST00000316985.3
WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr16_-_69385681 1.13 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr5_-_114632307 1.12 ENST00000506442.1
ENST00000379611.5
CCDC112
coiled-coil domain containing 112
chr7_-_48068671 1.10 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr17_-_47286729 1.10 ENST00000300406.2
ENST00000511277.1
ENST00000511673.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr5_+_137673945 1.09 ENST00000513056.1
ENST00000511276.1
FAM53C
family with sequence similarity 53, member C
chr7_-_48068643 1.06 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr13_+_49551020 1.04 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr14_+_32414059 1.02 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chrX_+_105855160 0.97 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr14_-_69444957 0.96 ENST00000556571.1
ENST00000553659.1
ENST00000555616.1
ACTN1
actinin, alpha 1
chr2_+_162480967 0.94 ENST00000421911.1
SLC4A10
solute carrier family 4, sodium bicarbonate transporter, member 10
chr2_+_105471969 0.92 ENST00000361360.2
POU3F3
POU class 3 homeobox 3
chr4_-_159094194 0.91 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr7_+_114562909 0.89 ENST00000423503.1
ENST00000427207.1
MDFIC
MyoD family inhibitor domain containing
chr19_+_56368803 0.88 ENST00000587891.1
NLRP4
NLR family, pyrin domain containing 4
chr4_-_141075330 0.83 ENST00000509479.2
MAML3
mastermind-like 3 (Drosophila)
chr15_-_98417780 0.83 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr11_+_55650773 0.81 ENST00000449290.2
TRIM51
tripartite motif-containing 51
chr6_-_112115074 0.80 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr8_+_53207015 0.74 ENST00000522228.1
RP11-1023P17.2
RP11-1023P17.2
chr14_-_51297360 0.73 ENST00000496749.1
NIN
ninein (GSK3B interacting protein)
chr5_-_169725231 0.73 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_50016364 0.73 ENST00000322246.4
DEFB112
defensin, beta 112
chr9_+_18474098 0.72 ENST00000327883.7
ENST00000431052.2
ENST00000380570.4
ADAMTSL1
ADAMTS-like 1
chr8_-_23315190 0.72 ENST00000356206.6
ENST00000358689.4
ENST00000417069.2
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
chr7_-_24957699 0.71 ENST00000441059.1
ENST00000415162.1
OSBPL3
oxysterol binding protein-like 3
chr17_-_47286244 0.69 ENST00000503070.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr12_+_2912363 0.66 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr5_+_157158205 0.66 ENST00000231198.7
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr15_+_26360970 0.65 ENST00000556159.1
ENST00000557523.1
LINC00929
long intergenic non-protein coding RNA 929
chr14_+_22976633 0.65 ENST00000390503.1
TRAJ34
T cell receptor alpha joining 34
chr14_-_51297837 0.63 ENST00000245441.5
ENST00000389868.3
ENST00000382041.3
ENST00000324330.9
ENST00000453196.1
ENST00000453401.2
NIN
ninein (GSK3B interacting protein)
chr4_-_74088800 0.62 ENST00000509867.2
ANKRD17
ankyrin repeat domain 17
chr4_+_69313145 0.61 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr1_-_98515395 0.60 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr19_-_37019562 0.59 ENST00000523638.1
ZNF260
zinc finger protein 260
chr8_-_135522425 0.57 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chr4_+_115519894 0.57 ENST00000507710.1
UGT8
UDP glycosyltransferase 8
chr8_-_23315131 0.55 ENST00000518718.1
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
chr12_-_108714412 0.55 ENST00000412676.1
ENST00000550573.1
CMKLR1
chemokine-like receptor 1
chr15_-_55700522 0.55 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr6_-_66417107 0.55 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr8_+_21823726 0.54 ENST00000433566.4
XPO7
exportin 7
chr8_+_62747349 0.53 ENST00000517953.1
ENST00000520097.1
ENST00000519766.1
RP11-705O24.1
RP11-705O24.1
chr3_+_62304648 0.51 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr16_+_21716284 0.50 ENST00000388957.3
OTOA
otoancorin
chr16_-_52640834 0.48 ENST00000510238.3
CASC16
cancer susceptibility candidate 16 (non-protein coding)
chr7_+_50135433 0.48 ENST00000297001.6
C7orf72
chromosome 7 open reading frame 72
chr1_+_20617362 0.48 ENST00000375079.2
ENST00000289815.8
ENST00000375083.4
ENST00000289825.4
VWA5B1
von Willebrand factor A domain containing 5B1
chr17_+_51062861 0.45 ENST00000441889.1
C17orf112
chromosome 17 open reading frame 112
chr14_-_51297197 0.44 ENST00000382043.4
NIN
ninein (GSK3B interacting protein)
chr15_+_26360932 0.44 ENST00000556213.1
LINC00929
long intergenic non-protein coding RNA 929
chr1_-_99470368 0.43 ENST00000263177.4
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr1_-_99470558 0.43 ENST00000370188.3
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr11_-_44972418 0.42 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr15_-_38519066 0.42 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr8_+_78311303 0.41 ENST00000518706.2
RP11-38H17.1
RP11-38H17.1
chr3_-_129375556 0.41 ENST00000510323.1
TMCC1
transmembrane and coiled-coil domain family 1
chr4_-_108204904 0.40 ENST00000510463.1
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr3_-_150264272 0.38 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1
stress-associated endoplasmic reticulum protein 1
chr4_+_160188889 0.38 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr1_-_186344802 0.37 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr4_-_147043058 0.34 ENST00000512063.1
ENST00000507726.1
RP11-6L6.3
long intergenic non-protein coding RNA 1095
chrX_+_69509927 0.33 ENST00000374403.3
KIF4A
kinesin family member 4A
chr11_-_88796803 0.30 ENST00000418177.2
ENST00000455756.2
GRM5
glutamate receptor, metabotropic 5
chr4_+_2814011 0.29 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr2_+_219840955 0.29 ENST00000598002.1
ENST00000432733.1
LINC00608
long intergenic non-protein coding RNA 608
chr3_-_53164423 0.29 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1
RFT1 homolog (S. cerevisiae)
chr1_-_152131703 0.28 ENST00000316073.3
RPTN
repetin
chr4_-_113207048 0.28 ENST00000361717.3
TIFA
TRAF-interacting protein with forkhead-associated domain
chr1_+_12524965 0.28 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr11_+_66008698 0.28 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr2_+_219110149 0.27 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr9_+_108424738 0.27 ENST00000334077.3
TAL2
T-cell acute lymphocytic leukemia 2
chr7_-_97881429 0.27 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr3_-_18480173 0.26 ENST00000414509.1
SATB1
SATB homeobox 1
chr5_-_159766528 0.26 ENST00000505287.2
CCNJL
cyclin J-like
chrX_-_129402857 0.26 ENST00000447817.1
ENST00000370978.4
ZNF280C
zinc finger protein 280C
chr11_-_44972476 0.24 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr13_+_111766897 0.24 ENST00000317133.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr5_-_87974254 0.23 ENST00000506014.1
ENST00000502301.1
ENST00000513026.1
LINC00461
long intergenic non-protein coding RNA 461
chr7_-_92855762 0.23 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr15_-_55700216 0.23 ENST00000569205.1
CCPG1
cell cycle progression 1
chr3_-_33700933 0.22 ENST00000480013.1
CLASP2
cytoplasmic linker associated protein 2
chr17_-_9725388 0.22 ENST00000399363.4
RP11-477N12.3
Putative germ cell-specific gene 1-like protein 2
chr3_-_46069223 0.22 ENST00000309285.3
XCR1
chemokine (C motif) receptor 1
chr3_-_52719546 0.22 ENST00000439181.1
ENST00000449505.1
PBRM1
polybromo 1
chr17_+_44790515 0.21 ENST00000576346.1
NSF
N-ethylmaleimide-sensitive factor
chr12_+_58166370 0.21 ENST00000300209.8
METTL21B
methyltransferase like 21B
chr9_+_125796806 0.20 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chrX_+_70798261 0.20 ENST00000373696.3
ACRC
acidic repeat containing
chr15_+_40650408 0.20 ENST00000267889.3
DISP2
dispatched homolog 2 (Drosophila)
chr12_+_79371565 0.20 ENST00000551304.1
SYT1
synaptotagmin I
chr3_+_119298429 0.19 ENST00000478927.1
ADPRH
ADP-ribosylarginine hydrolase
chr3_-_114477787 0.19 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_33700589 0.19 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr20_+_57226841 0.18 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr6_-_119031228 0.17 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L
centrosomal protein 85kDa-like
chr14_+_24540154 0.17 ENST00000559778.1
ENST00000560761.1
ENST00000557889.1
CPNE6
copine VI (neuronal)
chr6_-_117150198 0.16 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr12_+_58166431 0.16 ENST00000333012.5
METTL21B
methyltransferase like 21B
chr17_-_37764128 0.16 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr11_+_32154200 0.15 ENST00000525133.1
RP1-65P5.5
RP1-65P5.5
chr11_-_6008215 0.15 ENST00000332249.4
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chrX_+_69509870 0.15 ENST00000374388.3
KIF4A
kinesin family member 4A
chr15_+_85144217 0.15 ENST00000540936.1
ENST00000448803.2
ENST00000546275.1
ENST00000546148.1
ENST00000442073.3
ENST00000334141.3
ENST00000358472.3
ENST00000502939.2
ENST00000379358.3
ENST00000327179.6
ZSCAN2
zinc finger and SCAN domain containing 2
chr1_+_110881945 0.14 ENST00000602849.1
ENST00000487146.2
RBM15
RNA binding motif protein 15
chr15_-_55700457 0.14 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr3_+_137728842 0.14 ENST00000183605.5
CLDN18
claudin 18
chr4_-_153456153 0.13 ENST00000603548.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_74301880 0.13 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr16_-_4896205 0.12 ENST00000589389.1
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr6_+_116442320 0.12 ENST00000430695.1
AL121963.1
Uncharacterized protein
chr20_-_34117447 0.11 ENST00000246199.2
ENST00000424444.1
ENST00000374345.4
ENST00000444723.1
C20orf173
chromosome 20 open reading frame 173
chr10_+_51565108 0.11 ENST00000438493.1
ENST00000452682.1
NCOA4
nuclear receptor coactivator 4
chr2_+_162480901 0.10 ENST00000535165.1
SLC4A10
solute carrier family 4, sodium bicarbonate transporter, member 10
chr12_+_50794947 0.10 ENST00000552445.1
LARP4
La ribonucleoprotein domain family, member 4
chr5_+_173316341 0.10 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr14_+_20665495 0.10 ENST00000357366.3
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr22_+_20877924 0.10 ENST00000445189.1
MED15
mediator complex subunit 15
chr17_+_80858418 0.09 ENST00000574422.1
TBCD
tubulin folding cofactor D
chr6_+_73076432 0.09 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_51565188 0.09 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr17_-_39597173 0.09 ENST00000246646.3
KRT38
keratin 38
chr3_-_18480260 0.09 ENST00000454909.2
SATB1
SATB homeobox 1
chr2_+_186603355 0.08 ENST00000343098.5
FSIP2
fibrous sheath interacting protein 2
chr1_+_185126598 0.08 ENST00000450350.1
SWT1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr1_-_205091115 0.08 ENST00000264515.6
ENST00000367164.1
RBBP5
retinoblastoma binding protein 5
chr4_+_2813946 0.07 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr10_-_74114714 0.06 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr17_-_61045902 0.05 ENST00000581596.1
RP11-180P8.3
RP11-180P8.3
chr4_-_87028478 0.05 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr3_-_178984759 0.04 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr9_+_2158443 0.04 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_137717571 0.04 ENST00000343735.4
CLDN18
claudin 18
chr8_-_95449155 0.04 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr12_+_50794891 0.04 ENST00000517559.1
LARP4
La ribonucleoprotein domain family, member 4
chr9_+_2158485 0.04 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr20_-_30060816 0.03 ENST00000317676.2
DEFB124
defensin, beta 124
chr16_+_14726672 0.03 ENST00000261658.2
ENST00000563971.1
BFAR
bifunctional apoptosis regulator
chr10_+_17794251 0.02 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr6_+_31887761 0.02 ENST00000413154.1
C2
complement component 2

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.6 1.8 GO:0090222 centrosome-templated microtubule nucleation(GO:0090222)
0.6 1.8 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.6 2.9 GO:0042631 cellular response to water deprivation(GO:0042631)
0.5 2.4 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.4 1.3 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.3 1.3 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.3 4.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 2.8 GO:0070269 pyroptosis(GO:0070269)
0.3 6.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 2.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2 1.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 6.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.2 2.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 0.9 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.2 2.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.2 2.0 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 2.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 0.9 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 1.9 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:0045799 negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 3.4 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 2.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.4 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.3 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.1 1.4 GO:0033227 dsRNA transport(GO:0033227)
0.1 1.9 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.1 1.4 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 1.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 1.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 1.0 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.3 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.5 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 2.6 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 0.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.2 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.4 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 1.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.7 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 1.6 GO:0007602 phototransduction(GO:0007602)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.9 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 0.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.4 GO:0009967 positive regulation of signal transduction(GO:0009967)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.5 GO:0097441 basilar dendrite(GO:0097441)
0.7 2.8 GO:0031251 PAN complex(GO:0031251)
0.4 1.3 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.3 2.8 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 0.7 GO:0036398 TCR signalosome(GO:0036398)
0.1 3.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.8 GO:0060091 kinocilium(GO:0060091)
0.1 1.8 GO:0036449 microtubule minus-end(GO:0036449)
0.1 2.4 GO:0042588 zymogen granule(GO:0042588)
0.1 1.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 2.1 GO:0033270 paranode region of axon(GO:0033270)
0.1 2.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0005916 fascia adherens(GO:0005916)
0.0 1.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.7 GO:0032433 filopodium tip(GO:0032433)
0.0 5.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 2.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 5.7 GO:0005938 cell cortex(GO:0005938)
0.0 0.2 GO:0044754 autolysosome(GO:0044754)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 1.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 2.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 0.7 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.2 1.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 0.7 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 4.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 3.8 GO:0043495 protein anchor(GO:0043495)
0.1 2.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.4 GO:0031489 myosin V binding(GO:0031489)
0.1 0.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 1.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 1.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.8 GO:0003924 GTPase activity(GO:0003924)
0.0 0.9 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.2 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 1.9 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 1.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.0 1.4 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 4.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.8 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 5.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 5.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 2.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.4 PID ATM PATHWAY ATM pathway
0.0 1.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 2.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 2.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 2.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 5.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle