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Illumina Body Map 2, young vs old

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Results for BHLHE40

Z-value: 0.35

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.4 basic helix-loop-helix family member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_5020952-0.086.8e-01Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_43637996 1.98 ENST00000528956.1
ENST00000529956.1
WDR65
WD repeat domain 65
chr14_+_93389425 1.74 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr22_+_48885272 1.50 ENST00000402357.1
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr8_-_99129384 1.41 ENST00000521560.1
ENST00000254878.3
HRSP12
heat-responsive protein 12
chr8_-_99129338 1.38 ENST00000520507.1
HRSP12
heat-responsive protein 12
chr1_-_47407111 1.36 ENST00000371904.4
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr1_-_112046110 1.30 ENST00000369716.4
ADORA3
adenosine A3 receptor
chr22_+_48885379 1.16 ENST00000336769.5
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr16_+_29911864 1.09 ENST00000308748.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr6_-_136871957 1.07 ENST00000354570.3
MAP7
microtubule-associated protein 7
chr11_-_57282349 1.06 ENST00000528450.1
SLC43A1
solute carrier family 43 (amino acid system L transporter), member 1
chr8_+_125985531 1.02 ENST00000319286.5
ZNF572
zinc finger protein 572
chr21_+_38071430 1.00 ENST00000290399.6
SIM2
single-minded family bHLH transcription factor 2
chr16_+_29911666 1.00 ENST00000563177.1
ENST00000483405.1
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr7_+_147830776 0.99 ENST00000538075.1
CNTNAP2
contactin associated protein-like 2
chr5_+_179078298 0.95 ENST00000418535.2
ENST00000425471.1
AC136604.1
Uncharacterized protein
chr18_+_580367 0.90 ENST00000327228.3
CETN1
centrin, EF-hand protein, 1
chr11_-_3240043 0.89 ENST00000332314.3
MRGPRG
MAS-related GPR, member G
chr13_+_111972980 0.85 ENST00000283547.1
TEX29
testis expressed 29
chr1_-_112046289 0.85 ENST00000241356.4
ADORA3
adenosine A3 receptor
chr5_+_121187625 0.84 ENST00000321339.1
FTMT
ferritin mitochondrial
chr19_-_16045619 0.83 ENST00000402119.4
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr19_-_16045665 0.81 ENST00000248041.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr1_+_119957554 0.81 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr17_+_72428218 0.79 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr22_-_30953587 0.77 ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr19_+_41497178 0.76 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr14_-_102026643 0.76 ENST00000555882.1
ENST00000554441.1
ENST00000553729.1
ENST00000557109.1
ENST00000557532.1
ENST00000554694.1
ENST00000554735.1
ENST00000555174.1
ENST00000557661.1
DIO3OS
DIO3 opposite strand/antisense RNA (head to head)
chr19_+_7660716 0.76 ENST00000160298.4
ENST00000446248.2
CAMSAP3
calmodulin regulated spectrin-associated protein family, member 3
chr17_-_7193711 0.76 ENST00000571464.1
YBX2
Y box binding protein 2
chr19_-_23185947 0.74 ENST00000594710.1
ZNF728
zinc finger protein 728
chr21_-_45079341 0.73 ENST00000443485.1
ENST00000291560.2
HSF2BP
heat shock transcription factor 2 binding protein
chr1_+_76262552 0.72 ENST00000263187.3
MSH4
mutS homolog 4
chr19_+_51774520 0.71 ENST00000595566.1
ENST00000594261.1
CTD-3187F8.11
CTD-3187F8.11
chr1_+_44445549 0.71 ENST00000356836.6
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr1_-_43638168 0.71 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chrX_+_66764375 0.70 ENST00000374690.3
AR
androgen receptor
chrX_+_43515467 0.69 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr13_+_100741269 0.69 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chr16_-_56701933 0.67 ENST00000568675.1
ENST00000569500.1
ENST00000444837.2
ENST00000379811.3
MT1G
metallothionein 1G
chr5_+_421030 0.65 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr4_+_41983713 0.65 ENST00000333141.5
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr7_-_107642348 0.62 ENST00000393561.1
LAMB1
laminin, beta 1
chr5_+_6766004 0.61 ENST00000506093.1
RP11-332J15.3
RP11-332J15.3
chr9_+_706842 0.60 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr9_+_131902283 0.59 ENST00000436883.1
ENST00000414510.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr19_+_51774540 0.59 ENST00000600813.1
CTD-3187F8.11
CTD-3187F8.11
chr16_+_66461175 0.57 ENST00000536005.2
ENST00000299694.8
ENST00000561796.1
BEAN1
brain expressed, associated with NEDD4, 1
chr15_+_93124059 0.57 ENST00000555864.1
RP11-386M24.3
RP11-386M24.3
chr1_-_43637915 0.56 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chr13_-_98829501 0.56 ENST00000267291.6
RNF113B
ring finger protein 113B
chr17_+_72428266 0.56 ENST00000582473.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr9_+_131684027 0.55 ENST00000426694.1
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr5_+_89770664 0.54 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr1_+_118472343 0.54 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr22_-_37505449 0.54 ENST00000406725.1
TMPRSS6
transmembrane protease, serine 6
chr17_-_61850894 0.54 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr19_+_12305895 0.51 ENST00000451691.2
CTD-2666L21.1
CTD-2666L21.1
chr11_+_60609537 0.50 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr15_-_23692381 0.50 ENST00000567107.1
ENST00000345070.5
ENST00000312015.5
GOLGA6L2
golgin A6 family-like 2
chr17_+_40811283 0.49 ENST00000251412.7
TUBG2
tubulin, gamma 2
chr5_-_101834712 0.48 ENST00000506729.1
ENST00000389019.3
ENST00000379810.1
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr3_+_174577070 0.48 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr2_+_103236004 0.48 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr2_-_179343226 0.47 ENST00000434643.2
FKBP7
FK506 binding protein 7
chr15_+_58724184 0.47 ENST00000433326.2
LIPC
lipase, hepatic
chrX_+_55101495 0.46 ENST00000374974.3
ENST00000374971.1
PAGE2B
P antigen family, member 2B
chr16_-_19729453 0.46 ENST00000564480.1
KNOP1
lysine-rich nucleolar protein 1
chr19_+_12305824 0.45 ENST00000415793.1
ENST00000440004.1
ENST00000426044.1
CTD-2666L21.1
CTD-2666L21.1
chr6_-_36842784 0.45 ENST00000373699.5
PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr2_-_179343268 0.44 ENST00000424785.2
FKBP7
FK506 binding protein 7
chr1_+_203830703 0.44 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr15_+_68924327 0.44 ENST00000543950.1
CORO2B
coronin, actin binding protein, 2B
chr4_+_57302297 0.44 ENST00000399688.3
ENST00000512576.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr5_-_36152031 0.43 ENST00000296603.4
LMBRD2
LMBR1 domain containing 2
chr5_-_101834617 0.41 ENST00000513675.1
ENST00000379807.3
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr17_+_15635561 0.41 ENST00000584301.1
ENST00000580596.1
ENST00000464963.1
ENST00000437605.2
ENST00000579428.1
TBC1D26
TBC1 domain family, member 26
chr7_-_229557 0.40 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr8_+_109455830 0.40 ENST00000524143.1
EMC2
ER membrane protein complex subunit 2
chr6_-_36410620 0.40 ENST00000454782.2
PXT1
peroxisomal, testis specific 1
chr21_-_30391636 0.40 ENST00000493196.1
RWDD2B
RWD domain containing 2B
chr10_-_49459800 0.39 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr17_-_8661860 0.39 ENST00000328794.6
SPDYE4
speedy/RINGO cell cycle regulator family member E4
chr6_+_151561085 0.38 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr16_-_79804198 0.37 ENST00000568389.1
RP11-345M22.2
RP11-345M22.2
chr6_-_151773232 0.37 ENST00000444024.1
ENST00000367303.4
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr2_+_183989157 0.37 ENST00000541912.1
NUP35
nucleoporin 35kDa
chr11_+_73019282 0.36 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chrX_-_55187531 0.36 ENST00000489298.1
ENST00000477847.2
FAM104B
family with sequence similarity 104, member B
chrX_-_128977781 0.35 ENST00000357166.6
ZDHHC9
zinc finger, DHHC-type containing 9
chr21_-_27107344 0.35 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr21_-_27107283 0.35 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr19_-_5719860 0.34 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr1_+_44514040 0.33 ENST00000431800.1
ENST00000437643.1
RP5-1198O20.4
RP5-1198O20.4
chr14_+_77924373 0.33 ENST00000216479.3
ENST00000535854.2
ENST00000555517.1
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr4_+_57301896 0.33 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_+_13106383 0.33 ENST00000397661.2
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_+_131100515 0.33 ENST00000537561.1
ENST00000359850.3
ENST00000521288.1
ENST00000502852.1
NUDT16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr19_+_15121532 0.32 ENST00000292574.3
CCDC105
coiled-coil domain containing 105
chrX_-_128977364 0.31 ENST00000371064.3
ZDHHC9
zinc finger, DHHC-type containing 9
chr1_+_9648921 0.31 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
TMEM201
transmembrane protein 201
chr21_-_27107881 0.30 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr7_-_73133959 0.29 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr16_-_79804394 0.29 ENST00000567993.1
RP11-345M22.2
RP11-345M22.2
chr17_+_61851157 0.29 ENST00000578681.1
ENST00000583590.1
DDX42
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr2_+_183989083 0.29 ENST00000295119.4
NUP35
nucleoporin 35kDa
chr12_+_14369524 0.28 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chrX_-_16887963 0.28 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr1_-_113498943 0.28 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr17_-_53046058 0.28 ENST00000571584.1
ENST00000299335.3
COX11
cytochrome c oxidase assembly homolog 11 (yeast)
chr18_+_55712915 0.28 ENST00000592846.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr14_+_71648152 0.27 ENST00000561794.1
RP6-91H8.2
RP6-91H8.2
chr13_+_35516390 0.26 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA
neurobeachin
chrX_-_128977875 0.26 ENST00000406492.2
ZDHHC9
zinc finger, DHHC-type containing 9
chr16_+_19729586 0.26 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
IQCK
IQ motif containing K
chr5_+_89770696 0.25 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr10_+_49514698 0.25 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8
mitogen-activated protein kinase 8
chr13_-_38172863 0.25 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr2_+_105654441 0.25 ENST00000258455.3
MRPS9
mitochondrial ribosomal protein S9
chr16_-_20362147 0.24 ENST00000396142.2
UMOD
uromodulin
chr1_+_35247859 0.24 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr5_+_161274685 0.24 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_-_58165870 0.24 ENST00000257848.7
METTL1
methyltransferase like 1
chr2_-_136743436 0.24 ENST00000441323.1
ENST00000449218.1
DARS
aspartyl-tRNA synthetase
chr6_+_167684651 0.24 ENST00000503433.1
UNC93A
unc-93 homolog A (C. elegans)
chr4_-_57301748 0.23 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr5_+_36152179 0.22 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr5_-_89770582 0.22 ENST00000316610.6
MBLAC2
metallo-beta-lactamase domain containing 2
chr11_-_56258871 0.21 ENST00000327216.2
OR5M8
olfactory receptor, family 5, subfamily M, member 8
chr5_+_94982435 0.21 ENST00000511684.1
ENST00000380005.4
RFESD
Rieske (Fe-S) domain containing
chr2_+_190649107 0.21 ENST00000441310.2
ENST00000409985.1
ENST00000446877.1
ENST00000418224.3
ENST00000409823.3
ENST00000374826.4
ENST00000424766.1
ENST00000447232.2
ENST00000432292.3
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr1_+_20465805 0.21 ENST00000375102.3
PLA2G2F
phospholipase A2, group IIF
chr14_+_73393040 0.20 ENST00000358377.2
ENST00000353777.3
ENST00000394234.2
ENST00000509153.1
ENST00000555042.1
DCAF4
DDB1 and CUL4 associated factor 4
chr12_-_122710556 0.20 ENST00000446652.1
ENST00000541273.1
ENST00000353548.6
ENST00000267169.6
ENST00000464942.2
DIABLO
diablo, IAP-binding mitochondrial protein
chr7_-_100493744 0.20 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr12_-_55042140 0.20 ENST00000293371.6
ENST00000456047.2
DCD
dermcidin
chr5_-_71616043 0.19 ENST00000508863.2
ENST00000522095.1
ENST00000513900.1
ENST00000515404.1
ENST00000457646.4
ENST00000261413.5
MRPS27
mitochondrial ribosomal protein S27
chr6_+_144164455 0.19 ENST00000367576.5
LTV1
LTV1 homolog (S. cerevisiae)
chr3_+_99536663 0.19 ENST00000421999.2
ENST00000463526.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr9_-_95640218 0.19 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr8_-_72459885 0.18 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr16_-_4897266 0.18 ENST00000591451.1
ENST00000436648.5
ENST00000381983.3
ENST00000588297.1
ENST00000321919.9
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr10_-_35379524 0.18 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr7_+_141463897 0.18 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr4_-_100009856 0.17 ENST00000296412.8
ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr7_-_155326532 0.16 ENST00000406197.1
ENST00000321736.5
CNPY1
canopy FGF signaling regulator 1
chr12_+_66217911 0.16 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr8_+_109455845 0.15 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr12_-_25101920 0.15 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr9_+_130469257 0.15 ENST00000373295.2
C9orf117
chromosome 9 open reading frame 117
chr19_-_37064145 0.15 ENST00000591340.1
ENST00000334116.7
ZNF529
zinc finger protein 529
chr6_+_13615554 0.15 ENST00000451315.2
NOL7
nucleolar protein 7, 27kDa
chr9_-_139258159 0.15 ENST00000371739.3
DNLZ
DNL-type zinc finger
chr2_+_207630081 0.15 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr8_+_55047763 0.14 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr17_+_61851504 0.14 ENST00000359353.5
ENST00000389924.2
DDX42
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr20_-_35374456 0.13 ENST00000373803.2
ENST00000359675.2
ENST00000540765.1
ENST00000349004.1
NDRG3
NDRG family member 3
chr5_-_137090028 0.13 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr17_+_53046096 0.12 ENST00000376352.2
ENST00000299341.4
ENST00000405898.1
ENST00000434978.2
ENST00000398391.2
STXBP4
syntaxin binding protein 4
chr5_+_140588269 0.12 ENST00000541609.1
ENST00000239450.2
PCDHB12
protocadherin beta 12
chr3_+_63638339 0.12 ENST00000343837.3
ENST00000469440.1
SNTN
sentan, cilia apical structure protein
chr16_+_57844549 0.12 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chr17_+_33307503 0.12 ENST00000378526.4
ENST00000585941.1
ENST00000262327.5
ENST00000592690.1
ENST00000585740.1
LIG3
ligase III, DNA, ATP-dependent
chr10_+_23481233 0.12 ENST00000376504.3
PTF1A
pancreas specific transcription factor, 1a
chr6_-_154677866 0.12 ENST00000367220.4
IPCEF1
interaction protein for cytohesin exchange factors 1
chr14_+_101359265 0.11 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr15_-_35088340 0.11 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr10_-_35379241 0.11 ENST00000374748.1
ENST00000374749.3
CUL2
cullin 2
chr8_+_99129513 0.11 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr6_+_31865552 0.10 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr12_-_25102252 0.10 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr16_-_3149229 0.10 ENST00000572431.1
ENST00000572548.1
ZSCAN10
zinc finger and SCAN domain containing 10
chr18_+_32402321 0.10 ENST00000587723.1
DTNA
dystrobrevin, alpha
chr12_+_93861282 0.09 ENST00000552217.1
ENST00000393128.4
ENST00000547098.1
MRPL42
mitochondrial ribosomal protein L42
chr15_+_77713299 0.08 ENST00000559099.1
HMG20A
high mobility group 20A
chrX_+_129040094 0.08 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr5_+_36152163 0.08 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr20_-_42939782 0.08 ENST00000396825.3
FITM2
fat storage-inducing transmembrane protein 2
chr9_+_131901661 0.07 ENST00000423100.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr5_-_89770171 0.07 ENST00000514906.1
MBLAC2
metallo-beta-lactamase domain containing 2
chr3_-_98312548 0.07 ENST00000264193.2
CPOX
coproporphyrinogen oxidase
chr15_-_74988281 0.07 ENST00000566828.1
ENST00000563009.1
ENST00000568176.1
ENST00000566243.1
ENST00000566219.1
ENST00000426797.3
ENST00000566119.1
ENST00000315127.4
EDC3
enhancer of mRNA decapping 3
chr17_-_13505219 0.06 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr5_+_36152091 0.06 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr9_-_99540328 0.05 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr6_+_44215603 0.04 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_+_173793777 0.04 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr22_-_38245304 0.04 ENST00000609454.1
ANKRD54
ankyrin repeat domain 54
chr12_+_93861264 0.04 ENST00000549982.1
ENST00000361630.2
MRPL42
mitochondrial ribosomal protein L42
chr2_+_74154032 0.04 ENST00000356837.6
DGUOK
deoxyguanosine kinase
chr2_-_10587897 0.03 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr22_-_30987849 0.03 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr22_-_30987837 0.03 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr17_-_10600818 0.03 ENST00000577427.1
ENST00000255390.5
SCO1
SCO1 cytochrome c oxidase assembly protein
chr11_+_34664014 0.02 ENST00000527935.1
EHF
ets homologous factor
chr22_-_50523807 0.02 ENST00000442311.1
ENST00000538737.1
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_-_47142884 0.02 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr19_+_54058073 0.02 ENST00000505949.1
ENST00000513265.1
ZNF331
zinc finger protein 331
chr16_-_79804435 0.02 ENST00000562921.1
ENST00000566729.1
RP11-345M22.2
RP11-345M22.2
chr2_-_112642267 0.01 ENST00000341068.3
ANAPC1
anaphase promoting complex subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0061110 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.4 1.6 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.3 1.4 GO:0003095 pressure natriuresis(GO:0003095)
0.3 1.0 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 0.7 GO:0045720 negative regulation of integrin biosynthetic process(GO:0045720)
0.2 0.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 0.8 GO:0009386 translational attenuation(GO:0009386)
0.1 0.6 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.1 0.7 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 0.3 GO:0046707 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.1 0.3 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.8 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 1.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 2.1 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.3 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.4 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.7 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.8 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.2 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.1 0.8 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.2 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.5 GO:0006983 ER overload response(GO:0006983)
0.0 0.2 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.6 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.3 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.7 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.3 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0032571 response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523)
0.0 0.8 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.3 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.2 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.4 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.7 GO:0042117 monocyte activation(GO:0042117)
0.0 0.1 GO:1902775 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 1.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.5 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.0 0.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097)
0.0 0.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.0 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.0 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0043257 laminin-8 complex(GO:0043257)
0.2 0.7 GO:0005713 recombination nodule(GO:0005713)
0.1 0.7 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.8 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 1.7 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.4 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 1.0 GO:0033010 paranodal junction(GO:0033010)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.3 GO:0030891 VCB complex(GO:0030891)
0.0 1.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.7 GO:0005652 nuclear lamina(GO:0005652) nuclear pore nuclear basket(GO:0044615)
0.0 0.8 GO:0005915 zonula adherens(GO:0005915)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.0 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.5 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.3 1.4 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.2 0.8 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 0.9 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.2 2.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.7 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.7 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.3 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.1 0.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.7 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.8 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.8 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.7 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.3 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.9 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.8 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.2 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 1.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 2.6 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.4 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.0 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism