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Illumina Body Map 2, young vs old

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Results for CBFB

Z-value: 0.50

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67063142_670631530.212.6e-01Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_43343886 2.54 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr6_-_75912508 2.09 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chr22_+_23222886 2.04 ENST00000390319.2
IGLV3-1
immunoglobulin lambda variable 3-1
chr14_-_61116168 1.97 ENST00000247182.6
SIX1
SIX homeobox 1
chr1_+_47264711 1.94 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
chr20_+_44637526 1.61 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr3_-_99569821 1.40 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr4_+_71091786 1.29 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr14_-_24977457 1.21 ENST00000250378.3
ENST00000206446.4
CMA1
chymase 1, mast cell
chr2_-_158300556 1.19 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr8_+_104384616 1.11 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr2_+_173955327 1.03 ENST00000422149.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr17_-_34417479 0.99 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr7_+_120628731 0.96 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr15_+_49715449 0.90 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr11_-_1912084 0.85 ENST00000391480.1
C11orf89
chromosome 11 open reading frame 89
chr14_+_22919081 0.81 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr12_-_68553512 0.75 ENST00000229135.3
IFNG
interferon, gamma
chr12_-_53575120 0.67 ENST00000542115.1
CSAD
cysteine sulfinic acid decarboxylase
chr3_+_157154578 0.64 ENST00000295927.3
PTX3
pentraxin 3, long
chr3_-_71834318 0.63 ENST00000353065.3
PROK2
prokineticin 2
chrX_+_68048803 0.61 ENST00000204961.4
EFNB1
ephrin-B1
chr14_+_85996471 0.61 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_+_49715293 0.61 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr2_+_68592305 0.58 ENST00000234313.7
PLEK
pleckstrin
chr1_+_159770292 0.57 ENST00000536257.1
ENST00000321935.6
FCRL6
Fc receptor-like 6
chr9_-_130541017 0.56 ENST00000314830.8
SH2D3C
SH2 domain containing 3C
chr3_-_71834207 0.56 ENST00000295619.3
PROK2
prokineticin 2
chr1_+_196621156 0.55 ENST00000359637.2
CFH
complement factor H
chr14_+_22748980 0.54 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr2_-_64881018 0.53 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr10_-_29811456 0.53 ENST00000535393.1
SVIL
supervillin
chr17_+_1633755 0.51 ENST00000545662.1
WDR81
WD repeat domain 81
chr14_+_85996507 0.50 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_-_66103932 0.50 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr15_+_73976545 0.50 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276
CD276 molecule
chr5_+_35856951 0.49 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr11_-_66103867 0.43 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr6_-_113953705 0.42 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr11_+_114310102 0.41 ENST00000265881.5
REXO2
RNA exonuclease 2
chr18_-_53089723 0.41 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chrX_+_115567767 0.41 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr1_+_196621002 0.39 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr20_+_54987168 0.36 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chrX_-_153718988 0.35 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
SLC10A3
solute carrier family 10, member 3
chrX_-_49041242 0.34 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr11_+_114310164 0.33 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2
RNA exonuclease 2
chr2_+_103035102 0.33 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr3_-_11610255 0.32 ENST00000424529.2
VGLL4
vestigial like 4 (Drosophila)
chr11_-_66104237 0.31 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr11_+_114310237 0.29 ENST00000539119.1
REXO2
RNA exonuclease 2
chr15_+_67390920 0.29 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chr2_+_207024306 0.29 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr18_-_53089538 0.28 ENST00000566777.1
TCF4
transcription factor 4
chr2_-_87248975 0.27 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr6_+_30908747 0.26 ENST00000462446.1
ENST00000304311.2
DPCR1
diffuse panbronchiolitis critical region 1
chr1_+_209859510 0.25 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chrX_-_70838306 0.24 ENST00000373691.4
ENST00000373693.3
CXCR3
chemokine (C-X-C motif) receptor 3
chr3_+_132843652 0.23 ENST00000508711.1
TMEM108
transmembrane protein 108
chr6_+_27925019 0.23 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr21_-_36421535 0.23 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr1_+_89246647 0.23 ENST00000544045.1
PKN2
protein kinase N2
chr14_-_59951112 0.22 ENST00000247194.4
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr2_+_234826016 0.22 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr11_-_64885111 0.20 ENST00000528598.1
ENST00000310597.4
ZNHIT2
zinc finger, HIT-type containing 2
chr1_-_52499443 0.19 ENST00000371614.1
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr20_+_62492566 0.18 ENST00000369916.3
ABHD16B
abhydrolase domain containing 16B
chr11_-_58343319 0.18 ENST00000395074.2
LPXN
leupaxin
chr21_-_36421626 0.18 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr12_+_25205568 0.17 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr17_+_75316336 0.16 ENST00000591934.1
SEPT9
septin 9
chr21_-_36421401 0.15 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr6_+_52051171 0.15 ENST00000340057.1
IL17A
interleukin 17A
chr14_-_85996332 0.15 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr14_+_22959438 0.14 ENST00000390489.1
TRAJ48
T cell receptor alpha joining 48
chr20_+_54987305 0.13 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr1_-_184723942 0.13 ENST00000318130.8
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr12_-_53594227 0.12 ENST00000550743.2
ITGB7
integrin, beta 7
chr6_-_34524093 0.12 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr8_-_28747424 0.11 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9
chrX_-_19688475 0.11 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr6_-_34524049 0.11 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr21_+_35107346 0.09 ENST00000456489.1
ITSN1
intersectin 1 (SH3 domain protein)
chr3_-_147123837 0.09 ENST00000462748.2
ZIC4
Zic family member 4
chr14_-_59950724 0.08 ENST00000481608.1
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr9_-_35079911 0.07 ENST00000448890.1
FANCG
Fanconi anemia, complementation group G
chr6_+_42847649 0.07 ENST00000424341.2
ENST00000602561.1
RPL7L1
ribosomal protein L7-like 1
chr3_+_187957646 0.06 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_-_28747717 0.06 ENST00000416984.2
INTS9
integrator complex subunit 9
chr22_+_42665742 0.03 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3
Z83851.3
chr2_-_127977654 0.03 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr16_+_53088885 0.02 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr19_-_14049184 0.02 ENST00000339560.5
PODNL1
podocan-like 1
chr8_-_134072593 0.02 ENST00000427060.2
SLA
Src-like-adaptor
chr1_+_17634689 0.02 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr12_-_52585765 0.02 ENST00000313234.5
ENST00000394815.2
KRT80
keratin 80
chr12_-_4754356 0.01 ENST00000540967.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_248058889 0.00 ENST00000360358.3
OR2W3
olfactory receptor, family 2, subfamily W, member 3
chr1_-_157014865 0.00 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr17_+_32582293 0.00 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.5 2.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.4 1.2 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.3 0.8 GO:2000309 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.2 1.6 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.2 1.9 GO:0018879 biphenyl metabolic process(GO:0018879)
0.2 1.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 1.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 0.7 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 1.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.6 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 0.6 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.1 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 1.2 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.0 0.2 GO:0097106 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) postsynaptic density organization(GO:0097106)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 1.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 2.0 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.2 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 2.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 1.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.7 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 0.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.3 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 2.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.9 GO:0070330 aromatase activity(GO:0070330)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.7 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 4.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 3.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.3 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.7 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 1.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters