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Illumina Body Map 2, young vs old

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Results for DMBX1

Z-value: 0.48

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
ENSG00000197587.6 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_469726690.144.6e-01Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_59654146 1.48 ENST00000441660.1
RP5-827L5.1
chr20_+_31805131 1.41 ENST00000375454.3
ENST00000375452.3
BPI fold containing family A, member 3
chr3_+_188664988 1.27 ENST00000433971.1
tumor protein p63 regulated 1
chr17_+_4643337 1.17 ENST00000592813.1
zinc finger, MYND-type containing 15
chr17_+_4643300 1.12 ENST00000433935.1
zinc finger, MYND-type containing 15
chr20_+_34556488 1.12 ENST00000373973.3
ENST00000349339.1
ENST00000538900.1
cyclic nucleotide binding domain containing 2
chr5_-_54988448 1.10 ENST00000503817.1
ENST00000512595.1
solute carrier family 38, member 9
chr14_+_22265444 1.08 ENST00000390430.2
T cell receptor alpha variable 8-1
chr5_-_54988559 1.06 ENST00000502247.1
solute carrier family 38, member 9
chr15_+_74165945 1.01 ENST00000535547.2
ENST00000300504.2
ENST00000562056.1
TBC1 domain family, member 21
chr5_+_169659950 0.99 ENST00000593851.1
chromosome 5 open reading frame 58
chr7_-_48068671 0.98 ENST00000297325.4
Sad1 and UNC84 domain containing 3
chr17_-_38859996 0.90 ENST00000264651.2
keratin 24
chr18_+_5748793 0.88 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
chr15_-_49102781 0.80 ENST00000558591.1
centrosomal protein 152kDa
chr2_-_27486951 0.78 ENST00000432351.1
solute carrier family 30 (zinc transporter), member 3
chr17_-_4643114 0.73 ENST00000293778.6
chemokine (C-X-C motif) ligand 16
chr5_+_175740083 0.72 ENST00000332772.4
SUMO-interacting motifs containing 1
chr12_-_103310987 0.72 ENST00000307000.2
phenylalanine hydroxylase
chr14_+_22204418 0.71 ENST00000390426.2
T cell receptor alpha variable 4
chr7_-_142181009 0.70 ENST00000390368.2
T cell receptor beta variable 6-5
chr17_-_4643161 0.70 ENST00000574412.1
chemokine (C-X-C motif) ligand 16
chr16_-_31076332 0.68 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
zinc finger protein 668
chr15_-_61521495 0.68 ENST00000335670.6
RAR-related orphan receptor A
chr10_-_99030395 0.67 ENST00000355366.5
ENST00000371027.1
Rho GTPase activating protein 19
chr11_+_61248583 0.67 ENST00000432063.2
ENST00000338608.2
protein phosphatase 1, regulatory subunit 32
chr3_-_49058479 0.59 ENST00000440857.1
DALR anticodon binding domain containing 3
chr3_-_48369831 0.59 ENST00000434006.1
serine peptidase inhibitor, Kazal type 8 (putative)
chr16_-_54304608 0.58 ENST00000561336.1
HCG2045435; Uncharacterized protein
chr20_-_43729750 0.58 ENST00000537075.1
ENST00000306117.1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr3_+_49057876 0.57 ENST00000326912.4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr6_-_33297013 0.55 ENST00000453407.1
death-domain associated protein
chr8_-_125577940 0.53 ENST00000519168.1
ENST00000395508.2
metastasis suppressor 1
chr3_+_111393659 0.50 ENST00000477665.1
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr7_-_48068643 0.48 ENST00000453192.2
Sad1 and UNC84 domain containing 3
chr19_-_17186229 0.47 ENST00000253669.5
ENST00000448593.2
HAUS augmin-like complex, subunit 8
chr2_-_165811983 0.47 ENST00000409058.1
ENST00000409149.3
solute carrier family 38, member 11
chr12_-_21487829 0.46 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
solute carrier organic anion transporter family, member 1A2
chr3_+_111393501 0.45 ENST00000393934.3
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_+_103986085 0.44 ENST00000370005.3
ELOVL fatty acid elongase 3
chr18_-_35145728 0.44 ENST00000361795.5
ENST00000603232.1
CUGBP, Elav-like family member 4
chr15_+_63413990 0.43 ENST00000261893.4
lactamase, beta
chr16_-_31076273 0.43 ENST00000426488.2
zinc finger protein 668
chrX_-_102565932 0.42 ENST00000372674.1
ENST00000372677.3
brain expressed X-linked 2
chr19_+_46001697 0.41 ENST00000451287.2
ENST00000324688.4
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr15_+_63414760 0.40 ENST00000557972.1
lactamase, beta
chr3_-_179692042 0.39 ENST00000468741.1
peroxisomal biogenesis factor 5-like
chr12_+_53693812 0.39 ENST00000549488.1
chromosome 12 open reading frame 10
chr12_-_118628315 0.38 ENST00000540561.1
TAO kinase 3
chr2_-_165812028 0.38 ENST00000303735.4
solute carrier family 38, member 11
chr19_-_51538148 0.37 ENST00000319590.4
ENST00000250351.4
kallikrein-related peptidase 12
chr5_+_50679506 0.35 ENST00000511384.1
ISL LIM homeobox 1
chr1_-_28384598 0.34 ENST00000373864.1
eyes absent homolog 3 (Drosophila)
chr5_-_92023923 0.34 ENST00000503489.1
CTC-529L17.2
chr11_-_45940343 0.33 ENST00000532681.1
peroxisomal biogenesis factor 16
chr6_+_130339710 0.33 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr8_+_110656344 0.33 ENST00000499579.1
Uncharacterized protein
chr2_-_70780572 0.33 ENST00000450929.1
transforming growth factor, alpha
chr2_+_37571845 0.32 ENST00000537448.1
glutaminyl-peptide cyclotransferase
chr7_+_127116878 0.31 ENST00000448311.1
AC000124.1
chr19_-_51538118 0.30 ENST00000529888.1
kallikrein-related peptidase 12
chr1_+_120839005 0.30 ENST00000369390.3
ENST00000452190.1
family with sequence similarity 72, member B
chr5_+_50678921 0.30 ENST00000230658.7
ISL LIM homeobox 1
chr2_-_70780770 0.30 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
transforming growth factor, alpha
chr17_-_39465505 0.30 ENST00000391352.1
keratin associated protein 16-1
chr18_-_35145593 0.30 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CUGBP, Elav-like family member 4
chr18_-_35145689 0.29 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CUGBP, Elav-like family member 4
chr18_+_29027696 0.25 ENST00000257189.4
desmoglein 3
chr19_-_17185848 0.25 ENST00000593360.1
HAUS augmin-like complex, subunit 8
chrX_+_72062802 0.25 ENST00000373533.1
DMRT-like family C1B
chr1_+_206138457 0.24 ENST00000367128.3
ENST00000431655.2
family with sequence similarity 72, member A
chr1_+_12851545 0.24 ENST00000332296.7
PRAME family member 1
chr2_-_165811756 0.23 ENST00000409662.1
solute carrier family 38, member 11
chr12_-_56321649 0.23 ENST00000454792.2
ENST00000408946.2
within bgcn homolog (Drosophila)
chr2_+_131513158 0.22 ENST00000431758.1
APC membrane recruitment protein 3
chr1_+_81001398 0.22 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
chr4_+_41937131 0.22 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr17_+_48911942 0.22 ENST00000426127.1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr12_-_118628350 0.22 ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chrX_-_72097698 0.22 ENST00000373530.1
DMRT-like family C1
chr11_+_124055923 0.21 ENST00000318666.6
olfactory receptor, family 10, subfamily D, member 3 (non-functional)
chrX_+_72062617 0.21 ENST00000440247.1
DMRT-like family C1B
chr3_+_49058444 0.21 ENST00000326925.6
ENST00000395458.2
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr1_-_13452656 0.20 ENST00000376132.3
PRAME family member 13
chr1_-_247836365 0.20 ENST00000359688.2
olfactory receptor, family 13, subfamily G, member 1
chr14_-_23395623 0.19 ENST00000556043.1
protein arginine methyltransferase 5
chr7_-_142143973 0.19 ENST00000390373.2
T cell receptor beta variable 6-7 (non-functional)
chr15_+_93443419 0.19 ENST00000557381.1
ENST00000420239.2
chromodomain helicase DNA binding protein 2
chr17_-_48207157 0.17 ENST00000330175.4
ENST00000503131.1
sterile alpha motif domain containing 14
chr19_+_41284121 0.16 ENST00000594800.1
ENST00000357052.2
ENST00000602173.1
RAB4B, member RAS oncogene family
chr2_-_220252068 0.16 ENST00000430206.1
ENST00000429013.1
aspartyl aminopeptidase
chr7_-_17500294 0.16 ENST00000439046.1
AC019117.2
chr12_-_49581152 0.15 ENST00000550811.1
tubulin, alpha 1a
chr12_+_115800817 0.14 ENST00000547948.1
HCG2038717; Uncharacterized protein
chr1_-_143913143 0.14 ENST00000400889.1
family with sequence similarity 72, member D
chr12_-_56321397 0.13 ENST00000557259.1
ENST00000549939.1
within bgcn homolog (Drosophila)
chr3_-_19975665 0.12 ENST00000295824.9
ENST00000389256.4
EF-hand domain family, member B
chr9_-_21994344 0.11 ENST00000530628.2
ENST00000361570.3
cyclin-dependent kinase inhibitor 2A
chr21_+_18811205 0.11 ENST00000440664.1
chromosome 21 open reading frame 37
chr18_-_70532906 0.10 ENST00000299430.2
ENST00000397929.1
neuropilin (NRP) and tolloid (TLL)-like 1
chr7_-_99774945 0.10 ENST00000292377.2
glypican 2
chr9_+_74920408 0.09 ENST00000451152.1
RP11-63P12.6
chr4_+_619347 0.09 ENST00000255622.6
phosphodiesterase 6B, cGMP-specific, rod, beta
chr7_-_96132835 0.09 ENST00000356686.1
chromosome 7 open reading frame 76
chr9_-_21994597 0.09 ENST00000579755.1
cyclin-dependent kinase inhibitor 2A
chr4_-_54232144 0.09 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
sec1 family domain containing 2
chrX_-_64754611 0.09 ENST00000374807.5
ENST00000374811.3
ENST00000374804.5
ENST00000312391.8
LAS1-like (S. cerevisiae)
chr4_+_619386 0.09 ENST00000496514.1
phosphodiesterase 6B, cGMP-specific, rod, beta
chr3_-_137851220 0.08 ENST00000236709.3
alpha-1,4-N-acetylglucosaminyltransferase
chr17_-_39324424 0.08 ENST00000391356.2
keratin associated protein 4-3
chr2_+_73461410 0.08 ENST00000399032.2
ENST00000398422.2
ENST00000537131.1
ENST00000538797.1
chaperonin containing TCP1, subunit 7 (eta)
chr17_+_60536002 0.07 ENST00000582809.1
tousled-like kinase 2
chr3_+_99986036 0.07 ENST00000471098.1
TBC1 domain family, member 23
chr1_+_35734562 0.06 ENST00000314607.6
ENST00000373297.2
zinc finger, MYM-type 4
chr1_-_47655686 0.06 ENST00000294338.2
PDZK1 interacting protein 1
chr14_+_22919081 0.06 ENST00000390473.1
T cell receptor delta joining 1
chr12_-_10959892 0.06 ENST00000240615.2
taste receptor, type 2, member 8
chr3_+_136649311 0.05 ENST00000469404.1
ENST00000467911.1
NCK adaptor protein 1
chrX_-_48931648 0.05 ENST00000376386.3
ENST00000376390.4
PRA1 domain family, member 2
chr12_-_56727487 0.05 ENST00000548043.1
ENST00000425394.2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr12_-_110937351 0.04 ENST00000552130.2
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr16_-_20710212 0.04 ENST00000523065.1
acyl-CoA synthetase medium-chain family member 1
chr6_+_10585979 0.04 ENST00000265012.4
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr19_+_36157715 0.03 ENST00000379013.2
ENST00000222275.2
uroplakin 1A
chr17_-_19651598 0.03 ENST00000570414.1
aldehyde dehydrogenase 3 family, member A1
chr3_+_138340067 0.03 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr2_+_73461364 0.02 ENST00000540468.1
ENST00000539919.1
ENST00000258091.5
chaperonin containing TCP1, subunit 7 (eta)
chr12_-_76461249 0.02 ENST00000551524.1
nucleosome assembly protein 1-like 1
chr2_-_14541060 0.00 ENST00000418420.1
ENST00000417751.1
long intergenic non-protein coding RNA 276
chr6_-_26250835 0.00 ENST00000446824.2
histone cluster 1, H3f

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.2 0.7 GO:0048936 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.1 0.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.3 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.6 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.8 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 1.0 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.5 GO:0030035 microspike assembly(GO:0030035)
0.1 0.2 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.1 0.8 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 1.5 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.6 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 1.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.7 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 2.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.7 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.4 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.2 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.6 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.0 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.0 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 2.3 GO:0007286 spermatid development(GO:0007286)
0.0 1.8 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.8 GO:0098536 deuterosome(GO:0098536)
0.1 1.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.7 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0015633 zinc transporting ATPase activity(GO:0015633)
0.2 0.7 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.7 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.1 1.0 GO:0042835 BRE binding(GO:0042835)
0.1 0.3 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.6 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.7 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.5 GO:0032183 SUMO binding(GO:0032183)
0.0 3.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.1 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.3 GO:0042826 histone deacetylase binding(GO:0042826)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins