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Illumina Body Map 2, young vs old

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Results for DUXA

Z-value: 0.20

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Transcription factors associated with DUXA

Gene Symbol Gene ID Gene Info
DUXA
ENSG00000258873.2 double homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DUXAhg19_v2_chr19_-_57678811_57678811-0.057.8e-01Click!

Activity profile of DUXA motif

Sorted Z-values of DUXA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_175629164 7.49 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr16_+_6533729 5.22 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_175629135 3.71 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr10_-_69425399 3.55 ENST00000330298.6
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr16_+_6533380 3.54 ENST00000552089.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr5_+_173472607 3.53 ENST00000303177.3
ENST00000519867.1
NSG2
Neuron-specific protein family member 2
chr11_-_16419067 3.53 ENST00000533411.1
SOX6
SRY (sex determining region Y)-box 6
chr4_-_46126093 3.38 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr10_+_69865866 3.24 ENST00000354393.2
MYPN
myopalladin
chr7_+_54398390 3.23 ENST00000458615.1
ENST00000426205.1
RP11-436F9.1
RP11-436F9.1
chr9_-_23779367 3.09 ENST00000440102.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr4_-_6557336 3.03 ENST00000507294.1
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr11_-_89653576 2.83 ENST00000420869.1
TRIM49D1
tripartite motif containing 49D1
chr22_+_31518938 2.71 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr2_-_166930131 2.67 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr11_+_55029628 2.63 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr10_-_98118724 2.59 ENST00000393870.2
OPALIN
oligodendrocytic myelin paranodal and inner loop protein
chr19_-_51472031 2.53 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr19_+_52932435 2.53 ENST00000301085.4
ZNF534
zinc finger protein 534
chr9_-_28670283 2.53 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr2_+_149632783 2.52 ENST00000435030.1
KIF5C
kinesin family member 5C
chr2_-_224467093 2.25 ENST00000305409.2
SCG2
secretogranin II
chr19_-_51471381 2.24 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr15_+_80733570 2.18 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr19_-_51471362 2.04 ENST00000376853.4
ENST00000424910.2
KLK6
kallikrein-related peptidase 6
chr6_+_53883708 1.94 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
MLIP
muscular LMNA-interacting protein
chr6_+_35748783 1.94 ENST00000373861.5
ENST00000542261.1
CLPSL1
colipase-like 1
chr15_-_26874230 1.93 ENST00000400188.3
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr15_+_71228826 1.93 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49
leucine rich repeat containing 49
chr14_-_80697396 1.86 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr11_-_117688216 1.84 ENST00000525836.1
DSCAML1
Down syndrome cell adhesion molecule like 1
chr7_-_14942467 1.81 ENST00000407950.1
ENST00000444700.2
DGKB
diacylglycerol kinase, beta 90kDa
chr3_-_181160240 1.81 ENST00000460993.1
RP11-275H4.1
RP11-275H4.1
chr9_+_139877445 1.79 ENST00000408973.2
LCNL1
lipocalin-like 1
chrX_+_18725758 1.79 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr12_+_26164645 1.77 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_234667504 1.75 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr7_-_14942283 1.73 ENST00000402815.1
DGKB
diacylglycerol kinase, beta 90kDa
chr6_+_73076432 1.66 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_68685764 1.66 ENST00000361320.4
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr16_-_57219721 1.65 ENST00000562406.1
ENST00000568671.1
ENST00000567044.1
FAM192A
family with sequence similarity 192, member A
chr1_+_92632542 1.63 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr2_+_166428839 1.62 ENST00000342316.4
CSRNP3
cysteine-serine-rich nuclear protein 3
chr19_-_57967854 1.57 ENST00000321039.3
VN1R1
vomeronasal 1 receptor 1
chr15_+_45028520 1.53 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr1_-_165414414 1.53 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr10_+_18689637 1.52 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr4_+_48485341 1.52 ENST00000273861.4
SLC10A4
solute carrier family 10, member 4
chr16_-_75734044 1.52 ENST00000398113.2
ENST00000538623.1
AC025287.1
Uncharacterized protein
chr17_-_57158523 1.50 ENST00000581468.1
TRIM37
tripartite motif containing 37
chr16_+_76587314 1.50 ENST00000563764.1
RP11-58C22.1
Uncharacterized protein
chr10_-_29811456 1.50 ENST00000535393.1
SVIL
supervillin
chr8_-_107782463 1.49 ENST00000311955.3
ABRA
actin-binding Rho activating protein
chrX_+_85969626 1.49 ENST00000484479.1
DACH2
dachshund homolog 2 (Drosophila)
chrX_-_72095808 1.47 ENST00000373529.5
DMRTC1
DMRT-like family C1
chr8_-_7673238 1.45 ENST00000335021.2
DEFB107A
defensin, beta 107A
chr3_+_108321623 1.45 ENST00000497905.1
ENST00000463306.1
DZIP3
DAZ interacting zinc finger protein 3
chr21_+_34398153 1.44 ENST00000382357.3
ENST00000430860.1
ENST00000333337.3
OLIG2
oligodendrocyte lineage transcription factor 2
chr8_+_7353368 1.44 ENST00000355602.2
DEFB107B
defensin, beta 107B
chr8_-_7343922 1.44 ENST00000335479.2
DEFB106B
defensin, beta 106B
chr12_-_81763184 1.42 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chrX_+_69501943 1.41 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr11_+_49050504 1.41 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chr6_+_155538093 1.39 ENST00000462408.2
TIAM2
T-cell lymphoma invasion and metastasis 2
chr10_-_61900762 1.39 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_-_128684488 1.39 ENST00000511204.1
RP11-723O4.6
Uncharacterized protein FLJ43738
chr16_-_21314360 1.38 ENST00000219599.3
ENST00000576703.1
CRYM
crystallin, mu
chrX_-_138724677 1.35 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chrX_-_84363974 1.35 ENST00000395409.3
ENST00000332921.5
ENST00000509231.1
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr1_-_72566613 1.35 ENST00000306821.3
NEGR1
neuronal growth regulator 1
chr16_-_57219966 1.33 ENST00000565760.1
ENST00000309137.8
ENST00000570184.1
ENST00000562324.1
FAM192A
family with sequence similarity 192, member A
chr6_+_12717892 1.32 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr12_-_81763127 1.31 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr4_+_79567233 1.31 ENST00000514130.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr18_-_70532906 1.30 ENST00000299430.2
ENST00000397929.1
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr12_+_111284764 1.27 ENST00000545036.1
ENST00000308208.5
CCDC63
coiled-coil domain containing 63
chr3_+_159943362 1.26 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr6_-_163612840 1.24 ENST00000419182.1
AL078585.1
Uncharacterized protein; cDNA FLJ58069
chr1_+_50569575 1.23 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr5_-_87986845 1.23 ENST00000513893.1
LINC00461
long intergenic non-protein coding RNA 461
chr14_+_62584197 1.23 ENST00000334389.4
LINC00643
long intergenic non-protein coding RNA 643
chr1_+_12851545 1.23 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr6_+_53883790 1.22 ENST00000509997.1
MLIP
muscular LMNA-interacting protein
chr8_+_7682694 1.22 ENST00000335186.2
DEFB106A
defensin, beta 106A
chr12_-_11062161 1.20 ENST00000390677.2
TAS2R13
taste receptor, type 2, member 13
chr2_-_224467002 1.20 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr1_-_13390765 1.20 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr20_+_23471727 1.19 ENST00000449810.1
ENST00000246012.1
CST8
cystatin 8 (cystatin-related epididymal specific)
chr8_-_16859690 1.19 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr3_-_51909600 1.18 ENST00000446461.1
IQCF5
IQ motif containing F5
chr18_+_61616510 1.16 ENST00000408945.3
HMSD
histocompatibility (minor) serpin domain containing
chr13_-_45775162 1.16 ENST00000405872.1
KCTD4
potassium channel tetramerization domain containing 4
chr7_-_141541221 1.13 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr1_-_13452656 1.13 ENST00000376132.3
PRAMEF13
PRAME family member 13
chr17_-_39553844 1.11 ENST00000251645.2
KRT31
keratin 31
chr8_-_114449112 1.11 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chrX_-_148571884 1.10 ENST00000537071.1
IDS
iduronate 2-sulfatase
chr2_+_86333340 1.09 ENST00000409783.2
ENST00000409277.3
PTCD3
pentatricopeptide repeat domain 3
chr4_-_76649546 1.07 ENST00000508510.1
ENST00000509561.1
ENST00000499709.2
ENST00000511868.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr12_-_45315625 1.05 ENST00000552993.1
NELL2
NEL-like 2 (chicken)
chr16_+_32264040 1.05 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr10_-_46620012 1.02 ENST00000508602.1
ENST00000374339.3
ENST00000502254.1
ENST00000437863.1
ENST00000374342.2
ENST00000395722.3
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr6_+_97010424 1.02 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
FHL5
four and a half LIM domains 5
chr16_-_57219926 1.02 ENST00000566584.1
ENST00000566481.1
ENST00000566077.1
ENST00000564108.1
ENST00000565458.1
ENST00000566681.1
ENST00000567439.1
FAM192A
family with sequence similarity 192, member A
chr11_-_132812987 1.02 ENST00000541867.1
OPCML
opioid binding protein/cell adhesion molecule-like
chr18_+_5748793 1.01 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
RP11-945C19.1
chr7_-_137028498 1.01 ENST00000393083.2
PTN
pleiotrophin
chrX_-_138072729 1.00 ENST00000455663.1
FGF13
fibroblast growth factor 13
chr15_-_93353028 1.00 ENST00000557398.2
FAM174B
family with sequence similarity 174, member B
chr11_-_123525289 0.98 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
SCN3B
sodium channel, voltage-gated, type III, beta subunit
chr2_+_96257766 0.98 ENST00000272395.2
TRIM43
tripartite motif containing 43
chr7_-_82792215 0.97 ENST00000333891.9
ENST00000423517.2
PCLO
piccolo presynaptic cytomatrix protein
chr4_-_87028478 0.97 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr12_-_90049828 0.97 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr7_-_137028534 0.96 ENST00000348225.2
PTN
pleiotrophin
chr15_-_42749711 0.95 ENST00000565611.1
ENST00000263805.4
ENST00000565948.1
ZNF106
zinc finger protein 106
chr8_+_11225911 0.93 ENST00000284481.3
C8orf12
chromosome 8 open reading frame 12
chr11_+_125616184 0.92 ENST00000305738.5
ENST00000437148.2
PATE1
prostate and testis expressed 1
chr11_-_41481135 0.92 ENST00000528697.1
ENST00000530763.1
LRRC4C
leucine rich repeat containing 4C
chr3_-_128186091 0.92 ENST00000319153.3
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr4_+_79567057 0.91 ENST00000503259.1
ENST00000507802.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chrX_+_64708615 0.91 ENST00000338957.4
ENST00000423889.3
ZC3H12B
zinc finger CCCH-type containing 12B
chr5_+_36606700 0.91 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_73935163 0.90 ENST00000370388.3
KHDC1L
KH homology domain containing 1-like
chr3_+_107364683 0.90 ENST00000413213.1
BBX
bobby sox homolog (Drosophila)
chr11_-_89654935 0.89 ENST00000530311.2
TRIM49D1
tripartite motif containing 49D1
chr5_+_142149955 0.89 ENST00000378004.3
ARHGAP26
Rho GTPase activating protein 26
chr6_-_130182410 0.89 ENST00000368143.1
TMEM244
transmembrane protein 244
chr4_+_646960 0.88 ENST00000488061.1
ENST00000429163.2
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr6_-_71666732 0.88 ENST00000230053.6
B3GAT2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr12_-_119199461 0.87 ENST00000536572.1
ENST00000542577.1
RP11-3L23.2
RP11-3L23.2
chr14_+_53019993 0.87 ENST00000542169.2
ENST00000555622.1
GPR137C
G protein-coupled receptor 137C
chr10_-_48806939 0.87 ENST00000374233.3
ENST00000507417.1
ENST00000512321.1
ENST00000395660.2
ENST00000374235.2
ENST00000395661.3
PTPN20B
protein tyrosine phosphatase, non-receptor type 20B
chr2_+_46706725 0.86 ENST00000434431.1
TMEM247
transmembrane protein 247
chr7_-_14942944 0.86 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr12_-_90049878 0.84 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr6_+_30856507 0.84 ENST00000513240.1
ENST00000424544.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr17_+_61151306 0.83 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr12_+_111284805 0.83 ENST00000552694.1
CCDC63
coiled-coil domain containing 63
chr6_+_26199737 0.82 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr19_+_32836499 0.81 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr9_-_107361788 0.81 ENST00000374779.2
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr9_-_8857776 0.81 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr11_-_89540388 0.81 ENST00000532501.2
TRIM49
tripartite motif containing 49
chr3_-_39321512 0.80 ENST00000399220.2
CX3CR1
chemokine (C-X3-C motif) receptor 1
chrX_+_30260054 0.80 ENST00000378982.2
MAGEB4
melanoma antigen family B, 4
chr11_-_123525648 0.80 ENST00000527836.1
SCN3B
sodium channel, voltage-gated, type III, beta subunit
chr12_-_112123524 0.80 ENST00000327551.6
BRAP
BRCA1 associated protein
chr2_+_54342574 0.79 ENST00000303536.4
ENST00000394666.3
ACYP2
acylphosphatase 2, muscle type
chr22_+_41956767 0.78 ENST00000306149.7
CSDC2
cold shock domain containing C2, RNA binding
chr18_-_74839891 0.78 ENST00000581878.1
MBP
myelin basic protein
chr10_+_134150835 0.78 ENST00000432555.2
LRRC27
leucine rich repeat containing 27
chr3_-_196242233 0.77 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr6_-_76072719 0.77 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr3_+_126911974 0.77 ENST00000398112.1
C3orf56
chromosome 3 open reading frame 56
chr22_+_27043175 0.77 ENST00000440347.1
ENST00000450203.1
ENST00000430483.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chr7_+_123488124 0.76 ENST00000476325.1
HYAL4
hyaluronoglucosaminidase 4
chr12_+_120740119 0.76 ENST00000536460.1
ENST00000202967.4
SIRT4
sirtuin 4
chr12_-_48963829 0.76 ENST00000301046.2
ENST00000549817.1
LALBA
lactalbumin, alpha-
chr3_-_164914640 0.75 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chrX_-_24690771 0.75 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr8_-_18744528 0.75 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_167098059 0.75 ENST00000392764.1
ENST00000474464.1
ENST00000392766.2
ENST00000485651.1
ZBBX
zinc finger, B-box domain containing
chr5_+_140227048 0.74 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr13_+_109248500 0.74 ENST00000356711.2
MYO16
myosin XVI
chr7_+_30589829 0.74 ENST00000579437.1
RP4-777O23.1
RP4-777O23.1
chr5_-_9712312 0.74 ENST00000506620.1
ENST00000514078.1
ENST00000606744.1
TAS2R1
CTD-2143L24.1
taste receptor, type 2, member 1
CTD-2143L24.1
chr2_+_11674213 0.74 ENST00000381486.2
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_168434678 0.73 ENST00000496008.1
KIF25
kinesin family member 25
chr5_-_78809950 0.73 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr11_+_55650773 0.73 ENST00000449290.2
TRIM51
tripartite motif-containing 51
chr16_-_52119019 0.72 ENST00000561513.1
ENST00000565742.1
LINC00919
long intergenic non-protein coding RNA 919
chr12_+_127221553 0.72 ENST00000535118.1
LINC00943
long intergenic non-protein coding RNA 943
chr2_-_40680578 0.71 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_12976450 0.71 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr8_-_54163972 0.71 ENST00000520287.1
OPRK1
opioid receptor, kappa 1
chr4_+_76649797 0.70 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr3_-_33759699 0.69 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chr19_-_14945933 0.69 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr16_-_32688053 0.69 ENST00000398682.4
TP53TG3
TP53 target 3
chr15_+_62853562 0.69 ENST00000561311.1
TLN2
talin 2
chrX_+_33744503 0.68 ENST00000439992.1
RP11-305F18.1
RP11-305F18.1
chr3_-_47950745 0.68 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr3_+_107364769 0.68 ENST00000449271.1
ENST00000425868.1
ENST00000449213.1
BBX
bobby sox homolog (Drosophila)
chr19_-_56709162 0.68 ENST00000589938.1
ENST00000587032.2
ENST00000586855.2
ZSCAN5B
zinc finger and SCAN domain containing 5B
chr15_+_101402041 0.68 ENST00000558475.1
ENST00000558641.1
ENST00000559673.1
RP11-66B24.1
RP11-66B24.1
chrX_+_154444643 0.67 ENST00000286428.5
VBP1
von Hippel-Lindau binding protein 1
chr12_+_114514938 0.67 ENST00000552413.1
RP11-100F15.1
RP11-100F15.1
chr5_+_98109322 0.67 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chrX_+_109602039 0.67 ENST00000520821.1
RGAG1
retrotransposon gag domain containing 1
chrX_-_55187588 0.67 ENST00000472571.2
ENST00000332132.4
ENST00000425133.2
ENST00000358460.4
FAM104B
family with sequence similarity 104, member B
chr11_-_40315640 0.66 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr12_+_72332618 0.65 ENST00000333850.3
TPH2
tryptophan hydroxylase 2
chr1_-_13673511 0.65 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr8_+_82192501 0.65 ENST00000297258.6
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr7_-_88425025 0.64 ENST00000297203.2
C7orf62
chromosome 7 open reading frame 62
chr8_+_7397150 0.64 ENST00000533250.1
RP11-1118M6.1
proline rich 23 domain containing 1
chr17_+_61271355 0.63 ENST00000583356.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_+_68671310 0.63 ENST00000255078.3
ENST00000539224.1
IGHMBP2
immunoglobulin mu binding protein 2
chr5_+_118965244 0.63 ENST00000515256.1
ENST00000509264.1
FAM170A
family with sequence similarity 170, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of DUXA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 11.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.8 5.0 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.7 2.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.4 1.3 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.4 2.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.3 1.0 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.3 3.5 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.3 6.8 GO:0016540 protein autoprocessing(GO:0016540)
0.3 0.8 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.3 1.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.3 0.8 GO:1903216 regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.3 0.8 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.3 1.5 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 1.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.7 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.2 1.2 GO:0061760 antifungal innate immune response(GO:0061760)
0.2 1.8 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.2 1.6 GO:0019236 response to pheromone(GO:0019236)
0.2 1.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 0.7 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 0.5 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 1.8 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 2.7 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.2 2.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.2 1.0 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.2 0.8 GO:0060127 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.2 0.9 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.7 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.1 3.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.4 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.8 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.8 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.5 GO:0033122 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) negative regulation of purine nucleotide catabolic process(GO:0033122)
0.1 1.2 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.6 GO:0061015 snRNA import into nucleus(GO:0061015)
0.1 0.6 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.1 4.0 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.1 0.7 GO:0042435 serotonin biosynthetic process(GO:0042427) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 2.0 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.5 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 3.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 7.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.3 GO:1902955 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 2.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 3.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.2 GO:0018969 thiocyanate metabolic process(GO:0018969)
0.1 2.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 1.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.1 1.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 3.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.3 GO:0070293 renal sodium ion transport(GO:0003096) renal absorption(GO:0070293) renal sodium ion absorption(GO:0070294)
0.1 1.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.5 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.1 0.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 2.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.2 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 0.3 GO:0007343 egg activation(GO:0007343)
0.1 1.1 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 1.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 2.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.3 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 0.2 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.1 0.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.3 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 2.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.5 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.4 GO:0048478 replication fork protection(GO:0048478)
0.0 0.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.5 GO:0015846 polyamine transport(GO:0015846)
0.0 2.7 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.4 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.5 GO:0001701 in utero embryonic development(GO:0001701)
0.0 2.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 1.9 GO:0032094 response to food(GO:0032094)
0.0 0.5 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 1.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.8 GO:0001709 cell fate determination(GO:0001709)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 1.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 1.0 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.1 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.0 1.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.6 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 2.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.2 GO:0007154 cell communication(GO:0007154)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.8 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 1.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.9 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.0 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.4 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0060136 enucleate erythrocyte differentiation(GO:0043353) embryonic process involved in female pregnancy(GO:0060136)
0.0 0.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 3.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.4 GO:0045087 innate immune response(GO:0045087)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.7 GO:0008038 neuron recognition(GO:0008038)
0.0 1.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.8 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.9 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 1.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.3 GO:0007631 feeding behavior(GO:0007631)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.1 GO:0090170 regulation of Golgi inheritance(GO:0090170)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 1.2 GO:1990742 microvesicle(GO:1990742)
0.2 4.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 2.5 GO:0035253 ciliary rootlet(GO:0035253)
0.2 3.5 GO:0005916 fascia adherens(GO:0005916)
0.1 0.4 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 1.4 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 3.5 GO:0031045 dense core granule(GO:0031045)
0.1 2.0 GO:0036449 microtubule minus-end(GO:0036449)
0.1 3.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 1.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.7 GO:0097452 GAIT complex(GO:0097452)
0.1 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.7 GO:0016272 prefoldin complex(GO:0016272)
0.1 4.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.6 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 3.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 0.6 GO:0070552 BRISC complex(GO:0070552)
0.1 0.8 GO:0033269 internode region of axon(GO:0033269)
0.1 1.4 GO:0043194 axon initial segment(GO:0043194)
0.0 5.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 3.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.6 GO:0032797 SMN complex(GO:0032797)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.5 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 10.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.9 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 3.2 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 4.4 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 3.1 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.4 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.9 GO:0043197 dendritic spine(GO:0043197)
0.0 1.4 GO:0030017 sarcomere(GO:0030017)
0.0 0.1 GO:0032982 myosin filament(GO:0032982)
0.0 3.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.1 GO:1990904 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0016503 pheromone receptor activity(GO:0016503)
0.5 2.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 1.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.4 11.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.4 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.4 1.1 GO:0004423 iduronate-2-sulfatase activity(GO:0004423)
0.3 1.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 3.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.3 3.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.3 0.8 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.2 2.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.2 1.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.7 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.2 1.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 1.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 2.7 GO:0052658 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2 0.8 GO:0047708 biotinidase activity(GO:0047708)
0.2 0.5 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 1.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 0.7 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.2 4.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.5 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 0.8 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.4 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 5.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.5 GO:0016499 orexin receptor activity(GO:0016499)
0.1 2.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 2.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 2.7 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.7 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.5 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 1.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 3.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.5 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 1.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.2 GO:0036393 thiocyanate peroxidase activity(GO:0036393)
0.1 0.6 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.4 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 1.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 2.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.4 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.9 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 0.3 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 1.1 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.7 GO:0004985 opioid receptor activity(GO:0004985)
0.0 2.8 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 0.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 4.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 12.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.6 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.9 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.0 0.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.9 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.4 GO:0045503 dynein light chain binding(GO:0045503)
0.0 1.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 3.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 2.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 6.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.4 ST GAQ PATHWAY G alpha q Pathway
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 0.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.3 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 4.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 4.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.7 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 3.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.0 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade