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Illumina Body Map 2, young vs old

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Results for E4F1

Z-value: 0.24

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Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
E4F1
ENSG00000167967.11 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273645_2273717-0.611.9e-04Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_34664612 1.17 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr6_+_139456226 1.08 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chr6_+_64282447 0.97 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_32812420 0.95 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr17_-_7165662 0.89 ENST00000571881.2
ENST00000360325.7
CLDN7
claudin 7
chr5_+_138210919 0.87 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr19_-_46088068 0.79 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr7_+_30174574 0.78 ENST00000409688.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr14_-_50053081 0.78 ENST00000396020.3
ENST00000245458.6
RPS29
ribosomal protein S29
chr11_-_67276100 0.75 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr19_+_1941117 0.72 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr1_+_26496362 0.71 ENST00000374266.5
ENST00000270812.5
ZNF593
zinc finger protein 593
chr6_+_32812568 0.70 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_53213587 0.70 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5
ELOVL fatty acid elongase 5
chr17_-_4643114 0.68 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr5_-_95297534 0.67 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr6_-_53213780 0.67 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr17_-_40540586 0.64 ENST00000264657.5
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr5_-_95297678 0.63 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr7_-_129592700 0.60 ENST00000472396.1
ENST00000355621.3
UBE2H
ubiquitin-conjugating enzyme E2H
chr7_+_30174668 0.59 ENST00000415604.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr7_-_140624499 0.58 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr3_-_156877997 0.58 ENST00000295926.3
CCNL1
cyclin L1
chr6_+_64281906 0.58 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_8086343 0.58 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1
ERBB receptor feedback inhibitor 1
chr1_+_39456895 0.57 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr6_+_47445467 0.55 ENST00000359314.5
CD2AP
CD2-associated protein
chr17_+_7211656 0.52 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr20_+_44420570 0.52 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr10_+_119000604 0.50 ENST00000298472.5
SLC18A2
solute carrier family 18 (vesicular monoamine transporter), member 2
chr12_-_110011288 0.50 ENST00000540016.1
ENST00000266839.5
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type
chr2_-_240964716 0.49 ENST00000404554.1
ENST00000407129.3
ENST00000307300.4
ENST00000443626.1
ENST00000252711.2
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr5_+_68513622 0.49 ENST00000512880.1
ENST00000602380.1
MRPS36
mitochondrial ribosomal protein S36
chr19_-_59066452 0.49 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr12_+_107168418 0.49 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8B
RIC8 guanine nucleotide exchange factor B
chr12_+_107168342 0.48 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr4_+_47487285 0.48 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr1_-_47184745 0.45 ENST00000544071.1
EFCAB14
EF-hand calcium binding domain 14
chr20_+_33146510 0.45 ENST00000397709.1
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr1_-_32110467 0.45 ENST00000440872.2
ENST00000373703.4
PEF1
penta-EF-hand domain containing 1
chr20_+_44420617 0.45 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr17_-_40540484 0.45 ENST00000588969.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr15_-_41047421 0.45 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr19_-_10024496 0.44 ENST00000593091.1
OLFM2
olfactomedin 2
chr19_-_59066327 0.43 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr17_+_7476136 0.43 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr7_-_129592471 0.42 ENST00000473814.2
ENST00000490974.1
UBE2H
ubiquitin-conjugating enzyme E2H
chr22_-_38902300 0.42 ENST00000403230.1
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr2_-_216300784 0.42 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr22_+_39101728 0.42 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr5_+_133707252 0.41 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr11_-_6633799 0.41 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr9_+_125026882 0.41 ENST00000297908.3
ENST00000373730.3
ENST00000546115.1
ENST00000344641.3
MRRF
mitochondrial ribosome recycling factor
chr1_-_47184723 0.40 ENST00000371933.3
EFCAB14
EF-hand calcium binding domain 14
chr9_+_131644781 0.40 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_-_150602035 0.39 ENST00000503241.1
ENST00000369016.4
ENST00000339643.5
ENST00000271690.8
ENST00000356527.5
ENST00000362052.7
ENST00000503345.1
ENST00000369014.5
ENST00000369009.3
ENSA
endosulfine alpha
chr12_+_122150646 0.38 ENST00000449592.2
TMEM120B
transmembrane protein 120B
chr9_+_125027127 0.38 ENST00000441707.1
ENST00000373723.5
ENST00000373729.1
MRRF
mitochondrial ribosome recycling factor
chr22_-_41252962 0.38 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr5_+_68513557 0.38 ENST00000256441.4
MRPS36
mitochondrial ribosomal protein S36
chr21_-_40720995 0.37 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chr6_-_144416737 0.37 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr17_-_40540377 0.37 ENST00000404395.3
ENST00000389272.3
ENST00000585517.1
ENST00000588065.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr22_+_32340447 0.36 ENST00000248975.5
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr21_-_40720974 0.36 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr9_+_131644398 0.35 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr9_-_99381660 0.35 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr6_+_33176265 0.34 ENST00000374656.4
RING1
ring finger protein 1
chr1_-_16482554 0.34 ENST00000358432.5
EPHA2
EPH receptor A2
chr7_+_30174426 0.34 ENST00000324453.8
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr22_+_18121356 0.33 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr1_+_110527308 0.33 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr4_+_75311019 0.33 ENST00000502307.1
AREG
amphiregulin
chr6_+_30029008 0.33 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
ZNRD1
zinc ribbon domain containing 1
chr9_-_99382065 0.32 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr17_-_80231300 0.30 ENST00000398519.5
ENST00000580446.1
CSNK1D
casein kinase 1, delta
chr17_-_685559 0.30 ENST00000301329.6
GLOD4
glyoxalase domain containing 4
chr7_-_86849836 0.30 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr19_+_45349432 0.29 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_+_12696102 0.29 ENST00000527636.1
ENST00000527376.1
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr19_+_54704718 0.28 ENST00000391752.1
ENST00000402367.1
ENST00000391751.3
RPS9
ribosomal protein S9
chr16_-_3767551 0.28 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr4_+_75310851 0.27 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr7_-_137686791 0.27 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chrX_+_153672468 0.27 ENST00000393600.3
FAM50A
family with sequence similarity 50, member A
chr9_-_125027079 0.26 ENST00000417201.3
RBM18
RNA binding motif protein 18
chr15_-_53082178 0.26 ENST00000305901.5
ONECUT1
one cut homeobox 1
chr22_+_18121562 0.26 ENST00000355028.3
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr16_-_3767506 0.26 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr22_+_32340481 0.25 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr3_-_185655795 0.25 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr12_-_51566592 0.25 ENST00000257915.5
ENST00000548115.1
TFCP2
transcription factor CP2
chr9_+_131644388 0.25 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr5_+_133706865 0.24 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr7_-_86849883 0.24 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr3_+_38206975 0.24 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr22_-_38902325 0.23 ENST00000396821.3
ENST00000381633.3
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr19_+_54704990 0.23 ENST00000391753.2
RPS9
ribosomal protein S9
chr19_+_54704610 0.23 ENST00000302907.4
RPS9
ribosomal protein S9
chr12_-_51566562 0.22 ENST00000548108.1
TFCP2
transcription factor CP2
chr14_+_105219437 0.22 ENST00000329967.6
ENST00000347067.5
ENST00000553810.1
SIVA1
SIVA1, apoptosis-inducing factor
chr2_-_62115659 0.22 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr11_+_4116054 0.22 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr17_+_41476327 0.22 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr20_-_5591626 0.22 ENST00000379019.4
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr12_-_51566849 0.22 ENST00000549867.1
ENST00000307660.4
TFCP2
transcription factor CP2
chrX_+_153237740 0.21 ENST00000369982.4
TMEM187
transmembrane protein 187
chr14_-_23388338 0.20 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr8_-_66754172 0.20 ENST00000401827.3
PDE7A
phosphodiesterase 7A
chr19_+_54705025 0.20 ENST00000441429.1
RPS9
ribosomal protein S9
chr1_+_109289279 0.19 ENST00000370008.3
STXBP3
syntaxin binding protein 3
chr2_+_75185619 0.19 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr20_+_33292068 0.19 ENST00000374810.3
ENST00000374809.2
ENST00000451665.1
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr9_-_131644202 0.19 ENST00000320665.6
ENST00000436267.2
CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr16_+_29973351 0.18 ENST00000602948.1
ENST00000279396.6
ENST00000575829.2
ENST00000561899.2
TMEM219
transmembrane protein 219
chr17_-_685493 0.18 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
GLOD4
glyoxalase domain containing 4
chr20_+_33292507 0.17 ENST00000414082.1
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr11_-_77185094 0.17 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr4_-_104119488 0.17 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr10_+_64893039 0.17 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chr11_+_4116005 0.17 ENST00000300738.5
RRM1
ribonucleotide reductase M1
chr11_+_18720316 0.17 ENST00000280734.2
TMEM86A
transmembrane protein 86A
chr11_+_12695944 0.16 ENST00000361905.4
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr17_+_39845134 0.16 ENST00000591776.1
ENST00000469257.1
EIF1
eukaryotic translation initiation factor 1
chr1_-_212208842 0.16 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7
integrator complex subunit 7
chr2_-_64881018 0.16 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr9_-_131644306 0.15 ENST00000302586.3
CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr6_-_47445214 0.15 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr3_-_134092561 0.15 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2
angiomotin like 2
chr2_-_62115725 0.15 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr2_-_157189180 0.14 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr8_-_95274536 0.14 ENST00000297596.2
ENST00000396194.2
GEM
GTP binding protein overexpressed in skeletal muscle
chr19_+_10527449 0.14 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_+_52693259 0.14 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr19_+_45504688 0.13 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr12_+_122516626 0.13 ENST00000319080.7
MLXIP
MLX interacting protein
chrX_-_83757399 0.12 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr11_+_3819049 0.12 ENST00000396986.2
ENST00000300730.6
ENST00000532535.1
ENST00000396993.4
ENST00000396991.2
ENST00000532523.1
ENST00000459679.1
ENST00000464261.1
ENST00000464906.2
ENST00000464441.1
PGAP2
post-GPI attachment to proteins 2
chr1_+_70820451 0.12 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr16_+_68056844 0.12 ENST00000565263.1
DUS2
dihydrouridine synthase 2
chr8_-_116680833 0.11 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr6_-_163148780 0.11 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2
parkin RBR E3 ubiquitin protein ligase
chr11_-_8680383 0.11 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr16_+_68057179 0.11 ENST00000567100.1
ENST00000432752.1
ENST00000569289.1
ENST00000564781.1
DUS2
dihydrouridine synthase 2
chr6_-_163148700 0.10 ENST00000366894.1
ENST00000338468.3
PARK2
parkin RBR E3 ubiquitin protein ligase
chr1_-_70820357 0.10 ENST00000370944.4
ENST00000262346.6
ANKRD13C
ankyrin repeat domain 13C
chr10_-_119134918 0.10 ENST00000334464.5
PDZD8
PDZ domain containing 8
chr17_+_18087553 0.10 ENST00000399138.4
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr4_-_76598544 0.10 ENST00000515457.1
ENST00000357854.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr17_-_80231557 0.09 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr6_+_44355257 0.09 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr20_-_62258394 0.09 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr15_+_50716645 0.09 ENST00000560982.1
USP8
ubiquitin specific peptidase 8
chr19_-_10341948 0.08 ENST00000590320.1
ENST00000592342.1
ENST00000588952.1
S1PR2
DNMT1
sphingosine-1-phosphate receptor 2
DNA (cytosine-5-)-methyltransferase 1
chr6_-_27440837 0.08 ENST00000211936.6
ZNF184
zinc finger protein 184
chr17_+_25621102 0.08 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1
WD repeat and SOCS box containing 1
chr16_+_68057153 0.08 ENST00000358896.6
ENST00000568099.2
DUS2
dihydrouridine synthase 2
chr4_+_1873100 0.07 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr1_+_9599540 0.06 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr6_-_27440460 0.06 ENST00000377419.1
ZNF184
zinc finger protein 184
chr17_+_53342311 0.06 ENST00000226067.5
HLF
hepatic leukemia factor
chr17_-_4643161 0.06 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr6_-_29595779 0.06 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_-_29208183 0.06 ENST00000240100.2
DUSP4
dual specificity phosphatase 4
chr2_-_128145498 0.04 ENST00000409179.2
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr11_-_3818932 0.04 ENST00000324932.7
ENST00000359171.4
NUP98
nucleoporin 98kDa
chr4_-_76598326 0.04 ENST00000503660.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr3_+_101292939 0.04 ENST00000265260.3
ENST00000469941.1
ENST00000296024.5
PCNP
PEST proteolytic signal containing nuclear protein
chr17_+_71161140 0.04 ENST00000357585.2
SSTR2
somatostatin receptor 2
chr12_+_111471828 0.04 ENST00000261726.6
CUX2
cut-like homeobox 2
chr6_-_30523865 0.03 ENST00000433809.1
GNL1
guanine nucleotide binding protein-like 1
chr11_-_33183048 0.02 ENST00000438862.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr1_-_151254362 0.02 ENST00000447795.2
RP11-126K1.2
Uncharacterized protein
chr6_+_127588020 0.02 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146
ring finger protein 146
chr6_+_15249128 0.02 ENST00000397311.3
JARID2
jumonji, AT rich interactive domain 2
chr17_+_685513 0.02 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr6_+_110299501 0.00 ENST00000414000.2
GPR6
G protein-coupled receptor 6

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.2 0.9 GO:1903722 regulation of centriole elongation(GO:1903722)
0.2 0.9 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 0.5 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.2 0.7 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 0.9 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.4 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.1 0.5 GO:0009386 translational attenuation(GO:0009386)
0.1 0.5 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 1.4 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.3 GO:0048320 axial mesoderm formation(GO:0048320)
0.1 0.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.8 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 0.5 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 1.0 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 0.7 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.4 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 0.6 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 0.5 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.5 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.1 0.8 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.6 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) lung vasculature development(GO:0060426) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.0 0.5 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.6 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.8 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.3 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.7 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.4 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.7 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955)
0.0 0.6 GO:0008211 steroid catabolic process(GO:0006706) glucocorticoid metabolic process(GO:0008211)
0.0 1.7 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.5 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.4 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.4 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.0 0.4 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.3 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0097447 dendritic tree(GO:0097447)
0.2 1.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.9 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.7 GO:0033503 HULC complex(GO:0033503)
0.1 0.9 GO:0016600 flotillin complex(GO:0016600)
0.1 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.4 GO:0000125 PCAF complex(GO:0000125)
0.0 0.5 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.5 GO:0044754 autolysosome(GO:0044754)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031177 phosphopantetheine binding(GO:0031177)
0.1 1.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.5 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.9 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 1.4 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.4 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 1.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 2.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 1.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.6 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.4 GO:0016504 peptidase activator activity(GO:0016504)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.7 PID FOXO PATHWAY FoxO family signaling
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.4 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation