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Illumina Body Map 2, young vs old

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Results for EVX2

Z-value: 1.30

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EVX2hg19_v2_chr2_-_176948641_176948641-0.222.3e-01Click!

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_111717511 3.55 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr3_+_111718036 3.37 ENST00000455401.2
TAGLN3
transgelin 3
chr3_+_111717600 3.29 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111718173 2.81 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_115342349 2.31 ENST00000393780.3
GAP43
growth associated protein 43
chr5_-_96478466 2.26 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr5_-_96478457 1.93 ENST00000512378.1
LIX1
Lix1 homolog (chicken)
chr6_-_62996066 1.76 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr13_+_78315466 1.06 ENST00000314070.5
ENST00000462234.1
SLAIN1
SLAIN motif family, member 1
chr19_-_47137942 1.04 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr13_+_78315528 1.04 ENST00000496045.1
SLAIN1
SLAIN motif family, member 1
chr12_+_15699286 0.90 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr1_+_28261492 0.63 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr11_-_115375107 0.62 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr17_-_9929581 0.60 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr1_+_28261621 0.58 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr1_+_28261533 0.50 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr4_+_144312659 0.39 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr1_+_160160283 0.39 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr4_+_144354644 0.35 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr15_+_63050785 0.33 ENST00000472902.1
TLN2
talin 2
chr1_+_160160346 0.33 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr8_+_92261516 0.26 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr15_-_55562451 0.24 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chr20_-_50419055 0.11 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr4_-_41884582 0.09 ENST00000499082.2
LINC00682
long intergenic non-protein coding RNA 682
chr17_+_37809333 0.09 ENST00000443521.1
STARD3
StAR-related lipid transfer (START) domain containing 3
chr6_-_111927449 0.06 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr12_+_64798826 0.05 ENST00000540203.1
XPOT
exportin, tRNA
chr12_+_28410128 0.02 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr17_-_27418537 0.01 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr6_-_111927062 0.00 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of EVX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 2.3 GO:0016198 axon choice point recognition(GO:0016198)
0.1 1.0 GO:0019236 response to pheromone(GO:0019236)
0.1 1.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.6 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 4.2 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.7 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 1.8 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.7 GO:0014802 terminal cisterna(GO:0014802)
0.0 13.0 GO:0043209 myelin sheath(GO:0043209)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 1.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 13.4 GO:0051015 actin filament binding(GO:0051015)
0.0 0.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions