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Illumina Body Map 2, young vs old

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Results for GAUAUGU

Z-value: 0.21

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miRNA associated with seed GAUAUGU

NamemiRBASE accession
hsa-miR-190a-5p
MIMAT0000458
hsa-miR-190b
MIMAT0004929

Activity profile of GAUAUGU motif

Sorted Z-values of GAUAUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_33146477 0.90 ENST00000378677.2
DMD
dystrophin
chr20_-_48099182 0.72 ENST00000371741.4
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr14_+_55034599 0.67 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr10_-_131762105 0.62 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr13_-_103053946 0.62 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr5_+_175223313 0.55 ENST00000359546.4
CPLX2
complexin 2
chr2_+_179059365 0.53 ENST00000190611.4
OSBPL6
oxysterol binding protein-like 6
chr5_-_45696253 0.52 ENST00000303230.4
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr8_-_23712312 0.49 ENST00000290271.2
STC1
stanniocalcin 1
chr14_+_79745746 0.48 ENST00000281127.7
NRXN3
neurexin 3
chr3_-_126076264 0.44 ENST00000296233.3
KLF15
Kruppel-like factor 15
chr6_+_69345166 0.30 ENST00000370598.1
BAI3
brain-specific angiogenesis inhibitor 3
chr10_+_125425871 0.28 ENST00000284674.1
GPR26
G protein-coupled receptor 26
chr21_-_39870339 0.26 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr3_+_173116225 0.23 ENST00000457714.1
NLGN1
neuroligin 1
chr6_+_73331776 0.23 ENST00000370398.1
KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr11_-_106889250 0.20 ENST00000526355.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr3_-_160283348 0.18 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr11_-_70507901 0.15 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_+_145470504 0.14 ENST00000323397.4
ANKRD34A
ankyrin repeat domain 34A
chr19_-_5340730 0.13 ENST00000372412.4
ENST00000357368.4
ENST00000262963.6
ENST00000348075.2
ENST00000353284.2
PTPRS
protein tyrosine phosphatase, receptor type, S
chr5_-_44388899 0.13 ENST00000264664.4
FGF10
fibroblast growth factor 10
chr12_-_102874416 0.11 ENST00000392904.1
ENST00000337514.6
IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_-_2151523 0.11 ENST00000350812.6
ENST00000355272.6
ENST00000356926.4
ENST00000345016.5
AP3D1
adaptor-related protein complex 3, delta 1 subunit
chr18_+_60382672 0.11 ENST00000400316.4
ENST00000262719.5
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr11_-_30038490 0.09 ENST00000328224.6
KCNA4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr12_-_31744031 0.09 ENST00000389082.5
DENND5B
DENN/MADD domain containing 5B
chr3_+_187930719 0.09 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_-_93115445 0.08 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_114055052 0.07 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr1_+_61547894 0.07 ENST00000403491.3
NFIA
nuclear factor I/A
chr15_+_36887069 0.07 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
C15orf41
chromosome 15 open reading frame 41
chr4_+_128703295 0.07 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr18_-_35145593 0.07 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CELF4
CUGBP, Elav-like family member 4
chr12_-_28124903 0.07 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr11_-_31839488 0.05 ENST00000419022.1
ENST00000379132.3
ENST00000379129.2
PAX6
paired box 6
chr2_-_197457335 0.05 ENST00000260983.3
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr20_+_56964169 0.04 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr12_-_111021110 0.04 ENST00000354300.3
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr8_+_61591337 0.04 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr12_-_118797475 0.03 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr18_-_53255766 0.02 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr18_-_72921303 0.01 ENST00000322342.3
ZADH2
zinc binding alcohol dehydrogenase domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of GAUAUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.2 GO:0098942 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.0 0.1 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.1 GO:0071338 proximal/distal axis specification(GO:0009946) bronchiole development(GO:0060435) submandibular salivary gland formation(GO:0060661) secretion by lung epithelial cell involved in lung growth(GO:0061033) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.5 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.1 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:0001834 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.4 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.9 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.5 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.9 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction