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Illumina Body Map 2, young vs old

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Results for GCCUGUC

Z-value: 0.37

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miRNA associated with seed GCCUGUC

NamemiRBASE accession
hsa-miR-214-5p
MIMAT0004564

Activity profile of GCCUGUC motif

Sorted Z-values of GCCUGUC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_19157248 0.38 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr11_+_76494253 0.29 ENST00000333090.4
TSKU
tsukushi, small leucine rich proteoglycan
chr2_-_19558373 0.29 ENST00000272223.2
OSR1
odd-skipped related transciption factor 1
chr2_-_217560248 0.25 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr6_-_39197226 0.24 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr4_+_55095264 0.23 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr1_+_39957292 0.22 ENST00000331593.5
BMP8A
bone morphogenetic protein 8a
chrX_+_99839799 0.20 ENST00000373031.4
TNMD
tenomodulin
chr6_+_21593972 0.18 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr3_+_37493610 0.17 ENST00000264741.5
ITGA9
integrin, alpha 9
chr7_-_27239703 0.14 ENST00000222753.4
HOXA13
homeobox A13
chr20_-_10654639 0.14 ENST00000254958.5
JAG1
jagged 1
chr5_-_146833485 0.14 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr10_-_71892555 0.14 ENST00000307864.1
AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr10_-_118032697 0.14 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr10_+_99473455 0.14 ENST00000285605.6
MARVELD1
MARVEL domain containing 1
chr14_-_61116168 0.13 ENST00000247182.6
SIX1
SIX homeobox 1
chr13_+_73632897 0.12 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr1_+_210406121 0.11 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr14_-_24898731 0.11 ENST00000267406.6
CBLN3
cerebellin 3 precursor
chr12_-_56652111 0.10 ENST00000267116.7
ANKRD52
ankyrin repeat domain 52
chr22_-_50746027 0.10 ENST00000425954.1
ENST00000449103.1
PLXNB2
plexin B2
chr2_-_42991257 0.10 ENST00000378661.2
OXER1
oxoeicosanoid (OXE) receptor 1
chr11_+_118754475 0.08 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr1_+_180199393 0.07 ENST00000263726.2
LHX4
LIM homeobox 4
chr11_-_57283159 0.07 ENST00000533263.1
ENST00000278426.3
SLC43A1
solute carrier family 43 (amino acid system L transporter), member 1
chr6_+_44187242 0.07 ENST00000393844.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr5_-_137090028 0.07 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr20_-_23030296 0.07 ENST00000377103.2
THBD
thrombomodulin
chr9_-_127533519 0.07 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr16_+_29789561 0.07 ENST00000400752.4
ZG16
zymogen granule protein 16
chr8_-_103668114 0.07 ENST00000285407.6
KLF10
Kruppel-like factor 10
chr19_-_15560730 0.06 ENST00000389282.4
ENST00000263381.7
WIZ
widely interspaced zinc finger motifs
chr1_-_203055129 0.06 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr2_-_114036488 0.06 ENST00000263335.7
ENST00000397647.3
ENST00000348715.5
ENST00000429538.3
PAX8
paired box 8
chr13_+_114238997 0.06 ENST00000538138.1
ENST00000375370.5
TFDP1
transcription factor Dp-1
chr15_-_89456593 0.06 ENST00000558029.1
ENST00000539437.1
ENST00000542878.1
ENST00000268151.7
ENST00000566497.1
MFGE8
milk fat globule-EGF factor 8 protein
chr2_-_97535708 0.06 ENST00000305476.5
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr3_-_197686847 0.05 ENST00000265239.6
IQCG
IQ motif containing G
chr6_+_17281573 0.05 ENST00000379052.5
RBM24
RNA binding motif protein 24
chr2_+_36582857 0.05 ENST00000280527.2
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr15_-_65715401 0.05 ENST00000352385.2
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr2_+_25015968 0.05 ENST00000380834.2
ENST00000473706.1
CENPO
centromere protein O
chr17_-_72919317 0.05 ENST00000319642.1
USH1G
Usher syndrome 1G (autosomal recessive)
chr19_+_39616410 0.04 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr20_-_36889127 0.04 ENST00000279024.4
KIAA1755
KIAA1755
chr4_-_39460520 0.04 ENST00000503040.1
ENST00000504470.1
ENST00000508595.1
ENST00000295955.9
RPL9
ribosomal protein L9
chr17_-_61523535 0.04 ENST00000584031.1
ENST00000392976.1
CYB561
cytochrome b561
chr3_+_152017181 0.04 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr15_-_50558223 0.04 ENST00000267845.3
HDC
histidine decarboxylase
chr12_-_54673871 0.04 ENST00000209875.4
CBX5
chromobox homolog 5
chr15_-_41408409 0.04 ENST00000361937.3
INO80
INO80 complex subunit
chr11_+_14665263 0.04 ENST00000282096.4
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr19_+_30433110 0.03 ENST00000542441.2
ENST00000392271.1
URI1
URI1, prefoldin-like chaperone
chr1_-_23857698 0.03 ENST00000361729.2
E2F2
E2F transcription factor 2
chr14_-_76127519 0.03 ENST00000256319.6
C14orf1
chromosome 14 open reading frame 1
chr3_+_3841108 0.03 ENST00000319331.3
LRRN1
leucine rich repeat neuronal 1
chrX_-_107979616 0.03 ENST00000372129.2
IRS4
insulin receptor substrate 4
chr12_-_121342170 0.03 ENST00000353487.2
SPPL3
signal peptide peptidase like 3
chr1_-_244013384 0.03 ENST00000366539.1
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr19_+_1752372 0.03 ENST00000382349.4
ONECUT3
one cut homeobox 3
chr11_-_118305921 0.03 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr18_-_18691739 0.03 ENST00000399799.2
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chrX_+_53078273 0.03 ENST00000332582.4
GPR173
G protein-coupled receptor 173
chr17_+_2240775 0.03 ENST00000268989.3
ENST00000426855.2
SGSM2
small G protein signaling modulator 2
chr5_-_66492562 0.03 ENST00000256447.4
CD180
CD180 molecule
chr11_-_62572901 0.02 ENST00000439713.2
ENST00000531131.1
ENST00000530875.1
ENST00000531709.2
ENST00000294172.2
NXF1
nuclear RNA export factor 1
chr4_+_87856129 0.02 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr2_-_220025548 0.02 ENST00000356853.5
NHEJ1
nonhomologous end-joining factor 1
chr16_+_54964740 0.02 ENST00000394636.4
IRX5
iroquois homeobox 5
chr3_-_196756646 0.02 ENST00000439320.1
ENST00000296351.4
ENST00000296350.5
MFI2
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr3_+_113775576 0.02 ENST00000485050.1
ENST00000281273.4
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr14_-_77787198 0.02 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chr4_+_128703295 0.02 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr16_-_85722530 0.02 ENST00000253462.3
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr9_-_74980113 0.02 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr7_-_130080977 0.01 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr6_+_4021554 0.01 ENST00000337659.6
PRPF4B
pre-mRNA processing factor 4B
chr1_+_36348790 0.01 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chr9_-_117568365 0.01 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chrX_-_71351678 0.01 ENST00000609883.1
ENST00000545866.1
RGAG4
retrotransposon gag domain containing 4
chr22_+_30279144 0.01 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr4_+_699537 0.01 ENST00000419774.1
ENST00000362003.5
ENST00000400151.2
ENST00000427463.1
ENST00000470161.2
PCGF3
polycomb group ring finger 3
chr5_+_167718604 0.01 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chrX_-_19002696 0.01 ENST00000379942.4
PHKA2
phosphorylase kinase, alpha 2 (liver)
chr3_-_50649192 0.00 ENST00000443053.2
ENST00000348721.3
CISH
cytokine inducible SH2-containing protein
chr17_-_39890893 0.00 ENST00000393939.2
ENST00000347901.4
ENST00000341193.5
ENST00000310778.5
HAP1
huntingtin-associated protein 1
chrX_+_117861535 0.00 ENST00000371666.3
ENST00000371642.1
IL13RA1
interleukin 13 receptor, alpha 1
chr2_+_201676256 0.00 ENST00000452206.1
ENST00000410110.2
ENST00000409600.1
BZW1
basic leucine zipper and W2 domains 1
chr2_-_211036051 0.00 ENST00000418791.1
ENST00000452086.1
ENST00000281772.9
KANSL1L
KAT8 regulatory NSL complex subunit 1-like
chr1_+_145524891 0.00 ENST00000369304.3
ITGA10
integrin, alpha 10
chr7_-_127983877 0.00 ENST00000415472.2
ENST00000478061.1
ENST00000223073.2
ENST00000459726.1
RBM28
RNA binding motif protein 28

Network of associatons between targets according to the STRING database.

First level regulatory network of GCCUGUC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.3 GO:0023016 osmosensory signaling pathway(GO:0007231) signal transduction by trans-phosphorylation(GO:0023016) kidney smooth muscle tissue development(GO:0072194) pattern specification involved in metanephros development(GO:0072268)
0.1 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.2 GO:0035910 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.2 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.2 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.1 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.1 GO:0014735 regulation of muscle atrophy(GO:0014735)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.0 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005018 platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.0 0.1 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.0 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.0 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor