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Illumina Body Map 2, young vs old
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Results for GRHL1
Z-value: 1.36
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Transcription factors associated with GRHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GRHL1 | hg19_v2_chr2_+_10091783_10091811 | 0.69 | 1.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_61002584 Show fit | 8.63 |
ENST00000252998.1
|
RBBP8 N-terminal like |
|
| chr20_-_18038521 Show fit | 6.69 |
ENST00000278780.6
|
ovo-like zinc finger 2 |
|
| chr1_-_201368707 Show fit | 5.88 |
ENST00000391967.2
|
ladinin 1 |
|
| chr2_+_95940220 Show fit | 5.78 |
ENST00000542147.1
|
prominin 2 |
|
| chr1_-_201368653 Show fit | 5.46 |
ENST00000367313.3
|
ladinin 1 |
|
| chr11_+_706595 Show fit | 5.11 |
ENST00000531348.1
ENST00000530636.1 |
EPS8-like 2 |
|
| chr11_+_76493294 Show fit | 4.52 |
ENST00000533752.1
|
tsukushi, small leucine rich proteoglycan |
|
| chr19_+_45312310 Show fit | 4.41 |
ENST00000589651.1
|
basal cell adhesion molecule (Lutheran blood group) |
|
| chr8_+_144821557 Show fit | 4.03 |
ENST00000534398.1
|
FAM83H antisense RNA 1 (head to head) |
|
| chr2_+_95940186 Show fit | 3.89 |
ENST00000403131.2
ENST00000317668.4 ENST00000317620.9 |
prominin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GRHL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 9.7 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 1.1 | 6.7 | GO:0060214 | endocardium formation(GO:0060214) |
| 0.0 | 6.6 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.1 | 6.3 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.3 | 5.1 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 1.1 | 4.5 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.1 | 3.6 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 2.8 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.1 | 2.8 | GO:0039694 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 2.7 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | GO:0005604 | basement membrane(GO:0005604) |
| 1.9 | 9.7 | GO:0044393 | microspike(GO:0044393) |
| 0.0 | 6.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 5.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 3.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.8 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 2.8 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 2.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 2.2 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 2.2 | GO:0036019 | endolysosome(GO:0036019) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 9.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 2.6 | 7.9 | GO:0005055 | laminin receptor activity(GO:0005055) |
| 0.0 | 6.3 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 5.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 3.6 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.3 | 2.8 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.4 | 2.7 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.6 | 2.3 | GO:0031716 | calcitonin receptor binding(GO:0031716) |
| 0.1 | 2.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.8 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 2.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.7 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 0.4 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |