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Illumina Body Map 2, young vs old

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Results for HDX

Z-value: 0.28

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_83757487-0.144.6e-01Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_159684371 1.79 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr5_-_41213607 1.77 ENST00000337836.5
ENST00000433294.1
C6
complement component 6
chr12_-_103344615 1.70 ENST00000546844.1
PAH
phenylalanine hydroxylase
chr15_-_54025300 1.44 ENST00000559418.1
WDR72
WD repeat domain 72
chr3_-_165555200 1.29 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr5_-_135290651 1.27 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr5_-_35230649 0.99 ENST00000382002.5
PRLR
prolactin receptor
chr5_-_35230771 0.94 ENST00000342362.5
PRLR
prolactin receptor
chr5_-_135290705 0.90 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr7_-_121944491 0.85 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr5_-_35230434 0.82 ENST00000504500.1
PRLR
prolactin receptor
chr11_-_66675371 0.79 ENST00000393955.2
PC
pyruvate carboxylase
chr2_+_128403439 0.75 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr2_+_128403720 0.72 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr1_+_21880560 0.63 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr12_+_123849462 0.61 ENST00000543072.1
hsa-mir-8072
hsa-mir-8072
chr6_-_116381918 0.56 ENST00000606080.1
FRK
fyn-related kinase
chr10_-_21186144 0.49 ENST00000377119.1
NEBL
nebulette
chr5_-_35230569 0.48 ENST00000515839.1
PRLR
prolactin receptor
chr16_+_1877204 0.44 ENST00000427358.2
FAHD1
fumarylacetoacetate hydrolase domain containing 1
chr10_-_14372870 0.44 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr2_+_113735575 0.42 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr19_-_58485895 0.40 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr9_+_6215799 0.34 ENST00000417746.2
ENST00000456383.2
IL33
interleukin 33
chr1_-_209825674 0.32 ENST00000367030.3
ENST00000356082.4
LAMB3
laminin, beta 3
chr4_+_48807155 0.29 ENST00000504654.1
OCIAD1
OCIA domain containing 1
chr2_-_40657397 0.29 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr12_-_39734783 0.27 ENST00000552961.1
KIF21A
kinesin family member 21A
chr2_+_102758271 0.24 ENST00000428279.1
IL1R1
interleukin 1 receptor, type I
chr8_+_145065705 0.24 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr13_+_24144796 0.21 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_+_84630367 0.19 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84630352 0.17 ENST00000450730.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_102758210 0.17 ENST00000450319.1
IL1R1
interleukin 1 receptor, type I
chr12_+_101869096 0.17 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr19_+_36602104 0.13 ENST00000585332.1
ENST00000262637.4
OVOL3
ovo-like zinc finger 3
chr3_+_107241882 0.13 ENST00000416476.2
BBX
bobby sox homolog (Drosophila)
chr12_-_15815626 0.12 ENST00000540613.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr1_+_47489240 0.10 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr6_+_98264571 0.10 ENST00000607823.1
RP11-436D23.1
RP11-436D23.1
chr18_+_29027696 0.10 ENST00000257189.4
DSG3
desmoglein 3
chr5_+_140165876 0.09 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1
protocadherin alpha 1
chr5_+_140625147 0.07 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr1_+_84629976 0.06 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr13_+_24144509 0.06 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chrX_+_27608490 0.06 ENST00000451261.2
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr12_+_10460417 0.05 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr12_-_31743901 0.04 ENST00000354285.4
DENND5B
DENN/MADD domain containing 5B
chrX_+_27608517 0.04 ENST00000431122.2
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr14_+_79745682 0.03 ENST00000557594.1
NRXN3
neurexin 3
chr18_-_53804580 0.03 ENST00000590484.1
ENST00000589293.1
ENST00000587904.1
ENST00000591974.1
RP11-456O19.4
RP11-456O19.4
chr14_+_79745746 0.01 ENST00000281127.7
NRXN3
neurexin 3
chr22_+_40440804 0.01 ENST00000441751.1
ENST00000301923.9
TNRC6B
trinucleotide repeat containing 6B

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0014016 neuroblast differentiation(GO:0014016)
0.4 3.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.4 1.8 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 0.6 GO:0071529 cementum mineralization(GO:0071529)
0.2 0.8 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.2 0.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.8 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.1 1.7 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 1.5 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.3 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.1 1.4 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.4 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.4 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.5 GO:0055003 cardiac myofibril assembly(GO:0055003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.6 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 3.2 GO:0031904 endosome lumen(GO:0031904)
0.0 0.3 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0033265 choline binding(GO:0033265)
0.5 3.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 1.7 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.1 0.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.4 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.8 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 0.4 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 1.5 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis