Project

Illumina Body Map 2, young vs old

Navigation
Downloads

Results for HESX1

Z-value: 0.19

Motif logo

Transcription factors associated with HESX1

Gene Symbol Gene ID Gene Info
ENSG00000163666.4 HESX homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HESX1hg19_v2_chr3_-_57233966_57234014-0.183.1e-01Click!

Activity profile of HESX1 motif

Sorted Z-values of HESX1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90198535 9.32 ENST00000390276.2
immunoglobulin kappa variable 1D-12
chr2_-_89310012 8.96 ENST00000493819.1
immunoglobulin kappa variable 1-9
chr2_-_89292422 8.55 ENST00000495489.1
immunoglobulin kappa variable 1-8
chr14_-_106406090 8.49 ENST00000390593.2
immunoglobulin heavy variable 6-1
chr2_-_89513402 8.02 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr2_+_90229045 7.89 ENST00000390278.2
immunoglobulin kappa variable 1D-42 (non-functional)
chr2_+_89952792 7.82 ENST00000390265.2
immunoglobulin kappa variable 1D-33
chr2_+_90259593 7.54 ENST00000471857.1
immunoglobulin kappa variable 1D-8
chr2_-_89568263 7.50 ENST00000473726.1
immunoglobulin kappa variable 1-33
chr2_-_89399845 7.12 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr2_-_89340242 6.70 ENST00000480492.1
immunoglobulin kappa variable 1-12
chr2_+_90192768 6.22 ENST00000390275.2
immunoglobulin kappa variable 1D-13
chr2_-_89247338 6.19 ENST00000496168.1
immunoglobulin kappa variable 1-5
chr2_+_114163945 5.73 ENST00000453673.3
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr2_+_90248739 5.09 ENST00000468879.1
immunoglobulin kappa variable 1D-43
chr2_+_90458201 5.03 ENST00000603238.1
Uncharacterized protein
chr16_+_56995762 3.48 ENST00000200676.3
ENST00000379780.2
cholesteryl ester transfer protein, plasma
chr17_-_31404 3.32 ENST00000343572.7
double C2-like domains, beta
chr11_+_67222818 2.70 ENST00000325656.5
calcium binding protein 4
chr11_-_5276008 2.62 ENST00000336906.4
hemoglobin, gamma G
chr1_-_203320617 2.56 ENST00000354955.4
fibromodulin
chr1_+_159175201 2.49 ENST00000368121.2
Duffy blood group, atypical chemokine receptor
chrX_+_135730297 2.47 ENST00000370629.2
CD40 ligand
chr14_-_91884150 2.46 ENST00000553403.1
coiled-coil domain containing 88C
chr3_+_14860469 2.43 ENST00000285046.5
FYVE, RhoGEF and PH domain containing 5
chr16_+_215965 2.27 ENST00000356815.3
hemoglobin, mu
chr6_-_46703069 2.24 ENST00000538237.1
ENST00000274793.7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_+_130126165 2.23 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
mesoderm specific transcript
chr16_+_56995854 2.03 ENST00000566128.1
cholesteryl ester transfer protein, plasma
chr1_+_45265897 2.02 ENST00000372201.4
polo-like kinase 3
chr2_-_197036289 1.98 ENST00000263955.4
serine/threonine kinase 17b
chrX_+_135730373 1.93 ENST00000370628.2
CD40 ligand
chr5_+_40679584 1.91 ENST00000302472.3
prostaglandin E receptor 4 (subtype EP4)
chr19_+_42082506 1.87 ENST00000187608.9
ENST00000401445.2
carcinoembryonic antigen-related cell adhesion molecule 21
chr6_+_26273144 1.76 ENST00000377733.2
histone cluster 1, H2bi
chr14_-_106068065 1.74 ENST00000390541.2
immunoglobulin heavy constant epsilon
chr12_-_55367361 1.70 ENST00000532804.1
ENST00000531122.1
ENST00000533446.1
thymocyte expressed, positive selection associated 1
chr2_-_1748214 1.66 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
peroxidasin homolog (Drosophila)
chr11_+_50257784 1.63 ENST00000529219.1
RP11-347H15.4
chr8_-_16035454 1.55 ENST00000355282.2
macrophage scavenger receptor 1
chr19_-_45579762 1.50 ENST00000303809.2
zinc finger protein 296
chr19_-_19739321 1.47 ENST00000588461.1
lysophosphatidic acid receptor 2
chr4_-_144826682 1.44 ENST00000358615.4
ENST00000437468.2
glycophorin E (MNS blood group)
chr19_+_42388437 1.43 ENST00000378152.4
ENST00000337665.4
Rho guanine nucleotide exchange factor (GEF) 1
chr19_+_41698927 1.41 ENST00000310054.4
cytochrome P450, family 2, subfamily S, polypeptide 1
chr1_-_20446020 1.24 ENST00000375105.3
phospholipase A2, group IID
chr14_+_78227105 1.19 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
chromosome 14 open reading frame 178
chr19_+_45312310 1.13 ENST00000589651.1
basal cell adhesion molecule (Lutheran blood group)
chr19_+_41699135 1.11 ENST00000542619.1
ENST00000600561.1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr12_-_55367331 1.09 ENST00000526532.1
ENST00000532757.1
thymocyte expressed, positive selection associated 1
chr14_-_25103472 1.09 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr10_+_90672113 1.07 ENST00000371922.1
STAM binding protein-like 1
chr1_+_19967014 1.06 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr6_+_31939608 1.06 ENST00000375331.2
ENST00000375333.2
serine/threonine kinase 19
chr8_+_124084899 1.03 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1 domain family, member 31
chr5_+_149340282 1.02 ENST00000286298.4
solute carrier family 26 (anion exchanger), member 2
chr17_+_47572647 1.00 ENST00000172229.3
nerve growth factor receptor
chr1_-_205290865 1.00 ENST00000367157.3
NUAK family, SNF1-like kinase, 2
chr19_+_45312347 0.99 ENST00000270233.6
ENST00000591520.1
basal cell adhesion molecule (Lutheran blood group)
chr6_-_144329384 0.99 ENST00000417959.2
pleiomorphic adenoma gene-like 1
chr16_-_67217844 0.98 ENST00000563902.1
ENST00000561621.1
ENST00000290881.7
KIAA0895-like
chr21_+_33784670 0.98 ENST00000300255.2
eva-1 homolog C (C. elegans)
chr11_-_1912084 0.97 ENST00000391480.1
chromosome 11 open reading frame 89
chr7_-_47621229 0.96 ENST00000434451.1
tensin 3
chr5_-_179780312 0.95 ENST00000253778.8
glutamine-fructose-6-phosphate transaminase 2
chr12_-_53228079 0.93 ENST00000330553.5
keratin 79
chr5_+_52285144 0.91 ENST00000296585.5
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr22_+_31892373 0.90 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
Sfi1 homolog, spindle assembly associated (yeast)
chr20_-_62493217 0.90 ENST00000601296.1
C20ORF135
chr6_-_46703092 0.89 ENST00000541026.1
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_+_115850547 0.88 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
testis derived transcript (3 LIM domains)
chr5_+_149340339 0.87 ENST00000433184.1
solute carrier family 26 (anion exchanger), member 2
chr19_+_11457232 0.87 ENST00000587531.1
coiled-coil domain containing 159
chr3_+_46921732 0.86 ENST00000418619.1
parathyroid hormone 1 receptor
chr9_+_1051481 0.84 ENST00000358146.2
ENST00000259622.6
doublesex and mab-3 related transcription factor 2
chr8_+_19536083 0.84 ENST00000519803.1
RP11-1105O14.1
chr22_+_50354104 0.84 ENST00000360612.4
pim-3 oncogene
chr20_-_590944 0.84 ENST00000246080.3
transcription factor 15 (basic helix-loop-helix)
chr17_+_45286387 0.83 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
myosin, light chain 4, alkali; atrial, embryonic
chr3_-_46735155 0.83 ENST00000318962.4
ALS2 C-terminal like
chr6_-_31138439 0.82 ENST00000259915.8
POU class 5 homeobox 1
chr3_-_46735132 0.79 ENST00000415953.1
ALS2 C-terminal like
chr2_-_70944855 0.77 ENST00000415348.1
adducin 2 (beta)
chr12_+_53491220 0.75 ENST00000548547.1
ENST00000301464.3
insulin-like growth factor binding protein 6
chr5_-_171881491 0.75 ENST00000311601.5
SH3 and PX domains 2B
chr10_-_5541525 0.74 ENST00000380332.3
calmodulin-like 5
chr2_-_128399706 0.72 ENST00000426981.1
LIM and senescent cell antigen-like domains 2
chr14_-_25103388 0.72 ENST00000526004.1
ENST00000415355.3
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr7_+_4815238 0.71 ENST00000348624.4
ENST00000401897.1
adaptor-related protein complex 5, zeta 1 subunit
chr2_-_43823119 0.71 ENST00000403856.1
ENST00000404790.1
ENST00000405975.2
ENST00000415080.2
thyroid adenoma associated
chr4_+_129349188 0.70 ENST00000511497.1
RP11-420A23.1
chr11_+_73019282 0.68 ENST00000263674.3
Rho guanine nucleotide exchange factor (GEF) 17
chr6_+_52285046 0.68 ENST00000371068.5
EF-hand domain (C-terminal) containing 1
chr22_+_20105259 0.67 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chr11_-_57148619 0.66 ENST00000287143.2
proteoglycan 3
chr14_-_106066376 0.66 ENST00000412518.1
ENST00000428654.1
ENST00000427543.1
ENST00000420153.1
ENST00000577108.1
ENST00000576077.1
AL928742.12
immunoglobulin heavy constant epsilon
chr1_-_117021430 0.66 ENST00000423907.1
ENST00000434879.1
ENST00000443219.1
RP4-655J12.4
chr10_-_101380121 0.65 ENST00000370495.4
solute carrier family 25 (mitochondrial iron transporter), member 28
chr14_+_45553296 0.65 ENST00000355765.6
ENST00000553605.1
pre-mRNA processing factor 39
chr6_-_167275991 0.65 ENST00000510118.1
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr17_+_36861735 0.62 ENST00000378137.5
ENST00000325718.7
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_+_19496624 0.62 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATA zinc finger domain containing 2A
chr2_-_43823093 0.61 ENST00000405006.4
thyroid adenoma associated
chr4_+_156588350 0.60 ENST00000296518.7
guanylate cyclase 1, soluble, alpha 3
chr14_-_88200641 0.60 ENST00000556168.1
RP11-1152H15.1
chr17_+_45286706 0.58 ENST00000393450.1
ENST00000572303.1
myosin, light chain 4, alkali; atrial, embryonic
chr20_-_32274179 0.56 ENST00000343380.5
E2F transcription factor 1
chr6_-_29600832 0.55 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
gamma-aminobutyric acid (GABA) B receptor, 1
chr19_+_19496728 0.54 ENST00000537887.1
ENST00000417582.2
GATA zinc finger domain containing 2A
chr4_-_2264015 0.53 ENST00000337190.2
MAX dimerization protein 4
chr14_+_61654271 0.53 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
protein kinase C, eta
chr9_+_132094579 0.53 ENST00000427109.1
RP11-65J3.1
chr11_+_101918153 0.52 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
chromosome 11 open reading frame 70
chr11_-_7904464 0.51 ENST00000502624.2
ENST00000527565.1
RP11-35J10.5
chr17_+_19282064 0.51 ENST00000603493.1
mitogen-activated protein kinase 7
chr5_-_159797627 0.51 ENST00000393975.3
C1q and tumor necrosis factor related protein 2
chr6_+_116937636 0.49 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
radial spoke head 4 homolog A (Chlamydomonas)
chr12_-_49582593 0.49 ENST00000295766.5
tubulin, alpha 1a
chr7_+_99746514 0.47 ENST00000341942.5
ENST00000441173.1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr8_+_27182862 0.46 ENST00000521164.1
ENST00000346049.5
protein tyrosine kinase 2 beta
chr7_+_12727250 0.46 ENST00000404894.1
ADP-ribosylation factor-like 4A
chr1_-_1356628 0.45 ENST00000442470.1
ENST00000537107.1
ankyrin repeat domain 65
chr9_-_131486367 0.45 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
zinc finger, DHHC-type containing 12
chr17_-_15168624 0.45 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
peripheral myelin protein 22
chr8_-_101734308 0.43 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
poly(A) binding protein, cytoplasmic 1
chr7_+_72742178 0.43 ENST00000442793.1
ENST00000413573.2
ENST00000252037.4
FK506 binding protein 6, 36kDa
chr2_+_220071490 0.43 ENST00000409206.1
ENST00000409594.1
ENST00000289528.5
ENST00000422255.1
ENST00000409412.1
ENST00000409097.1
ENST00000409336.1
ENST00000409217.1
ENST00000409319.1
ENST00000444522.2
zinc finger, AN1-type domain 2B
chr20_-_62587735 0.43 ENST00000354216.6
ENST00000369892.3
ENST00000358711.3
uridine-cytidine kinase 1-like 1
chr19_+_37407212 0.42 ENST00000427117.1
ENST00000587130.1
ENST00000333987.7
ENST00000415168.1
ENST00000444991.1
zinc finger protein 568
chr8_-_93029865 0.42 ENST00000422361.2
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_54637997 0.41 ENST00000536061.1
CDNA: FLJ21031 fis, clone CAE07336; HCG1780521; Uncharacterized protein
chr19_-_50370799 0.40 ENST00000600910.1
ENST00000322344.3
ENST00000600573.1
polynucleotide kinase 3'-phosphatase
chr16_+_1662326 0.40 ENST00000397412.3
Crm, cramped-like (Drosophila)
chr12_-_49259643 0.39 ENST00000309739.5
Rho family GTPase 1
chr4_+_144303093 0.38 ENST00000505913.1
GRB2-associated binding protein 1
chr12_-_121019165 0.38 ENST00000341039.2
ENST00000357500.4
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr19_+_38397839 0.38 ENST00000222345.6
signal-induced proliferation-associated 1 like 3
chr21_+_38445539 0.36 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
tetratricopeptide repeat domain 3
chr21_-_38445443 0.36 ENST00000360525.4
phosphatidylinositol glycan anchor biosynthesis, class P
chr6_-_41888843 0.35 ENST00000434077.1
ENST00000409312.1
mediator complex subunit 20
chr3_+_9944303 0.35 ENST00000421412.1
ENST00000295980.3
interleukin 17 receptor E
chr6_+_52285131 0.34 ENST00000433625.2
EF-hand domain (C-terminal) containing 1
chr6_-_83775442 0.34 ENST00000369745.5
ubiquitin protein ligase E3D
chr1_+_47799446 0.33 ENST00000371873.5
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr5_-_122759032 0.32 ENST00000510582.3
ENST00000328236.5
ENST00000306481.6
ENST00000508442.2
ENST00000395431.2
centrosomal protein 120kDa
chr8_-_101963482 0.31 ENST00000419477.2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr13_+_108870714 0.31 ENST00000375898.3
abhydrolase domain containing 13
chr19_-_36004543 0.30 ENST00000339686.3
ENST00000447113.2
ENST00000440396.1
dermokine
chr8_-_101734170 0.30 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr1_+_3614591 0.30 ENST00000378290.4
tumor protein p73
chr1_-_17216143 0.28 ENST00000457075.1
RP11-108M9.4
chr16_+_56659687 0.28 ENST00000568293.1
ENST00000330439.6
metallothionein 1E
chr12_-_121476750 0.28 ENST00000543677.1
2'-5'-oligoadenylate synthetase-like
chr6_-_41888814 0.28 ENST00000409060.1
ENST00000265350.4
mediator complex subunit 20
chr3_-_196695733 0.27 ENST00000443835.1
phosphatidylinositol glycan anchor biosynthesis, class Z
chr18_-_70535177 0.26 ENST00000327305.6
neuropilin (NRP) and tolloid (TLL)-like 1
chr5_-_159546396 0.26 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP domain containing 2A
chr19_+_19431490 0.25 ENST00000392313.6
ENST00000262815.8
ENST00000609122.1
MAU2 sister chromatid cohesion factor
chr16_+_23847355 0.25 ENST00000498058.1
protein kinase C, beta
chr8_+_146277764 0.25 ENST00000331434.6
chromosome 8 open reading frame 33
chr9_+_37120536 0.25 ENST00000336755.5
ENST00000534928.1
ENST00000322831.6
zinc finger, CCHC domain containing 7
chr19_-_50370509 0.25 ENST00000596014.1
polynucleotide kinase 3'-phosphatase
chr2_+_208576259 0.24 ENST00000392209.3
cyclin Y-like 1
chr5_-_122758994 0.24 ENST00000306467.5
ENST00000515110.1
centrosomal protein 120kDa
chr2_+_208576355 0.24 ENST00000420822.1
ENST00000295414.3
ENST00000339882.5
cyclin Y-like 1
chr12_-_51785393 0.23 ENST00000605138.1
ENST00000604381.1
ENST00000605055.1
ENST00000605617.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr6_-_44400720 0.22 ENST00000595057.1
AL133262.1
chr16_+_19421803 0.21 ENST00000541464.1
transmembrane channel-like 5
chr2_-_160654745 0.21 ENST00000259053.4
ENST00000429078.2
CD302 molecule
chr17_-_36906058 0.21 ENST00000580830.1
polycomb group ring finger 2
chr9_+_37079968 0.21 ENST00000588403.1
RP11-220I1.1
chr6_+_43739697 0.21 ENST00000230480.6
vascular endothelial growth factor A
chr19_-_14201507 0.21 ENST00000533683.2
sterile alpha motif domain containing 1
chr12_+_131438443 0.21 ENST00000261654.5
G protein-coupled receptor 133
chr4_+_175204818 0.20 ENST00000503780.1
centrosomal protein 44kDa
chr19_+_46498704 0.20 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
coiled-coil domain containing 61
chr20_+_35807512 0.19 ENST00000373622.5
ribophorin II
chr7_+_1022973 0.19 ENST00000340150.6
cytochrome P450, family 2, subfamily W, polypeptide 1
chr6_-_83775489 0.19 ENST00000369747.3
ubiquitin protein ligase E3D
chr20_+_35807449 0.18 ENST00000237530.6
ribophorin II
chr12_+_123717967 0.18 ENST00000536130.1
ENST00000546132.1
chromosome 12 open reading frame 65
chr14_-_57197224 0.18 ENST00000554597.1
ENST00000556696.1
Uncharacterized protein
chr18_-_18691739 0.17 ENST00000399799.2
Rho-associated, coiled-coil containing protein kinase 1
chr15_-_82824843 0.17 ENST00000560826.1
ENST00000559187.1
ENST00000330339.7
ribosomal protein S17
chr1_-_165738085 0.17 ENST00000464650.1
ENST00000392129.6
transmembrane and coiled-coil domains 1
chr11_+_71249071 0.16 ENST00000398534.3
keratin associated protein 5-8
chr20_+_35807714 0.16 ENST00000373632.4
ribophorin II
chr4_+_160203650 0.16 ENST00000514565.1
Rap guanine nucleotide exchange factor (GEF) 2
chr18_+_44497455 0.16 ENST00000592005.1
katanin p60 subunit A-like 2
chr12_+_54379569 0.15 ENST00000513209.1
RP11-834C11.12
chr16_-_30134441 0.14 ENST00000395200.1
mitogen-activated protein kinase 3
chr6_+_56819773 0.14 ENST00000370750.2
BEN domain containing 6
chrX_+_118602363 0.13 ENST00000317881.8
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr3_+_148415571 0.13 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
angiotensin II receptor, type 1
chr4_+_15683369 0.13 ENST00000503617.1
family with sequence similarity 200, member B
chr2_-_214017151 0.13 ENST00000452786.1
IKAROS family zinc finger 2 (Helios)
chr7_-_112758665 0.13 ENST00000397764.3
long intergenic non-protein coding RNA 998
chr18_+_56892724 0.13 ENST00000456142.3
ENST00000530323.1
gastrin-releasing peptide
chr1_+_47799542 0.12 ENST00000471289.2
ENST00000450808.2
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr4_+_15683404 0.11 ENST00000422728.2
family with sequence similarity 200, member B

Network of associatons between targets according to the STRING database.

First level regulatory network of HESX1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0007113 endomitotic cell cycle(GO:0007113)
0.6 1.9 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.5 2.6 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.5 2.7 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.4 2.8 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.4 8.8 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.3 1.3 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.3 55.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 0.9 GO:0033341 regulation of collagen binding(GO:0033341)
0.3 0.8 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 1.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.2 53.9 GO:0002377 immunoglobulin production(GO:0002377)
0.2 1.8 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.2 0.7 GO:0001694 histamine biosynthetic process(GO:0001694)
0.2 0.7 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.2 0.6 GO:0098502 DNA dephosphorylation(GO:0098502)
0.2 1.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.2 1.9 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 4.9 GO:0015671 oxygen transport(GO:0015671)
0.2 0.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 0.5 GO:0070377 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.2 1.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 3.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 2.0 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.8 GO:0061055 myotome development(GO:0061055)
0.1 0.6 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 2.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.5 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.2 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 1.0 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 1.5 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 0.7 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.5 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.8 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.4 GO:0044211 CTP salvage(GO:0044211)
0.1 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.4 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.1 GO:2000657 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.0 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 1.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 2.4 GO:0031648 protein destabilization(GO:0031648)
0.0 0.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 1.5 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.3 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.4 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.8 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.5 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.2 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 1.4 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.3 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.4 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0015853 adenine transport(GO:0015853)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 1.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 6.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.0 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 1.0 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 5.8 GO:0002250 adaptive immune response(GO:0002250)
0.0 1.0 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:0071294 cellular response to zinc ion(GO:0071294)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 GO:0005833 hemoglobin complex(GO:0005833)
0.2 5.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 10.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 0.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 0.5 GO:0001534 radial spoke(GO:0001534)
0.2 0.9 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 4.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 29.5 GO:0072562 blood microparticle(GO:0072562)
0.1 0.5 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.4 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.8 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.5 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.6 GO:0000243 commitment complex(GO:0000243)
0.0 0.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 3.3 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0071986 Ragulator complex(GO:0071986)
0.0 2.7 GO:0043195 terminal bouton(GO:0043195)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 59.5 GO:0005615 extracellular space(GO:0005615)
0.0 1.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0043218 compact myelin(GO:0043218)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0008021 synaptic vesicle(GO:0008021) exocytic vesicle(GO:0070382)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 1.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 0.9 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0005174 CD40 receptor binding(GO:0005174)
1.4 5.5 GO:0017129 triglyceride binding(GO:0017129)
0.7 2.1 GO:0005055 laminin receptor activity(GO:0005055)
0.4 99.9 GO:0003823 antigen binding(GO:0003823)
0.3 1.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 2.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.3 3.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.3 1.4 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.2 4.9 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 0.6 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.2 1.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.2 0.9 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.2 0.6 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 1.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.1 GO:0016015 morphogen activity(GO:0016015)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 1.0 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.3 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 1.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 2.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 1.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 2.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 6.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 3.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.7 GO:0008494 translation activator activity(GO:0008494)
0.0 0.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 3.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.0 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 2.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.9 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 ST GA12 PATHWAY G alpha 12 Pathway
0.0 2.8 PID P73PATHWAY p73 transcription factor network
0.0 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 1.9 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 3.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 1.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 4.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.5 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates