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Illumina Body Map 2, young vs old
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Results for HMGA1
Z-value: 0.01
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Transcription factors associated with HMGA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA1 | hg19_v2_chr6_+_34204642_34204664 | -0.17 | 3.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.0 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 12.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.4 | 8.0 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.9 | 7.4 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 7.2 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 6.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 6.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 5.6 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.5 | 5.5 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 4.7 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.4 | 11.0 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 9.1 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.4 | 7.4 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.4 | 6.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 6.3 | GO:0016605 | PML body(GO:0016605) |
| 1.0 | 5.9 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 5.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 5.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 4.7 | GO:0005916 | fascia adherens(GO:0005916) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.4 | 15.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 13.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 10.9 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.4 | 7.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 6.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 5.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.3 | 4.2 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 4.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 3.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 5.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 3.4 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 2.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 2.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 2.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.0 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 17.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 3.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 3.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.0 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 2.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.7 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 2.6 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |