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Illumina Body Map 2, young vs old

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Results for HMX1

Z-value: 0.23

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Transcription factors associated with HMX1

Gene Symbol Gene ID Gene Info
HMX1
ENSG00000215612.5 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMX1hg19_v2_chr4_-_8873531_88735430.076.9e-01Click!

Activity profile of HMX1 motif

Sorted Z-values of HMX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142326335 4.93 ENST00000390393.3
TRBV19
T cell receptor beta variable 19
chr7_+_50344289 4.02 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_204801471 3.96 ENST00000316386.6
ENST00000435193.1
ICOS
inducible T-cell co-stimulator
chr16_-_776431 3.05 ENST00000293889.6
CCDC78
coiled-coil domain containing 78
chr11_-_64815333 2.90 ENST00000533842.1
ENST00000532802.1
ENST00000530139.1
ENST00000526516.1
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr1_-_167059830 2.87 ENST00000367868.3
GPA33
glycoprotein A33 (transmembrane)
chr6_-_31550192 2.59 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr12_-_55378470 2.57 ENST00000524668.1
ENST00000533607.1
TESPA1
thymocyte expressed, positive selection associated 1
chr16_-_86542652 2.54 ENST00000599749.1
FENDRR
FOXF1 adjacent non-coding developmental regulatory RNA
chr16_+_28996364 2.53 ENST00000564277.1
LAT
linker for activation of T cells
chr7_-_16844611 2.48 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr1_-_25256368 2.45 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr13_+_43148281 2.39 ENST00000239849.6
ENST00000398795.2
ENST00000544862.1
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr11_-_128392085 2.39 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr20_+_30639991 2.30 ENST00000534862.1
ENST00000538448.1
ENST00000375862.2
HCK
hemopoietic cell kinase
chr20_+_30640004 2.24 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
HCK
hemopoietic cell kinase
chr11_+_45944190 2.24 ENST00000401752.1
ENST00000389968.3
ENST00000325468.5
ENST00000536139.1
GYLTL1B
glycosyltransferase-like 1B
chr22_-_37640277 2.23 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chrX_+_13587712 2.19 ENST00000361306.1
ENST00000380602.3
EGFL6
EGF-like-domain, multiple 6
chr16_-_86542455 2.18 ENST00000595886.1
ENST00000597578.1
ENST00000593604.1
FENDRR
FOXF1 adjacent non-coding developmental regulatory RNA
chr4_-_109087445 2.15 ENST00000512172.1
LEF1
lymphoid enhancer-binding factor 1
chr1_-_207095212 2.13 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr3_+_47021168 2.13 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
NBEAL2
neurobeachin-like 2
chr15_+_81489213 1.94 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr22_-_37640456 1.94 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr4_-_109087906 1.92 ENST00000515500.1
LEF1
lymphoid enhancer-binding factor 1
chr4_-_109087872 1.91 ENST00000510624.1
LEF1
lymphoid enhancer-binding factor 1
chr17_-_72709050 1.89 ENST00000583937.1
ENST00000301573.9
ENST00000326165.6
ENST00000469092.1
CD300LF
CD300 molecule-like family member f
chr2_-_175462456 1.89 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chrX_+_131157322 1.87 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr14_-_25103472 1.86 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr4_-_2420335 1.82 ENST00000503000.1
ZFYVE28
zinc finger, FYVE domain containing 28
chrX_+_131157290 1.81 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr16_+_28996416 1.80 ENST00000395456.2
ENST00000454369.2
LAT
linker for activation of T cells
chr17_-_8868991 1.80 ENST00000447110.1
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr19_-_45579762 1.75 ENST00000303809.2
ZNF296
zinc finger protein 296
chr11_+_826136 1.73 ENST00000528315.1
ENST00000533803.1
EFCAB4A
EF-hand calcium binding domain 4A
chr6_-_32157947 1.72 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr17_-_7165662 1.71 ENST00000571881.2
ENST00000360325.7
CLDN7
claudin 7
chrX_-_153599578 1.67 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chr14_-_25103388 1.67 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr12_-_55378452 1.66 ENST00000449076.1
TESPA1
thymocyte expressed, positive selection associated 1
chr16_+_11439286 1.66 ENST00000312499.5
ENST00000576027.1
RMI2
RecQ mediated genome instability 2
chr12_+_4382917 1.65 ENST00000261254.3
CCND2
cyclin D2
chr6_+_41606176 1.55 ENST00000441667.1
ENST00000230321.6
ENST00000373050.4
ENST00000446650.1
ENST00000435476.1
MDFI
MyoD family inhibitor
chr19_+_6464243 1.52 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chrX_+_47444613 1.48 ENST00000445623.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr19_-_2308127 1.48 ENST00000404279.1
LINGO3
leucine rich repeat and Ig domain containing 3
chr12_+_7060432 1.47 ENST00000318974.9
ENST00000456013.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr3_+_101546827 1.47 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr6_-_7911042 1.45 ENST00000379757.4
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr11_-_67275542 1.42 ENST00000531506.1
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr12_+_7060508 1.42 ENST00000541698.1
ENST00000542462.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_-_42418999 1.41 ENST00000340840.2
ENST00000354325.2
TRERF1
transcriptional regulating factor 1
chr12_+_7060414 1.41 ENST00000538715.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_+_74381343 1.39 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr2_-_175462934 1.39 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr16_-_67190152 1.37 ENST00000486556.1
TRADD
TNFRSF1A-associated via death domain
chr15_-_38852251 1.37 ENST00000558432.1
RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr11_-_417308 1.32 ENST00000397632.3
ENST00000382520.2
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr16_+_28996572 1.30 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
LAT
linker for activation of T cells
chr9_-_130331297 1.29 ENST00000373312.3
FAM129B
family with sequence similarity 129, member B
chr5_-_158636512 1.28 ENST00000424310.2
RNF145
ring finger protein 145
chr14_-_55369525 1.26 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GCH1
GTP cyclohydrolase 1
chr12_+_57482665 1.23 ENST00000300131.3
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr16_+_50280020 1.22 ENST00000564965.1
ADCY7
adenylate cyclase 7
chr19_-_46526304 1.22 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr2_+_203499901 1.20 ENST00000303116.6
ENST00000392238.2
FAM117B
family with sequence similarity 117, member B
chr2_-_219925189 1.20 ENST00000295731.6
IHH
indian hedgehog
chr1_-_207095324 1.19 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr2_+_10091783 1.15 ENST00000324883.5
GRHL1
grainyhead-like 1 (Drosophila)
chr7_+_130131907 1.15 ENST00000223215.4
ENST00000437945.1
MEST
mesoderm specific transcript
chr5_-_81046841 1.15 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2
single-stranded DNA binding protein 2
chr15_+_90611465 1.15 ENST00000559360.1
ZNF710
zinc finger protein 710
chr17_-_79876010 1.14 ENST00000328666.6
SIRT7
sirtuin 7
chr13_+_42031679 1.14 ENST00000379359.3
RGCC
regulator of cell cycle
chr4_-_2420357 1.14 ENST00000511071.1
ENST00000509171.1
ENST00000290974.2
ZFYVE28
zinc finger, FYVE domain containing 28
chr2_+_10091815 1.13 ENST00000324907.9
GRHL1
grainyhead-like 1 (Drosophila)
chr6_+_33043703 1.12 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_-_49066811 1.12 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr1_-_201476274 1.11 ENST00000340006.2
CSRP1
cysteine and glycine-rich protein 1
chr8_-_67525473 1.11 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr8_-_67525524 1.10 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr17_-_8151353 1.09 ENST00000315684.8
CTC1
CTS telomere maintenance complex component 1
chr22_-_39268308 1.09 ENST00000407418.3
CBX6
chromobox homolog 6
chr17_-_79212884 1.08 ENST00000300714.3
ENTHD2
ENTH domain containing 2
chr2_+_30454390 1.08 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH
limb bud and heart development
chr5_-_81046904 1.07 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr7_-_127672146 1.06 ENST00000476782.1
LRRC4
leucine rich repeat containing 4
chr5_+_141016508 1.04 ENST00000444782.1
ENST00000521367.1
ENST00000297164.3
RELL2
RELT-like 2
chr9_-_131940526 1.04 ENST00000372491.2
IER5L
immediate early response 5-like
chr19_-_52227221 1.01 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr11_-_417388 1.01 ENST00000332725.3
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_+_156030937 1.00 ENST00000361084.5
RAB25
RAB25, member RAS oncogene family
chr17_+_74723031 0.99 ENST00000586200.1
METTL23
methyltransferase like 23
chr19_+_1407517 0.99 ENST00000336761.6
ENST00000233078.4
DAZAP1
DAZ associated protein 1
chr4_-_80993854 0.98 ENST00000346652.6
ANTXR2
anthrax toxin receptor 2
chr5_-_81046922 0.98 ENST00000514493.1
ENST00000320672.4
SSBP2
single-stranded DNA binding protein 2
chr17_-_78450398 0.97 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr2_-_192016276 0.96 ENST00000413064.1
STAT4
signal transducer and activator of transcription 4
chr17_-_27278304 0.95 ENST00000577226.1
PHF12
PHD finger protein 12
chr21_-_36259445 0.94 ENST00000399240.1
RUNX1
runt-related transcription factor 1
chr22_+_37447771 0.94 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr2_-_74776586 0.94 ENST00000420535.1
LOXL3
lysyl oxidase-like 3
chr7_+_12726623 0.93 ENST00000439721.1
ARL4A
ADP-ribosylation factor-like 4A
chr13_-_76111945 0.93 ENST00000355801.4
ENST00000406936.3
COMMD6
COMM domain containing 6
chr2_-_233352531 0.92 ENST00000304546.1
ECEL1
endothelin converting enzyme-like 1
chr4_-_80993717 0.92 ENST00000307333.7
ANTXR2
anthrax toxin receptor 2
chr16_+_30210552 0.91 ENST00000338971.5
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr8_+_77318769 0.90 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr2_-_101925055 0.90 ENST00000295317.3
RNF149
ring finger protein 149
chr3_+_127391769 0.90 ENST00000393363.3
ENST00000232744.8
ENST00000453791.2
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr22_-_29196511 0.89 ENST00000344347.5
XBP1
X-box binding protein 1
chr11_+_129245796 0.89 ENST00000281437.4
BARX2
BARX homeobox 2
chr1_-_154946825 0.88 ENST00000368453.4
ENST00000368450.1
ENST00000366442.2
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr19_+_6464502 0.87 ENST00000308243.7
CRB3
crumbs homolog 3 (Drosophila)
chr4_-_177713788 0.87 ENST00000280193.2
VEGFC
vascular endothelial growth factor C
chr13_-_38443860 0.86 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4
transient receptor potential cation channel, subfamily C, member 4
chr3_-_13461807 0.86 ENST00000254508.5
NUP210
nucleoporin 210kDa
chr16_+_30212378 0.85 ENST00000569485.1
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr7_-_150675372 0.85 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr12_-_49318715 0.85 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa
chr10_-_99531709 0.85 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr3_+_5020801 0.83 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr12_+_57482877 0.81 ENST00000342556.6
ENST00000357680.4
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr6_+_33359582 0.81 ENST00000450504.1
KIFC1
kinesin family member C1
chr16_+_29472707 0.81 ENST00000565290.1
SULT1A4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
chr14_+_31343747 0.81 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
COCH
cochlin
chr17_+_77751931 0.81 ENST00000310942.4
ENST00000269399.5
CBX2
chromobox homolog 2
chr17_-_27278445 0.80 ENST00000268756.3
ENST00000584685.1
PHF12
PHD finger protein 12
chr22_-_39096661 0.79 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr22_-_39096925 0.79 ENST00000456626.1
ENST00000412832.1
JOSD1
Josephin domain containing 1
chr1_+_110163709 0.78 ENST00000369840.2
ENST00000527846.1
AMPD2
adenosine monophosphate deaminase 2
chr22_-_39268192 0.78 ENST00000216083.6
CBX6
chromobox homolog 6
chr14_+_31343951 0.78 ENST00000556908.1
ENST00000555881.1
ENST00000460581.2
COCH
cochlin
chr3_-_52312337 0.78 ENST00000469000.1
WDR82
WD repeat domain 82
chr5_+_176784837 0.78 ENST00000408923.3
RGS14
regulator of G-protein signaling 14
chr6_+_30524663 0.78 ENST00000376560.3
PRR3
proline rich 3
chr1_+_154947126 0.77 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr1_-_154946792 0.77 ENST00000412170.1
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_+_154947148 0.77 ENST00000368436.1
ENST00000308987.5
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr16_-_88752889 0.76 ENST00000332281.5
SNAI3
snail family zinc finger 3
chr1_+_150522222 0.75 ENST00000369039.5
ADAMTSL4
ADAMTS-like 4
chr5_+_141016969 0.75 ENST00000518856.1
RELL2
RELT-like 2
chr1_-_201476220 0.74 ENST00000526723.1
ENST00000524951.1
CSRP1
cysteine and glycine-rich protein 1
chr22_-_29196546 0.74 ENST00000403532.3
ENST00000216037.6
XBP1
X-box binding protein 1
chr10_+_72432559 0.74 ENST00000373208.1
ENST00000373207.1
ADAMTS14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr22_-_39096981 0.74 ENST00000427389.1
JOSD1
Josephin domain containing 1
chr1_+_110163202 0.74 ENST00000531203.1
ENST00000256578.3
AMPD2
adenosine monophosphate deaminase 2
chr12_+_112451222 0.74 ENST00000552052.1
ERP29
endoplasmic reticulum protein 29
chr6_-_2245892 0.74 ENST00000380815.4
GMDS
GDP-mannose 4,6-dehydratase
chr4_-_11430221 0.72 ENST00000514690.1
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr17_+_40440481 0.71 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr19_+_41305406 0.71 ENST00000406058.2
ENST00000593726.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr1_+_150521876 0.70 ENST00000369041.5
ENST00000271643.4
ENST00000538795.1
ADAMTSL4
AL356356.1
ADAMTS-like 4
Protein LOC100996516
chr17_-_6947225 0.70 ENST00000574600.1
ENST00000308009.1
ENST00000447225.1
SLC16A11
solute carrier family 16, member 11
chr1_+_110163682 0.69 ENST00000358729.4
AMPD2
adenosine monophosphate deaminase 2
chr19_-_42721819 0.69 ENST00000336034.4
ENST00000598200.1
ENST00000598727.1
ENST00000596251.1
DEDD2
death effector domain containing 2
chr15_-_41166414 0.69 ENST00000220507.4
RHOV
ras homolog family member V
chr19_-_10697895 0.68 ENST00000591240.1
ENST00000589684.1
ENST00000591676.1
ENST00000250244.6
ENST00000590923.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr7_-_132261253 0.67 ENST00000321063.4
PLXNA4
plexin A4
chr14_+_56585048 0.67 ENST00000267460.4
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr1_+_110162448 0.67 ENST00000342115.4
ENST00000469039.2
ENST00000474459.1
ENST00000528667.1
AMPD2
adenosine monophosphate deaminase 2
chr17_-_62097927 0.67 ENST00000578313.1
ENST00000584084.1
ENST00000579788.1
ENST00000579687.1
ENST00000578379.1
ENST00000578892.1
ENST00000412356.1
ENST00000418105.1
ICAM2
intercellular adhesion molecule 2
chrX_-_100914781 0.67 ENST00000431597.1
ENST00000458024.1
ENST00000413506.1
ENST00000440675.1
ENST00000328766.5
ENST00000356824.4
ARMCX2
armadillo repeat containing, X-linked 2
chr19_+_1407733 0.66 ENST00000592453.1
DAZAP1
DAZ associated protein 1
chr19_+_41305612 0.65 ENST00000594380.1
ENST00000593397.1
ENST00000601733.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr3_-_128840604 0.65 ENST00000476465.1
ENST00000315150.5
ENST00000393304.1
ENST00000393308.1
ENST00000393307.1
ENST00000393305.1
RAB43
RAB43, member RAS oncogene family
chr14_+_23564700 0.65 ENST00000554203.1
C14orf119
chromosome 14 open reading frame 119
chr17_+_40440094 0.65 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr3_-_194119083 0.65 ENST00000401815.1
GP5
glycoprotein V (platelet)
chr20_+_44098385 0.65 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr14_+_52164675 0.65 ENST00000555936.1
FRMD6
FERM domain containing 6
chr22_-_32022280 0.64 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr9_-_136024721 0.64 ENST00000393160.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr1_+_29241027 0.64 ENST00000373797.1
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_-_10687907 0.63 ENST00000589348.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_+_41305627 0.62 ENST00000593525.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr7_-_132261223 0.61 ENST00000423507.2
PLXNA4
plexin A4
chr14_+_56584414 0.61 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr20_+_44098346 0.61 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr3_-_107941230 0.60 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr1_-_54405773 0.60 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr1_+_226411319 0.60 ENST00000542034.1
ENST00000366810.5
MIXL1
Mix paired-like homeobox
chr14_+_90422239 0.59 ENST00000393452.3
ENST00000554180.1
ENST00000393454.2
ENST00000553617.1
ENST00000335725.4
ENST00000357382.3
ENST00000556867.1
ENST00000553527.1
TDP1
tyrosyl-DNA phosphodiesterase 1
chr9_+_100000717 0.59 ENST00000375205.2
ENST00000357054.1
ENST00000395220.1
ENST00000375202.2
ENST00000411667.2
CCDC180
coiled-coil domain containing 180
chr5_-_180230830 0.58 ENST00000427865.2
ENST00000514283.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr12_-_49365501 0.58 ENST00000403957.1
ENST00000301061.4
WNT10B
wingless-type MMTV integration site family, member 10B
chr15_-_79103757 0.57 ENST00000388820.4
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr8_-_74005349 0.57 ENST00000297354.6
SBSPON
somatomedin B and thrombospondin, type 1 domain containing
chrX_-_20284958 0.57 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr18_-_45935663 0.56 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
ZBTB7C
zinc finger and BTB domain containing 7C
chr4_+_2420659 0.55 ENST00000382849.2
RP11-503N18.1
RP11-503N18.1
chr19_+_41305740 0.55 ENST00000596517.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr16_+_67226019 0.55 ENST00000379378.3
E2F4
E2F transcription factor 4, p107/p130-binding
chr22_-_29196030 0.55 ENST00000405219.3
XBP1
X-box binding protein 1
chr11_-_65308082 0.55 ENST00000532661.1
LTBP3
latent transforming growth factor beta binding protein 3
chr1_-_153949751 0.54 ENST00000428469.1
JTB
jumping translocation breakpoint
chr2_-_192015697 0.54 ENST00000409995.1
STAT4
signal transducer and activator of transcription 4
chr5_+_148206156 0.54 ENST00000305988.4
ADRB2
adrenoceptor beta 2, surface

Network of associatons between targets according to the STRING database.

First level regulatory network of HMX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.9 6.0 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.8 2.4 GO:0051466 positive regulation of corticotropin-releasing hormone secretion(GO:0051466) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.7 2.2 GO:1903489 epithelial cell differentiation involved in salivary gland development(GO:0060690) epithelial cell maturation involved in salivary gland development(GO:0060691) regulation of plasma cell differentiation(GO:1900098) positive regulation of plasma cell differentiation(GO:1900100) positive regulation of lactation(GO:1903489)
0.7 4.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.6 1.9 GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214)
0.6 4.2 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.6 0.6 GO:0051885 positive regulation of anagen(GO:0051885)
0.6 1.7 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.5 2.5 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.5 1.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.5 5.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.4 3.5 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4 1.3 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.4 1.2 GO:0032827 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.4 1.2 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.3 2.0 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.3 3.0 GO:0098535 de novo centriole assembly(GO:0098535)
0.3 2.3 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.3 1.3 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.3 1.3 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.3 2.5 GO:2000035 regulation of stem cell division(GO:2000035)
0.3 2.4 GO:0030578 PML body organization(GO:0030578)
0.3 2.6 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.3 1.1 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.3 1.1 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.3 0.9 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.3 2.9 GO:0032264 IMP salvage(GO:0032264)
0.3 1.0 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 3.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 1.8 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 0.7 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.2 4.0 GO:0002517 T cell tolerance induction(GO:0002517)
0.2 1.4 GO:0032252 secretory granule localization(GO:0032252)
0.2 1.4 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 0.9 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 0.7 GO:0042351 'de novo' GDP-L-fucose biosynthetic process(GO:0042351)
0.2 1.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 0.5 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.2 0.5 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.2 0.5 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 1.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 0.5 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.7 GO:0043335 protein unfolding(GO:0043335)
0.1 2.0 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 0.6 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 1.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 1.2 GO:0003383 apical constriction(GO:0003383)
0.1 3.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.4 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 0.6 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 1.1 GO:0048539 bone marrow development(GO:0048539)
0.1 0.8 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 0.7 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 2.3 GO:0002934 desmosome organization(GO:0002934)
0.1 1.9 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 3.4 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.4 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.1 0.5 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 0.7 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.1 0.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 1.4 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 0.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.5 GO:0003418 growth plate cartilage chondrocyte differentiation(GO:0003418)
0.1 1.3 GO:0035878 nail development(GO:0035878)
0.1 5.6 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1 0.4 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 1.2 GO:0007498 mesoderm development(GO:0007498)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.4 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.1 0.3 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 1.7 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 1.5 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.1 1.0 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.1 0.6 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 0.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.5 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.1 0.9 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 0.4 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.7 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.1 0.1 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.0 1.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 1.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.0 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 1.7 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.6 GO:0000012 single strand break repair(GO:0000012)
0.0 0.8 GO:0070986 left/right axis specification(GO:0070986)
0.0 1.7 GO:0000732 strand displacement(GO:0000732)
0.0 0.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.0 1.4 GO:0030220 platelet formation(GO:0030220)
0.0 0.3 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.8 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.6 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 2.3 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250) toll-like receptor 2 signaling pathway(GO:0034134)
0.0 1.9 GO:1901998 toxin transport(GO:1901998)
0.0 1.1 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 1.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.5 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.6 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 1.6 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.0 GO:1904351 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.0 0.2 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.6 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.9 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 3.5 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 1.8 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.8 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334) cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 1.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)
0.0 0.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.7 GO:0030262 cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 1.5 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.2 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.8 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.5 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 1.6 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.1 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.2 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.4 3.0 GO:0098536 deuterosome(GO:0098536)
0.4 6.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.4 1.7 GO:0031523 Myb complex(GO:0031523)
0.3 4.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 4.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 1.7 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 1.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.2 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.2 0.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 0.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 7.0 GO:0042629 mast cell granule(GO:0042629)
0.1 0.7 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 1.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.2 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 1.1 GO:0044292 dendrite terminus(GO:0044292)
0.1 1.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 1.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 4.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.2 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.1 GO:0001772 immunological synapse(GO:0001772)
0.0 3.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 1.0 GO:0031143 pseudopodium(GO:0031143)
0.0 4.3 GO:0005901 caveola(GO:0005901)
0.0 1.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 1.9 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.3 GO:0008305 integrin complex(GO:0008305)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 3.4 GO:0005604 basement membrane(GO:0005604)
0.0 2.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 9.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 2.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.8 GO:0034702 ion channel complex(GO:0034702)
0.0 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 1.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.4 1.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 6.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.3 1.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.3 1.8 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.3 2.9 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 1.1 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.2 1.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 1.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 1.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 1.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 3.1 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 1.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 0.6 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.2 1.7 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 0.5 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.1 2.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.6 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 1.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 1.1 GO:0043426 MRF binding(GO:0043426)
0.1 0.6 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 6.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.3 GO:0005522 profilin binding(GO:0005522)
0.1 0.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 7.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.9 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.6 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 1.2 GO:0005113 patched binding(GO:0005113)
0.1 1.3 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 2.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 2.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 2.9 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.2 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 0.2 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 1.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.5 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 3.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.4 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.2 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
0.1 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.3 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 1.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 4.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.1 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.3 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 3.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 2.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 2.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 5.2 GO:0000988 transcription factor activity, protein binding(GO:0000988) transcription factor activity, transcription factor binding(GO:0000989)
0.0 0.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 2.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.0 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 8.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 6.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 7.3 PID EPO PATHWAY EPO signaling pathway
0.1 3.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 1.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.5 PID IL27 PATHWAY IL27-mediated signaling events
0.1 0.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 4.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 4.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 3.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 4.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.4 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 3.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 4.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 2.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 8.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 2.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 3.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 5.1 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 3.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 2.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.8 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 4.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.1 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 2.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion