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Illumina Body Map 2, young vs old

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Results for HOXB3

Z-value: 0.53

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Transcription factors associated with HOXB3

Gene Symbol Gene ID Gene Info
ENSG00000120093.7 homeobox B3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB3hg19_v2_chr17_-_46667594_466676190.327.8e-02Click!

Activity profile of HOXB3 motif

Sorted Z-values of HOXB3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_89160770 7.43 ENST00000390240.2
immunoglobulin kappa joining 3
chr2_-_89161432 7.19 ENST00000390242.2
immunoglobulin kappa joining 1
chr2_-_89161064 6.47 ENST00000390241.2
immunoglobulin kappa joining 2
chr12_-_123201337 5.46 ENST00000528880.2
hydroxycarboxylic acid receptor 3
chr15_-_44969022 5.14 ENST00000560110.1
protein associated with topoisomerase II homolog 2 (yeast)
chr14_-_106494587 4.91 ENST00000390597.2
immunoglobulin heavy variable 2-5
chr12_-_123187890 4.31 ENST00000328880.5
hydroxycarboxylic acid receptor 2
chr2_+_90043607 4.26 ENST00000462693.1
immunoglobulin kappa variable 2D-24 (non-functional)
chr2_-_89476644 4.12 ENST00000484817.1
immunoglobulin kappa variable 2-24
chr1_+_81106951 3.91 ENST00000443565.1
RP5-887A10.1
chr21_+_43823983 3.87 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
ubiquitin associated and SH3 domain containing A
chr19_+_17638059 3.62 ENST00000599164.1
ENST00000449408.2
ENST00000600871.1
ENST00000599124.1
family with sequence similarity 129, member C
chr14_+_22564294 3.52 ENST00000390452.2
T cell receptor delta variable 1
chr22_+_22730353 3.50 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr14_+_22465771 3.24 ENST00000390445.2
T cell receptor alpha variable 17
chr2_+_89999259 3.22 ENST00000558026.1
immunoglobulin kappa variable 2D-28
chr15_-_44969086 3.22 ENST00000434130.1
ENST00000560780.1
protein associated with topoisomerase II homolog 2 (yeast)
chr2_+_89184868 3.19 ENST00000390243.2
immunoglobulin kappa variable 4-1
chr11_-_118083600 3.17 ENST00000524477.1
adhesion molecule, interacts with CXADR antigen 1
chr4_-_25865159 2.97 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chrX_+_135730373 2.94 ENST00000370628.2
CD40 ligand
chr2_+_90077680 2.92 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr14_-_107179265 2.76 ENST00000390634.2
immunoglobulin heavy variable 2-70
chr19_+_17638041 2.74 ENST00000601861.1
family with sequence similarity 129, member C
chr4_+_40198527 2.71 ENST00000381799.5
ras homolog family member H
chrX_+_135730297 2.71 ENST00000370629.2
CD40 ligand
chr3_+_114012819 2.70 ENST00000383671.3
T cell immunoreceptor with Ig and ITIM domains
chr7_+_142353445 2.68 ENST00000390396.1
T cell receptor beta variable 23-1 (non-functional)
chr16_+_12059050 2.66 ENST00000396495.3
tumor necrosis factor receptor superfamily, member 17
chr14_+_22180536 2.51 ENST00000390424.2
T cell receptor alpha variable 2
chr1_-_206671061 2.25 ENST00000367119.1
chromosome 1 open reading frame 147
chr1_+_222910538 2.24 ENST00000434700.1
ENST00000445590.2
family with sequence similarity 177, member B
chr16_+_31366536 2.16 ENST00000562522.1
integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_-_151047327 2.16 ENST00000325602.5
purinergic receptor P2Y, G-protein coupled, 13
chr14_+_22320634 2.13 ENST00000390435.1
T cell receptor alpha variable 8-3
chr11_-_107729287 2.09 ENST00000375682.4
solute carrier family 35, member F2
chr3_-_39321512 2.08 ENST00000399220.2
chemokine (C-X3-C motif) receptor 1
chrX_-_70326455 2.04 ENST00000374251.5
chromosome X open reading frame 65
chr14_-_106926724 2.03 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr11_-_107729504 2.01 ENST00000265836.7
solute carrier family 35, member F2
chr2_+_87769459 2.00 ENST00000414030.1
ENST00000437561.1
long intergenic non-protein coding RNA 152
chr22_-_32651326 1.90 ENST00000266086.4
solute carrier family 5 (glucose activated ion channel), member 4
chr1_+_222910625 1.86 ENST00000360827.2
family with sequence similarity 177, member B
chr11_-_107729887 1.85 ENST00000525815.1
solute carrier family 35, member F2
chr12_-_8088773 1.85 ENST00000544291.1
solute carrier family 2 (facilitated glucose transporter), member 3
chr11_+_63273811 1.83 ENST00000340246.5
lectin, galactoside-binding, soluble, 12
chr3_+_121774202 1.82 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr4_+_86525299 1.81 ENST00000512201.1
Rho GTPase activating protein 24
chr17_+_72595971 1.77 ENST00000581412.1
CTD-2006K23.1
chr18_+_61554932 1.71 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr14_+_61654271 1.60 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
protein kinase C, eta
chr3_-_130745403 1.58 ENST00000504725.1
ENST00000509060.1
asteroid homolog 1 (Drosophila)
chr2_-_112237835 1.57 ENST00000442293.1
ENST00000439494.1
MIR4435-1 host gene (non-protein coding)
chr17_-_8770956 1.53 ENST00000311434.9
phosphoinositide-3-kinase, regulatory subunit 6
chr6_-_116866773 1.52 ENST00000368602.3
trafficking protein particle complex 3-like
chr11_-_104827425 1.49 ENST00000393150.3
caspase 4, apoptosis-related cysteine peptidase
chr8_+_92261516 1.49 ENST00000276609.3
ENST00000309536.2
solute carrier family 26 (anion exchanger), member 7
chr20_+_58571419 1.47 ENST00000244049.3
ENST00000350849.6
ENST00000456106.1
cadherin 26
chr12_-_8088871 1.47 ENST00000075120.7
solute carrier family 2 (facilitated glucose transporter), member 3
chr15_-_55562479 1.43 ENST00000564609.1
RAB27A, member RAS oncogene family
chr11_-_104905840 1.43 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
caspase 1, apoptosis-related cysteine peptidase
chr15_-_55563072 1.42 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A, member RAS oncogene family
chr19_-_54824344 1.38 ENST00000346508.3
ENST00000446712.3
ENST00000432233.3
ENST00000301219.3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr1_+_161691353 1.37 ENST00000367948.2
Fc receptor-like B
chr7_-_92777606 1.37 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr17_+_62223320 1.36 ENST00000580828.1
ENST00000582965.1
small nucleolar RNA, H/ACA box 76
chr16_+_50730910 1.36 ENST00000300589.2
nucleotide-binding oligomerization domain containing 2
chr6_-_62996066 1.35 ENST00000281156.4
KH domain containing, RNA binding, signal transduction associated 2
chr15_-_55562582 1.35 ENST00000396307.2
RAB27A, member RAS oncogene family
chr12_+_56522001 1.29 ENST00000267113.4
ENST00000541590.1
extended synaptotagmin-like protein 1
chr12_+_56521840 1.27 ENST00000394048.5
extended synaptotagmin-like protein 1
chr14_+_22947861 1.27 ENST00000390482.1
T cell receptor alpha joining 57
chr11_-_104817919 1.26 ENST00000533252.1
caspase 4, apoptosis-related cysteine peptidase
chr18_+_61557781 1.25 ENST00000443281.1
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr9_+_125132803 1.22 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr15_-_55562451 1.21 ENST00000568803.1
RAB27A, member RAS oncogene family
chr11_+_5710919 1.20 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr17_-_8113542 1.20 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
aurora kinase B
chr17_-_62208169 1.18 ENST00000606895.1
endoplasmic reticulum to nucleus signaling 1
chr5_+_148737562 1.15 ENST00000274569.4
prenylcysteine oxidase 1 like
chr12_-_10022735 1.14 ENST00000228438.2
C-type lectin domain family 2, member B
chr1_-_21620877 1.13 ENST00000527991.1
endothelin converting enzyme 1
chr11_-_26593677 1.13 ENST00000527569.1
mucin 15, cell surface associated
chr19_+_1077393 1.11 ENST00000590577.1
histocompatibility (minor) HA-1
chr21_-_15918618 1.11 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr20_-_56647116 1.11 ENST00000441277.2
ENST00000452842.1
RP13-379L11.1
chr6_+_130339710 1.09 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr17_-_73258425 1.08 ENST00000578348.1
ENST00000582486.1
ENST00000582717.1
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr12_+_66582919 1.08 ENST00000545837.1
ENST00000457197.2
interleukin-1 receptor-associated kinase 3
chr9_+_125133315 1.05 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_-_33102338 1.04 ENST00000610140.1
5'-nucleotidase, cytosolic IIIA
chr14_+_100485712 1.04 ENST00000544450.2
Enah/Vasp-like
chr1_+_158978768 1.04 ENST00000447473.2
interferon, gamma-inducible protein 16
chr7_-_33102399 1.03 ENST00000242210.7
5'-nucleotidase, cytosolic IIIA
chr7_+_30589829 1.03 ENST00000579437.1
RP4-777O23.1
chr8_+_92114060 1.01 ENST00000518304.1
leucine rich repeat containing 69
chr12_+_55248289 1.01 ENST00000308796.6
mucin-like 1
chr16_-_21431078 1.00 ENST00000458643.2
nuclear pore complex interacting protein family, member B3
chr19_+_49990811 0.99 ENST00000391857.4
ENST00000467825.2
ribosomal protein L13a
chr11_-_13517565 0.99 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr4_-_111563279 0.97 ENST00000511837.1
paired-like homeodomain 2
chr2_-_101925055 0.97 ENST00000295317.3
ring finger protein 149
chr2_+_143635222 0.95 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
kynureninase
chr8_+_27169138 0.93 ENST00000522338.1
protein tyrosine kinase 2 beta
chr10_-_4285835 0.92 ENST00000454470.1
long intergenic non-protein coding RNA 702
chr9_-_125590818 0.92 ENST00000259467.4
phosducin-like
chr11_+_47293795 0.91 ENST00000422579.1
MAP-kinase activating death domain
chr4_-_40632881 0.90 ENST00000511598.1
RNA binding motif protein 47
chrX_-_21676442 0.89 ENST00000379499.2
kelch-like family member 34
chr15_+_64680003 0.89 ENST00000261884.3
thyroid hormone receptor interactor 4
chr14_+_23002427 0.86 ENST00000390527.1
T cell receptor alpha joining 10
chr14_+_56584414 0.85 ENST00000559044.1
pellino E3 ubiquitin protein ligase family member 2
chr7_-_55620433 0.85 ENST00000418904.1
vesicular, overexpressed in cancer, prosurvival protein 1
chr11_-_96076334 0.85 ENST00000524717.1
mastermind-like 2 (Drosophila)
chr14_-_24711764 0.84 ENST00000557921.1
ENST00000558476.1
TERF1 (TRF1)-interacting nuclear factor 2
chr6_+_26501449 0.83 ENST00000244513.6
butyrophilin, subfamily 1, member A1
chr2_+_172309634 0.83 ENST00000339506.3
DDB1 and CUL4 associated factor 17
chr11_+_121447469 0.83 ENST00000532694.1
ENST00000534286.1
sortilin-related receptor, L(DLR class) A repeats containing
chr4_-_164534657 0.82 ENST00000339875.5
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr13_-_30160925 0.81 ENST00000450494.1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr16_+_12059091 0.81 ENST00000562385.1
tumor necrosis factor receptor superfamily, member 17
chr3_-_112564797 0.81 ENST00000398214.1
ENST00000448932.1
CD200 receptor 1-like
chr7_-_99716914 0.80 ENST00000431404.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr14_+_57671888 0.80 ENST00000391612.1
AL391152.1
chr9_-_3489406 0.79 ENST00000457373.1
regulatory factor X, 3 (influences HLA class II expression)
chr6_+_26045603 0.78 ENST00000540144.1
histone cluster 1, H3c
chr11_-_124981475 0.78 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr4_-_109541539 0.78 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34 antisense RNA 1 (head to head)
chr18_-_44181442 0.77 ENST00000398722.4
lipoxygenase homology domains 1
chr12_-_10605929 0.77 ENST00000347831.5
ENST00000359151.3
killer cell lectin-like receptor subfamily C, member 1
chr4_-_40632844 0.77 ENST00000505414.1
RNA binding motif protein 47
chr9_+_131062367 0.76 ENST00000601297.1
CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr17_-_57229155 0.75 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr19_+_9296279 0.75 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chr14_-_24711470 0.75 ENST00000559969.1
TERF1 (TRF1)-interacting nuclear factor 2
chr4_-_111563076 0.74 ENST00000354925.2
ENST00000511990.1
paired-like homeodomain 2
chr4_-_120243545 0.74 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr16_-_21868739 0.73 ENST00000415645.2
nuclear pore complex interacting protein family, member B4
chr19_-_3985455 0.73 ENST00000309311.6
eukaryotic translation elongation factor 2
chr3_-_130745571 0.73 ENST00000514044.1
ENST00000264992.3
asteroid homolog 1 (Drosophila)
chr1_+_28261492 0.72 ENST00000373894.3
sphingomyelin phosphodiesterase, acid-like 3B
chr4_-_74486109 0.72 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_21625486 0.71 ENST00000481130.2
endothelin converting enzyme 1
chr2_+_138722028 0.69 ENST00000280096.5
histamine N-methyltransferase
chr17_-_40337470 0.69 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr20_-_55100981 0.68 ENST00000243913.4
glucosaminyl (N-acetyl) transferase family member 7
chr13_+_73632897 0.68 ENST00000377687.4
Kruppel-like factor 5 (intestinal)
chr1_+_46972668 0.67 ENST00000371956.4
ENST00000360032.3
diencephalon/mesencephalon homeobox 1
chr2_+_143635067 0.67 ENST00000264170.4
kynureninase
chr4_-_19458597 0.67 ENST00000505347.1
RP11-3J1.1
chr8_+_27168988 0.67 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
protein tyrosine kinase 2 beta
chr11_-_59950622 0.66 ENST00000323961.3
ENST00000412309.2
membrane-spanning 4-domains, subfamily A, member 6A
chr16_-_21868978 0.66 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
nuclear pore complex interacting protein family, member B4
chr19_+_48949030 0.66 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr1_+_24019099 0.66 ENST00000443624.1
ENST00000458455.1
ribosomal protein L11
chrX_+_77166172 0.65 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr14_-_24711806 0.64 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TERF1 (TRF1)-interacting nuclear factor 2
chr3_-_185538849 0.63 ENST00000421047.2
insulin-like growth factor 2 mRNA binding protein 2
chr7_+_129015484 0.63 ENST00000490911.1
adenosylhomocysteinase-like 2
chr8_-_623547 0.62 ENST00000522893.1
glutamate-rich 1
chr1_+_192605252 0.62 ENST00000391995.2
ENST00000543215.1
regulator of G-protein signaling 13
chr5_+_150639360 0.62 ENST00000523004.1
GM2 ganglioside activator
chr16_-_30257122 0.61 ENST00000520915.1
Putative NPIP-like protein LOC613037
chrX_+_10031499 0.61 ENST00000454666.1
WWC family member 3
chr1_+_79115503 0.61 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr2_-_70780572 0.61 ENST00000450929.1
transforming growth factor, alpha
chr16_-_21436459 0.61 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
nuclear pore complex interacting protein family, member B3
chr14_-_24711865 0.61 ENST00000399423.4
ENST00000267415.7
TERF1 (TRF1)-interacting nuclear factor 2
chr7_+_99717230 0.60 ENST00000262932.3
canopy FGF signaling regulator 4
chr17_-_44657017 0.59 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ADP-ribosylation factor-like 17A
chr19_+_48949087 0.59 ENST00000598711.1
glutamate-rich WD repeat containing 1
chr11_-_26593779 0.59 ENST00000529533.1
mucin 15, cell surface associated
chr19_+_36632485 0.59 ENST00000586963.1
calpain, small subunit 1
chr2_+_28618532 0.59 ENST00000545753.1
FOS-like antigen 2
chr8_+_32579271 0.58 ENST00000518084.1
neuregulin 1
chr11_-_59950486 0.57 ENST00000426738.2
ENST00000533023.1
ENST00000420732.2
membrane-spanning 4-domains, subfamily A, member 6A
chr16_-_29415350 0.56 ENST00000524087.1
nuclear pore complex interacting protein family, member B11
chr7_-_99764907 0.56 ENST00000413800.1
galactose-3-O-sulfotransferase 4
chr14_-_90085458 0.56 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
forkhead box N3
chr16_-_3350614 0.55 ENST00000268674.2
tigger transposable element derived 7
chr2_+_172778952 0.55 ENST00000392584.1
ENST00000264108.4
histone acetyltransferase 1
chr1_+_159750776 0.54 ENST00000368107.1
dual specificity phosphatase 23
chr11_-_63439013 0.54 ENST00000398868.3
atlastin GTPase 3
chr11_-_59950519 0.53 ENST00000528851.1
membrane-spanning 4-domains, subfamily A, member 6A
chr6_-_32095968 0.53 ENST00000375203.3
ENST00000375201.4
activating transcription factor 6 beta
chr19_-_3557570 0.53 ENST00000355415.2
major facilitator superfamily domain containing 12
chr1_-_1709845 0.53 ENST00000341426.5
ENST00000344463.4
NAD kinase
chr7_+_5919458 0.52 ENST00000416608.1
oncomodulin
chr5_+_140019004 0.52 ENST00000394671.3
ENST00000511410.1
ENST00000537378.1
transmembrane and coiled-coil domains 6
chr17_-_10372875 0.52 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr17_-_44439084 0.52 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ADP-ribosylation factor-like 17B
chr4_-_69111401 0.51 ENST00000332644.5
transmembrane protease, serine 11B
chr12_+_6419877 0.51 ENST00000536531.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr6_+_36562132 0.51 ENST00000373715.6
ENST00000339436.7
serine/arginine-rich splicing factor 3
chrX_-_48824793 0.51 ENST00000376477.1
potassium voltage-gated channel, Shal-related subfamily, member 1
chrX_-_39923656 0.51 ENST00000413905.1
BCL6 corepressor
chrX_-_77225135 0.50 ENST00000458128.1
phosphoglycerate mutase family member 4
chr7_+_26331678 0.50 ENST00000446848.2
sorting nexin 10
chr7_-_142242747 0.50 ENST00000390362.1
T cell receptor beta variable 5-3 (non-functional)
chr1_+_248084320 0.50 ENST00000319968.4
olfactory receptor, family 2, subfamily T, member 8

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.7 4.3 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.7 2.1 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.7 3.3 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.6 1.8 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.5 8.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 1.6 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.4 1.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.4 4.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.4 2.8 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.3 1.7 GO:0021763 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.3 1.4 GO:0060584 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.3 1.0 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.3 1.8 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 0.8 GO:1902769 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.2 1.6 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.2 5.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.2 1.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.2 0.9 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.2 1.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.2 1.6 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.2 0.7 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.2 0.6 GO:0071284 cellular response to lead ion(GO:0071284)
0.2 0.8 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 2.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.2 GO:0070055 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054) mRNA endonucleolytic cleavage involved in unfolded protein response(GO:0070055)
0.1 1.7 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.5 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 1.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.9 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 2.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.9 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 3.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.5 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 19.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 2.7 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 2.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.5 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 1.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.3 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.1 0.8 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 0.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.4 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.1 1.0 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.2 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.5 GO:0019532 oxalate transport(GO:0019532)
0.1 0.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 14.4 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.7 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.7 GO:2000767 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.1 3.0 GO:0042730 fibrinolysis(GO:0042730)
0.1 1.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.6 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.4 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.6 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0044053 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.0 1.9 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.7 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.3 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.0 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0001692 histamine metabolic process(GO:0001692)
0.0 1.4 GO:0050777 negative regulation of immune response(GO:0050777)
0.0 1.0 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 1.9 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.5 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.0 1.5 GO:0042269 regulation of natural killer cell mediated cytotoxicity(GO:0042269)
0.0 3.5 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 1.0 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.3 GO:1902363 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.4 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.3 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 1.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 2.7 GO:0045576 mast cell activation(GO:0045576)
0.0 0.6 GO:0009615 response to virus(GO:0009615)
0.0 1.0 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 2.0 GO:0050994 regulation of lipid catabolic process(GO:0050994)
0.0 0.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.3 GO:0060613 fat pad development(GO:0060613)
0.0 0.4 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 2.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.1 GO:0006270 DNA replication initiation(GO:0006270)
0.0 6.7 GO:0002250 adaptive immune response(GO:0002250)
0.0 1.8 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 0.3 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 1.6 GO:0006281 DNA repair(GO:0006281)
0.0 1.4 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.9 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.0 0.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.7 GO:0051145 smooth muscle cell differentiation(GO:0051145)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.4 1.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.4 7.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 1.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 2.8 GO:0070187 telosome(GO:0070187)
0.2 0.8 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.2 0.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 1.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.1 1.5 GO:0030008 TRAPP complex(GO:0030008)
0.1 2.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 1.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.4 GO:0043231 intracellular membrane-bounded organelle(GO:0043231)
0.1 0.4 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 1.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 8.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 4.7 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 2.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.7 GO:0001772 immunological synapse(GO:0001772)
0.0 2.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.0 1.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 4.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 6.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.3 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0005174 CD40 receptor binding(GO:0005174)
0.7 2.1 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.7 3.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.6 1.8 GO:0030395 lactose binding(GO:0030395)
0.5 2.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 2.1 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.3 1.6 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.3 1.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 1.6 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 0.9 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.2 5.5 GO:0050700 CARD domain binding(GO:0050700)
0.2 1.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 5.6 GO:0031489 myosin V binding(GO:0031489)
0.2 0.6 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.2 0.9 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 1.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 1.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.8 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 1.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 0.5 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 2.8 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 26.1 GO:0003823 antigen binding(GO:0003823)
0.1 1.4 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.3 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.4 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 1.9 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 2.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.8 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 1.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.4 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 2.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 1.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
0.0 2.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.0 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.6 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.8 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.9 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.7 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 PID ARF 3PATHWAY Arf1 pathway
0.0 4.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 2.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 4.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 5.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 5.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 9.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.8 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 3.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 1.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 5.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 2.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.3 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.2 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers