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Illumina Body Map 2, young vs old

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Results for HOXC11

Z-value: 0.64

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Transcription factors associated with HOXC11

Gene Symbol Gene ID Gene Info
ENSG00000123388.4 homeobox C11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC11hg19_v2_chr12_+_54366894_543669220.115.4e-01Click!

Activity profile of HOXC11 motif

Sorted Z-values of HOXC11 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_104831472 5.60 ENST00000262231.10
ENST00000507740.1
regulating synaptic membrane exocytosis 2
chr12_+_54384370 4.30 ENST00000504315.1
homeobox C6
chr2_-_190044480 4.24 ENST00000374866.3
collagen, type V, alpha 2
chr5_-_111091948 4.21 ENST00000447165.2
neuronal regeneration related protein
chr17_-_38821373 4.07 ENST00000394052.3
keratin 222
chr1_-_204135450 3.93 ENST00000272190.8
ENST00000367195.2
renin
chr8_+_76452097 3.90 ENST00000396423.2
hepatocyte nuclear factor 4, gamma
chr12_+_52203789 3.66 ENST00000599343.1
HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
chrX_+_105192423 3.45 ENST00000540278.1
Nik related kinase
chr10_-_96829246 3.38 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
cytochrome P450, family 2, subfamily C, polypeptide 8
chr1_+_110993795 3.32 ENST00000271331.3
prokineticin 1
chr8_+_134203273 3.02 ENST00000250160.6
WNT1 inducible signaling pathway protein 1
chr2_+_166428839 2.84 ENST00000342316.4
cysteine-serine-rich nuclear protein 3
chr18_+_68002675 2.83 ENST00000584919.1
Uncharacterized protein
chr4_+_95972822 2.68 ENST00000509540.1
ENST00000440890.2
bone morphogenetic protein receptor, type IB
chr8_+_134203303 2.63 ENST00000519433.1
ENST00000517423.1
ENST00000377863.2
ENST00000220856.6
WNT1 inducible signaling pathway protein 1
chr22_+_41956767 2.60 ENST00000306149.7
cold shock domain containing C2, RNA binding
chr3_+_164924716 2.50 ENST00000470138.1
ENST00000498616.1
RP11-85M11.2
chr1_+_209878182 2.37 ENST00000367027.3
hydroxysteroid (11-beta) dehydrogenase 1
chr6_+_88054530 2.34 ENST00000388923.4
chromosome 6 open reading frame 163
chr4_-_87028478 2.32 ENST00000515400.1
ENST00000395157.3
mitogen-activated protein kinase 10
chr8_+_104831440 2.27 ENST00000515551.1
regulating synaptic membrane exocytosis 2
chr19_-_10420459 2.26 ENST00000403352.1
ENST00000403903.3
zinc finger, GATA-like protein 1
chr20_+_58179582 2.23 ENST00000371015.1
ENST00000395639.4
phosphatase and actin regulator 3
chr2_+_228678550 2.21 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr12_-_96184533 2.14 ENST00000343702.4
ENST00000344911.4
netrin 4
chr7_+_134464414 2.07 ENST00000361901.2
caldesmon 1
chr15_-_83952071 2.06 ENST00000569704.1
basonuclin 1
chr8_-_71157595 2.05 ENST00000519724.1
nuclear receptor coactivator 2
chr4_-_174451370 2.05 ENST00000359562.4
heart and neural crest derivatives expressed 2
chr8_+_104831554 2.04 ENST00000408894.2
regulating synaptic membrane exocytosis 2
chr19_+_46367518 2.03 ENST00000302177.2
forkhead box A3
chr7_+_134464376 1.99 ENST00000454108.1
ENST00000361675.2
caldesmon 1
chr20_+_52105495 1.98 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr12_-_94673956 1.95 ENST00000551941.1
Uncharacterized protein
chr7_+_35756400 1.94 ENST00000585952.1
AC018647.3
chr5_-_115872124 1.92 ENST00000515009.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrX_-_10851762 1.90 ENST00000380785.1
ENST00000380787.1
midline 1 (Opitz/BBB syndrome)
chr6_+_108487245 1.83 ENST00000368986.4
nuclear receptor subfamily 2, group E, member 1
chr5_-_34043310 1.82 ENST00000231338.7
C1q and tumor necrosis factor related protein 3
chr7_+_35756092 1.81 ENST00000458087.3
AC018647.3
chr4_+_169013666 1.76 ENST00000359299.3
annexin A10
chr1_+_199996702 1.75 ENST00000367362.3
nuclear receptor subfamily 5, group A, member 2
chr14_+_101295638 1.73 ENST00000523671.2
maternally expressed 3 (non-protein coding)
chr19_-_19626838 1.66 ENST00000360913.3
testis-specific serine kinase 6
chr1_+_209859510 1.64 ENST00000367028.2
ENST00000261465.1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_-_96184913 1.62 ENST00000538383.1
netrin 4
chr2_+_177001685 1.61 ENST00000432796.2
homeobox D3
chr10_-_21806759 1.60 ENST00000444772.3
SKI/DACH domain containing 1
chr5_-_36301984 1.60 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RAN binding protein 3-like
chr2_+_211421262 1.59 ENST00000233072.5
carbamoyl-phosphate synthase 1, mitochondrial
chr13_-_46679185 1.54 ENST00000439329.3
carboxypeptidase B2 (plasma)
chr11_-_126810521 1.53 ENST00000530572.1
RP11-688I9.4
chr2_-_166930131 1.51 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr8_-_18666360 1.49 ENST00000286485.8
pleckstrin and Sec7 domain containing 3
chr17_-_39684550 1.47 ENST00000455635.1
ENST00000361566.3
keratin 19
chrX_+_65382433 1.47 ENST00000374727.3
hephaestin
chr9_-_73736511 1.45 ENST00000377110.3
ENST00000377111.2
transient receptor potential cation channel, subfamily M, member 3
chr17_-_77924627 1.45 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1 domain family, member 16
chrX_+_65384052 1.43 ENST00000336279.5
ENST00000458621.1
hephaestin
chr13_-_46679144 1.42 ENST00000181383.4
carboxypeptidase B2 (plasma)
chr12_+_54410664 1.41 ENST00000303406.4
homeobox C4
chr7_+_35756186 1.41 ENST00000430518.1
AC018647.3
chr2_+_176987088 1.40 ENST00000249499.6
homeobox D9
chrX_+_65382381 1.40 ENST00000519389.1
hephaestin
chr7_-_93519471 1.38 ENST00000451238.1
tissue factor pathway inhibitor 2
chrX_+_107683096 1.34 ENST00000328300.6
ENST00000361603.2
collagen, type IV, alpha 5
chrX_+_65384182 1.33 ENST00000441993.2
ENST00000419594.1
hephaestin
chr1_-_12679171 1.30 ENST00000606790.1
RP11-474O21.5
chr15_-_53097139 1.29 ENST00000560818.1
RP11-209K10.2
chr6_+_152011628 1.27 ENST00000404742.1
ENST00000440973.1
estrogen receptor 1
chr1_+_26485511 1.26 ENST00000374268.3
family with sequence similarity 110, member D
chr15_+_69854027 1.25 ENST00000498938.2
RP11-279F6.1
chr7_+_35756066 1.25 ENST00000449644.1
AC018647.3
chr7_-_41742697 1.22 ENST00000242208.4
inhibin, beta A
chrX_-_105282712 1.20 ENST00000372563.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr4_-_25865159 1.19 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr14_-_57277163 1.18 ENST00000555006.1
orthodenticle homeobox 2
chr5_-_115872142 1.18 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr2_-_158295915 1.15 ENST00000418920.1
cytohesin 1 interacting protein
chr14_-_64846033 1.13 ENST00000556556.1
CTD-2555O16.1
chr3_-_79816965 1.12 ENST00000464233.1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr20_+_42984330 1.10 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
hepatocyte nuclear factor 4, alpha
chr11_-_5537920 1.10 ENST00000380184.1
ubiquilin-like
chr2_+_177015122 1.09 ENST00000468418.3
homeobox D3
chr7_-_81399438 1.08 ENST00000222390.5
hepatocyte growth factor (hepapoietin A; scatter factor)
chr10_-_106240032 1.05 ENST00000447860.1
RP11-127O4.3
chr2_-_157198860 1.04 ENST00000409572.1
nuclear receptor subfamily 4, group A, member 2
chr8_-_73793975 1.04 ENST00000523881.1
RP11-1145L24.1
chr7_+_128784712 1.02 ENST00000289407.4
tetraspanin 33
chr17_+_7533439 1.01 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
sex hormone-binding globulin
chr2_-_200320768 1.01 ENST00000428695.1
SATB homeobox 2
chr9_-_124976185 1.01 ENST00000464484.2
LIM homeobox 6
chr14_-_57277178 1.00 ENST00000339475.5
ENST00000554559.1
ENST00000555804.1
orthodenticle homeobox 2
chr7_-_75401513 0.98 ENST00000005180.4
chemokine (C-C motif) ligand 26
chr7_-_81399355 0.98 ENST00000457544.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr18_-_77276057 0.94 ENST00000597412.1
Uncharacterized protein
chr9_+_130026756 0.93 ENST00000314904.5
ENST00000373387.4
GTPase activating Rap/RanGAP domain-like 3
chr2_-_50574856 0.93 ENST00000342183.5
neurexin 1
chr7_-_11871815 0.92 ENST00000423059.4
thrombospondin, type I, domain containing 7A
chr4_-_48683188 0.90 ENST00000505759.1
FRY-like
chr3_-_20053741 0.90 ENST00000389050.4
protein phosphatase 2C-like domain containing 1
chr17_-_46690839 0.89 ENST00000498634.2
homeobox B8
chr5_-_169626104 0.87 ENST00000520275.1
ENST00000506431.2
CTB-27N1.1
chr19_-_19626351 0.86 ENST00000585580.3
testis-specific serine kinase 6
chr8_+_38831683 0.85 ENST00000302495.4
HtrA serine peptidase 4
chr12_+_70219052 0.85 ENST00000552032.2
ENST00000547771.2
myelin regulatory factor-like
chrX_-_107682702 0.85 ENST00000372216.4
collagen, type IV, alpha 6
chr3_+_190105909 0.83 ENST00000456423.1
claudin 16
chr9_+_97766409 0.82 ENST00000425634.2
chromosome 9 open reading frame 3
chr12_+_25205155 0.78 ENST00000550945.1
lymphoid-restricted membrane protein
chr10_-_73497581 0.77 ENST00000398786.2
chromosome 10 open reading frame 105
chr2_-_51259292 0.75 ENST00000401669.2
neurexin 1
chr2_-_51259229 0.75 ENST00000405472.3
neurexin 1
chr14_-_69444957 0.74 ENST00000556571.1
ENST00000553659.1
ENST00000555616.1
actinin, alpha 1
chr17_-_46657473 0.74 ENST00000332503.5
homeobox B4
chr11_-_132812987 0.73 ENST00000541867.1
opioid binding protein/cell adhesion molecule-like
chr18_+_72922710 0.71 ENST00000322038.5
teashirt zinc finger homeobox 1
chr1_+_183774240 0.69 ENST00000360851.3
ral guanine nucleotide dissociation stimulator-like 1
chr19_+_55996316 0.68 ENST00000205194.4
N-acetyltransferase 14 (GCN5-related, putative)
chr15_+_49715293 0.68 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr9_+_97766469 0.67 ENST00000433691.2
chromosome 9 open reading frame 3
chr11_+_113185778 0.67 ENST00000524580.2
tetratricopeptide repeat domain 12
chr10_+_26505179 0.64 ENST00000376261.3
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr19_+_35634146 0.64 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD domain containing ion transport regulator 7
chr20_+_4702548 0.64 ENST00000305817.2
prion protein 2 (dublet)
chr22_-_30642782 0.64 ENST00000249075.3
leukemia inhibitory factor
chr9_-_124976154 0.63 ENST00000482062.1
LIM homeobox 6
chr8_+_70378852 0.63 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
sulfatase 1
chr9_-_16705069 0.63 ENST00000471301.2
basonuclin 2
chr12_-_95510743 0.62 ENST00000551521.1
FYVE, RhoGEF and PH domain containing 6
chr12_+_25205568 0.61 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr14_-_101295407 0.61 ENST00000596284.1
AL117190.2
chr18_-_48351743 0.61 ENST00000588444.1
ENST00000256425.2
ENST00000428869.2
maestro
chr2_-_40739501 0.60 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_-_81399329 0.60 ENST00000453411.1
ENST00000444829.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_+_10000640 0.59 ENST00000451755.1
AC006373.1
chr6_+_6588902 0.58 ENST00000230568.4
lymphocyte antigen 86
chr2_+_10223908 0.58 ENST00000425235.1
AC104794.4
chr20_+_58713514 0.58 ENST00000432910.1
RP5-1043L13.1
chr11_+_34663913 0.58 ENST00000532302.1
ets homologous factor
chr7_+_141418962 0.57 ENST00000493845.1
WEE1 homolog 2 (S. pombe)
chr9_+_105757590 0.57 ENST00000374798.3
ENST00000487798.1
cylicin, basic protein of sperm head cytoskeleton 2
chr1_+_183774285 0.57 ENST00000539189.1
ral guanine nucleotide dissociation stimulator-like 1
chr11_+_124481361 0.56 ENST00000284288.2
pannexin 3
chr11_-_132813627 0.56 ENST00000374778.4
opioid binding protein/cell adhesion molecule-like
chr11_-_132813566 0.51 ENST00000331898.7
opioid binding protein/cell adhesion molecule-like
chr6_+_26156551 0.51 ENST00000304218.3
histone cluster 1, H1e
chr15_-_37783009 0.50 ENST00000561054.1
RP11-720L8.1
chr12_-_24102576 0.50 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
SRY (sex determining region Y)-box 5
chr7_-_15014398 0.49 ENST00000437998.1
diacylglycerol kinase, beta 90kDa
chr10_-_24770632 0.48 ENST00000596413.1
AL353583.1
chr6_-_64029879 0.48 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
lengsin, lens protein with glutamine synthetase domain
chr11_+_34664014 0.48 ENST00000527935.1
ets homologous factor
chr3_-_51813009 0.48 ENST00000398780.3
IQ motif containing F6
chr12_+_64173583 0.47 ENST00000261234.6
transmembrane protein 5
chr5_+_159656437 0.47 ENST00000402432.3
fatty acid binding protein 6, ileal
chr2_-_74726710 0.47 ENST00000377566.4
ladybird homeobox 2
chr16_-_67978016 0.47 ENST00000264005.5
lecithin-cholesterol acyltransferase
chr7_-_81399411 0.47 ENST00000423064.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_+_1173853 0.46 ENST00000391429.1
basic helix-loop-helix family, member a9
chr16_-_21663919 0.46 ENST00000569602.1
immunoglobulin superfamily, member 6
chr3_+_173116225 0.46 ENST00000457714.1
neuroligin 1
chr9_+_44868935 0.46 ENST00000448436.2
RP11-160N1.10
chr4_+_114214125 0.46 ENST00000509550.1
ankyrin 2, neuronal
chr3_+_164924769 0.45 ENST00000494915.1
RP11-85M11.2
chr22_+_39916558 0.45 ENST00000337304.2
ENST00000396680.1
activating transcription factor 4
chr15_+_49715449 0.45 ENST00000560979.1
fibroblast growth factor 7
chr17_+_7461580 0.44 ENST00000483039.1
ENST00000396542.1
tumor necrosis factor (ligand) superfamily, member 13
chr1_+_66999268 0.44 ENST00000371039.1
ENST00000424320.1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr8_-_114449112 0.44 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CUB and Sushi multiple domains 3
chr9_-_124989804 0.44 ENST00000373755.2
ENST00000373754.2
LIM homeobox 6
chr9_+_75229616 0.43 ENST00000340019.3
transmembrane channel-like 1
chr12_+_25205666 0.43 ENST00000547044.1
lymphoid-restricted membrane protein
chr9_-_124990680 0.41 ENST00000541397.2
ENST00000560485.1
LIM homeobox 6
chr3_+_63428982 0.41 ENST00000479198.1
ENST00000460711.1
ENST00000465156.1
synaptoporin
chr16_-_21863541 0.40 ENST00000543654.1
nuclear pore complex interacting protein family, member B4
chr17_+_7461613 0.39 ENST00000438470.1
ENST00000436057.1
tumor necrosis factor (ligand) superfamily, member 13
chr2_+_78143006 0.39 ENST00000443419.1
AC073628.1
chr18_-_73967160 0.37 ENST00000579714.1
RP11-94B19.7
chr8_-_57123815 0.37 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
pleiomorphic adenoma gene 1
chr11_-_31531121 0.36 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr9_-_133814455 0.35 ENST00000448616.1
fibrinogen C domain containing 1
chr2_+_3800169 0.34 ENST00000399143.3
doublecortin domain containing 2C
chr12_+_130646999 0.34 ENST00000539839.1
ENST00000229030.4
frizzled family receptor 10
chr11_-_27723158 0.34 ENST00000395980.2
brain-derived neurotrophic factor
chr3_-_45837959 0.30 ENST00000353278.4
ENST00000456124.2
solute carrier family 6 (proline IMINO transporter), member 20
chr3_+_41236325 0.30 ENST00000426215.1
ENST00000405570.1
catenin (cadherin-associated protein), beta 1, 88kDa
chr11_-_84844167 0.30 ENST00000527088.1
discs, large homolog 2 (Drosophila)
chr14_+_62164340 0.29 ENST00000557538.1
ENST00000539097.1
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr10_-_115614127 0.25 ENST00000369305.1
DNA cross-link repair 1A
chr8_+_56074008 0.25 ENST00000522559.1
Uncharacterized protein
chrX_-_100604184 0.24 ENST00000372902.3
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr8_+_26435359 0.24 ENST00000311151.5
dihydropyrimidinase-like 2
chr3_-_45838011 0.23 ENST00000358525.4
ENST00000413781.1
solute carrier family 6 (proline IMINO transporter), member 20
chr18_+_55024383 0.23 ENST00000586360.1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr5_+_176731572 0.23 ENST00000503853.1
PRELI domain containing 1
chr12_-_71148413 0.22 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
protein tyrosine phosphatase, receptor type, R
chr7_-_81399287 0.21 ENST00000354224.6
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_122840015 0.21 ENST00000194130.2
solute carrier family 13 (sodium/sulfate symporter), member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.9 3.4 GO:0060723 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.8 3.9 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.8 9.9 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.7 3.0 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.7 2.2 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.7 2.1 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.6 3.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 1.6 GO:1903718 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.5 3.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.5 1.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 2.0 GO:0061032 cardiac right ventricle formation(GO:0003219) visceral serous pericardium development(GO:0061032)
0.4 1.2 GO:0060279 positive regulation of ovulation(GO:0060279)
0.4 2.7 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.4 1.1 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.3 2.8 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 2.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 2.4 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.3 1.0 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 2.7 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.2 1.1 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.2 1.6 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.2 1.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 0.6 GO:0035038 female pronucleus assembly(GO:0035038)
0.2 1.8 GO:0071638 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.2 2.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 2.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 5.6 GO:0006825 copper ion transport(GO:0006825)
0.2 0.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 2.5 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 4.0 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 0.7 GO:0060023 soft palate development(GO:0060023)
0.1 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.5 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.5 GO:0048789 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.1 0.3 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 1.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 1.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 1.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.5 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1 0.7 GO:0048539 bone marrow development(GO:0048539)
0.1 2.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.6 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.1 0.5 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.3 GO:0007403 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.1 0.3 GO:0051541 neural fold elevation formation(GO:0021502) elastin metabolic process(GO:0051541)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.8 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.5 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.4 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.6 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1 0.2 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 1.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.2 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 1.5 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.0 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.6 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.6 GO:0034214 protein hexamerization(GO:0034214)
0.0 1.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.4 GO:0050773 regulation of dendrite development(GO:0050773)
0.0 0.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.5 GO:0015824 proline transport(GO:0015824)
0.0 1.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.8 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.3 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.9 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 1.8 GO:0008038 neuron recognition(GO:0008038)
0.0 2.3 GO:0048599 oocyte development(GO:0048599)
0.0 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 1.5 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 0.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 1.4 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.2 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 3.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.6 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 2.8 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 1.8 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0005588 collagen type V trimer(GO:0005588)
0.4 1.2 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.3 4.1 GO:0030478 actin cap(GO:0030478)
0.2 2.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.2 2.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 0.6 GO:0033150 cytoskeletal calyx(GO:0033150)
0.2 1.5 GO:1990357 terminal web(GO:1990357)
0.1 9.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.5 GO:1990037 Lewy body core(GO:1990037)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.7 GO:0005916 fascia adherens(GO:0005916)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 2.7 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 2.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 3.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 6.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 6.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.1 GO:0030427 site of polarized growth(GO:0030427)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.7 2.2 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.7 3.4 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.5 5.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 1.7 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.4 3.8 GO:0043237 laminin-1 binding(GO:0043237)
0.4 2.1 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.2 2.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 0.6 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.0 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.2 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 6.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.3 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 3.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 4.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.5 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 3.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.0 GO:0005497 androgen binding(GO:0005497)
0.1 2.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.6 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 0.6 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.5 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.5 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 7.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 3.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 7.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 11.5 GO:0044325 ion channel binding(GO:0044325)
0.0 1.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.5 GO:0032052 bile acid binding(GO:0032052)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0008061 chitin binding(GO:0008061)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.7 GO:0008083 growth factor activity(GO:0008083)
0.0 1.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 2.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 5.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.7 PID BMP PATHWAY BMP receptor signaling
0.0 3.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 6.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 7.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 5.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 4.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 2.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 6.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 4.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 2.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.1 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 4.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 2.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis