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Illumina Body Map 2, young vs old

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Results for HOXD1

Z-value: 0.15

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.11 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_1770534020.318.2e-02Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_26593649 4.37 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr11_-_26593779 4.28 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr11_-_26593677 3.77 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr8_+_92261516 2.95 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr11_+_65554493 2.00 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr11_+_71900703 1.87 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr2_+_135596180 1.85 ENST00000283054.4
ENST00000392928.1
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_+_135596106 1.83 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr11_+_71900572 1.81 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr6_+_78400375 1.80 ENST00000602452.2
MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr7_-_73256838 1.37 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr5_+_176811431 1.37 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr20_-_50419055 1.23 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr3_-_151034734 1.22 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr11_-_102651343 1.08 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr7_+_133812052 1.02 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr20_-_50418972 0.97 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr1_-_190446759 0.95 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chrX_+_43515467 0.93 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr8_+_55528627 0.93 ENST00000220676.1
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr3_-_126327398 0.90 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr3_+_2933893 0.89 ENST00000397459.2
CNTN4
contactin 4
chr11_+_101918153 0.87 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70
chr4_-_150736962 0.85 ENST00000502345.1
ENST00000510975.1
ENST00000511993.1
RP11-526A4.1
RP11-526A4.1
chr14_+_20187174 0.83 ENST00000557414.1
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chrX_+_114827818 0.82 ENST00000420625.2
PLS3
plastin 3
chr8_-_49834299 0.81 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr20_-_50418947 0.78 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr4_-_139051839 0.77 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
LINC00616
long intergenic non-protein coding RNA 616
chr4_+_105828492 0.76 ENST00000506148.1
RP11-556I14.1
RP11-556I14.1
chr2_+_78143006 0.75 ENST00000443419.1
AC073628.1
AC073628.1
chr15_+_63050785 0.70 ENST00000472902.1
TLN2
talin 2
chr19_-_36001113 0.69 ENST00000434389.1
DMKN
dermokine
chr8_-_49833978 0.67 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr12_-_23737534 0.67 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr4_-_74486109 0.62 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chrX_-_19504642 0.61 ENST00000469203.2
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr11_+_118398178 0.60 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr4_+_105828537 0.59 ENST00000515649.1
RP11-556I14.1
RP11-556I14.1
chr1_-_201140673 0.52 ENST00000367333.2
TMEM9
transmembrane protein 9
chr3_-_99569821 0.51 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr4_-_138453606 0.51 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr4_-_74486217 0.49 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr17_-_10372875 0.49 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr16_-_52061283 0.48 ENST00000566314.1
C16orf97
chromosome 16 open reading frame 97
chr5_-_96478466 0.47 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr7_+_37723420 0.44 ENST00000476620.1
EPDR1
ependymin related 1
chr15_+_58702742 0.43 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr4_+_86748898 0.43 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr9_+_124329336 0.42 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr4_-_138453559 0.41 ENST00000511115.1
PCDH18
protocadherin 18
chr10_+_99205959 0.40 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr5_-_96478457 0.39 ENST00000512378.1
LIX1
Lix1 homolog (chicken)
chr4_-_74486347 0.32 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr9_-_5339873 0.32 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr10_+_99205894 0.30 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_-_146261573 0.30 ENST00000610239.1
RP11-142A22.4
RP11-142A22.4
chr6_+_130742231 0.29 ENST00000545622.1
TMEM200A
transmembrane protein 200A
chr7_-_81399438 0.29 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr20_+_43990576 0.28 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr11_+_4615269 0.26 ENST00000530443.2
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr15_-_37393406 0.26 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr11_-_102709441 0.22 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_-_38956205 0.22 ENST00000306658.7
KRT28
keratin 28
chr11_-_74800799 0.22 ENST00000305159.3
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr18_-_33709268 0.21 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr4_+_86749045 0.18 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr11_-_95657231 0.17 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr14_+_60386853 0.17 ENST00000570145.1
LRRC9
leucine rich repeat containing 9
chr11_-_124190184 0.16 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr7_-_99716940 0.13 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_+_113568207 0.13 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr7_-_99717463 0.12 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_99716952 0.11 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_+_148287657 0.11 ENST00000307003.2
C7orf33
chromosome 7 open reading frame 33
chrX_+_107288239 0.11 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr11_+_4615037 0.10 ENST00000450052.2
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr11_+_60163775 0.10 ENST00000300187.6
ENST00000395005.2
MS4A14
membrane-spanning 4-domains, subfamily A, member 14
chr19_+_11071546 0.09 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr19_-_3557570 0.08 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr22_-_28490123 0.07 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr1_-_151431909 0.07 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr12_+_10163231 0.07 ENST00000396502.1
ENST00000338896.5
CLEC12B
C-type lectin domain family 12, member B
chr1_-_112032284 0.06 ENST00000414219.1
ADORA3
adenosine A3 receptor
chr12_-_52761262 0.06 ENST00000257901.3
KRT85
keratin 85
chr2_+_228736335 0.06 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr11_-_71823796 0.05 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr2_+_191221240 0.05 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chrX_+_107288197 0.05 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_53171128 0.04 ENST00000332411.2
KRT76
keratin 76
chr5_+_63802109 0.03 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr7_-_81399329 0.03 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr18_-_44181442 0.03 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr1_+_12834984 0.02 ENST00000357726.4
PRAMEF12
PRAME family member 12
chr1_-_151431674 0.01 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.5 3.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.5 1.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.5 1.4 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.4 2.0 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.4 1.8 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.2 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 2.9 GO:0019532 oxalate transport(GO:0019532)
0.1 12.4 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.7 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.4 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.9 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 0.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.7 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 1.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.9 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.2 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of receptor catabolic process(GO:2000645)
0.0 0.1 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.9 GO:0097352 autophagosome maturation(GO:0097352)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.4 GO:1990032 parallel fiber(GO:1990032)
0.1 1.0 GO:0002177 manchette(GO:0002177)
0.1 12.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.8 GO:0000800 lateral element(GO:0000800)
0.0 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.0 GO:0000792 heterochromatin(GO:0000792)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 2.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 0.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 3.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 11.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 3.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 3.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane