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Illumina Body Map 2, young vs old

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Results for HSF4

Z-value: 0.05

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF4hg19_v2_chr16_+_67198683_671987150.392.8e-02Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_73072534 3.43 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr13_-_31736027 2.51 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr13_-_31736132 2.49 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr13_-_31736478 2.48 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr14_+_63671105 2.25 ENST00000316754.3
RHOJ
ras homolog family member J
chr19_-_14629224 2.19 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_+_161494036 2.17 ENST00000309758.4
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr4_+_76932326 2.16 ENST00000513353.1
ENST00000341029.5
ART3
ADP-ribosyltransferase 3
chr1_-_173638976 2.15 ENST00000333279.2
ANKRD45
ankyrin repeat domain 45
chr10_-_115423792 2.13 ENST00000369360.3
ENST00000360478.3
ENST00000359988.3
ENST00000369358.4
NRAP
nebulin-related anchoring protein
chr19_-_51893827 2.01 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr11_-_111794446 1.89 ENST00000527950.1
CRYAB
crystallin, alpha B
chr4_+_41258786 1.87 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_-_60539405 1.80 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_+_53925063 1.77 ENST00000371445.3
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr20_+_18794370 1.76 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr11_-_111782484 1.75 ENST00000533971.1
CRYAB
crystallin, alpha B
chr12_-_88423164 1.73 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr17_-_74137374 1.71 ENST00000322957.6
FOXJ1
forkhead box J1
chr11_-_111782696 1.60 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr11_-_111781554 1.57 ENST00000526167.1
ENST00000528961.1
CRYAB
crystallin, alpha B
chr4_+_76932375 1.55 ENST00000513122.1
ART3
ADP-ribosyltransferase 3
chr20_+_55904815 1.51 ENST00000371263.3
ENST00000345868.4
ENST00000371260.4
ENST00000418127.1
SPO11
SPO11 meiotic protein covalently bound to DSB
chr15_-_58357932 1.49 ENST00000347587.3
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr11_-_111781610 1.48 ENST00000525823.1
CRYAB
crystallin, alpha B
chr17_+_33474826 1.48 ENST00000268876.5
ENST00000433649.1
ENST00000378449.1
UNC45B
unc-45 homolog B (C. elegans)
chr15_+_96869165 1.47 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_+_34087888 1.44 ENST00000586491.1
ENST00000588628.1
ENST00000285023.4
C17orf50
chromosome 17 open reading frame 50
chr11_-_111781454 1.44 ENST00000533280.1
CRYAB
crystallin, alpha B
chr17_+_33474860 1.42 ENST00000394570.2
UNC45B
unc-45 homolog B (C. elegans)
chr19_+_6135646 1.39 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr15_-_58357866 1.39 ENST00000537372.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr11_+_63953587 1.38 ENST00000305218.4
ENST00000538945.1
STIP1
stress-induced-phosphoprotein 1
chr12_+_2904102 1.36 ENST00000001008.4
FKBP4
FK506 binding protein 4, 59kDa
chr1_+_156308245 1.35 ENST00000368253.2
ENST00000470342.1
ENST00000368254.1
TSACC
TSSK6 activating co-chaperone
chr14_-_102553371 1.33 ENST00000553585.1
ENST00000216281.8
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr1_-_60539422 1.33 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr2_-_27362263 1.30 ENST00000432962.1
ENST00000335524.3
C2orf53
chromosome 2 open reading frame 53
chr1_+_92683467 1.28 ENST00000370375.3
ENST00000370373.2
C1orf146
chromosome 1 open reading frame 146
chr9_-_79267432 1.25 ENST00000424866.1
PRUNE2
prune homolog 2 (Drosophila)
chr3_-_36781352 1.23 ENST00000416516.2
DCLK3
doublecortin-like kinase 3
chr22_+_48972118 1.23 ENST00000358295.5
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr8_-_57359131 1.22 ENST00000518974.1
ENST00000523051.1
ENST00000518770.1
ENST00000451791.2
PENK
proenkephalin
chr11_+_111782934 1.18 ENST00000304298.3
HSPB2
Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA.
chr11_+_63953691 1.16 ENST00000543847.1
STIP1
stress-induced-phosphoprotein 1
chr21_+_35445827 1.15 ENST00000608209.1
ENST00000381151.3
SLC5A3
SLC5A3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr6_+_160693591 1.12 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr19_-_51893782 1.09 ENST00000570516.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr19_-_14628645 1.07 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_-_182369751 1.06 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr5_+_421030 1.05 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr6_+_44215603 1.03 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr11_-_122933043 1.02 ENST00000534624.1
ENST00000453788.2
ENST00000527387.1
HSPA8
heat shock 70kDa protein 8
chr15_-_51610687 1.02 ENST00000559646.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr3_-_42452050 1.02 ENST00000441172.1
ENST00000287748.3
LYZL4
lysozyme-like 4
chr19_-_474880 1.01 ENST00000382696.3
ENST00000315489.4
ODF3L2
outer dense fiber of sperm tails 3-like 2
chr19_+_751122 1.01 ENST00000215582.6
MISP
mitotic spindle positioning
chr5_+_140501581 1.00 ENST00000194152.1
PCDHB4
protocadherin beta 4
chr17_-_74722672 0.98 ENST00000397625.4
ENST00000445478.2
JMJD6
jumonji domain containing 6
chr1_+_156308403 0.98 ENST00000481479.1
ENST00000368252.1
ENST00000466306.1
ENST00000368251.1
TSACC
TSSK6 activating co-chaperone
chr7_-_151107767 0.97 ENST00000477459.1
WDR86
WD repeat domain 86
chr5_+_147258266 0.97 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr8_+_142524738 0.97 ENST00000427937.1
AC138647.1
Uncharacterized protein
chr11_+_75273246 0.97 ENST00000526397.1
ENST00000529643.1
ENST00000525492.1
ENST00000530284.1
ENST00000532356.1
ENST00000524558.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr11_+_75273101 0.96 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr8_+_143781513 0.92 ENST00000292430.6
ENST00000561179.1
ENST00000518841.1
ENST00000519387.1
LY6K
lymphocyte antigen 6 complex, locus K
chr19_+_11650709 0.91 ENST00000586059.1
CNN1
calponin 1, basic, smooth muscle
chr19_-_55672037 0.90 ENST00000588076.1
DNAAF3
dynein, axonemal, assembly factor 3
chr6_-_32339649 0.88 ENST00000527965.1
ENST00000532023.1
ENST00000447241.2
ENST00000375007.4
ENST00000534588.1
C6orf10
chromosome 6 open reading frame 10
chr19_-_14628234 0.88 ENST00000595139.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr7_-_100493744 0.88 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr7_+_75931861 0.85 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr11_-_89956227 0.84 ENST00000457199.2
ENST00000530765.1
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr17_-_74722536 0.84 ENST00000585429.1
JMJD6
jumonji domain containing 6
chr2_+_228678550 0.83 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr2_-_238499303 0.82 ENST00000409576.1
RAB17
RAB17, member RAS oncogene family
chr9_-_138591341 0.81 ENST00000298466.5
ENST00000425225.1
SOHLH1
spermatogenesis and oogenesis specific basic helix-loop-helix 1
chr11_-_89956461 0.81 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr18_-_71814999 0.80 ENST00000269500.5
FBXO15
F-box protein 15
chr16_-_1494490 0.79 ENST00000389176.3
ENST00000409671.1
CCDC154
coiled-coil domain containing 154
chr14_-_81425828 0.79 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chrX_-_128782722 0.78 ENST00000427399.1
APLN
apelin
chr4_-_152147579 0.78 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr19_+_49891533 0.76 ENST00000598730.1
ENST00000594905.1
ENST00000595828.1
ENST00000594043.1
CCDC155
coiled-coil domain containing 155
chr6_-_32339671 0.75 ENST00000442822.2
ENST00000375015.4
ENST00000533191.1
C6orf10
chromosome 6 open reading frame 10
chr10_-_74856608 0.74 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr1_-_27709816 0.73 ENST00000374030.1
CD164L2
CD164 sialomucin-like 2
chr7_+_157129660 0.73 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr18_-_71815051 0.73 ENST00000582526.1
ENST00000419743.2
FBXO15
F-box protein 15
chr19_-_6720686 0.72 ENST00000245907.6
C3
complement component 3
chr6_+_35704855 0.72 ENST00000288065.2
ENST00000373866.3
ARMC12
armadillo repeat containing 12
chr20_+_5451845 0.71 ENST00000430097.2
RP5-828H9.1
RP5-828H9.1
chr4_-_129491686 0.70 ENST00000514265.1
RP11-184M15.1
RP11-184M15.1
chr14_-_61124977 0.70 ENST00000554986.1
SIX1
SIX homeobox 1
chr12_+_49121213 0.69 ENST00000548380.1
LINC00935
long intergenic non-protein coding RNA 935
chr21_+_31768348 0.68 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr16_+_28875126 0.68 ENST00000359285.5
ENST00000538342.1
SH2B1
SH2B adaptor protein 1
chr6_+_35704804 0.68 ENST00000373869.3
ARMC12
armadillo repeat containing 12
chr2_-_208989225 0.67 ENST00000264376.4
CRYGD
crystallin, gamma D
chr17_+_74723031 0.67 ENST00000586200.1
METTL23
methyltransferase like 23
chr20_-_23669590 0.66 ENST00000217423.3
CST4
cystatin S
chr6_+_54172653 0.65 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr22_-_24181174 0.65 ENST00000318109.7
ENST00000406855.3
ENST00000404056.1
ENST00000476077.1
DERL3
derlin 3
chr3_+_186501979 0.65 ENST00000498746.1
EIF4A2
eukaryotic translation initiation factor 4A2
chr17_+_45401139 0.64 ENST00000517310.1
EFCAB13
EF-hand calcium binding domain 13
chr18_-_6929829 0.63 ENST00000583840.1
ENST00000581571.1
ENST00000578497.1
ENST00000579012.1
LINC00668
long intergenic non-protein coding RNA 668
chrX_-_100548045 0.63 ENST00000372907.3
ENST00000372905.2
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr12_+_41136144 0.62 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr17_-_76573465 0.61 ENST00000585328.1
ENST00000389840.5
DNAH17
dynein, axonemal, heavy chain 17
chr5_+_140602904 0.61 ENST00000515856.2
ENST00000239449.4
PCDHB14
protocadherin beta 14
chr11_-_16419067 0.58 ENST00000533411.1
SOX6
SRY (sex determining region Y)-box 6
chrX_+_54947229 0.57 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO
trophinin
chrX_-_154563889 0.57 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr19_-_49567124 0.57 ENST00000301411.3
NTF4
neurotrophin 4
chr8_+_143915663 0.57 ENST00000522728.1
GML
glycosylphosphatidylinositol anchored molecule like
chr19_+_3224700 0.56 ENST00000292672.2
ENST00000541430.2
CELF5
CUGBP, Elav-like family member 5
chr16_+_28875268 0.56 ENST00000395532.4
SH2B1
SH2B adaptor protein 1
chr20_+_36149602 0.55 ENST00000062104.2
ENST00000346199.2
NNAT
neuronatin
chr9_+_123970052 0.55 ENST00000373823.3
GSN
gelsolin
chr7_+_157129738 0.55 ENST00000437030.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr15_+_45028753 0.54 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr19_-_49565254 0.53 ENST00000593537.1
NTF4
neurotrophin 4
chr1_-_27709793 0.52 ENST00000374027.3
ENST00000374025.3
CD164L2
CD164 sialomucin-like 2
chr11_-_122932730 0.52 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr2_-_238499131 0.50 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr15_+_85359911 0.49 ENST00000258888.5
ALPK3
alpha-kinase 3
chr2_+_61404545 0.48 ENST00000357022.2
AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr1_-_99470368 0.47 ENST00000263177.4
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr11_-_10590238 0.46 ENST00000256178.3
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr2_+_198365122 0.46 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr2_+_198365095 0.45 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr1_-_228613026 0.45 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr2_+_210444298 0.44 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr3_+_136676851 0.44 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr2_-_69180083 0.44 ENST00000328895.4
GKN2
gastrokine 2
chr9_-_13279406 0.43 ENST00000546205.1
MPDZ
multiple PDZ domain protein
chr11_-_10590118 0.43 ENST00000529598.1
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr12_-_4754339 0.42 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr2_-_208994548 0.42 ENST00000282141.3
CRYGC
crystallin, gamma C
chr17_+_45401308 0.41 ENST00000331493.2
ENST00000519772.1
ENST00000517484.1
EFCAB13
EF-hand calcium binding domain 13
chr16_-_18468926 0.41 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr21_+_39668478 0.41 ENST00000398927.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_46716647 0.40 ENST00000608940.1
RP11-357H14.17
RP11-357H14.17
chr3_-_126327398 0.38 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_-_248005254 0.38 ENST00000355784.2
OR11L1
olfactory receptor, family 11, subfamily L, member 1
chr11_-_32816156 0.38 ENST00000531481.1
ENST00000335185.5
CCDC73
coiled-coil domain containing 73
chr12_-_122658746 0.38 ENST00000377035.1
IL31
interleukin 31
chr22_+_29168652 0.37 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
CCDC117
coiled-coil domain containing 117
chr4_+_5527117 0.37 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr2_+_210444142 0.36 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr4_+_5526883 0.36 ENST00000195455.2
C4orf6
chromosome 4 open reading frame 6
chrX_-_80377162 0.36 ENST00000430960.1
ENST00000447319.1
HMGN5
high mobility group nucleosome binding domain 5
chr14_+_96722539 0.35 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr2_-_69180012 0.35 ENST00000481498.1
GKN2
gastrokine 2
chr1_-_242162375 0.35 ENST00000357246.3
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr12_+_110940111 0.34 ENST00000409778.3
RAD9B
RAD9 homolog B (S. pombe)
chr3_+_101443476 0.34 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr2_-_198364581 0.34 ENST00000428204.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr17_+_73996987 0.33 ENST00000588812.1
ENST00000448471.1
CDK3
cyclin-dependent kinase 3
chr20_-_23731893 0.33 ENST00000398402.1
CST1
cystatin SN
chr21_+_44394742 0.33 ENST00000432907.2
PKNOX1
PBX/knotted 1 homeobox 1
chr19_+_50354393 0.33 ENST00000391842.1
PTOV1
prostate tumor overexpressed 1
chr21_+_45148735 0.33 ENST00000327574.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr16_+_29789561 0.32 ENST00000400752.4
ZG16
zymogen granule protein 16
chr17_+_78194261 0.32 ENST00000572725.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr17_+_78194205 0.31 ENST00000573809.1
ENST00000361193.3
ENST00000574967.1
ENST00000576126.1
ENST00000411502.3
ENST00000546047.2
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr9_+_109685630 0.30 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr7_-_1199781 0.30 ENST00000397083.1
ENST00000401903.1
ENST00000316495.3
ZFAND2A
zinc finger, AN1-type domain 2A
chr2_+_201171268 0.30 ENST00000423749.1
ENST00000428692.1
ENST00000457757.1
ENST00000453663.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr14_+_101293687 0.30 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr1_-_152386732 0.30 ENST00000271835.3
CRNN
cornulin
chr1_+_109265033 0.29 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr8_+_143916217 0.28 ENST00000220940.1
GML
glycosylphosphatidylinositol anchored molecule like
chr1_+_212782012 0.28 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3
chrX_-_80377118 0.28 ENST00000373250.3
HMGN5
high mobility group nucleosome binding domain 5
chr8_+_142402089 0.28 ENST00000521578.1
ENST00000520105.1
ENST00000523147.1
PTP4A3
protein tyrosine phosphatase type IVA, member 3
chr3_+_186501336 0.27 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr5_+_10250328 0.27 ENST00000515390.1
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr13_+_31191920 0.27 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr21_+_35445811 0.27 ENST00000399312.2
MRPS6
mitochondrial ribosomal protein S6
chr19_+_50354430 0.27 ENST00000599732.1
PTOV1
prostate tumor overexpressed 1
chrX_-_107225600 0.26 ENST00000302917.1
TEX13B
testis expressed 13B
chr2_+_201171577 0.26 ENST00000409397.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr5_-_13944652 0.25 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr17_+_7258442 0.25 ENST00000389982.4
ENST00000576060.1
ENST00000330767.4
TMEM95
transmembrane protein 95
chr20_-_43589109 0.25 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr11_-_62457371 0.25 ENST00000317449.4
LRRN4CL
LRRN4 C-terminal like
chr20_-_23807358 0.25 ENST00000304725.2
CST2
cystatin SA
chr2_+_121493717 0.25 ENST00000418323.1
GLI2
GLI family zinc finger 2
chrX_-_106243451 0.25 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr1_-_26232522 0.25 ENST00000399728.1
STMN1
stathmin 1
chr15_+_89921280 0.25 ENST00000560596.1
ENST00000558692.1
ENST00000538734.2
ENST00000559235.1
LINC00925
long intergenic non-protein coding RNA 925
chr12_+_110940005 0.24 ENST00000409246.1
ENST00000392672.4
ENST00000409300.1
ENST00000409425.1
RAD9B
RAD9 homolog B (S. pombe)
chr3_-_183735731 0.24 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chrX_-_106243294 0.24 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr12_-_4754356 0.23 ENST00000540967.1
AKAP3
A kinase (PRKA) anchor protein 3
chr2_+_210443993 0.23 ENST00000392193.1
MAP2
microtubule-associated protein 2
chr19_+_50354462 0.23 ENST00000601675.1
PTOV1
prostate tumor overexpressed 1
chr3_+_183815318 0.23 ENST00000425359.2
HTR3E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
chr11_-_82997371 0.22 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.5 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.6 1.9 GO:0007412 axon target recognition(GO:0007412)
0.6 1.7 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.4 1.7 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.4 9.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 1.5 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.4 1.5 GO:0009956 radial pattern formation(GO:0009956)
0.4 1.1 GO:0061193 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.3 2.2 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.3 1.5 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.3 2.9 GO:0035799 ureter maturation(GO:0035799)
0.3 5.0 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.3 0.8 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.3 1.3 GO:0043335 protein unfolding(GO:0043335)
0.3 1.3 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.3 0.8 GO:0051466 positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.3 1.0 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.3 1.0 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2 1.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 1.9 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.2 0.7 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.2 0.9 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.2 1.8 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.2 0.7 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 0.7 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.2 1.1 GO:0015798 myo-inositol transport(GO:0015798)
0.1 1.3 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.1 2.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.6 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.6 GO:0044856 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1 0.3 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.1 0.6 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.3 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.2 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 3.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.0 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 1.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.7 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.2 GO:0008355 olfactory learning(GO:0008355)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.6 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.7 GO:0019532 oxalate transport(GO:0019532)
0.0 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.9 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 1.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 1.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.6 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.6 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.0 1.2 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 3.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.2 GO:0061741 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
0.0 1.1 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.6 GO:0000076 DNA replication checkpoint(GO:0000076) intra-S DNA damage checkpoint(GO:0031573)
0.0 0.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.6 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.3 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:0072660 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.3 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.5 GO:0032460 negative regulation of protein oligomerization(GO:0032460)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.6 GO:0007340 acrosome reaction(GO:0007340) regulation of protein kinase A signaling(GO:0010738)
0.0 1.6 GO:0048477 oogenesis(GO:0048477)
0.0 0.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 1.2 GO:0045840 positive regulation of mitotic nuclear division(GO:0045840)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 1.8 GO:0030301 cholesterol transport(GO:0030301)
0.0 0.0 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.4 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.7 GO:0097512 cardiac myofibril(GO:0097512)
0.4 2.1 GO:0005927 muscle tendon junction(GO:0005927)
0.3 9.9 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 2.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 1.5 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.2 1.2 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.7 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 0.8 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.9 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.6 GO:0030478 actin cap(GO:0030478)
0.0 2.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.2 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.5 1.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.4 1.1 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.4 1.5 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.4 3.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 10.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.4 GO:0032767 copper-dependent protein binding(GO:0032767)
0.3 1.8 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.3 0.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.3 1.0 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.2 0.9 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.2 2.9 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.7 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 1.3 GO:0030911 TPR domain binding(GO:0030911)
0.1 0.4 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 5.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.1 0.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 4.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.3 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 0.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 2.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.0 GO:0003796 lysozyme activity(GO:0003796)
0.0 2.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 2.9 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.0 GO:0070330 aromatase activity(GO:0070330)
0.0 1.8 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0045159 myosin II binding(GO:0045159)
0.0 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 1.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.5 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.7 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0032183 SUMO binding(GO:0032183)
0.0 0.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 2.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.0 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.0 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 1.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.7 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 2.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 2.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.9 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)