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Illumina Body Map 2, young vs old

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Results for IKZF2

Z-value: 0.15

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Transcription factors associated with IKZF2

Gene Symbol Gene ID Gene Info
IKZF2
ENSG00000030419.12 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v2_chr2_-_214014959_2140150580.364.4e-02Click!

Activity profile of IKZF2 motif

Sorted Z-values of IKZF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_71532207 6.36 ENST00000543780.1
ENST00000391614.3
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71532601 6.34 ENST00000510614.1
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71532339 5.68 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr14_-_106552755 4.17 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr4_+_68424434 4.02 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr5_+_35852797 3.51 ENST00000508941.1
IL7R
interleukin 7 receptor
chr12_-_122240792 3.43 ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
ENST00000541657.1
AC084018.1
RHOF
AC084018.1
ras homolog family member F (in filopodia)
chr14_-_106926724 3.35 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr14_-_106668095 3.25 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr14_-_107114267 3.18 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr12_-_68845165 3.01 ENST00000360485.3
ENST00000441255.2
RP11-81H14.2
RP11-81H14.2
chr15_-_20193370 2.85 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr3_-_161089289 2.82 ENST00000497137.1
SPTSSB
serine palmitoyltransferase, small subunit B
chr17_-_46262541 2.68 ENST00000579336.1
SKAP1
src kinase associated phosphoprotein 1
chr2_+_98330009 2.65 ENST00000264972.5
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr1_+_171217622 2.48 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr14_-_106610852 2.47 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr5_-_34043310 2.38 ENST00000231338.7
C1QTNF3
C1q and tumor necrosis factor related protein 3
chr1_+_171217677 2.37 ENST00000402921.2
FMO1
flavin containing monooxygenase 1
chr4_-_109088940 2.35 ENST00000438313.2
LEF1
lymphoid enhancer-binding factor 1
chr12_-_68845417 2.28 ENST00000542875.1
RP11-81H14.2
RP11-81H14.2
chr16_-_33647696 2.18 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr22_+_40297079 2.17 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr11_+_58938903 2.15 ENST00000532982.1
DTX4
deltex homolog 4 (Drosophila)
chr1_-_47655686 2.14 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr21_-_34185944 2.09 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chrX_+_135730297 2.06 ENST00000370629.2
CD40LG
CD40 ligand
chr5_-_111091948 2.01 ENST00000447165.2
NREP
neuronal regeneration related protein
chr1_+_101185290 1.99 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
VCAM1
vascular cell adhesion molecule 1
chr2_+_114163945 1.97 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr2_-_190044480 1.91 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chrX_+_135730373 1.88 ENST00000370628.2
CD40LG
CD40 ligand
chr7_-_142139783 1.87 ENST00000390374.3
TRBV7-6
T cell receptor beta variable 7-6
chrX_-_45629661 1.87 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
RP6-99M1.2
chr1_+_209941942 1.84 ENST00000487271.1
ENST00000477431.1
TRAF3IP3
TRAF3 interacting protein 3
chr11_+_71903169 1.79 ENST00000393676.3
FOLR1
folate receptor 1 (adult)
chr14_+_91709279 1.78 ENST00000554096.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr7_-_142099977 1.73 ENST00000390359.3
TRBV7-8
T cell receptor beta variable 7-8
chr1_+_9711781 1.72 ENST00000536656.1
ENST00000377346.4
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr14_+_91709103 1.70 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr7_-_16505440 1.69 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr14_+_64932210 1.65 ENST00000394718.4
AKAP5
A kinase (PRKA) anchor protein 5
chr2_+_7865923 1.64 ENST00000417930.1
AC092580.4
AC092580.4
chr3_-_183273477 1.62 ENST00000341319.3
KLHL6
kelch-like family member 6
chr1_-_206306107 1.57 ENST00000436158.1
ENST00000455672.1
RP11-38J22.6
RP11-38J22.6
chr3_+_238273 1.54 ENST00000256509.2
CHL1
cell adhesion molecule L1-like
chr20_+_58179582 1.53 ENST00000371015.1
ENST00000395639.4
PHACTR3
phosphatase and actin regulator 3
chr2_+_204801471 1.51 ENST00000316386.6
ENST00000435193.1
ICOS
inducible T-cell co-stimulator
chr7_-_127672146 1.49 ENST00000476782.1
LRRC4
leucine rich repeat containing 4
chr17_-_46688334 1.48 ENST00000239165.7
HOXB7
homeobox B7
chr4_-_114900831 1.47 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr6_-_31846744 1.46 ENST00000414427.1
ENST00000229729.6
ENST00000375562.4
SLC44A4
solute carrier family 44, member 4
chr3_+_177159744 1.45 ENST00000439009.1
LINC00578
long intergenic non-protein coding RNA 578
chr2_+_177028805 1.45 ENST00000249440.3
HOXD3
homeobox D3
chr14_+_22748980 1.43 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr8_+_80523321 1.42 ENST00000518111.1
STMN2
stathmin-like 2
chr3_+_46395219 1.42 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr12_+_116985896 1.41 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr21_+_26934165 1.40 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr11_-_104893863 1.40 ENST00000260315.3
ENST00000526056.1
ENST00000531367.1
ENST00000456094.1
ENST00000444749.2
ENST00000393141.2
ENST00000418434.1
ENST00000393139.2
CASP5
caspase 5, apoptosis-related cysteine peptidase
chr6_-_159466136 1.40 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr17_+_7792101 1.39 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr5_+_140180635 1.38 ENST00000522353.2
ENST00000532566.2
PCDHA3
protocadherin alpha 3
chr9_-_73483926 1.38 ENST00000396283.1
ENST00000361823.5
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_-_6580094 1.36 ENST00000361716.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr5_+_92919043 1.36 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr3_-_27764190 1.35 ENST00000537516.1
EOMES
eomesodermin
chr3_-_112329110 1.34 ENST00000479368.1
CCDC80
coiled-coil domain containing 80
chr13_-_30160925 1.32 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr2_-_85637459 1.31 ENST00000409921.1
CAPG
capping protein (actin filament), gelsolin-like
chr4_-_87278857 1.31 ENST00000509464.1
ENST00000511167.1
MAPK10
mitogen-activated protein kinase 10
chr7_-_127671674 1.30 ENST00000478726.1
LRRC4
leucine rich repeat containing 4
chr12_+_93130311 1.30 ENST00000344636.3
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr6_+_27107053 1.29 ENST00000354348.2
HIST1H4I
histone cluster 1, H4i
chr11_-_75017734 1.29 ENST00000532525.1
ARRB1
arrestin, beta 1
chr11_+_61522844 1.29 ENST00000265460.5
MYRF
myelin regulatory factor
chr12_+_50690489 1.27 ENST00000598429.1
AC140061.12
Uncharacterized protein
chr14_-_60337684 1.25 ENST00000267484.5
RTN1
reticulon 1
chr3_+_177159695 1.24 ENST00000442937.1
LINC00578
long intergenic non-protein coding RNA 578
chr6_-_159466042 1.24 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr15_-_55541227 1.23 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr6_-_41715128 1.21 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chr6_+_106546808 1.21 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr6_+_31638156 1.21 ENST00000409525.1
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr12_-_109025849 1.21 ENST00000228463.6
SELPLG
selectin P ligand
chr9_-_117692697 1.21 ENST00000223795.2
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr9_-_16705069 1.20 ENST00000471301.2
BNC2
basonuclin 2
chr21_+_39628852 1.20 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_-_42947121 1.18 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr1_+_158801095 1.16 ENST00000368141.4
MNDA
myeloid cell nuclear differentiation antigen
chr21_-_15918618 1.16 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_24009879 1.16 ENST00000354585.4
RPSAP58
ribosomal protein SA pseudogene 58
chrX_+_73164149 1.14 ENST00000602938.1
ENST00000602294.1
ENST00000602920.1
ENST00000602737.1
ENST00000602772.1
JPX
JPX transcript, XIST activator (non-protein coding)
chr17_+_35294075 1.14 ENST00000254457.5
LHX1
LIM homeobox 1
chr11_-_33891362 1.13 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr19_-_47290535 1.13 ENST00000412532.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr15_+_81299370 1.12 ENST00000560091.1
C15orf26
chromosome 15 open reading frame 26
chr11_-_67141090 1.12 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr3_+_238427 1.10 ENST00000397491.2
CHL1
cell adhesion molecule L1-like
chr22_+_40297105 1.10 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr15_+_81475047 1.09 ENST00000559388.1
IL16
interleukin 16
chr1_-_169599314 1.08 ENST00000367786.2
ENST00000458599.2
ENST00000367795.2
ENST00000263686.6
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr9_+_26746951 1.08 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chrX_+_78003204 1.08 ENST00000435339.3
ENST00000514744.1
LPAR4
lysophosphatidic acid receptor 4
chr9_-_3469181 1.07 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr6_+_167536230 1.07 ENST00000341935.5
ENST00000349984.4
CCR6
chemokine (C-C motif) receptor 6
chr8_-_23282820 1.06 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr17_-_48785216 1.06 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr11_+_122526383 1.06 ENST00000284273.5
UBASH3B
ubiquitin associated and SH3 domain containing B
chr1_-_169599353 1.05 ENST00000367793.2
ENST00000367794.2
ENST00000367792.2
ENST00000367791.2
ENST00000367788.2
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr1_-_242612779 1.03 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr6_+_106534192 1.02 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr13_-_99959641 1.01 ENST00000376414.4
GPR183
G protein-coupled receptor 183
chr6_+_31637944 1.01 ENST00000375864.4
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr1_+_174933899 1.01 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_121740969 1.00 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1
immunoglobulin-like domain containing receptor 1
chrX_-_100662881 1.00 ENST00000218516.3
GLA
galactosidase, alpha
chr6_+_147830063 1.00 ENST00000367474.1
SAMD5
sterile alpha motif domain containing 5
chr4_-_123377880 1.00 ENST00000226730.4
IL2
interleukin 2
chr15_-_66545995 0.99 ENST00000395614.1
ENST00000288745.3
ENST00000422354.1
ENST00000395625.2
ENST00000360698.4
ENST00000409699.2
MEGF11
multiple EGF-like-domains 11
chr2_+_232135245 0.98 ENST00000446447.1
ARMC9
armadillo repeat containing 9
chr21_+_39628780 0.98 ENST00000417042.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr9_+_132099158 0.98 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chrX_-_133119476 0.98 ENST00000543339.1
GPC3
glypican 3
chr4_-_74486217 0.98 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr16_+_81272287 0.97 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr2_+_27301435 0.97 ENST00000380320.4
EMILIN1
elastin microfibril interfacer 1
chr6_-_160679905 0.95 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr16_+_50313426 0.95 ENST00000569265.1
ADCY7
adenylate cyclase 7
chrX_+_123097014 0.95 ENST00000394478.1
STAG2
stromal antigen 2
chr3_+_118905564 0.95 ENST00000460625.1
UPK1B
uroplakin 1B
chr6_-_112081113 0.93 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chr19_-_41859814 0.93 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr17_-_26127525 0.92 ENST00000313735.6
NOS2
nitric oxide synthase 2, inducible
chr15_-_90358048 0.91 ENST00000300060.6
ENST00000560137.1
ANPEP
alanyl (membrane) aminopeptidase
chr4_+_158141899 0.91 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr2_-_134326009 0.91 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr6_-_11779403 0.91 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr14_-_52436247 0.90 ENST00000597846.1
AL358333.1
HCG2013195; Uncharacterized protein
chrX_+_73164167 0.90 ENST00000414209.1
ENST00000602895.1
ENST00000453317.1
ENST00000602546.1
ENST00000602985.1
ENST00000415215.1
JPX
JPX transcript, XIST activator (non-protein coding)
chr4_-_74486347 0.90 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr8_-_82024290 0.90 ENST00000220597.4
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr6_+_33388013 0.88 ENST00000449372.2
SYNGAP1
synaptic Ras GTPase activating protein 1
chr11_-_15643937 0.88 ENST00000533082.1
RP11-531H8.2
RP11-531H8.2
chr2_-_237416071 0.88 ENST00000309507.5
ENST00000431676.2
IQCA1
IQ motif containing with AAA domain 1
chr1_+_111888890 0.87 ENST00000369738.4
PIFO
primary cilia formation
chr8_+_80523962 0.86 ENST00000518491.1
STMN2
stathmin-like 2
chr3_+_46395579 0.85 ENST00000421659.1
CCR2
chemokine (C-C motif) receptor 2
chr4_+_158141843 0.85 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chrX_+_133507389 0.84 ENST00000370800.4
PHF6
PHD finger protein 6
chr13_-_46756351 0.84 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_10068095 0.84 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr20_+_42574317 0.84 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr12_-_123921256 0.83 ENST00000280571.8
RILPL2
Rab interacting lysosomal protein-like 2
chr6_+_21593972 0.80 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr12_-_50677255 0.80 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr11_-_67141640 0.80 ENST00000533438.1
CLCF1
cardiotrophin-like cytokine factor 1
chr3_+_178276488 0.80 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_+_158979792 0.79 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr6_+_106988986 0.78 ENST00000457437.1
ENST00000535438.1
AIM1
absent in melanoma 1
chr4_+_158141806 0.78 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr20_-_3996036 0.78 ENST00000336095.6
RNF24
ring finger protein 24
chr8_-_133637624 0.77 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr6_+_26365387 0.77 ENST00000532865.1
ENST00000530653.1
ENST00000527417.1
BTN3A2
butyrophilin, subfamily 3, member A2
chr8_-_134114721 0.77 ENST00000522119.1
ENST00000523610.1
ENST00000521302.1
ENST00000519558.1
ENST00000519747.1
ENST00000517648.1
SLA
Src-like-adaptor
chr6_-_152639479 0.77 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_149539053 0.77 ENST00000451095.1
RP1-111D6.3
RP1-111D6.3
chr17_-_56082455 0.77 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr4_-_185303418 0.76 ENST00000610223.1
ENST00000608785.1
RP11-290F5.1
RP11-290F5.1
chrX_-_15683147 0.76 ENST00000380342.3
TMEM27
transmembrane protein 27
chr6_+_26365443 0.76 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr8_-_16043780 0.76 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr13_+_58206655 0.76 ENST00000377918.3
PCDH17
protocadherin 17
chr3_+_193853927 0.75 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr4_+_96012585 0.75 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr8_+_26240414 0.75 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr1_+_36038971 0.75 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr7_-_122840015 0.75 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr1_+_158979686 0.74 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr18_-_35145728 0.74 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr8_+_104831554 0.74 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr4_-_185776854 0.73 ENST00000511703.1
RP11-701P16.5
RP11-701P16.5
chr18_-_5540384 0.73 ENST00000584670.1
ENST00000582703.1
ENST00000580179.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr13_+_20268547 0.73 ENST00000601204.1
AL354808.2
AL354808.2
chr3_+_178525080 0.72 ENST00000358316.3
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_+_158979680 0.72 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr17_+_55055466 0.71 ENST00000262288.3
ENST00000572710.1
ENST00000575395.1
SCPEP1
serine carboxypeptidase 1
chr6_+_13925318 0.71 ENST00000423553.2
ENST00000537388.1
RNF182
ring finger protein 182
chr10_+_119302508 0.71 ENST00000442245.4
EMX2
empty spiracles homeobox 2
chr7_-_138482933 0.71 ENST00000310018.2
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr2_-_158182322 0.70 ENST00000420719.2
ENST00000409216.1
ERMN
ermin, ERM-like protein
chr4_-_11431389 0.70 ENST00000002596.5
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr20_+_15177480 0.70 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr7_-_138482849 0.70 ENST00000353492.4
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr11_+_65383227 0.69 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr15_-_34880646 0.69 ENST00000543376.1
GOLGA8A
golgin A8 family, member A
chr7_-_111424506 0.69 ENST00000450156.1
ENST00000494651.2
DOCK4
dedicator of cytokinesis 4
chr13_+_49551020 0.68 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr14_+_22988947 0.68 ENST00000390513.1
TRAJ24
T cell receptor alpha joining 24
chr19_+_18496957 0.68 ENST00000252809.3
GDF15
growth differentiation factor 15

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:1903980 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) positive regulation of microglial cell activation(GO:1903980)
1.1 3.3 GO:2000458 astrocyte chemotaxis(GO:0035700) regulation of astrocyte chemotaxis(GO:2000458)
0.7 2.2 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.6 1.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.6 1.8 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.6 2.3 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.5 4.9 GO:0070995 NADPH oxidation(GO:0070995)
0.5 1.5 GO:0048925 lateral line system development(GO:0048925)
0.5 1.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.4 2.6 GO:0043366 beta selection(GO:0043366)
0.4 0.4 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.4 1.6 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.4 1.2 GO:0035508 positive regulation of myosin-light-chain-phosphatase activity(GO:0035508)
0.4 1.1 GO:2000742 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.4 2.8 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.3 0.7 GO:1903979 negative regulation of microglial cell activation(GO:1903979)
0.3 1.7 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.3 2.4 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.3 0.9 GO:0044416 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.3 1.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.3 1.7 GO:0060374 positive regulation of neutrophil apoptotic process(GO:0033031) mast cell differentiation(GO:0060374)
0.3 2.0 GO:0022614 membrane to membrane docking(GO:0022614)
0.3 1.1 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.3 2.7 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.3 1.1 GO:0018277 protein deamination(GO:0018277)
0.3 1.0 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.3 0.8 GO:1990709 presynaptic active zone organization(GO:1990709)
0.2 1.0 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 3.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2 0.7 GO:0043132 NAD transport(GO:0043132)
0.2 0.9 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 1.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.2 1.9 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.2 0.8 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 1.2 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 1.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 14.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 1.2 GO:0043316 cytotoxic T cell degranulation(GO:0043316) positive regulation of constitutive secretory pathway(GO:1903435)
0.2 1.4 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.1 1.3 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 1.0 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 0.4 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 1.5 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.8 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.5 GO:0002572 pro-T cell differentiation(GO:0002572) regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1 2.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.5 GO:0090678 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 3.8 GO:0051023 regulation of immunoglobulin secretion(GO:0051023)
0.1 1.0 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 1.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 1.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 2.7 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.1 1.8 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.8 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 1.4 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.8 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.7 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 1.0 GO:0016139 glycoside catabolic process(GO:0016139) glycosylceramide catabolic process(GO:0046477)
0.1 2.1 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.2 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 0.7 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.7 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.8 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of grooming behavior(GO:2000821)
0.1 0.9 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.2 GO:0061055 myotome development(GO:0061055)
0.1 0.6 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.9 GO:1901374 acetate ester transport(GO:1901374)
0.1 0.4 GO:0035962 response to interleukin-13(GO:0035962)
0.1 0.2 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.9 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.1 1.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.9 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 1.1 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.1 1.7 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.3 GO:0003409 optic cup structural organization(GO:0003409)
0.1 2.3 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.4 GO:0006710 androgen catabolic process(GO:0006710)
0.1 0.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.2 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 0.4 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1 2.6 GO:0035640 exploration behavior(GO:0035640)
0.1 1.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.4 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.1 1.9 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 1.0 GO:0002517 T cell tolerance induction(GO:0002517)
0.1 0.2 GO:0071529 cementum mineralization(GO:0071529)
0.1 1.5 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 0.7 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.6 GO:0002467 germinal center formation(GO:0002467)
0.1 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.2 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.7 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.8 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.9 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 5.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.8 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 1.7 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 1.2 GO:0043586 tongue development(GO:0043586)
0.0 2.8 GO:0010107 potassium ion import(GO:0010107)
0.0 1.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.4 GO:0033504 floor plate development(GO:0033504)
0.0 0.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.9 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.7 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 4.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.2 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.0 0.7 GO:0090179 eyelid development in camera-type eye(GO:0061029) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.7 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.3 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.5 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.3 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0 1.5 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.8 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.7 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.6 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.7 GO:0006023 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0 0.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.9 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.3 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 2.6 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.3 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0 4.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.1 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.4 GO:0060347 heart trabecula formation(GO:0060347)
0.0 0.8 GO:0031529 ruffle organization(GO:0031529)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.3 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.3 GO:0003016 respiratory system process(GO:0003016)
0.0 1.4 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.3 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.5 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 0.2 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.6 1.9 GO:0005588 collagen type V trimer(GO:0005588)
0.4 1.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.4 2.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.3 15.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 0.7 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.2 2.8 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 1.4 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.2 1.0 GO:0097149 centralspindlin complex(GO:0097149)
0.2 2.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 1.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 5.3 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.4 GO:0005595 collagen type XII trimer(GO:0005595)
0.1 2.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 1.0 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.4 GO:0036398 TCR signalosome(GO:0036398)
0.1 1.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.6 GO:0008091 spectrin(GO:0008091)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.8 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.7 GO:0033269 internode region of axon(GO:0033269)
0.0 1.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 1.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 1.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.7 GO:0032059 bleb(GO:0032059)
0.0 1.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 8.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0071953 elastic fiber(GO:0071953)
0.0 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 1.7 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 1.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 2.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 0.5 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0005174 CD40 receptor binding(GO:0005174)
0.9 3.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.5 4.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.5 4.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.5 2.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.4 1.8 GO:0061714 folic acid receptor activity(GO:0061714)
0.4 1.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 3.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.4 2.8 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.3 1.0 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.3 1.0 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.3 1.1 GO:0030305 heparanase activity(GO:0030305)
0.2 1.0 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.2 0.9 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.2 15.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 1.7 GO:0098821 BMP receptor activity(GO:0098821)
0.2 1.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.2 0.8 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 1.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 1.5 GO:0045118 azole transporter activity(GO:0045118)
0.2 1.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 0.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.0 GO:0016936 galactoside binding(GO:0016936)
0.1 1.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.7 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 2.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.5 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.1 1.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 1.6 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 1.6 GO:0042731 PH domain binding(GO:0042731)
0.1 0.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 1.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.9 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.9 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 1.1 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 2.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.7 GO:0042835 BRE binding(GO:0042835)
0.1 0.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 7.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 3.9 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.4 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 1.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.3 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 1.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.7 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.1 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.5 GO:0035500 MH2 domain binding(GO:0035500)
0.0 1.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 2.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 1.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.5 GO:0005521 lamin binding(GO:0005521)
0.0 1.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0000150 recombinase activity(GO:0000150)
0.0 1.2 GO:0031489 myosin V binding(GO:0031489)
0.0 1.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.4 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 1.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.3 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 2.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.4 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.9 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.7 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.3 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 1.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 4.2 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.5 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 0.5 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 1.0 GO:0002020 protease binding(GO:0002020)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0005503 all-trans retinal binding(GO:0005503)
0.0 1.9 GO:0046332 SMAD binding(GO:0046332)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 6.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 6.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 2.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 3.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 3.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 3.7 PID FOXO PATHWAY FoxO family signaling
0.0 2.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 2.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.7 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 4.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 3.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.3 PID AURORA B PATHWAY Aurora B signaling
0.0 1.0 PID ATM PATHWAY ATM pathway
0.0 4.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 3.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.8 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 3.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 4.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.5 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.4 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 6.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.8 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0 1.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 2.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 3.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.6 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 3.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 6.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.5 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.0 0.2 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.2 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint