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Illumina Body Map 2, young vs old

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Results for ISL1

Z-value: 0.06

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ENSG00000016082.10 ISL LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_506789210.485.4e-03Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_168155169 3.09 ENST00000534949.1
ENST00000535728.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_-_50290839 2.89 ENST00000552863.1
Fas apoptotic inhibitory molecule 2
chr14_+_62462541 2.66 ENST00000430451.2
synaptotagmin XVI
chr14_+_62585332 2.52 ENST00000554895.1
long intergenic non-protein coding RNA 643
chr12_-_87232644 2.29 ENST00000549405.2
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_224467093 2.28 ENST00000305409.2
secretogranin II
chr5_+_140593509 2.13 ENST00000341948.4
protocadherin beta 13
chr1_-_114430169 2.13 ENST00000393316.3
BCL2-like 15
chr2_-_175711133 2.01 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr12_+_79439461 1.93 ENST00000552624.1
synaptotagmin I
chr18_-_40857493 1.92 ENST00000255224.3
synaptotagmin IV
chr9_+_34957477 1.89 ENST00000544237.1
KIAA1045
chr7_-_123673471 1.80 ENST00000455783.1
transmembrane protein 229A
chr5_+_137203557 1.79 ENST00000515645.1
myotilin
chr2_-_217560248 1.75 ENST00000233813.4
insulin-like growth factor binding protein 5
chr3_-_192445289 1.71 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
fibroblast growth factor 12
chr8_+_70404996 1.64 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chrX_-_15619076 1.62 ENST00000252519.3
angiotensin I converting enzyme 2
chrX_-_92928557 1.60 ENST00000373079.3
ENST00000475430.2
nucleosome assembly protein 1-like 3
chr16_-_52119019 1.59 ENST00000561513.1
ENST00000565742.1
long intergenic non-protein coding RNA 919
chrX_-_71526999 1.58 ENST00000453707.2
ENST00000373619.3
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr17_+_67957878 1.52 ENST00000420427.1
AC004562.1
chr5_+_137203465 1.51 ENST00000239926.4
myotilin
chr18_+_616672 1.50 ENST00000338387.7
clusterin-like 1 (retinal)
chr7_-_107880508 1.50 ENST00000425651.2
neuronal cell adhesion molecule
chrX_+_65382433 1.50 ENST00000374727.3
hephaestin
chr12_+_79357815 1.50 ENST00000547046.1
synaptotagmin I
chr2_-_224467002 1.48 ENST00000421386.1
ENST00000433889.1
secretogranin II
chr2_+_166152283 1.45 ENST00000375427.2
sodium channel, voltage-gated, type II, alpha subunit
chr4_-_176923483 1.42 ENST00000280187.7
ENST00000512509.1
glycoprotein M6A
chr7_+_103969104 1.42 ENST00000424859.1
ENST00000535008.1
ENST00000401970.2
ENST00000543266.1
lipoma HMGIC fusion partner-like 3
chr3_+_35721106 1.42 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
cAMP-regulated phosphoprotein, 21kDa
chr4_+_113970772 1.38 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr19_-_22806764 1.37 ENST00000598042.1
AC011516.2
chr4_-_87281196 1.37 ENST00000359221.3
mitogen-activated protein kinase 10
chr17_+_67957848 1.37 ENST00000455460.1
AC004562.1
chr7_-_81635106 1.35 ENST00000443883.1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr4_+_123300121 1.33 ENST00000446706.1
ENST00000296513.2
adenosine deaminase domain containing 1 (testis-specific)
chr11_-_107729287 1.32 ENST00000375682.4
solute carrier family 35, member F2
chr5_+_169659950 1.31 ENST00000593851.1
chromosome 5 open reading frame 58
chr18_+_616711 1.31 ENST00000579494.1
clusterin-like 1 (retinal)
chr11_-_107729504 1.30 ENST00000265836.7
solute carrier family 35, member F2
chr5_+_137203541 1.30 ENST00000421631.2
myotilin
chr4_-_87281224 1.29 ENST00000395169.3
ENST00000395161.2
mitogen-activated protein kinase 10
chr18_+_55018044 1.23 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr8_+_35092959 1.21 ENST00000404895.2
unc-5 homolog D (C. elegans)
chr3_-_107596910 1.21 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
long intergenic non-protein coding RNA 635
chr9_+_37667978 1.20 ENST00000539465.1
FERM and PDZ domain containing 1
chr15_+_48498480 1.20 ENST00000380993.3
ENST00000396577.3
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr20_-_5426332 1.19 ENST00000420529.1
long intergenic non-protein coding RNA 658
chr11_-_107729887 1.18 ENST00000525815.1
solute carrier family 35, member F2
chr2_+_207804278 1.16 ENST00000272852.3
carboxypeptidase O
chr7_+_107332334 1.16 ENST00000541474.1
ENST00000544569.1
solute carrier family 26 (anion exchanger), member 4
chr9_+_134165063 1.16 ENST00000372264.3
phosphatidic acid phosphatase type 2 domain containing 3
chr5_-_67829357 1.12 ENST00000515199.1
CTC-537E7.2
chr8_-_1922789 1.11 ENST00000521498.1
RP11-439C15.4
chr20_+_60174827 1.11 ENST00000543233.1
cadherin 4, type 1, R-cadherin (retinal)
chr6_+_42123141 1.10 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr8_-_99955042 1.09 ENST00000519420.1
serine/threonine kinase 3
chr7_-_150675372 1.08 ENST00000262186.5
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr9_+_103947311 1.08 ENST00000395056.2
Lipid phosphate phosphatase-related protein type 1
chr2_+_46706725 1.07 ENST00000434431.1
transmembrane protein 247
chrX_+_55478538 1.06 ENST00000342972.1
melanoma antigen family H, 1
chr2_-_175711978 1.06 ENST00000409089.2
chimerin 1
chr2_+_173724771 1.06 ENST00000538974.1
ENST00000540783.1
Rap guanine nucleotide exchange factor (GEF) 4
chr11_-_26744908 1.05 ENST00000533617.1
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr12_-_28124903 1.05 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
parathyroid hormone-like hormone
chrX_-_71526813 1.04 ENST00000246139.5
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chrX_+_65382381 1.02 ENST00000519389.1
hephaestin
chr11_-_40315640 1.00 ENST00000278198.2
leucine rich repeat containing 4C
chr5_+_173472744 1.00 ENST00000521585.1
Neuron-specific protein family member 2
chr4_+_169418195 1.00 ENST00000261509.6
ENST00000335742.7
palladin, cytoskeletal associated protein
chr1_-_79472365 0.98 ENST00000370742.3
EGF, latrophilin and seven transmembrane domain containing 1
chr7_-_31380502 0.96 ENST00000297142.3
neuronal differentiation 6
chr2_-_68547061 0.95 ENST00000263655.3
cannabinoid receptor interacting protein 1
chrX_-_30327495 0.95 ENST00000453287.1
nuclear receptor subfamily 0, group B, member 1
chr5_+_140772381 0.95 ENST00000398604.2
protocadherin gamma subfamily A, 8
chr5_-_88180342 0.94 ENST00000502983.1
myocyte enhancer factor 2C
chr19_-_50143452 0.93 ENST00000246792.3
related RAS viral (r-ras) oncogene homolog
chr16_-_3350614 0.92 ENST00000268674.2
tigger transposable element derived 7
chr21_-_34185989 0.90 ENST00000487113.1
ENST00000382373.4
chromosome 21 open reading frame 62
chr15_+_59903975 0.89 ENST00000560585.1
ENST00000396065.1
glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_-_66496430 0.89 ENST00000533211.1
spectrin, beta, non-erythrocytic 2
chr3_+_148508845 0.88 ENST00000491148.1
carboxypeptidase B1 (tissue)
chr19_-_17488143 0.88 ENST00000599426.1
ENST00000252590.4
plasmalemma vesicle associated protein
chr6_+_155537771 0.88 ENST00000275246.7
T-cell lymphoma invasion and metastasis 2
chr22_-_32651326 0.88 ENST00000266086.4
solute carrier family 5 (glucose activated ion channel), member 4
chr9_-_113761720 0.86 ENST00000541779.1
ENST00000374430.2
lysophosphatidic acid receptor 1
chrX_+_30261847 0.86 ENST00000378981.3
ENST00000397550.1
melanoma antigen family B, 1
chrX_-_102941596 0.85 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
mortality factor 4 like 2
chr5_+_140248518 0.85 ENST00000398640.2
protocadherin alpha 11
chr7_-_78400364 0.85 ENST00000535697.1
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_-_42878101 0.84 ENST00000552108.1
prickle homolog 1 (Drosophila)
chr22_+_40390930 0.84 ENST00000333407.6
family with sequence similarity 83, member F
chrX_-_49965663 0.84 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
A kinase (PRKA) anchor protein 4
chr16_+_76587314 0.84 ENST00000563764.1
Uncharacterized protein
chr1_+_197170592 0.83 ENST00000535699.1
crumbs homolog 1 (Drosophila)
chrX_-_138724994 0.83 ENST00000536274.1
MCF.2 cell line derived transforming sequence
chr11_-_5531215 0.82 ENST00000311659.4
ubiquilin 3
chr6_+_167704838 0.81 ENST00000366829.2
unc-93 homolog A (C. elegans)
chrX_-_117107680 0.81 ENST00000447671.2
ENST00000262820.3
kelch-like family member 13
chr4_+_169418255 0.81 ENST00000505667.1
ENST00000511948.1
palladin, cytoskeletal associated protein
chr11_-_125351481 0.80 ENST00000577924.1
fasciculation and elongation protein zeta 1 (zygin I)
chr5_-_41794313 0.80 ENST00000512084.1
3-oxoacid CoA transferase 1
chr5_-_102455801 0.80 ENST00000508629.1
ENST00000399004.2
gypsy retrotransposon integrase 1
chr4_+_88754113 0.79 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr11_-_5531159 0.78 ENST00000445998.1
ubiquilin 3
chr11_-_62783303 0.75 ENST00000336232.2
ENST00000430500.2
solute carrier family 22 (organic anion transporter), member 8
chr20_-_5426380 0.74 ENST00000609252.1
ENST00000422352.1
long intergenic non-protein coding RNA 658
chr1_-_156217875 0.74 ENST00000292291.5
progestin and adipoQ receptor family member VI
chr3_-_100712352 0.74 ENST00000471714.1
ENST00000284322.5
ABI family, member 3 (NESH) binding protein
chr17_+_35732916 0.74 ENST00000586700.1
chromosome 17 open reading frame 78
chrX_-_117119243 0.73 ENST00000539496.1
ENST00000469946.1
kelch-like family member 13
chr13_+_46276441 0.72 ENST00000310521.1
ENST00000533564.1
spermatid associated
chr2_+_172543919 0.72 ENST00000452242.1
ENST00000340296.4
dynein, cytoplasmic 1, intermediate chain 2
chrX_-_100129128 0.72 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NADPH oxidase 1
chr17_+_35732955 0.71 ENST00000300618.4
chromosome 17 open reading frame 78
chr11_-_62783276 0.71 ENST00000535878.1
ENST00000545207.1
solute carrier family 22 (organic anion transporter), member 8
chr7_-_122342988 0.71 ENST00000434824.1
ring finger protein 148
chr1_-_156217822 0.71 ENST00000368270.1
progestin and adipoQ receptor family member VI
chr8_-_133637624 0.70 ENST00000522789.1
leucine rich repeat containing 6
chr10_-_116444371 0.70 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr1_+_217804661 0.69 ENST00000366933.4
spermatogenesis associated 17
chr6_+_168418553 0.69 ENST00000354419.2
ENST00000351261.3
kinesin family member 25
chr12_+_96883347 0.68 ENST00000524981.4
ENST00000298953.3
chromosome 12 open reading frame 55
chr3_+_35685113 0.68 ENST00000419330.1
cAMP-regulated phosphoprotein, 21kDa
chr3_-_149095652 0.67 ENST00000305366.3
transmembrane 4 L six family member 1
chr21_-_42219065 0.67 ENST00000400454.1
Down syndrome cell adhesion molecule
chr3_-_138312971 0.66 ENST00000485115.1
ENST00000484888.1
ENST00000468900.1
ENST00000542237.1
ENST00000481834.1
centrosomal protein 70kDa
chr5_+_32710736 0.66 ENST00000415685.2
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr18_-_5544241 0.66 ENST00000341928.2
ENST00000540638.2
erythrocyte membrane protein band 4.1-like 3
chr3_+_35721130 0.66 ENST00000432450.1
cAMP-regulated phosphoprotein, 21kDa
chr11_-_5345582 0.66 ENST00000328813.2
olfactory receptor, family 51, subfamily B, member 2
chr3_-_121740969 0.65 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
immunoglobulin-like domain containing receptor 1
chr19_-_50666431 0.65 ENST00000293405.3
IZUMO family member 2
chr18_-_21977748 0.65 ENST00000399441.4
ENST00000319481.3
oxysterol binding protein-like 1A
chr9_-_113100088 0.64 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
thioredoxin domain containing 8 (spermatozoa)
chr11_-_64660916 0.63 ENST00000413053.1
microRNA 194-2
chr8_+_30496078 0.63 ENST00000517349.1
small integral membrane protein 18
chr5_+_55354822 0.62 ENST00000511861.1
CTD-2227I18.1
chr18_-_22804637 0.62 ENST00000577775.1
zinc finger protein 521
chr12_-_5352315 0.62 ENST00000536518.1
RP11-319E16.1
chr13_-_45768841 0.60 ENST00000379108.1
potassium channel tetramerization domain containing 4
chr5_-_138210977 0.60 ENST00000274711.6
ENST00000521094.2
leucine rich repeat transmembrane neuronal 2
chr2_+_173792893 0.59 ENST00000535187.1
Rap guanine nucleotide exchange factor (GEF) 4
chr14_+_32963433 0.59 ENST00000554410.1
A kinase (PRKA) anchor protein 6
chr20_+_61448376 0.58 ENST00000343916.3
collagen, type IX, alpha 3
chr7_+_129932974 0.58 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
carboxypeptidase A4
chr13_-_70682590 0.58 ENST00000377844.4
kelch-like family member 1
chr8_-_94179079 0.58 ENST00000521906.1
chromosome 8 open reading frame 87
chr3_-_100551141 0.58 ENST00000478235.1
ENST00000471901.1
ABI family, member 3 (NESH) binding protein
chr21_-_34186006 0.57 ENST00000490358.1
chromosome 21 open reading frame 62
chr2_+_234216454 0.57 ENST00000447536.1
ENST00000409110.1
S-antigen; retina and pineal gland (arrestin)
chr6_-_116575226 0.57 ENST00000420283.1
TSPY-like 4
chr3_-_100712292 0.57 ENST00000495063.1
ENST00000530539.1
ABI family, member 3 (NESH) binding protein
chr1_-_95391315 0.56 ENST00000545882.1
ENST00000415017.1
calponin 3, acidic
chr11_-_102668879 0.56 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr17_+_37824217 0.56 ENST00000394246.1
phenylethanolamine N-methyltransferase
chrX_+_114874727 0.55 ENST00000543070.1
plastin 3
chr14_-_92198403 0.55 ENST00000553329.1
ENST00000256343.3
catsper channel auxiliary subunit beta
chr3_-_21792838 0.54 ENST00000281523.2
zinc finger protein 385D
chr7_+_138915102 0.53 ENST00000486663.1
ubinuclein 2
chr11_-_7904464 0.53 ENST00000502624.2
ENST00000527565.1
RP11-35J10.5
chr5_+_34757309 0.52 ENST00000397449.1
retinoic acid induced 14
chr6_+_167704798 0.52 ENST00000230256.3
unc-93 homolog A (C. elegans)
chr12_+_54402790 0.52 ENST00000040584.4
homeobox C8
chr12_+_122356488 0.51 ENST00000397454.2
WD repeat domain 66
chr12_-_6484715 0.51 ENST00000228916.2
sodium channel, non-voltage-gated 1 alpha subunit
chr5_-_138211051 0.50 ENST00000518785.1
leucine rich repeat transmembrane neuronal 2
chr14_+_21566980 0.49 ENST00000418511.2
ENST00000554329.2
transmembrane protein 253
chr10_-_62332357 0.49 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_186877806 0.48 ENST00000355634.5
sorbin and SH3 domain containing 2
chr17_+_37824411 0.48 ENST00000269582.2
phenylethanolamine N-methyltransferase
chr1_-_154458520 0.47 ENST00000486773.1
Src homology 2 domain containing E
chr6_-_123958141 0.47 ENST00000334268.4
triadin
chr16_+_2198604 0.47 ENST00000210187.6
RAB26, member RAS oncogene family
chr10_-_75118611 0.45 ENST00000355577.3
ENST00000394865.1
ENST00000310715.3
ENST00000401621.2
tetratricopeptide repeat domain 18
chr7_-_122342966 0.45 ENST00000447240.1
ring finger protein 148
chr6_+_31515337 0.45 ENST00000376148.4
ENST00000376145.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chrX_-_15683147 0.45 ENST00000380342.3
transmembrane protein 27
chr5_+_102455853 0.44 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
diphosphoinositol pentakisphosphate kinase 2
chrX_+_144908928 0.44 ENST00000408967.2
transmembrane protein 257
chr4_-_9390709 0.44 ENST00000508324.1
Uncharacterized protein
chrX_-_117107542 0.44 ENST00000371878.1
kelch-like family member 13
chr5_-_63258261 0.44 ENST00000506598.1
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
chr10_+_123923205 0.43 ENST00000369004.3
ENST00000260733.3
transforming, acidic coiled-coil containing protein 2
chr6_+_149539053 0.43 ENST00000451095.1
RP1-111D6.3
chr15_+_76352178 0.43 ENST00000388942.3
chromosome 15 open reading frame 27
chr6_+_90272488 0.42 ENST00000485637.1
ENST00000522705.1
ankyrin repeat domain 6
chr3_+_38307293 0.42 ENST00000311856.4
solute carrier family 22 (organic anion/urate transporter), member 13
chr1_+_152178320 0.41 ENST00000429352.1
RP11-107M16.2
chr18_-_47721447 0.41 ENST00000285039.7
myosin VB
chr12_-_30887948 0.40 ENST00000433722.2
caprin family member 2
chrX_-_23926004 0.40 ENST00000379226.4
ENST00000379220.3
apolipoprotein O
chr12_-_87232771 0.39 ENST00000550014.1
RP11-202H2.1
chr8_+_92261516 0.39 ENST00000276609.3
ENST00000309536.2
solute carrier family 26 (anion exchanger), member 7
chr3_+_157154578 0.39 ENST00000295927.3
pentraxin 3, long
chr2_-_135805008 0.38 ENST00000414343.1
mitogen-activated protein kinase kinase kinase 19
chr1_+_100111479 0.38 ENST00000263174.4
palmdelphin
chr7_+_150811705 0.38 ENST00000335367.3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0048174 negative regulation of short-term neuronal synaptic plasticity(GO:0048174)
0.6 1.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.6 3.4 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.4 3.0 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.4 1.1 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.3 1.6 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.3 1.4 GO:0036371 protein localization to T-tubule(GO:0036371)
0.3 1.0 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.2 1.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 0.7 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.2 0.9 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.2 0.9 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.2 3.8 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.2 2.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 3.8 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.2 1.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2 0.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.4 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.2 0.8 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.2 1.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.9 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 3.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.5 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
0.1 0.8 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 1.5 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 1.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.3 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.1 1.0 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 0.7 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.1 1.2 GO:0015705 iodide transport(GO:0015705)
0.1 0.5 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.6 GO:0006825 copper ion transport(GO:0006825)
0.1 1.2 GO:0021859 pyramidal neuron differentiation(GO:0021859)
0.1 1.1 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 0.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.6 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 1.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 1.1 GO:0015074 DNA integration(GO:0015074)
0.1 0.2 GO:2000625 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.1 1.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.3 GO:0048749 compound eye development(GO:0048749)
0.1 1.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.7 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.5 GO:0070995 NADPH oxidation(GO:0070995)
0.1 3.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.3 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.1 1.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 1.9 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.4 GO:0032439 endosome localization(GO:0032439)
0.1 2.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0042407 inner mitochondrial membrane organization(GO:0007007) cristae formation(GO:0042407)
0.0 0.9 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.6 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.9 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.6 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0 0.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 2.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.9 GO:0021542 dentate gyrus development(GO:0021542)
0.0 1.8 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 1.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 1.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 1.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.9 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.6 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.3 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 1.5 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 1.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.1 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 1.0 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.6 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 2.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0032127 dense core granule membrane(GO:0032127)
0.4 3.3 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 1.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 1.8 GO:0042025 host cell nucleus(GO:0042025)
0.2 3.8 GO:0031045 dense core granule(GO:0031045)
0.2 0.5 GO:0001534 radial spoke(GO:0001534)
0.2 1.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.6 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.0 GO:0043194 axon initial segment(GO:0043194)
0.1 2.1 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.2 GO:0008091 spectrin(GO:0008091)
0.1 1.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.5 GO:0036128 CatSper complex(GO:0036128)
0.1 0.7 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.4 GO:0061617 MICOS complex(GO:0061617)
0.1 0.9 GO:0071438 invadopodium membrane(GO:0071438)
0.0 1.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.7 GO:0034706 sodium channel complex(GO:0034706)
0.0 7.1 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0045179 apical cortex(GO:0045179)
0.0 2.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0000322 storage vacuole(GO:0000322)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.9 GO:0005925 focal adhesion(GO:0005925)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 4.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.5 1.4 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.4 1.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.3 1.0 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.3 0.9 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.3 2.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.3 2.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 2.7 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 0.7 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.2 2.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.8 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.2 3.0 GO:0050693 LBD domain binding(GO:0050693)
0.2 1.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 0.9 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.2 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 0.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.6 GO:0002046 opsin binding(GO:0002046)
0.1 1.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 3.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 6.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.3 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 0.6 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 1.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.9 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.2 GO:0032093 SAM domain binding(GO:0032093)
0.1 1.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 2.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.6 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 1.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 2.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.0 1.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.6 GO:0030552 cAMP binding(GO:0030552)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.9 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 1.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.7 GO:0030276 clathrin binding(GO:0030276)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.8 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.0 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.8 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.9 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 3.4 GO:0005516 calmodulin binding(GO:0005516)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 3.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.9 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 4.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID AURORA B PATHWAY Aurora B signaling
0.0 3.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 4.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 4.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.7 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 1.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.0 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 4.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins