ISMARA results: KLF6

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Illumina Body Map 2, young vs old

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Results for KLF6

Z-value: 1.41

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Transcription factors associated with KLF6

Gene Symbol	Gene ID	Gene Info
KLF6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000067082.10	Kruppel like factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF6	hg19_v2_chr10_-_3827371_3827386	-0.14	4.5e-01	Click!

Activity profile of KLF6 motif

Sorted Z-values of KLF6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_102505468 Show fit	1.39	ENST00000361791.3 ENST00000355243.3 ENST00000428433.1 ENST00000370296.2	PAX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	paired box 2
chr2_+_105471969 Show fit	0.87	ENST00000361360.2	POU3F3 Ensembl NCBI GeneCards UniProt NextProt Show fit	POU class 3 homeobox 3
chr1_-_156051789 Show fit	0.86	ENST00000532414.2	MEX3A Ensembl NCBI GeneCards UniProt NextProt Show fit	mex-3 RNA binding family member A
chr16_+_67465016 Show fit	0.78	ENST00000326152.5	HSD11B2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hydroxysteroid (11-beta) dehydrogenase 2
chr14_+_94640633 Show fit	0.78	ENST00000304338.3	PPP4R4 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 4, regulatory subunit 4
chr11_+_94706804 Show fit	0.77	ENST00000335080.5	KDM4D Ensembl NCBI GeneCards UniProt NextProt Show fit	lysine (K)-specific demethylase 4D
chr20_+_31350184 Show fit	0.76	ENST00000328111.2 ENST00000353855.2 ENST00000348286.2	DNMT3B Ensembl NCBI GeneCards UniProt NextProt Show fit	DNA (cytosine-5-)-methyltransferase 3 beta
chr17_+_40932610 Show fit	0.74	ENST00000246914.5	WNK4 Ensembl NCBI GeneCards UniProt NextProt Show fit	WNK lysine deficient protein kinase 4
chr2_-_219925189 Show fit	0.72	ENST00000295731.6	IHH Ensembl NCBI GeneCards UniProt NextProt Show fit	indian hedgehog
chr1_+_169075554 Show fit	0.69	ENST00000367815.4	ATP1B1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, Na+/K+ transporting, beta 1 polypeptide

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1	1.6	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2	1.5	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.5	1.4	GO:0035566	regulation of metanephros size(GO:0035566)
0.0	1.3	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3	1.2	GO:0051796	regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.2	0.9	GO:0072240	DCT cell differentiation(GO:0072069) metanephric DCT cell differentiation(GO:0072240)
0.0	0.9	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.2	0.7	GO:0016539	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1	0.7	GO:0035426	extracellular matrix-cell signaling(GO:0035426)

Showing 1 to 10 of 159 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	GO:0031209	SCAR complex(GO:0031209)
0.0	1.7	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	1.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	1.2	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.8	GO:0034451	centriolar satellite(GO:0034451)
0.1	0.7	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.7	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	0.5	GO:0005960	glycine cleavage complex(GO:0005960)
0.0	0.5	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.5	GO:0030660	Golgi-associated vesicle membrane(GO:0030660)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.5	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	1.4	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	1.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.9	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.9	GO:0071837	HMG box domain binding(GO:0071837)
0.3	0.8	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2	0.8	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1	0.8	GO:0043237	laminin-1 binding(GO:0043237)
0.1	0.8	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.5	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
1.4	PID AR TF PATHWAY	Regulation of Androgen receptor activity
1.0	PID AURORA A PATHWAY	Aurora A signaling
0.8	PID EPHA FWDPATHWAY	EPHA forward signaling
0.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.6	PID REELIN PATHWAY	Reelin signaling pathway
0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
1.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.7	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.7	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.6	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling

Showing 1 to 10 of 18 entries

Results for KLF6

Z-value: 1.41

Motif logo

Transcription factors associated with KLF6

Activity-expression correlation:

Activity profile of KLF6 motif

Sorted Z-values of KLF6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: