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Illumina Body Map 2, young vs old

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Results for KLF7

Z-value: 0.13

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208031943_208031991-0.494.4e-03Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_186353756 2.33 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr1_-_19229014 2.08 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr1_-_19229248 2.01 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr1_-_19229218 1.82 ENST00000432718.1
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr16_+_20499024 1.67 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr6_+_31865552 1.58 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr1_-_21948906 1.46 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr8_-_6837602 1.44 ENST00000382692.2
DEFA1
defensin, alpha 1
chr8_-_6875778 1.35 ENST00000535841.1
ENST00000327857.2
DEFA1B
DEFA3
defensin, alpha 1B
defensin, alpha 3, neutrophil-specific
chr11_+_18417948 0.78 ENST00000542179.1
LDHA
lactate dehydrogenase A
chr15_+_96873921 0.77 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr2_-_188430478 0.62 ENST00000421427.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr16_+_31539183 0.61 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr16_-_65268795 0.61 ENST00000565901.1
ENST00000567058.1
RP11-256I9.2
RP11-256I9.2
chr14_+_38660185 0.54 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr18_+_72166564 0.54 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_+_41476327 0.52 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr6_+_30585486 0.51 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr8_+_115294296 0.44 ENST00000521523.1
ENST00000523682.1
ENST00000507929.2
ENST00000520543.1
ENST00000519248.1
RP11-267L5.1
RP11-267L5.1
chr3_+_105085734 0.40 ENST00000306107.5
ALCAM
activated leukocyte cell adhesion molecule
chr3_-_178865747 0.34 ENST00000435560.1
RP11-360P21.2
RP11-360P21.2
chr16_+_31539197 0.33 ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr13_-_108867101 0.32 ENST00000356922.4
LIG4
ligase IV, DNA, ATP-dependent
chr1_-_6453426 0.32 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr1_-_6453399 0.30 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr12_-_49581152 0.29 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr7_-_47492782 0.29 ENST00000413551.1
TNS3
tensin 3
chr19_+_39390587 0.24 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_+_73008755 0.23 ENST00000584208.1
ENST00000301585.5
ICT1
immature colon carcinoma transcript 1
chr3_-_33138624 0.22 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr6_-_109703634 0.22 ENST00000324953.5
ENST00000310786.4
ENST00000275080.7
ENST00000413644.2
CD164
CD164 molecule, sialomucin
chr5_+_141348598 0.21 ENST00000394520.2
ENST00000347642.3
RNF14
ring finger protein 14
chr19_-_14629224 0.20 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr9_+_130565147 0.19 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr8_+_72587535 0.19 ENST00000519840.1
ENST00000521131.1
RP11-1144P22.1
RP11-1144P22.1
chr5_+_141348721 0.19 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr2_+_74710194 0.18 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr6_-_33239612 0.17 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr19_+_7694623 0.16 ENST00000594797.1
ENST00000456958.3
ENST00000601406.1
PET100
PET100 homolog (S. cerevisiae)
chr6_-_109703600 0.16 ENST00000512821.1
CD164
CD164 molecule, sialomucin
chr6_-_33239712 0.16 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr6_-_109703663 0.15 ENST00000368961.5
CD164
CD164 molecule, sialomucin
chr9_+_130565568 0.12 ENST00000423577.1
FPGS
folylpolyglutamate synthase
chr6_+_43603552 0.12 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr19_-_40931891 0.11 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr16_+_81772633 0.11 ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
ENST00000565054.1
RP11-960L18.1
PLCG2
RP11-960L18.1
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_+_87380299 0.10 ENST00000370551.4
ENST00000370550.5
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr5_+_173315283 0.10 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr19_+_39390320 0.10 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr22_-_30987837 0.09 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr9_+_130565487 0.08 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr12_-_49582593 0.06 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr3_+_183817967 0.06 ENST00000335304.2
ENST00000431041.1
ENST00000436361.2
ENST00000440596.2
HTR3E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
chr8_+_17104539 0.05 ENST00000521829.1
ENST00000521005.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr3_+_178866199 0.04 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr22_-_30987849 0.04 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr2_-_61765732 0.03 ENST00000443240.1
ENST00000436018.1
XPO1
exportin 1 (CRM1 homolog, yeast)
chr19_-_39390350 0.03 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr17_-_18218270 0.03 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr15_+_26147507 0.02 ENST00000383019.2
ENST00000557171.1
RP11-1084I9.1
RP11-1084I9.1
chr17_-_48277552 0.02 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chrX_+_102631844 0.02 ENST00000372634.1
ENST00000299872.7
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr19_+_58011258 0.02 ENST00000593916.1
ENST00000598770.1
ENST00000599847.1
ENST00000282292.4
ZNF773
zinc finger protein 773
chr1_-_21503337 0.02 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_+_67624430 0.00 ENST00000272342.5
ETAA1
Ewing tumor-associated antigen 1
chr2_-_74710078 0.00 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr6_-_30585009 0.00 ENST00000376511.2
PPP1R10
protein phosphatase 1, regulatory subunit 10

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.9 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.5 1.5 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
0.4 1.4 GO:0035915 pore formation in membrane of other organism(GO:0035915)
0.2 0.8 GO:0009956 radial pattern formation(GO:0009956)
0.2 0.6 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.4 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.3 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.3 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.1 1.6 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.6 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 1.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.2 GO:0051413 response to cortisone(GO:0051413)
0.0 2.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.9 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.0 0.8 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0002316 follicular B cell differentiation(GO:0002316)
0.0 0.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990745 EARP complex(GO:1990745)
0.1 0.9 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 3.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.2 0.9 GO:0030492 hemoglobin binding(GO:0030492)
0.1 0.4 GO:0008841 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.1 0.5 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.1 0.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.8 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 2.8 REACTOME DEFENSINS Genes involved in Defensins
0.0 1.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 6.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.6 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation