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Illumina Body Map 2, young vs old
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Results for MAFB
Z-value: 2.46
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Transcription factors associated with MAFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFB | hg19_v2_chr20_-_39317868_39317884 | -0.00 | 9.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 12.1 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 0.4 | 10.6 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.0 | 7.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 7.6 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.9 | 7.2 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.6 | 7.0 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.3 | 6.4 | GO:0006500 | N-terminal protein palmitoylation(GO:0006500) |
| 0.3 | 6.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 1.5 | 6.1 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.3 | 14.8 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.3 | 13.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.3 | 13.0 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 12.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 12.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 11.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 11.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 10.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.4 | 9.1 | GO:0061202 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 22.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 20.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 12.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 10.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 9.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 9.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 8.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.3 | 8.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 8.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 7.4 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 10.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 8.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 7.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 6.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 6.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 6.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 5.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.2 | 5.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 5.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 13.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 10.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 10.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 9.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 9.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 8.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 8.5 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 7.3 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 6.9 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |